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Determination of Common Targets of Metal Complexes that Induce Programmed Cell Death of Cancer Cells and Development of New Anticancer Drugs

Research Project

Project/Area Number 20K05712
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 37010:Bio-related chemistry
Research InstitutionTokyo University of Science

Principal Investigator

Aoki Shin  東京理科大学, 薬学部生命創薬科学科, 教授 (00222472)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Keywordsイリジウム錯体-ペプチドハイブリッド / プログロム細胞死 / パラトーシス / 発光 / 小胞体 / ミトコンドリア / カルシウム / プログラム細胞死 / プログロム化細胞死 / がん / 金属錯体
Outline of Research at the Start

プログラムされた細胞死(Programmed Cell Death, PCD)は、固体の生命維持のために遺伝子によって制御された細胞死であり、発生時の形態形成や恒常性維持、がん、自己免疫疾患、ウィルス感染症等と密接に関わっている。従来、細胞死はapoptosisやnecrosisの他、necroptosis、autophagic cell death、paraptosisなど多様なPCD様式が明らかになり、それらを利用するがん治療に期待が寄せられている。そこで本研究は、PCDの一種であるparaptosisの分子機構を明らかにし、その知見をもとに新規抗がん剤の開発を行う。

Outline of Final Research Achievements

We previously reported on that a cyclometalated iridium (Ir) complex-peptide hybrid (IPH) functionalized with a cationic KKKGG peptide unit on the 2-phenylpyridine ligand of Ir complex induces paraptosis, a relatively newly found programmed cell death (PCD), in cancer cells via the direct transport of calcium (Ca2+) from the endoplasmic reticulum (ER) to mitochondria. The results in this work suggest that the induction of paraptosis by IPH is associated with membrane fusion between mitochondria and the ER, subsequent Ca2+ influx from the ER to mitochondria, and the decrease in mitochondrial membrane potential. On the other hand, celastrol, a naturally-occurring triterpenoid, induces paraptosis, while not via ER-mitochondria membrane fusion. We conclude that the paraptosis induced by IPH (referred to as paraptosis II) proceeds via different signaling pathway from that of the previously-known paraptosis induced by celastrol (referred to as paraptosis I).

Academic Significance and Societal Importance of the Research Achievements

プログラム細胞死(PCD)は、組織や器官の形成などに重要な役割を果たしており、代表的なPCDであるapoptosisの他、necroptosis、paraptosis、autophagyなどが報告されている。現在、がん細胞のapoptosisを誘導する抗がん剤が使われているが、耐性が生じ抗がん作用が減弱するなどの問題があるため、異なるPCDの誘起薬剤の開発が求められている。本研究は、従来報告されていたparaptosis (paraptosis I)に類似しているものの、異なるメカニズムで進行するparaptosis (paraptosis II)を発見し、新規抗がん剤設計の指針を示した。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (142 results)

All 2023 2022 2021 2020 Other

All Journal Article (29 results) (of which Int'l Joint Research: 14 results,  Peer Reviewed: 27 results,  Open Access: 16 results) Presentation (107 results) (of which Int'l Joint Research: 48 results,  Invited: 33 results) Book (2 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 1 results)

  • [Journal Article] Development of Wireless Power-Transmission-Based Photodynamic Therapy for the Induction of Cell Death in Cancer Cells by Cyclometalated Iridium(III) Complexes2023

    • Author(s)
      Kenta Yokoi, Yoshitaka Yasuda, Azusa Kanbe, Takehiro Imura, Shin Aoki
    • Journal Title

      Molecules

      Volume: 28 Issue: 3 Pages: 1433-1433

    • DOI

      10.3390/molecules28031433

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] パラトーシスのメカニズムを探る―知られざる複雑なプログラム細胞死―2023

    • Author(s)
      青木伸、横井健汰、山口晃平
    • Journal Title

      化学

      Volume: 78 Pages: 68-69

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Induction of Paraptosis by Cyclometalated Iridium Complex-Peptide Hybrids and CGP37157 via a Mitochondrial Ca<sup>2+</sup> Overload Triggered by Membrane Fusion between Mitochondria and the Endoplasmic Reticulum2022

    • Author(s)
      Yokoi Kenta、Yamaguchi Kohei、Umezawa Masakazu、Tsuchiya Koji、Aoki Shin
    • Journal Title

      Biochemistry

      Volume: 61 Issue: 8 Pages: 639-655

    • DOI

      10.1021/acs.biochem.2c00061

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potassium tert-Butoxide Promoted Intramolecular Mizoroki-Heck-Type Radical Cyclization: Photoluminescence Properties and Applications Live Cancer-Cell Imaging2022

    • Author(s)
      M. Sivaraman, S. Mayakrishnan, C. Balachandran, S. Aoki, N. U. Maheswari, P. T. Perumal
    • Journal Title

      Synlett,

      Volume: 33 Issue: 08 Pages: 785-790

    • DOI

      10.1055/a-1782-7150

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Design, Synthesis, and Anticancer Activity of Triptycene?Peptide Hybrids that Induce Paraptotic Cell Death in Cancer Cells2022

    • Author(s)
      Yamaguchi Kohei、Yokoi Kenta、Umezawa Masakazu、Tsuchiya Koji、Yamada Yasuyuki、Aoki Shin
    • Journal Title

      Bioconjugate Chemistry

      Volume: 33 Issue: 4 Pages: 691-717

    • DOI

      10.1021/acs.bioconjchem.2c00076

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design, synthesis and biological evaluation of 2-pyrrolone derivatives as radioprotectors2022

    • Author(s)
      Satoh Hidetoshi、Ochi Shintaro、Mizuno Kosuke、Saga Yutaka、Ujita Shohei、Toyoda Miyu、Nishiyama Yuichi、Tada Kasumi、Matsushita Yosuke、Deguchi Yuichi、Suzuki Keiji、Tanaka Yoshimasa、Ueda Hiroshi、Inaba Toshiya、Hosoi Yoshio、Morita Akinori、Aoki Shin
    • Journal Title

      Bioorganic & Medicinal Chemistry

      Volume: 67 Pages: 116764-116764

    • DOI

      10.1016/j.bmc.2022.116764

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Design, Synthesis of Spirooxiindole-Pyrrolidines Embedded with Indole and Pyridine Heterocycles by Multicomponent Reaction: Anticancer and In Silico Studies2022

    • Author(s)
      S. Mayakrishnan, D. Kathirvelan, Y. Arun, K. Saranraj, C. Balachandran, S. Aoki, S. Mayakrishnan, D. Kathirvelan, Y. Arun, K. Saranraj, C. Balachandran, S. Aoki, P. Yuvaraj, N. U. Maheswari
    • Journal Title

      New Journal of Chemistry

      Volume: 46 Issue: 21 Pages: 10089-10106

    • DOI

      10.1039/d1nj05839h

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Profiling Differential Effects of Five Selective Serotonin Reuptake Inhibitors on TLRs-Dependent and -Indiependent IL-6 Production in Immune Cells Indentifies Fluoxetine as Preferred Antiinflammatory Drug Candidate2022

    • Author(s)
      Y. Takenaka, R. Tanaka, K. Kitabatake, K. Kuramochi, S. Aoki, M. Tsukimoto
    • Journal Title

