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Memory priming of filial imprinting by the action of thyroid hormone in domestic chicks

Research Project

Project/Area Number 20K06747
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 44050:Animal physiological chemistry, physiology and behavioral biology-related
Research InstitutionTeikyo University

Principal Investigator

Homma Koichi  帝京大学, 薬学部, 教授 (90251438)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords刷り込み / 甲状腺ホルモン / 早期学習 / プライミング / ニワトリ / IMM
Outline of Research at the Start

刻印付けは、孵化後間もないヒナが最初の視覚経験をもとに形成する学習記憶である。記憶の獲得・維持・想起に関連する遺伝子を同定し、それら遺伝子の機能とともに、そのメカニズムを解明する。本研究では、「脳内甲状腺ホルモンによる鳥類早期学習プライミング機構の解明」を大目的とした以下の研究目的を遂行する。
1、T3の脳内流入が引き起こす神経微細構造内のアクチン骨格再編成の生化学的解明
2、刻印付け初期過程と記憶維持・想起領域とをつなぐ神経回路の生化学・薬理学的解明
3、メモリープライミング(T3)が高める認知的柔軟性の行動学的解明
4、刻印付けによるIMM領域とIMHA領域で起こる神経活動の生理学的解明

Outline of Final Research Achievements

Blockade of muscarinic acetylcholine receptor impaired imprinting. The dorsal arcopallium of chicks displayed the expression of orthologs of mammalian fear-related serotonin receptor subfamily genes. Fetal blockade of nicotinic acetylcholine transmission caused autism-like impairment of biological motion preference. Dopaminergic nuclei in the chick midbrain expressed serotonin receptor subfamily genes. Muscarinic acetylcholine receptors contributed subtype-selectively for imprinting. Thyroid hormone modulated the chick forebrain network for imprinting. Chick hippocampus displayed subdivision- and layer-selective expressions of serotonin receptor genes. The imprintability of newly hatched chicks was assessed by a high-time resolution apparatus based on a running disc.

Academic Significance and Societal Importance of the Research Achievements

これまで刷り込みは離巣性鳥類の親を覚える特殊な記憶学習であり、その後の個体発生の種々の学習に影響を及ぼす学習とは考えられていなかった。しかし、代表者らの研究の結果、学習に伴って脳内に流入する甲状腺ホルモンによってニワトリヒナの刷り込み学習が可能になると、その後の学習の習得力が飛躍的に向上することがわかった。本研究は、学習臨界期中に遷移する神経回路のキー分子として甲状腺ホルモンに焦点を当て、新たに開発した行動装置を利用して研究を遂行する独自性の高いものであり、視覚優先学習と聴覚優先学習における脳機能を比較しながら脳の機能的進化を考察できる点において、国内外の研究にはない視点と成果が期待できる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (24 results)

All 2022 2021 2020 2019 Other

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 7 results) Presentation (11 results) (of which Int'l Joint Research: 1 results,  Invited: 1 results) Remarks (4 results)

  • [Journal Article] Fetal blockade of nicotinic acetylcholine transmission causes autism-like impairment of biological motion preference in the neonatal chick2022

    • Author(s)
      Matsushima Toshiya、Miura Momoko、Patzke Nina、Toji Noriyuki、Wada Kazuhiro、Ogura Yukiko、Homma Koichi J、Sgado Paola、Vallortigara Giorgio
    • Journal Title

      Cerebral Cortex Communications

      Volume: ー Issue: 4

    • DOI

      10.1093/texcom/tgac041

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dopaminergic nuclei in the chick midbrain express serotonin receptor subfamily genes2022

    • Author(s)
      Toshiyuki Fujita, Naoya Aoki, Chihiro Mori, Shouta Serizawa, Fumiko Kihara-Negishi, Koichi J. Homma, Shinji Yamaguchi
    • Journal Title

