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Evolution of peptide signaling molecules during the plant terrestrialization process – the origin of land plant peptide hormones

Research Project

Project/Area Number 20K06770
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 45020:Evolutionary biology-related
Research InstitutionHiroshima University (2022)
Akita University (2021)
Kumamoto University (2020)

Principal Investigator

Furumizu Chihiro  広島大学, 自然科学研究支援開発センター, 助教 (90808479)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Keywords植物ペプチド情報伝達系 / 植物ペプチドホルモン / ゼニゴケ / 陸上植物の進化 / 分子進化 / 共進化 / 遺伝子重複 / 生物間相互作用 / 植物ホルモン / 異種生物間相互作用 / 植物ペプチド性情報因子の進化 / 植物ペプチド性情報因子受容体の進化 / 植物―動物間相互作用 / ペプチドホルモン / 藻類 / コケ植物
Outline of Research at the Start

陸上植物が藻類から進化し、多様化した過程には、「ペプチドホルモン」を介した細胞間コミュニケーションの成立と進化が寄与したと考えられるが、植物ペプチドホルモン情報伝達系がどのように誕生したのかは未解決のままである。そこで本研究では、① 基部陸上植物のペプチドホルモンを網羅的に探索して機能を明らかにし、② 陸上植物と近縁藻類の間に共通するペプチドホルモンの有無を検証することにより、植物ペプチドホルモンの起源を解明することを目的とする。本研究を行うことで、植物ペプチドホルモン情報伝達系の起源と進化の理解が深まることが期待され、新奇植物ペプチドホルモンの発見につながる可能性もある。

Outline of Final Research Achievements

Major achievements of this research project include the following: (1) it was shown how widely homologs of known peptide hormones and their receptors are present in land plants. The results were published as two refereed review articles; (2) sequence diversity was revealed in the RGF family signaling peptides. The results were published as a refereed research article; (3) evolution of the CLE peptide signaling system was examined and published as a review; (4) evolutionary trajectories of a subfamily of receptor-like kinases were elucidated and published as a refereed research article; and (5) the putative TPD1-EMS1 signaling pathway was functionally characterized in Marchantia polymorpha.

Academic Significance and Societal Importance of the Research Achievements

植物自身によって作られ、植物の成長を調節する短いペプチドが次々と見つかり、植物の生育を制御する技術の開発における生体内ターゲットとしても注目されている。本研究では、これらの生理活性ペプチドやその受容体をコードする遺伝子の進化について解析し、植物がもつペプチド情報伝達系の全容がダイナミックに進化してきた一端を明らかにした。本研究の成果は、新規の生理活性ペプチドの同定にも役立つことが期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (13 results)

All 2023 2022 2021 Other

All Int'l Joint Research (2 results) Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 7 results,  Open Access: 4 results) Presentation (2 results) (of which Invited: 1 results) Remarks (1 results)

  • [Int'l Joint Research] オスロ大学(ノルウェー)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] オスロ大学(ノルウェー)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Peptide signaling through leucine‐rich repeat receptor kinases: insight into land plant evolution2023

    • Author(s)
      Furumizu Chihiro、Aalen Reidunn Birgitta
    • Journal Title

      New Phytologist

      Volume: 238 Issue: 3 Pages: 977-982

    • DOI

      10.1111/nph.18827

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Method for Analyzing an Infection Process of Plant-parasitic Nematodes Using a Microfluidic Device2021

    • Author(s)
      Hida Hirotaka、Ebara Rika、Hayashi Shumpei、Kanno Isaku、Furumizu Chihiro、Sawa Shinichiro
    • Journal Title

      IEEJ Transactions on Sensors and Micromachines

      Volume: 141 Issue: 5 Pages: 141-146

    • DOI

      10.1541/ieejsmas.141.141

    • NAID

      130008033022

    • ISSN
      1341-8939, 1347-5525
    • Year and Date
      2021-05-01
    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Database mining of plant peptide homologues2021

    • Author(s)
      Yuan Na、Furumizu Chihiro、Zhang Baolong、Sawa Shinichiro
    • Journal Title

      Plant Biotechnology

      Volume: 38 Issue: 1 Pages: 137-143

    • DOI

      10.5511/plantbiotechnology.20.0720a

    • NAID

      130008002843

    • ISSN
      1342-4580, 1347-6114
    • Year and Date
      2021-03-25
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The RGF/GLV/CLEL Family of Short Peptides Evolved Through Lineage-Specific Losses and Diversification and Yet Conserves Its Signaling Role Between Vascular Plants and Bryophytes2021

    • Author(s)
      Furumizu Chihiro、Sawa Shinichiro
    • Journal Title

      Frontiers in Plant Science

      Volume: 12

    • DOI

      10.3389/fpls.2021.703012

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The sequenced genomes of nonflowering land plants reveal the innovative evolutionary history of peptide signaling2021

    • Author(s)
      Furumizu Chihiro、Krabbered Anders K.、Hammerstad Marta、Alling Renate M.、Wildhagen Mari、Sawa Shinichiro、Aalen Reidunn B.
    • Journal Title

      The Plant Cell

      Volume: 33 Issue: 9 Pages: 2915-2934

    • DOI

      10.1093/plcell/koab173

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Control of Fusarium and nematodes by entomopathogenic fungi for organic production of Zingiber officinale2021

    • Author(s)
      Yanagawa Aya、Krishanti Ni Putu Ratna Ayu、Sugiyama Akifumi、Chrysanti Emiria、Ragamustari Safendrri Komara、Kubo Minoru、Furumizu Chihiro、Sawa Shinichiro、Dara Surendra K.、Kobayashi Masaru
    • Journal Title

      Journal of Natural Medicines

      Volume: 76 Issue: 1 Pages: 291-297

    • DOI

      10.1007/s11418-021-01572-4

    • NAID

      40022800713

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Evolving research into CLE peptide signaling opens new doors to exploring land plant diversity2021

    • Author(s)
      古水 千尋、平川 有宇樹、澤 進一郎
    • Journal Title

      Regulation of Plant Growth & Development

      Volume: 56 Issue: 2 Pages: 85-91

    • DOI

      10.18978/jscrp.56.2_85

    • ISSN
      1346-5406, 2189-6305
    • Related Report
      2021 Research-status Report
  • [Journal Article] Insight into early diversification of leucine-rich repeat receptor-like kinases provided by the sequenced moss and hornwort genomes2021

    • Author(s)
      Furumizu, C., and Sawa, S
    • Journal Title

      Plant Mol. Biol

      Volume: - Issue: 4-5 Pages: 337-353

    • DOI

      10.1007/s11103-020-01100-0

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Presentation] 植物ペプチドシグナルの世も無常?ゲノムが語る栄枯転変の物語2022

    • Author(s)
      古水千尋
    • Organizer
      日本植物学会第86会大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 陸上植物におけるペプチドシグナル伝達系の進化2021

    • Author(s)
      古水千尋、澤進一郎
    • Organizer
      日本植物学会第84回大会
    • Related Report
      2020 Research-status Report
  • [Remarks] 研究内容の紹介ページ

    • URL

      https://evobio.hiroshima-u.ac.jp/about/

    • Related Report
      2022 Annual Research Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

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