      Frontiers in Pharmacology

      Volume: 13

    • DOI

      10.3389/fphar.2022.874375

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Promising Anticancer Activity with High Selectivity from DNA/Plasma Protein Targeting New Phthalazin-1(2H)-one Heterocyclic Scaffolds2022

    • Author(s)
      M. P. Kesavan, L. Ravi, C. Balachandran, T. D. Thangadural, S. Aoki, T. Webster, J. Rajesh,
    • Journal Title

      Journal of Molecular Structure

      Volume: 1274 Pages: 134423-134423

    • DOI

      10.1016/j.molstruc.2022.134423

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Post-complexation Functionalization of Cyclometalated Iridium(III) Complexes and Applications to Biomedical and Material Sciences2022

    • Author(s)
      Shin Aoki, Kenta Yokoi, Yosuke Hisamatsu, Chandrasekar Balachandran, Yuichi Tamura, Tomohiro Tanaka
    • Journal Title

      Topics in Current Chemistry

      Volume: 380 Issue: 5 Pages: 36-36

    • DOI

      10.1007/s41061-022-00401-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of N-Benzyl Group in Indole Scaffold of Thiosemicarbazones on the Biological Activity of Their Pd(II) Complexes: DFT, Biomolecular Interaction, in Silico Docking, ADME and Cytotoxicity Studies2022

    • Author(s)
      Nithya Balakrishnan, Jebiti Haribabu, Rahime Eshaghimalekshah, Srividya Swaminathan, Chandrasekar Balachandran, Nattamai S.P. Bhuvanesh, Shin Aoki, Ramasamy Karvembu,
    • Journal Title

      Inorganica Chimica Acta

      Volume: 534 Issue: 5

    • DOI

      10.1002/ejic.202100949

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Evaluation of sodium orthovanadate as a radioprotective agent under total-body irradiation and partial-body irradiation conditions in mice2021

    • Author(s)
      Nishiyama Yuichi、Morita Akinori、Wang Bing、Sakai Takuma、Ramadhani Dwi、Satoh Hidetoshi、Tanaka Kaoru、Sasatani Megumi、Ochi Shintaro、Tominaga Masahide、Ikushima Hitoshi、Ueno Junji、Nenoi Mitsuru、Aoki Shin
    • Journal Title

      International Journal of Radiation Biology

      Volume: 97 Issue: 9 Pages: 1241-1251

    • DOI

      10.1080/09553002.2021.1941377

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Design and Synthesis of Supramolecular Phosphatases Formed from a Bis(Zn2+-Cyclen) Complex, Barbital-Crown-K+ Conjugate and Cu2+ for the Catalytic Hydrolysis of Phosphate Monoester2021

    • Author(s)
      A. B. Rahman, H. Okamoto, Y. Miyazawa, S. Aoki,
    • Journal Title

      European Journal of Inorganic Chemistry

      Volume: 2021 Issue: 13 Pages: 1213-1223

    • DOI

      10.1002/ejic.202001009

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mefloquine, a Potent anti-Severe Acute Respiratory Syndrome- related Coronavirus 2 (SARS-CoV-2) drug as an entry inhibitor in vitro2021

    • Author(s)
      Kaho Shionoya, Masako Yamasaki, View ORCID ProfileShoya Iwanami, Yusuke Ito, Shuetsu Fukushi, Hirofumi Ohashi, Wakana Saso, Tomohiro Tanaka, Shin Aoki, Kouji Kuramochi, Shingo Iwami, Yoshimasa Takahashi, Tadaki Suzuki, Masamichi Muramatsu, Makoto Takeda, Takaji Wakita, Koichi Watashi
    • Journal Title

      Frontiers in Microbiology

      Volume: 1 Pages: 1-1

    • DOI

      10.3389/fmicb.2021.651403

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis and Anticancer Properties of Bis and Mono(cationic peptide) Hybrids of Cyclometalated Ir(III) Complexes: Effect of the Number of Peptide Units on Anticancer Activity2021

    • Author(s)
      H. Jebiti, Y. Tamura, K. Yokoi, C. Balachandran, M. Umezawa, K. Tsuchiya, Y. Yamada, and S. Aoki,
    • Journal Title

      European Journal of Inorganic Chemistry

      Volume: 2021 Issue: 18 Pages: 1796-1814

    • DOI

      10.1002/ejic.202100154

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Isohamnetin Promotes 53BP1 Recruitment through the Enhancement of ATM Phosphorylation and Protects Mice from Radiation Gastrointestinal Syndrome2021

    • Author(s)
      Yuichi Nishiyama, Akinori Morita, Shogo Tatsuta, Misaki Kanamaru, Masahiro Sakaue, Kenta Ueda, Manami Shono, Rie Fujita, Bing Wang, Yoshio Hosoi, Shin Aoki and Takeshi Sugai
    • Journal Title

      Genes

      Volume: 12 Issue: 12 Pages: 8523-8544

    • DOI

      10.1021/acs.jmedchem.1c00445

    • Related Report
      2021 Research-status Report
  • [Journal Article] Isorhamnetin Promotes 53BP1 Recruitment through the Enhancement of ATM Phosphorylation and Protects Mice from Radiation Gastrointestinal Syndrome2021

    • Author(s)
      Nishiyama Yuichi、Morita Akinori、Tatsuta Shogo、Kanamaru Misaki、Sakaue Masahiro、Ueda Kenta、Shono Manami、Fujita Rie、Wang Bing、Hosoi Yoshio、Aoki Shin、Sugai Takeshi
    • Journal Title

      Genes

      Volume: 12 Issue: 10 Pages: 1514-1514

    • DOI

      10.3390/genes12101514

    • NAID

      120007164907

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel RNA Synthesis Inhibitor, STK160830, Has Negligible DNA-Intercalating Activity for Triggering A p53 Response, and Can Inhibit p53-Dependent Apoptosis2021

    • Author(s)
      Morita Akinori、Ochi Shintaro、Satoh Hidetoshi、Ujita Shohei、Matsushita Yosuke、Tada Kasumi、Toyoda Mihiro、Nishiyama Yuichi、Mizuno Kosuke、Deguchi Yuichi、Suzuki Keiji、Tanaka Yoshimasa、Ueda Hiroshi、Inaba Toshiya、Hosoi Yoshio、Aoki Shin
    • Journal Title

      Life

      Volume: 11 Issue: 10 Pages: 1087-1087

    • DOI

      10.3390/life11101087

    • NAID

      120007164908

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cyclometalated Iridium(III) Complex-Cationic Peptide Hybrids Trigger Paraptosis in Cancer Cells via Intracellular Ca2+ Overload from Endoplasmic Reticulum and a Decrease in a Mitochondrial Membrane Potential2021

    • Author(s)
      Chandrasekar Balachandran, Kenta Yokoi, Kana Naito, Jebiti Haribabu, Yuichi Tamura, Masakazu Umezawa, Koji Tsuchiya, Toshitada Yoshihara, Seiji Tobita, and Shin Aok
    • Journal Title

      Molecules

      Volume: 26 Pages: 120701-120701

    • DOI

      10.1016/j.ica.2021.120701

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cyclometalated Iridium(III) Complex?Cationic Peptide Hybrids Trigger Paraptosis in Cancer Cells via an Intracellular Ca2+ Overload from the Endoplasmic Reticulum and a Decrease in Mitochondrial Membrane Potential2021

