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The role of non-allelic gene conversion in the evolution of Transposable Elements

Research Project

Project/Area Number 20K06761
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 45010:Genetics-related
Research InstitutionInstitute of Physical and Chemical Research

Principal Investigator

FAWCETT JEFFREY  国立研究開発法人理化学研究所, 数理創造プログラム, 上級研究員 (50727394)

Co-Investigator(Kenkyū-buntansha) 印南 秀樹  総合研究大学院大学, 先導科学研究科, 教授 (90444140)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2023: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
KeywordsTransposable Elements / gene conversion / genome evolution / Transposable Element / Gene conversion / evolution
Outline of Research at the Start

We will test the role of non-allelic gene conversion between Transposable Elements (TEs) in the evolution of TEs, and in the evolution of regulatory networks using computer simulation and genomic data analyses.

Outline of Final Research Achievements

Transposable Elements are thought to be key drivers of evolution and have most likely contributed to various evolutionary processes such as the rewiring of regulatory networks. We previously argued that understanding the evolution of TEs themselves, including the role of non-allelic gene conversion and selection amongst TEs is crucial for unravelling the role of TEs in evolution. One of the major achievement has been our results on the contribution of TEs to centromere evolution, a process in which rapid TE evolution via non-allelic gene conversion is thought to be involved, in buckwheat species. We found that the species specific activity of a particular LTR retrotransposon family of the CRM clade is associated with neocentromeres, suggesting its role in speciation via centromere turnover.

Academic Significance and Societal Importance of the Research Achievements

How Transposable Elements contribute to evolution is a central question in evolutionary biology. Here, we have provided a novel example showing that the rapid amplification and evolution of TEs is associated with the turnover of centromeres and most probably speciation.

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (2 results)

All 2023 2021

All Journal Article (1 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 1 results,  Open Access: 1 results) Presentation (1 results) (of which Invited: 1 results)

  • [Journal Article] Genome sequencing reveals the genetic architecture of heterostyly and domestication history of common buckwheat2023

    • Author(s)
      Fawcett JA, Takeshima R, Kikuchi S, Yazaki E, Katsube-Tanaka T, Dong Y, Li M, Hunt HV, Jones MK, Lister DL, Ohsako T, Ogiso-Tanaka E, Fujii K, Hara T, Matsui K, Mizuno N, Nishimura K, Nakazaki T, Saito H, Takeuchi N, Ueno M, Matsumoto D, Norizuki M, Shirasawa K, Li C, Hirakawa H, Ota T, Yasui Y.
    • Journal Title

      Nature Plants

      Volume: 9 Issue: 8 Pages: 1236-1251

    • DOI

      10.1038/s41477-023-01474-1

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] The role of gene conversion between Transposable Elements in rewiring regulatory systems2021

    • Author(s)
      Jeffrey Fawcett, Hideki Innan
    • Organizer
      Annual Meeting of the Molecular Biology Society of Japan
    • Related Report
      2021 Research-status Report
    • Invited

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Published: 2020-04-28   Modified: 2025-01-30  

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