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Exploration and analysis of the principle that enabled the acquisition of leaf-like organs in land plants

Research Project

Project/Area Number 20K06682
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 44030:Plant molecular biology and physiology-related
Research InstitutionThe University of Tokyo

Principal Investigator

Nakayama Hokuto  東京大学, 大学院理学系研究科(理学部), 助教 (30610935)

Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥520,000 (Direct Cost: ¥400,000、Indirect Cost: ¥120,000)
Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords発生進化学 / 発生学 / 進化学 / 植物 / 葉 / 多様性 / 発生 / 進化 / シロイヌナズナ / アンボレラ / 被子植物 / Amborella trichopoda / Arabidopsis thaliana / Evo-Devo / RNA-seq / インフォマティクス / 進化発生学 / Solanum lycopersicum / 形態 / トランスクリプトーム
Outline of Research at the Start

本研究計画は、陸上植物の中で最も反映している被子植物において、葉の獲得を可能にした分子機構を世界に先駆けて明らかにしようとするものである。植物において葉などの側生葉状器官の獲得は光合成の効率化をもたらし、放出される酸素が地球の大気組成の変化をももたらした。応募者は、これまでその詳細が全くの謎であった葉の獲得を可能にした分子機構を、進化学的観点から複数の植物群を選択し、分子生物学的手法、インフォマティクスなどを駆使して4年計画で明らかにする計画である。

Outline of Final Research Achievements

In this study, a comparison between Amborella trichopoda, which has been shown to diverge at the most basal in the phylogenetic tree of the present-day angiosperms, and Arabidopsis thaliana, a model plant for which the molecular mechanisms of leaf development are most understood, reveals that development, anatomy, and gene regulatory networks involved in leaf development are conserved among a wide range of angiosperms. This is a major achievement, as it provides a basis for identifying commonalities and uniqueness in the evolution of leaves in land plants, which have been shown to have been acquired multiple times independently.

Academic Significance and Societal Importance of the Research Achievements

研究成果の意義としては、葉の進化過程はこれまで化石研究が主であり、その進化過程も背景にある分子機構も全く明らかになっていなかった。今回の研究で被子植物において葉の発生に関わる遺伝子制御ネットワークが被子植物の間で保存されている事を明らかとし、陸上植物における葉の進化を考える上で比較基盤として利用できる点は成果と言える。またこの事は葉の発生に必要な根元的な遺伝子群を同定することに繋がるため、それらを用いて、葉を持たない植物、あるいは本来葉が発生しない部位に葉を持たせることで新奇形態の園芸植物や光合成効率を向上させた作物を作出する技術の基盤の創出を導くことができるという社会的意義も挙げられる。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (23 results)

All 2024 2023 2022 2021 2020 Other

All Int'l Joint Research (3 results) Journal Article (11 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 11 results,  Open Access: 7 results) Presentation (9 results) (of which Int'l Joint Research: 2 results,  Invited: 3 results)

  • [Int'l Joint Research] University of California, Davis(米国)

    • Related Report
      2022 Research-status Report
  • [Int'l Joint Research] University of California, Davis(米国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] University of California, Davis(米国)

    • Related Report
      2020 Research-status Report
  • [Journal Article] A chromosome-level genome assembly for the amphibious plant Rorippa aquatica reveals its allotetraploid origin and mechanisms of heterophylly upon submergence2024

    • Author(s)
      Sakamoto Tomoaki、Ikematsu Shuka、Nakayama Hokuto、Mand?kov? Terezie、Gohari Gholamreza、Sakamoto Takuya、Li Gaojie、Hou Hongwei、Matsunaga Sachihiro、Lysak Martin A.、Kimura Seisuke
    • Journal Title

      Communications Biology

      Volume: 7 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s42003-024-06088-7

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Leaf form diversity and evolution: a never-ending story in plant biology2024

    • Author(s)
      Nakayama Hokuto
    • Journal Title

      Journal of Plant Research

      Volume: - Issue: 4 Pages: 547-560

    • DOI

      10.1007/s10265-024-01541-4

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dancing in the sun: maize azimuthal canopy re-orientation for efficient light capture2024

    • Author(s)
      Jhu Min-Yao、Nakayama Hokuto
    • Journal Title

      The Plant Cell

      Volume: - Issue: 5 Pages: 1568-1569

    • DOI

      10.1093/plcell/koae026

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] How to utilize comparative transcriptomics to dissect morphological diversity in plants2023

    • Author(s)
      Li Siyu、Nakayama Hokuto、Sinha Neelima R.
    • Journal Title

      Current Opinion in Plant Biology

      Volume: 76 Pages: 102474-102474

    • DOI

      10.1016/j.pbi.2023.102474

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Regulatory Genes in Plant Development: Homeobox2023