      Frontiers in Physiology

      Volume: 13 Pages: 1030621-1030636

    • DOI

      10.3389/fphys.2022.1030621

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gene expression profiles of the muscarinic acetylcholine receptors in brain regions relating to filial imprinting of newly-hatched domestic chicks2022

    • Author(s)
      Mori Chihiro、Aoki Naoya、Fujita Toshiyuki、Yamaguchi Shinji、Matsushima Toshiya、Homma Koichi J.
    • Journal Title

      Behavioural Brain Research

      Volume: 420 Pages: 113708-113708

    • DOI

      10.1016/j.bbr.2021.113708

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subtype-selective contribution of muscarinic acetylcholine receptors for filial imprinting in newly-hatched domestic chicks2022

    • Author(s)
      Aoki Naoya、Mori Chihiro、Fujita Toshiyuki、Serizawa Shouta、Yamaguchi Shinji、Matsushima Toshiya、Homma Koichi J.
    • Journal Title

      Behavioural Brain Research

      Volume: 424 Pages: 113789-113789

    • DOI

      10.1016/j.bbr.2022.113789

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Suppressive Modulation of the Chick Forebrain Network for Imprinting by Thyroid Hormone: An in Vitro Study2022

    • Author(s)
      Saheki Yuriko、Aoki Naoya、Homma Koichi J.、Matsushima Toshiya
    • Journal Title

      Frontiers in Physiology

      Volume: 13 Pages: 822638-822638

    • DOI

      10.3389/fphys.2022.881947

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chick Hippocampal Formation Displays Subdivision- and Layer-Selective Expression Patterns of Serotonin Receptor Subfamily Genes2022

    • Author(s)
      Fujita Toshiyuki、Aoki Naoya、Mori Chihiro、Fujita Eiko、Matsushima Toshiya、Homma Koichi J.、Yamaguchi Shinji
    • Journal Title

      Frontiers in Physiology

      Volume: 13 Pages: 882633-882633

    • DOI

      10.3389/fphys.2022.882633

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Imprintability of Newly Hatched Domestic Chicks on an Artificial Object: A Novel High Time-Resolution Apparatus Based on a Running Disc2022

    • Author(s)
      Aoki Naoya、Mori Chihiro、Fujita Toshiyuki、Serizawa Shouta、Yamaguchi Shinji、Matsushima Toshiya、Homma Koichi J.
    • Journal Title

      Frontiers in Physiology

      Volume: 13 Pages: 881947-881947

    • DOI

      10.3389/fphys.2022.822638

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Blockade of muscarinic acetylcholine receptor by scopolamine impairs the memory formation of filial imprinting in domestic chicks (Gallus Gallus domesticus).2020

    • Author(s)
      Naoya Aoki, Toshiyuki Fujita, Chihiro Mori, Eiko Fujita, Shinji Yamaguchi, Toshiya Matsushima, Koichi J Homma
    • Journal Title

      Behavioural brain research

      Volume: 379 Pages: 112291-112291

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] The chick pallium displays divergent expression patterns of chick orthologues of mammalian neocortical deep layer-specific genes2019

    • Author(s)
      Fujita T, Aoki N, Fujita E, Matsushima T, Homma KJ, Yamaguchi S.
    • Journal Title

      Sci Rep.

      Volume: 9 Issue: 1 Pages: 20400-20400

    • DOI

      10.1038/s41598-019-56960-4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 鳥類認知機能の発達に及ぼす甲状腺ホルモンの役割2022

    • Author(s)
      本間光一
    • Organizer
      第46回日本比較内分泌学会大会・大会実行委員会主催シンポジウム, 東京大学農学部弥生講堂, 東京, 10月29日, 2022年
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 鳥類刻印付けにおけるムスカリン性アセチルコリン受容体サブタイプの寄与2022