    • Author(s)
      Balachandran Chandrasekar、Yokoi Kenta、Naito Kana、Haribabu Jebiti、Tamura Yuichi、Umezawa Masakazu、Tsuchiya Koji、Yoshihara Toshitada、Tobita Seiji、Aoki Shin
    • Journal Title

      Molecules

      Volume: 26 Issue: 22 Pages: 7028-7028

    • DOI

      10.3390/molecules26227028

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] N-Subsbtitution in Isatin Thiosemicarbazone Decides Nuclearity of Cu(II) Complexes -Spectroscopic, Molecular Docking and Cytotoxic Studies2021

    • Author(s)
      H. Jebiti, O. I. Alajrawy, K. Jeyelakshmi, C. Balachandran, D. A. Krishnan, N. Bhuvanesh, S. Aoki, and N. Karuppannan, R. Karvembu
    • Journal Title

      Spectrochimica Acta Part A:Molecular and Biomolecular Spectroscopy

      Volume: 246 Pages: 118963-118963

    • DOI

      10.1016/j.saa.2020.118963

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Potential Anti-COVID-19 Agents, Cepharanthine and Nelfinavir, and Their Usage for Combination Treatment2021

    • Author(s)
      H. Ohashi, K. Watashi, W. Saso, K. Shionoya, et al.
    • Journal Title

      iScience

      Volume: 24 Issue: 4 Pages: 335-337

    • DOI

      10.1016/j.isci.2021.102367

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of Metallosupramolecular Phosphatases Based on Combinatorial Self-Assembly of Metal Complexes and Organic Building Blocks for Catalytic Hydrolysis of Phosphate Monoesters2021

    • Author(s)
      S. Aoki, A. B. Rahman, Y. Hisamatsu, Y. Miyazawa, M. Zulkefeli, Y. Saga, T. Tanaka
    • Journal Title

      Results in Chemistry (a joint special issue with Inorganica Chimica Acta)

      Volume: 3 Pages: 100133-100133

    • DOI

      10.1016/j.rechem.2021.100133

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Synthesis, Anticancer and Molecular Docking Studies of New Class of Benzoisoxazolyl-piperidinyl-1,2,3-triazoles2020

    • Author(s)
      G. Muniyappan, S. Kathavarayan, C. Balachandran, E. Kalliyappan, S. M. Mahalingam, A. Ajees A. Salam, S. Aoki, N.Arumugam, A. I. Almansour, R. S. Kumar
    • Journal Title

      The Journal of King Saud University-Science,

      Volume: 32 Issue: 8 Pages: 3286-3292

    • DOI

      10.1016/j.jksus.2020.09.012

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Amphiphilic Cationic Triscyclometalated Iridium(III) Complex-Peptide Hybrids Induce Paraptosis-like Cell Death of Cancer Cells via an Intracellular Ca2+-Dependent Pathway2020

    • Author(s)
      K. Yokoi, C. Balachandran, M. Umezawa, K. Tsuchiya, A. Mitric, S. Aoki
    • Journal Title

      ACS Omega

      Volume: 5 Issue: 12 Pages: 6983-7001

    • DOI

      10.1021/acsomega.0c00337

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Synthesis, Characterization, Theoretical, Molecular Docking and in Vitro Biological Activity Studies of Ru(II) (e6-p-Cymene) Complexes with Novel Aniline Substituted Aroyl Selenoureas2020

    • Author(s)
      M. Musthafa, R. Konakanchi, R. Ganguly, C. Balachandran, S. Aoki, A. Sreekanth
    • Journal Title

      Journal of Biomolecular Structure and Dynamics

      Volume: none Issue: 12 Pages: 1778531-1778531

    • DOI

      10.1080/07391102.2020.1778531

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Design and Synthesis of Cyclometalated Iridium(III) Complex-Chromophore Hybrids that Exhibit Long-Emission Lifetimes Based on a Reversible Electronic Energy Transfer Mechanism2020

    • Author(s)
      A. Kazama, Y. Imai, Y. Okayasu, Y. Yamada, J. Yuasa, S. Aoki
    • Journal Title

      Inorganic Chemistry

      Volume: 59 Issue: 10 Pages: 6905-6922

    • DOI

      10.1021/acs.inorgchem.0c00363

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] ROS-Responsive Chitosan Coated Magnetic Iron Oxide Nanoparticles as Potential Vehicles for Targeted Drug Delivery in Cancer Therapy2020

    • Author(s)
      S. Ayyanaar, C. Balachandran, R. C. Bhaskar, M. P. Kesavan, S. Aoki, R. P. Raja, J. Rajesh, T. J. Webster, G. Rajagopal,
    • Journal Title

      International Journal of Nanomedicine

      Volume: 15 Pages: 3333-3346

    • DOI

      10.2147/ijn.s249240

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Protective Effects of p53 Regulatory Agents against High-LET Radiation-Induced Injury in Mice2020

    • Author(s)
      A. Morita, B. Wang, K. Tanaka, T. Katsube, M. Murakami, T. Shimokawa, Y. Nishiyama, S. Ochi, H. Satoh, M. Nenoi and S. Aoki
    • Journal Title

      Frontiers in Public Health

      Volume: 8

    • DOI

      10.3389/fpubh.2020.601124

    • NAID

      120006937553

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Design and Synthesis of Metallosupramolecular Catalysts Functionalized with Lewis Acidic Sites in the Two-Phase Solvent Systems and Analysis of the Interface between Organic and Aqueous Phases2023

    • Author(s)
      Shin Aoki, Hirokazu Okamoto, Akib Bin Rahman, Yoshito Tsuruda, Hiroshi Takemur
    • Organizer
      7th International Conference on Catalysis and Chemical Engineering (CCE-2023),
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Induction of Paraptosis, a Class of Programmed Cell Death, in Cancer Cells by the Hybrid Compounds of Cyclometalated Iridium(III) Complexes and Triptycenes with Peptides”2023

    • Author(s)
      Shin Aoki, Kenta Yokoi, Kanbe Azusa, Kohei Yamaguchi, Nii Mayuka, Masaki Kakihana, Nozomi Narushima, Chandrasekar Balachandran
    • Organizer
      The 5th International Conference on Pharma Research and Development (Pharma R & D 2023)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Point Cloud based Deep Molecular Pose Estimation for Structure-based Virtual Screening2023

    • Author(s)
      Ken Kariya, Go Irie, Ryosuke Furuta, Yota Yamamot, Shin Aoki, Yukinobu Taniguchi
    • Organizer
      The 29th International Workshop on Frontiers of Computer Vision (IW-FCV)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design, Synthesis and Biological Activity of Macrocyclic Polyamine-based Boron Agents for Boron Neutron Capture Therapy (BNCT)2023

    • Author(s)
      Shin Aoki
    • Organizer
      [5th European Public Health Webinar (online seminar)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アシクロビルの化学構造式から見た特性2023

    • Author(s)
      青木伸
    • Organizer
      第9回日本医療安全学会学術総会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 田中智博、上田大貴、鈴木実、櫻井良憲、上田真史、青木伸2023

    • Author(s)
      ホウ素中性子線捕捉療法のためのBSH-CPナノ粒子の開発
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大環状ポリアミン骨格を有するホウ素中性子捕捉療法用薬剤の開発2023

    • Author(s)
      上田大貴、鈴木実、櫻井良憲、田中智博、青木伸
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 亜鉛イオンによって促進されるシクロメタレート型イリジウム(III)錯体の分解反応の発見と機構解析2023

