| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Outline of Final Research Achievements |
PAS is responsible for initiating autophagy. The ubiquitin-like protein Atg8 is reversibly conjugated with phosphatidylethanolamine in an enzymatic reaction similar to the ubiquitin-binding system and is an important molecule directly involved in membrane elongation during autophagy. However, its precise role in autophagy has not yet been elucidated. By introducing a new perspective of liquid-liquid phase separation, this study revealed the mechanism of the actual regulation of the Atg8-conjugation reaction system in the cell.
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