    • Author(s)
      青木直哉、森千紘、芹澤祥太、本間光一
    • Organizer
      日本動物学会 第93回早稲田大会、早稲田大学・早稲田キャンパス、東京、9月8日~10日、2022年
    • Related Report
      2022 Annual Research Report
  • [Presentation] Identification of the brain area associated with intrinsic motivation for singing in zebra finches2022

    • Author(s)
      森千紘, Yunbok Kim, 青木直哉, 本間光一, 小島哲
    • Organizer
      NEURO2022(第45回日本神経科学大会), 沖縄コンベンションセンター・宜野湾市立体育館・ラグナガーデンホテルHybrid開催, 沖縄, 6月30~7月3日, 2022年
    • Related Report
      2022 Annual Research Report
  • [Presentation] ニワトリ胚後期における甲状腺ホルモン合成の低下は刷り込みを阻害する2022

    • Author(s)
      芹澤祥太, 青木直哉, 森千紘, 本間光一
    • Organizer
      日本動物学会関東支部 第74回大会, 2022年
    • Related Report
      2022 Annual Research Report
  • [Presentation] “Subtype-selective role of muscarinic acetylcholine receptors for memory formation of imprinting in newly-hatched domestic chicks”2021

    • Author(s)
      Koichi J. Homma
    • Organizer
      FAOBMB 2021, 16th Congress of the Federation of Asian and Oceanian Biochemists and Molecular Biologists
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] “Gene expression profiles of the muscarinic acetylcholine receptors in brain of newly-hatched domestic chicks”2021

    • Author(s)
      森千紘, 青木直哉, 藤田俊之, 山口真二, 本間光一
    • Organizer
      第44回日本神経科学大会・CJK第1回国際会議
    • Related Report
      2021 Research-status Report
  • [Presentation] “ムスカリン性アセチルコリン受容体M2, M5はニワトリの刷り込みにおける記憶形成に関わる”2021

    • Author(s)
      青木直哉, 森千紘, 藤田俊之, 山口真二, 本間光一
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Research-status Report
  • [Presentation] “円盤型トレーニング装置を用いた刷り込み行動解析”2021

    • Author(s)
      青木直哉, 森千紘, 藤田俊之, 山口真二, 本間光一
    • Organizer
      第92回日本動物学会
    • Related Report
      2021 Research-status Report
  • [Presentation] アセチルコリンはニワトリの刷り込みにおける記憶形成に関わる2020

    • Author(s)
      青木直哉、森千紘、藤田俊之、藤田永子、山口真二、本間光一
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report
  • [Presentation] ニワトリ終脳において、哺乳類の大脳新皮質深層選択的遺伝子オルソログの発現は、様々な領域に見られた2020

    • Author(s)
      Shinji Yamaguchi, Naoya Aoki, Koichi Homma, Toshiyuki Fujita
    • Organizer
      第53回発生生物学会
    • Related Report
      2020 Research-status Report
  • [Presentation] ニワトリ終脳におけるセロトニン受容体遺伝子の発現解析2020

    • Author(s)
      Toshiyuki Fujita, Naoya Aoki, Eiko Fujita, Koichi Homma, Shinji Yamaguchi
    • Organizer
      第53回発生生物学会
    • Related Report
      2020 Research-status Report
  • [Remarks] Researchmap本間光一

    • URL

      https://researchmap.jp/hommakj/

    • Related Report
      2022 Annual Research Report 2021 Research-status Report 2020 Research-status Report
  • [Remarks] 帝京大学薬学部ホームページ

    • URL

      http://www.pharm.teikyo-u.ac.jp/

    • Related Report
      2022 Annual Research Report 2021 Research-status Report 2020 Research-status Report
  • [Remarks] 帝京大学教員情報

    • URL

      https://www3.med.teikyo-u.ac.jp/profile/ja.a661daea46d098d0.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] 帝京大学教員情報

    • URL

      https://www.e-campus.gr.jp/staffinfo/public/staff/detail/450/1

    • Related Report
      2021 Research-status Report 2020 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

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