    • Author(s)
      Surajit Haldar、大和田紘喜、田村裕一、青木伸
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 複数のホウ素原子を有するホウ素中性子捕捉療法用大環状ポリアミン型ホウ素キャリア―の設計・合成と機能評価2023

    • Author(s)
      川本健太、上田大貴、鈴木実、櫻井良憲、田中智博、青木伸
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ミトコンドリア集積性を示すペプチドを導入したトリプチセン-ペプチドハイブリッドの合成・設計及び抗がん活性2023

    • Author(s)
      新居真由香、山口晃平、横井健汰、青木伸
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of Interdisciplinary Methods for Cancer Theranostics. ◯Shin Aoki (Invited lecture)2022

    • Author(s)
      Shin Aoki
    • Organizer
      Symposium on World Cancer Research 2022 (SWCR2022) (online seminar)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] アゾベンゼンユニットを含むキラル大環状化合物の設計・合成と光異性化反応2022

    • Author(s)
      青木伸、芝内涼太、磯部理沙、田中智博、棚田法男、景山義之
    • Organizer
      第19回ホストゲスト・超分子化学シンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] Post-complexation Functionalization of Iridium(III) Complexes and Applications to Pharmaceutical Sciences(イリジウム(III)錯体のPost-complexation functionalizationと薬学分野への展開)2022

    • Author(s)
      青木伸
    • Organizer
      第31回金属の関与する生体関連反応シンポジウム(SRM2022)
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Design and Synthesis of Metallosupramolecular Complexes and Their Applications to Bioorganic Chemistry and Biomedical Sciences in Association with 10 Years of iPoPS2022

    • Author(s)
      Shin Aoki
    • Organizer
      9th International Postgraduate Conference on Pharmaceutical Sciences 2022 (iPoPS2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design and Synthesis of Anti-SARS-CoV-2 Agent Based on Amodiaquine2022

    • Author(s)
      Tomohiro Tanaka, Kenta Yokoi, Hidetoshi Sato, Azusa Kanbe, Tomoe Morita, Yayoi Yoshimura, Masaaki Toyama, Mika Okamoto, Masanori Baba, Shin Aoki
    • Organizer
      9th International Postgraduate Conference on Pharmaceutical Sciences 2022 (iPoPS2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design and Synthesis of Cyclometalated Iridium Complex-Peptide Hybrids for the Induction of Programmed Cell Death in Cancer Cells2022

    • Author(s)
      Kenta Yokoi and Shin Aoki
    • Organizer
      9th International Postgraduate Conference on Pharmaceutical Sciences 2022 (iPoPS2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design and Synthesis of Optically Pure Triscyclometalated Iridium(III) Complexes via Diastereomeric Intermediates2022

    • Author(s)
      Azusa Kanbe, Kenta Yokoi, Yasuyuki Yamada, Daiji Ogata, Junpei Yuasa, Shin Aoki (
    • Organizer
      9th International Postgraduate Conference on Pharmaceutical Sciences 2022 (iPoPS2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design and Synthesis of Supramolecular Phosphatases Functionalized with Lewis Acidic Moieties for Catalytic Hydrolysis of Phosphate Monoesters in Two-Phase Solvent System2022

    • Author(s)
      Hirokazu Okamoto, Akib Bin Rahman, Yuya Miyazawa, Yoshito Tsuruda, Hiroshi Takemura, Shin Aoki
    • Organizer
      9th International Postgraduate Conference on Pharmaceutical Sciences 2022 (iPoPS2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design, Synthesis and Anticancer Activity of Triptycene-Peptide Hybrids for Targeting Mitochondria2022

    • Author(s)
      Mayuka Nii, Kohei Yamaguchi, Kenta Yokoi, Shin Aoki
    • Organizer
      9th International Postgraduate Conference on Pharmaceutical Sciences 2022 (iPoPS2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] p53制御剤による放射線被ばくに対する雄性妊孕性温存2022

    • Author(s)
      園山雄一郎、西山祐一、森田明典、王冰、佐藤秀哉、青木伸
    • Organizer
      第59回日本放射線主要学会生物部会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Induction of Paraptotic Cell Death in Cancer Cells Induced by the Hybrid Compounds of Cyclometalated Iridium(III) Complexes and Triptylenes with Amphiphilic Peptides2022

    • Author(s)
      Shin Aoki
    • Organizer
      3rd European Public Health Webinar (online seminar)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 多視点画像ベースの高速なバーチャルスクリーニング2022

    • Author(s)
      釘本晃佑、古田諒佑、山本洋太、入江豪、青木伸、谷口行信
    • Organizer
      第25回画像の認識・理解シンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] Design, Synthesis, and Biological Evaluation of Cyclometalated Iridium(III) Complex-Peptide Hybrids that Induce Paraptotic Programmed Cell Death in Cancer Cells2022

    • Author(s)
      Shin Aoki, Kenta Yokoi, Chandrasekar Balachandran
    • Organizer
      The 8th Asian Congress on Coordination Chemistry (ACCC8)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of Controlled Released Type Chelating Agent Based on Poly(2,2’-bipyridyl) Ligands for Cancer Therap2022

    • Author(s)
      Tomohiro Tanaka, Masumi Hirose, Ayako Fujita, Yasuyuki Yamada, Shin Aoki
    • Organizer
      The 8th Asian Congress on Coordination Chemistry (ACCC8)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Discovery and Mechanistic Analysis of Zn2+-Promoted Decomposition Reactions of Cyclometalated Iridium(III) Complexes2022

    • Author(s)
      Surajit Haldar, Hiroki Ohwada, Shin Aoki
    • Organizer
      The 8th Asian Congress on Coordination Chemistry (ACCC8)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Catalytic Hydrolysis of Phosphate Monoester by Supramolecular Phosphatases Functionalized with Lewis Acidic Moieties2022

    • Author(s)
      Hirokazu Okamoto, Akib Bin Rahman, Yuya Miyazawa, Yoshito Tsuruda, Hiroshi Takemura, Shin Aoki
    • Organizer
      The 8th Asian Congress on Coordination Chemistry (ACCC8)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design, Synthesis and Photophysical Properties of Optically Pure Triscyclometalated Iridium(III) Complexes Synthesized via Diastereomeric Intermediates2022

    • Author(s)
      Azusa Kanbe, Kenta Yokoi, Yasuyuki Yamada, Junpei Yuasa, Shin Aoki
    • Organizer
      The 8th Asian Congress on Coordination Chemistry (ACCC8)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of New Cyclometalated Iridium(III) Complexes for Induction of Programmed Cell Death, Detection of Dead Cells, and Mechanistic Study2022

    • Author(s)
      Shin Aoki, Kenta Yokoi, Chandrasekar Balachandran, and Kohei Yamaguchi
    • Organizer
      Baltic Conference and Fellow Summit, IAAM (International Association of Advanced Materials)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of Hybrid Compounds of Peptides with Metal Complex-type and Triptycene-type Core Units that Induce Paraptosis in Cancer Cells2022

    • Author(s)
      Shin Aoki, Kenta Yokoi, Chandrasekar Balachandran, Kohei Yamaguchi, Mayuka Nii
    • Organizer
      ACS Fall 2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] Design and Synthesis of Hybrid Compounds of Cyclometalated Iridium(III) Complexes and Triptycenes with Basic Peptides that Induce Paraptosis in Cancer Cells2022