    • Author(s)
      Nakayama Hokuto、Sinha Neelima R.
    • Journal Title

      Encyclopedia of Life Sciences

      Volume: 3 Pages: 1-9

    • DOI

      10.1002/9780470015902.a0029556

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evolution of two gene networks underlying adaptation to drought stress in the wild tomato<i>Solanum chilense</i>2023

    • Author(s)
      Wei Kai、Sharifova Saida、Zhao Xiaoyun、Sinha Neelima、Nakayama Hokuto、Tellier Aur?lien、Silva-Arias Gustavo A
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2023.01.18.524537

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Diversity of tomato leaf form provides novel insights into breeding2023

    • Author(s)
      Nakayama Hokuto、Ichihashi Yasunori、Kimura Seisuke
    • Journal Title

      Breeding Science

      Volume: 73 Issue: 1 Pages: 76-85

    • DOI

      10.1270/jsbbs.22061

    • ISSN
      1344-7610, 1347-3735
    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Molecular mechanisms underlying leaf development, morphological diversification, and beyond2022

    • Author(s)
      Nakayama Hokuto、Leichty Aaron R、Sinha Neelima R
    • Journal Title

      The Plant Cell

      Volume: 34 Issue: 7 Pages: 2534-2548

    • DOI

      10.1093/plcell/koac118

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Looking beyond the gene network ? metabolic and mechanical cell drivers of leaf morphogenesis2022

    • Author(s)
      Nakayama Hokuto、Koga Hiroyuki、Long Yuchen、Hamant Olivier、Ferjani Ali
    • Journal Title

      Journal of Cell Science

      Volume: 135 Issue: 8

    • DOI

      10.1242/jcs.259611

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Leaf form diversification in an ornamental heirloom tomato results from alterations in two different HOMEOBOX genes2021

    • Author(s)
      Nakayama Hokuto、Rowland Steven D.、Cheng Zizhang、Zumstein Kristina、Kang Julie、Kondo Yohei、Sinha Neelima R.
    • Journal Title

      Current Biology

      Volume: 31 Issue: 21 Pages: 4788-4799.e5

    • DOI

      10.1016/j.cub.2021.08.023

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Leaf shape is a predictor of fruit quality and cultivar performance in tomato2020

    • Author(s)
      Rowland Steven D.、Zumstein Kristina、Nakayama Hokuto、Cheng Zizhang、Flores Amber M.、Chitwood Daniel H.、Maloof Julin N.、Sinha Neelima R.
    • Journal Title

      New Phytologist

      Volume: 226 Issue: 3 Pages: 851-865

    • DOI

      10.1111/nph.16403

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Amborella trichopodaとシロイヌナズナのトランスクリプトーム/ゲノムデータを用いた被子植物の葉の獲得に関する進化発生学的研究2024

    • Author(s)
      中山北斗、塚谷裕一
    • Organizer
      日本植物生理学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 「UJA留学のすゝめ2023」 日本の科学技術を推進するネットワーク構築2023

    • Author(s)
      中山北斗
    • Organizer
      日本分子生物学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Toward elucidating the mechanisms of angiosperm leaf evolution2023

    • Author(s)
      Hokuto Nakayama
    • Organizer
      Taiwan-Japan Plant Biology
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Crassothonna属(キク科)の多肉葉に見られる細胞サイズの増加は核内倍化と関連する2023

    • Author(s)
      中山北斗、澤﨑賢斗、ドル有生、古賀皓之、森山安武、塚谷裕一
    • Organizer
      日本植物学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Investigation of the relationship between petiole formation and the adaxial-abaxial patterning in Arabidopsis2023

    • Author(s)
      YUJIE ZHAO, 中山北斗, 塚谷裕一
    • Organizer
      日本植物形態学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Exploring Genetic Regulation of Compound Leaf Development in Eudicots: A Comparative Transcriptomic Approach2023

    • Author(s)
      Siyu Li, Hokuto Nakayama, Neelima, R., Sinha
    • Organizer
      The American Society of Plant Biologists
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 被子植物の葉の獲得とその形態の多様化に関する進化発生生物学研究2022

    • Author(s)
      中山北斗
    • Organizer
      日本植物学会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 現生被子植物の最基部で分岐した系統であるAmborella trichopodaを用いたトランスクリプトーム解析2021

    • Author(s)
      中山北斗、塚谷裕一
    • Organizer
      日本植物学会 第85回
    • Related Report
      2021 Research-status Report
  • [Presentation] 現生被子植物の系統樹上で最基部に位置するAmborella trichopodaを用いた葉の獲得に関わる進化発生学的研究2020

    • Author(s)
      中山北斗、塚谷裕一
    • Organizer
      日本植物生理学会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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