    • Author(s)
      Shin Aoki, Kenta Yokoi, Kohei Yamaguchi, Azusa Kanbe, Mayuka Nii, Chandrasekar Balachandran, Masaki Kakihana
    • Organizer
      The 3rd International Conference on Pharmacology and Toxicology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 点群レジストレーションと分子表面表現最適化による阻害剤結合時のポーズ推定2022

    • Author(s)
      Shin Aoki, Kenta Yokoi, Kohei Yamaguchi, Azusa Kanbe, Mayuka Nii, Chandrasekar Balachandran, Masaki Kakihana
    • Organizer
      2022年度第50回画像電子学会年次大会
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Circulating Tumor Cells Detection by Brightness Values Analysis and Circularity2022

    • Author(s)
      Hua Wei, Tomohiro Tanaka, Shin Aoki, Takeshi Yamada, Takahiro Natori, Naoyuki Aikawa
    • Organizer
      7th International Conference on Frontiers of Signal Processing (ICFSP 2022
    • Related Report
      2022 Annual Research Report
  • [Presentation] シクロメタレート型イリジウム錯体―カチオン性ペプチドハイブリッドによるがん細胞のプログラム細胞死誘導と分子メカニズム解明2022

    • Author(s)
      青木 伸、横井 健汰、山口晃平、新居真由香、Chandrasekar Balachandran
    • Organizer
      第16回バイオ関連化学シンポジウム(Hybrid)
    • Related Report
      2022 Annual Research Report
  • [Presentation] 2-Pyrrolone型放射線防護剤の設計と合成及び作用メカニズム解析2022

    • Author(s)
      佐藤秀哉、越智進太朗、氏田将平、豊田美裕、西山祐一、多田佳寿美、松下 洋輔、出口 雄一、鈴木啓司、田中義正、植田弘師、稲葉俊哉、細井義夫、森田明典、青木伸
    • Organizer
      第66回日本薬学会関東支部大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] プログラム細胞死誘導活性の向上を目指したシクロメタレート型イリジウム錯体-ペプチドハイブリッドの設計と合成および抗がん活性評価2022

    • Author(s)
      垣花真輝、横井健汰、神戸梓、青木伸
    • Organizer
      第66回日本薬学会関東支部大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ミトコンドリア集積性の増強を目的としたトリプチセン-ペプチドハイブリッドの合成・設計及び抗がん活性評価 ◯新居真由香2022

    • Author(s)
      新居真由香、山口晃平、横井健汰、青木伸
    • Organizer
      第66回日本薬学会関東支部大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 炎症性サイトカインIL-6産生におけるDynaminの関与2022

    • Author(s)
      竹中洋平、田中智博、北畠和己、青木伸、月本光俊
    • Organizer
      第66回日本薬学会関東支部大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Post-Complexation Functionalizations of Cyclometalated Iridium(III) Complexes and Their Applications to Biological and Material Sciences2022

    • Author(s)
      Shin Aoki
    • Organizer
      Nankai Mini-symposium on Advanced Functionalized Materials (online seminar)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Design and Synthesis of Metallosupramolecualr Phosphatases Inspired by an Active Center of Alkaline Phosphtaseand Effect of Reaction Conditions2022

    • Author(s)
      Hirokazu Okamoto, Akib Bin Rahman, Yuya Miyazawa, Yoshito Tsuruda, Hiroshi Takemura, Shin Aoki
    • Organizer
      錯体化学会第72回討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Optical Resolution of Cyclometalated Iridium(III) Complexes via Diastereomeric Intermediates and Biological Evaluation of Optically Pure Ir(III) Complex-Peptide Hybrids2022

    • Author(s)
      Azusa Kanbe, Kenta Yokoi, Yasuyuki Yamada, Daiji Ogata, Junpei Yuasa, Shin Aoki (
    • Organizer
      錯体化学会第72回討論会
    • Related Report
      2022 Annual Research Report
  • [Presentation] ホウ素中性子捕捉療法のためのDNA標的型ホウ素薬剤の開発2022

    • Author(s)
      上田大貴、鈴木実、櫻井良憲、田中智博、青木伸
    • Organizer
      第18回日本中性子捕捉療法学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Design and Synthesis of Boron-Containing Macrocyclic Polyamines as Boron Neutron Capture Therapy (BNCT) Agents2022

    • Author(s)
      Shin Aoki, Hiroki Ueda, Tomohiro Tanaka, Minoru Suzuki, Yoshinori Sakurai
    • Organizer
      nternational Congress on Pure & Applied Chemistry Kona Kitabalu (ICPAC Kona Kitabalu)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 大環状ポリアミン型のホウ素中性子捕捉療法(BNCT)用含ホウ素薬剤の設計と合成2022

    • Author(s)
      青木 伸、上田 大貴、田中 智博、鈴木 実、櫻井 良憲
    • Organizer
      第39回メディシナルケミストリーシンポジウム
    • Related Report
      2022 Annual Research Report
  • [Presentation] esign and Synthesis of Metal Complex-Peptide Hybirds that Possess Dual Functions as Paraptosis Inducers in Cancer Cells and Detectors of Dead Cells.2022

    • Author(s)
      Shin Aoki, Kenta Yokoi, Chandrasekar Balachandran, Azusa Kanbe
    • Organizer
      10th Asian Biological Inoganic Chemistry Conference (AsBIC10)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Toll様受容体依存的/非依存的IL-6産生に対する選択的セロトニン再取り込み阻害薬(SSRI)の抑制効果2022

    • Author(s)
      竹中 洋平、田中 隆、北畠 和己、倉持 幸司、青木 伸、月本 光俊
    • Organizer
      第96回日本薬理学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of Cyclometalated Iridium(III) Complex-Peptide Hybrids that Induce Cell Death in Cancer Cells and Detect Dead Cells2022

    • Author(s)
      Shin Aoki, Kenta Yokoi, Azusa Kanbe, Nozomi Narushima, Chandrasekar Balachandran, Masaki Kakihana
    • Organizer
      27th International SPACC Symposium
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Design and Synthesis of Metallosupramolecular Catalysts Formed by the Self-Assembly of Functionalized Building Blocks to Mimic Natural Enzymes2022

    • Author(s)
      Shin Aoki, Akib Bin Rahman, Hirokazu Okamoto
    • Organizer
      6th International Conference on Catalysis and Chemical Engineering (CCE-2022)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Induction and Mechanistic Study of Programmed Cell Death in Cancer Cells by the Hybrid Compounds of Cyclometalated Iridium(III) Complexes with Peptides2022

    • Author(s)
      Shin Aoki
    • Organizer
      The 4th International Conference on Pharma Research and Development (Pharma R & D 2022),
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] BNCTを目的とする糖および大環状ポリアミン型ホウ素キャリアの設計・合成および活性評価2022

    • Author(s)
      青木伸、上田大貴、田中智博、鈴木実、櫻井良憲
    • Organizer
      令和3年度京都大学複合原子力科学研究所専門研究会「京都大学複合科学研究所におけるBNCT研究の多様化・高度化に関する研究会」
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Induction of Paraptosis in Cancer Cells by Cyclometalated Iridium(III) Complex-Peptide Hybrids via Intracellular Ca2+-Dependent Pathway2022

    • Author(s)
      Kenta Yokoi, Chandrasekar Balachandran, Haribabu Jebit, Shin Aoki
    • Organizer
      [4th International Webinar on Chemistry and Medicinal Chemistry (online seminar)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Design and Synthesis, and Evaluation of Anticancer Activity of Iridium(III) Complex-Peptide Hybrids that Induce Programmed Cell Death in Cancer Cells2022

    • Author(s)
      Shin Aokii
    • Organizer
      [2nd European Public Health Webinar (online seminar)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 金属錯体をビルディングブロックとする新たな機能性分子の設計・合成と生化学および物質科学への展開2022

    • Author(s)
      青木伸
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Design and Synthesis of Luminescent Iridium Complex-Peptide Hybrids for the Theranostics of Cancer2021

    • Author(s)
      Shin Aoki
    • Organizer
      Molecules Webinar “Future Trends in Bioorganic Chemistry”
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] p53を標的とした放射線防護剤の粒子線治療における役割2021

    • Author(s)
      森田 明典、王 冰、田中 薫、勝部 孝則、村上 正弘、下川 卓志、西山 祐一、越智 進太郎、佐藤 秀哉、根井 充、青木 伸
    • Organizer
      第49回放射線による制癌シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] 多視点画像に基づくバーチャルスクリーニングの高速化2021

    • Author(s)
      釘本 晃佑、古田 諒祐、入江 豪、青木 伸、谷口 行信
    • Organizer
      第27回画像センシングシンポジウム(SSII2021)
    • Related Report
      2021 Research-status Report
  • [Presentation] 3次元点群レジストレーションに基づくタンパク質阻害剤の高速探索2021

    • Author(s)
      苅谷 健、古田 諒祐、入江 豪、青木 伸、谷口 行信
    • Organizer
      第27回画像センシングシンポジウム(SSII2021)
    • Related Report
      2021 Research-status Report
  • [Presentation] ホウ素中性子捕捉療法(BNCT)用薬剤のための大環状ポリアミン誘導体と亜鉛(II)錯体の設計・合成および活性評価2021

    • Author(s)
      上田 大貴、田中 智博、鈴木 実、青木伸
    • Organizer
      第30回金属の関与する生体関連反応シンポジウム(SRM2021)
    • Related Report
      2021 Research-status Report
  • [Presentation] シクロメタレート型イリジウム錯体-ペプチドハイブリッドによるパラトーシス誘導と分子機構の解明―小胞体-ミトコンドリア接着因子の検討―2021

    • Author(s)
      横井健汰、青木伸
    • Organizer
      日本ケミカルバイオロジー学会第14回年会
    • Related Report
      2021 Research-status Report
  • [Presentation] Design and Synthesis of Hybrid Compounds of Cyclometalated Iridium(III) Complexes for the Theranostics of Cancer2021

    • Author(s)
      Shin Aoki, Kenta Yokoi, Chandrasekar Balachandran, Haribabu Jebiti, Azusa Kanbe, Yuichi Tamura
    • Organizer
      21th Tetrahedron Symposium,
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] ルイス酸で修飾された超分子ホスファターゼの設計・合成とリン酸モノエステルの二相系溶媒中触媒的加水分解2021

    • Author(s)
      岡本 紘知、Akib Bin Rahman、青木 伸
    • Organizer
      第18回ホストゲスト・超分子化学シンポジウム
    • Related Report
      2021 Research-status Report
  • [Presentation] Design and Synthesis of Hybrid Compounds of Cyclometalated Iridium(III) Complexes with Peptides and Chromophores via Post-complexation Functionalization.2021

    • Author(s)
      Shin Aok
    • Organizer
      Bilateral Webinar of SRM (Sri Ramaswamy Memorial) University, India, & Tokyo University of Science, Japan
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Combinatorial Synthesis of Metallosupramolecular Phosphatases formed by the Self-Assembly of Functionalized Building Blocks2021

    • Author(s)
      Shin Aoki, Akib Bin Rahman, Hirokazu Okamoto
    • Organizer
      The 3rd International Conference on Material Science & Nanotechnology (ICMSN 2021),
    • Related Report
      2021 Research-status Report
  • [Presentation] シクロメタレート型イリジウム錯体―カチオン性ペプチドハイブリッドによるがん細胞のプログラム細胞死誘導と分子メカニズム解明2021

    • Author(s)
      横井 健汰、Chandrasekar Balachandran、Haribabu Jebiti、小山田 有紗、梅澤 雅和、土屋 好司、青木 伸
    • Organizer
      第15回バイオ関連化学シンポジウム(Online)
    • Related Report
      2021 Research-status Report
  • [Presentation] がん細胞のプログラム細胞誘導死を目的としたトリプチセン-ペプチドハイブリッドの合成・設計及び生物活性評価2021

    • Author(s)
      山口 晃平、横井 健汰、青木伸
    • Organizer
      第65回日本薬学会関東支部大会(Online)
    • Related Report
      2021 Research-status Report
  • [Presentation] Interdisciplinary Research on Luminescent Metal Complexes by Post-complexation Functionalization in Biomedical and Material Sciences2021

    • Author(s)
      Shin Aoki
    • Organizer
      Advanced Materials Lecture Series (AMLS) of International Association of Advanced Materials (IAAM)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of Boron-containing Macrocyclic Polyamines and Their Zn(Ⅱ) Complexes for Boron Neutron Capture Therapy2021

    • Author(s)
      Hiroki Ueda, Minoru Suzuki, Tomohiro Tanaka, Shin Aokii
    • Organizer
      錯体化学会第71回討論会(Online)
    • Related Report
      2021 Research-status Report
  • [Presentation] Mechanistic Studies of Paraptosis Induced by Cyclometalated Iridium Complex-Peptide Hybrids: Roles of Ca2+ Transfer from ER to mitochondria2021

    • Author(s)
      Kenta Yokoi and Shin Aoki
    • Organizer
      錯体化学会第71回討論会(Online)
    • Related Report
      2021 Research-status Report
  • [Presentation] Combinatorial Construction of Metallosupramolecular Complexes to Mimic Natural Alkaline Phosphatases by the Self-Assembly of Functionalized Building Blocks2021

    • Author(s)
      Shin Aoki, Hirokazu Okamoto, Akib Bin Rahman and Mohd Zulkefeli
    • Organizer
      International Research Network Initiative (IRNI) and 8th International Postgraduate Conference on Pharmaceutical Sciences 2021 (iPoPS2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design and Synthesis of Poly(2,2’-bipyridyl) Ligands Directed toward Chelation Therapy of Cancer2021

    • Author(s)
      Masumi Hirose, Zue Jun Jie, Chandrasekar Balacahndran, Tomohiro Tanaka, Yosuke Hisamatsu, Yasuyuki Yamada, Shin Aoki
    • Organizer
      International Research Network Initiative (IRNI) and 8th International Postgraduate Conference on Pharmaceutical Sciences 2021 (iPoPS2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design, Synthesis, and Anticancer Activity of Amphiphilic Anticancer Agents Having Cationic Peptides for the Induction of Programmed Cell Death in Cancer Cells2021

    • Author(s)
      Kohei Yamaguchi, Kenta Yokoi, and Shin Aoki
    • Organizer
      International Research Network Initiative (IRNI) and 8th International Postgraduate Conference on Pharmaceutical Sciences 2021 (iPoPS2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design, Synthesis, and Biological Property of Boron Compounds Having Sugar and Macrocyclic Polyamine Scaffolds for Boron Neutron Capture Therapy (BNCT)2021

    • Author(s)
      Shin Aoki
    • Organizer
      Advanced Nanomaterials Congress
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Design, Synthesis, and Biological Property of Boron Compounds Having Sugar and Macrocyclic Polyamine Scaffolds for Boron Neutron Capture Therapy (BNCT)2021

    • Author(s)
      Shin Aoki
    • Organizer
      Annual Meeting of European Society of Medicine (ESMED2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Mefloquine Has a Potent Antiviral Activity against Severe Acute Respiratory Syndrome Related Coronavirus 22021

    • Author(s)
      Kaho Shionoya, Masako Yamasaki, Shoya Iwanami, Yusuke Ito, Shuetsu Fukushi, Hirofumi Ohashi, Wakana Saso, Tomohiro Tanaka, Shin Aoki, Kouji Kuramochi, Shingo Iwami, Yoshimasa Takahashi, Tadaki Suzuki, Masamichi Muramatsu, Makoto Takeda, Takaji Wakita and Koichi Watashi
    • Organizer
      第68回日本ウイルス学会学術学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Induction of Paraptosis in Cancer Cells by Cyclometalated Iridium(III) Complex-Peptide Hybrids and Its Mechanistic Study2021

    • Author(s)
      Kenta Yokoi, Jebiti Haribabu, Chandrasekar Balachandran, Masakazu Umezawa, Koji Tsuchiya, Shin Aoki
    • Organizer
      13th AFMC International Medicinal Chemistry Symposium (AIMECS 2021),
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] ワイヤレス電力伝送による光線力学療法に向けたがん細胞を用いた基礎実験2021

    • Author(s)
      安田 祥隆、居村 岳広、堀 洋一、横井 健汰、神戸 梓、垣花 真輝、 青木 伸
    • Organizer
      無線電力伝送研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] Design and Synthesis of Triscyclometalated Iridium(III) Complex-peptide Hybrids that Induce Programmed Cell Death of Cancer Cells2021

    • Author(s)
      hin Aoki、Kenta Yokoi, Chandrasekar Balachandran, Haribabu Jebiti, Arisa Koyamada, Masakazu Umezawa, and Koji Tsuchiya
    • Organizer
      2021 International Chemical Congress of Pacific Basin Societies (PACICHEM2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Design and Synthesis of Triscyclometalated Iridium(III) Complex-Peptide Hybrids that Induce Paraptosis-like Cell Death of Cancer Cells via Intracellular Ca2+-Dependent Pathway2021

    • Author(s)
      Kenta Yokoi, Chandrasekar Balachandran, Masakazu Umezawa, Koji Tsuchiya, Aleksandra Mitric and Shin Aoki
    • Organizer
      2021 International Chemical Congress of Pacific Basin Societies (PACICHEM2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design, Synthesis and Anticancer Activity of Cyclometalated Iridium (III) Complex-Peptide Hybrid that Have a Cationic Cyclic Peptide2021

    • Author(s)
      Arisa Koyamada, Kenta Yokoi, Chandrasekar Balachandran, Masakazu Umezawa, Koji Tsuchiya, and Shin Aoki
    • Organizer
      2021 International Chemical Congress of Pacific Basin Societies (PACICHEM2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design, Synthesis, and Anticancer Activity of Triptycene-Peptide Hybrids for Inducing Programmed Cell Death in Cancer Cells2021

    • Author(s)
      Kohei Yamaguchi, Kenta Yokoi, Shin Aoki
    • Organizer
      2021 International Chemical Congress of Pacific Basin Societies (PACICHEM2021)
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 田中 智博、上田 大貴、鈴木 実、櫻井 良憲、青木 伸2021

    • Author(s)
      ホウ素中性子捕捉療法を指向したBSH含有ナノ粒子の開発
    • Organizer
      第55回京都大学複合原子力科学研究所学術講演会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] ホウ素中性子捕捉療法のためのポリアミン誘導体の創製2021

    • Author(s)
      上田 大貴、田中 智博、鈴木 実、櫻井 良憲、青木 伸
    • Organizer
      第55回京都大学複合原子力科学研究所学術講演会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] Expression Analysis of Genes Associated with the Radioprotective Effect of p53 Modulator 5CHQ on Acute Intestinal Radiation Injury2021

    • Author(s)
      Takuma Sakai, Akinori Morita, Akinori Kanai, Bing Wang, et al.
    • Organizer
      The 5th International Symposium of the Network-type Joint Usage/Research Center for Radiation Disaster and Medical Science-Nuclear Disaster Management
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Design and Synthesis of Metallosupramolecular Catalysts Formed by the Self-Assembly of Functionalized Building Blocks to Mimic Natural Enzymes2021

    • Author(s)
      Shin Aoki, Akib Bin Rahman, Hirokazu Okamoto, Yuya Miyazawa, and Yutaka Saga
    • Organizer
      5th International Conference on Catalysis and Chemical Engineering (CCE-2021)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Development of Facile Synthesis of Cyclic Oligosaccharides by One-Pot Glycosylation of Glycosyl Donor/Acceptor Molecules2021

    • Author(s)
      Shin Aoki, Hidehisa Someya, Takehito Seki, Gota Ishigami, nd Tomohiro Tanaka
    • Organizer
      7th International Conference on Biochemistry and Glyco Science (online)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 3次元点群を用いたタンパク質阻害剤の高速探索2021

    • Author(s)
      苅谷 健、古田 諒祐、入江 豪、青木 伸、谷口 行信
    • Organizer
      2021年電子情報通信学会総合大会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] 多視点画像とCNNを用いたバーチャルスクリーニング2021

    • Author(s)
      釘本 晃佑、古田 諒祐、入江 豪、青木 伸、谷口 行信
    • Organizer
      2021年電子情報通信学会総合大会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] Design and Synthesis of Supramolecular Phosphatases Functionalized with Lewis Acid Moieties for Catalytic Hydrolysis of Phosphate Monoester in Two-Phase Solvent System2021

    • Author(s)
      青木 伸、Akib Bin Rahman、岡本 紘知、宮澤 有哉
    • Organizer
      日本化学会第101春季年会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] 次の時代の迅速診断・迅速治療に向けた東京理科大学の異分野連携研究2021

    • Author(s)
      青木 伸
    • Organizer
      理化学研究所―東京理科大学合同シンポジウム(オンライン)
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] Identification and Development of Novel Compounds Inhibitory to SARS-CoV-2 Replication2021

    • Author(s)
      Masanori Baba, Mika Okamoto, Shin Aoki, Yoshiki Yagi, Masaaki Toyama, Tomohiro Tanaka, Takuro Niwa
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] カチオン性ポリマーを用いたホウ素中性子捕捉療法のためのBSH含有ナノ粒子の開発2021

    • Author(s)
      田中智博、上田大貴、鈴木実、櫻井良憲、青木 伸
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] シクロメタレート型イリジウム錯体―ペプチドハイブリッドのがん細胞死誘導活性評価およびカルシウム依存的な誘導メカニズムの解析2021

    • Author(s)
      横井 健汰、Chandrasekar Balachandran、青木 伸
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] がん細胞のプログラム細胞誘導死を目的としたトリプチセン-ペプチドハイブリッドの合成・設計及び生物活性評価2021

    • Author(s)
      山口 晃平、横井 健汰、青木 伸
    • Organizer
      日本薬学会第141年会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] Design, Synthesis, and Photophysical and Biological Property of Hybrid Compounds of Cyclometalated Iridium(III) Complexes with Peptides and Chromophores2020

    • Author(s)
      Shin Aoki, Kenta Yokoi, Chandrasekar Balachandran, Haribabu Jebiti, Abdullah-Al Masum, Ayami Kazama and Kana Naito
    • Organizer
      International Webinar on Chemistry and Biology: Sustainable Progress of Human Civilization
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] シクロメタレート型イリジウム錯体―カチオン性ペプチドハイブリッドによるがん細胞のパラトーシス誘導と作用機序2020

    • Author(s)
      木伸、横井健汰、Chandrasekar Balachandran、Haribabu Jebit、小山田有紗、梅澤雅和、土屋好司
    • Organizer
      第14回バイオ関連化学シンポジウム(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] ホウ素中性子線捕捉療法のためのBSH含有ナノ粒子の創製2020

    • Author(s)
      田中智博、上田大貴、鈴木実、櫻井良憲、青木伸
    • Organizer
      第64回日本薬学会関東支部大会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] Design, Synthesis and Anticancer Properties of Bis-, and Mono(Cationic Peptide) Hybrids of Ir(III) Complexes: Effect of the Number of Peptide Units on Anticancer Activity2020

    • Author(s)
      Haribabu Jebiti, Yuichi Tamura, Kenta Yokoi, Chandrasekar Balachandran, and Shin Aoki
    • Organizer
      第64回日本薬学会関東支部大会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] Design and Synthesis of Supramolecular Phosphatase Mimics Formed by the Self-Assembly of Monoalkylated Bis(Zn2+-cyclen) Complex, Copper and Functionalized Diimide Units2020

    • Author(s)
      Akib Bin Rahman, Yuya Miyazawa, Shin Aoki
    • Organizer
      第64回日本薬学会関東支部大会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] カルシウム依存的ながん細胞死を誘導するシクロメタレート型イリジウム錯体―ペプチドハイブリッドの設計、合成および生物学的評価2020

    • Author(s)
      横井健汰、Balachandran Chandrasekar、青木伸
    • Organizer
      第64回日本薬学会関東支部大会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] BNCT用ポリアミン誘導体の設計・合成および生物学的評価2020

    • Author(s)
      上田大貴、田中 智博、鈴木 実、櫻井 良憲、青木伸
    • Organizer
      第64回日本薬学会関東支部大会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] 放射線防護活性を有する2-pyrrolone類縁体の設計、合成、活性評価及び標的分子の探索2020

    • Author(s)
      佐藤秀哉、越智進太郎、水野皓介、氏田将平、多田佳寿美、松下洋輔2、出口雄一、鈴木啓司、田中義正、植田弘師、稲葉俊哉、細井義夫、森田明典、青木伸
    • Organizer
      第64回日本薬学会関東支部大会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] Design and Synthesis of Cyclometalated Iridium (III) Complex-Peptide Hybrids that Induce Paraptosis of Cancer Cells2020

    • Author(s)
      Shin Aoki
    • Organizer
      Webinar on Dementia Congress, Biotechnology Congress, Chemistry and Toxicology Congress
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Design and Synthesis of Cyclometalated Iridium(III) Complex-Chromophore Hybrids that Have Long Emission Lifetimes Based on a Reversible Electronic Energy Transfer (REET) Mechanism2020

    • Author(s)
      Shin Aoki, Ayami Kazama, Kenta Yokoi, Yasuyuki Yamada, and Junpei Yuasa
    • Organizer
      錯体化学会第70回討論会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] Design, Synthesis and Anticancer Activity of Bis-, and Mono(Cationic Peptide) Hybrids of Cyclometalated Iridium(III) Complexes: Effect of the Number of Peptide Units on Anticancer Property2020

    • Author(s)
      Haribabu Jebiti, Kenta Yokoi,Yuichi Tamura, Chandrasekar Balachandran, Shin Aoki
    • Organizer
      錯体化学会第70回討論会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] Amphiphilic Cationic Triscyclometalated Iridium(III) Complex-Peptide Hybrids Induce Paraptosis of Cancer Cells via Ca2+ Transfer from ER to Mitochondria2020

    • Author(s)
      Kenta Yokoi, Chandrasekar Balachandran, and Shin Aoki
    • Organizer
      錯体化学会第70回討論会(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] Design, Synthesis, and Biological Evaluation of Luminescent Cyclometalated Iridium(III) Complex-Peptide Hybrids for the Detection and Programmed Cell Death Induction of Cancer Cells2020

    • Author(s)
      Shin Aoki, Kenta Yokoi, Heribabu Jebiti, Chandrasekar Balachandran
    • Organizer
      6th International Electronic Conference on Medicinal Chemistry (Online)
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 放射線防護活性を有する2-Pyrrolone類の設計、合成、活性評価及び標的探索2020

    • Author(s)
      佐藤 秀哉、越智 進太郎、森田 明典、青木 伸
    • Organizer
      東京理科大学・日本医科大学第7回合同シンポジウム(オンライン)
    • Related Report
      2020 Research-status Report
  • [Presentation] ホウ素中性子捕捉療法のための環状ポリアミン誘導体の開発2020

    • Author(s)
      上田 大貴、田中 智博、鈴木 実、櫻井 良憲、青木 伸
    • Organizer
      東京理科大学・日本医科大学第7回合同シンポジウム(オンライン)
    • Related Report
      2020 Research-status Report
  • [Book] Characteristics and Applications of Boron2022

    • Author(s)
      S. Aoki, H. Ueda, T. Tanaka, T. Itoh, M. Suzuki, Y. Sakurai
    • Total Pages
      23
    • Publisher
      IntechOpen, Croatia
    • ISBN
      9781803564654
    • Related Report
      2022 Annual Research Report
  • [Book] 16.スタンダード薬学シリーズII 9 “薬学演習II. 基礎科学”2021

    • Author(s)
      日本薬学会編,
    • Total Pages
      493
    • Publisher
      東京化学同人
    • ISBN
      9784807917242
    • Related Report
      2021 Research-status Report
  • [Remarks] 東京理科大学薬学部生物有機化学研究室ホームページ

    • URL

      https://www.rs.noda.tus.ac.jp/aokilab/

    • Related Report
      2022 Annual Research Report
  • [Remarks] Lighting Up Iridium Complexes

    • URL

      https://researchoutreach.org/articles/lighting-up-iridium-complexes/

    • Related Report
      2020 Research-status Report
  • [Patent(Industrial Property Rights)] 抗SARS-CoV-2薬2021

    • Inventor(s)
      馬場昌範、岡本美佳、外山政明、青木伸、田中智博
    • Industrial Property Rights Holder
      馬場昌範、岡本美佳、外山政明、青木伸、田中智博
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Research-status Report
    • Overseas
  • [Patent(Industrial Property Rights)] 抗SARS-CoV-2薬2021

    • Inventor(s)
      馬場昌範、岡本美佳、外山政明、青木伸、田中智博、横井健汰
    • Industrial Property Rights Holder
      馬場昌範、岡本美佳、外山政明、青木伸、田中智博、横井健汰
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2021-184512
    • Filing Date
      2021
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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