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Modeling study on the impact of detailed biophysical properties of individual neurons on global network dynamics in the cerebellum

Research Project

Project/Area Number 20K06850
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 46010:Neuroscience-general-related
Research InstitutionThe University of Electro-Communications

Principal Investigator

Yamazaki Tadashi  電気通信大学, 大学院情報理工学研究科, 准教授 (40392162)

Co-Investigator(Kenkyū-buntansha) 五十嵐 潤  国立研究開発法人理化学研究所, 情報システム本部, 上級研究員 (60452827)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywords小脳 / マルチコンパートメント / シミュレーション / 樹状突起計算 / マルチコンパートメントモデル / 高性能計算 / ネットワーク
Outline of Research at the Start

神経細胞 (ニューロン) の複雑な形態は、それそのものが高度な情報処理機能を担っていることが示唆されている。単体でも十分複雑な形態を持つニューロンが多数接続したときに、ネットワークとしてどのような機能が実現されうるのか、また遺伝子疾患によって引き起こされる形態の変化によってその機能がどう変化するのかは未だ不明である。これらを実験的に解明するのは技術的に困難であるため、数理モデルを用いた数値シミュレーションが有効な手法である。本研究では、これまでに構築してきたニューロンの形態まで再現した小脳皮質回路モデルの大規模な数値シミュレーションを実施する。

Outline of Final Research Achievements

To investigate how the detailed structure of individual neurons, such as spatial morphology and distribution of ion channels, influences information processing in the cerebellum, multi-compartment models of granule cells, Golgi cells, and Purkinje cells were implemented, and a network model of the cerebellar cortex was constructed. To speed up simulations, we adopted an explicit method to calculate membrane potentials. Then, we examined the intracellular dynamics and learning capabilities of Purkinje cells in response to sequential stimuli of parallel fibers. Furthermore, we examined how shrinkage of dendrites in Purkinje cells affect the spatiotemporal activity of downstream deep cerebellar nucleus neurons. These findings have been summarized in peer-reviewed papers and a textbook.

Academic Significance and Societal Importance of the Research Achievements

脳の機能はニューロンのネットワークのダイナミクスとして生じるというのが一般的なコンセンサスであり、翻って個々のニューロンは単純な素子であると暗に仮定される場合がある。本研究は、その暗黙の仮定に反論するものであり、単一ニューロンであっても樹状突起とイオンチャネルの非線形性を巧みに利用することで、高度な情報処理が可能になることを示唆するものであり、その点で学術的意義がある。また、複雑なニューロンモデルのシミュレーションを高速に行うための数値計算手法を開発しており、シミュレーション研究の普及・発展に貢献するという意義もある。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (16 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (1 results) Journal Article (5 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (8 results) (of which Int'l Joint Research: 5 results,  Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Int'l Joint Research] University of Pavia(イタリア)

    • Related Report
      2020 Research-status Report
  • [Journal Article] Discrimination and learning of temporal input sequences in a cerebellar Purkinje cell model2023

    • Author(s)
      Kaaya Tamura, Yuki Yamamoto, Taira Kobayashi, Rin Kuriyama, Tadashi Yamazaki
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 17

    • DOI

      10.3389/fncel.2023.1075005

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Deploying and Optimizing Embodied Simulations of Large-Scale Spiking Neural Networks on HPC Infrastructure2022

    • Author(s)
      Benedikt Feldotto, Jochen Martin Eppler, Cristian Jimenez-Romero, Christopher Bignamini, Carlos Enrique Gutierrez, Ugo Albanese, Eloy Retamino, Viktor Vorobev, Vahid Zolfaghari, Alex Upton, Tadashi Yamazaki, et al.
    • Journal Title

      Frontiers in Neuroinformatics

      Volume: 16

    • DOI

      10.3389/fninf.2022.884180

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Testing an Explicit Method for Multi-compartment Neuron Model Simulation on a GPU2021

    • Author(s)
      Kobayashi Taira、Kuriyama Rin、Yamazaki Tadashi
    • Journal Title

      Cognitive Computation

      Volume: - Issue: 4 Pages: 1118-1131

    • DOI

      10.1007/s12559-021-09942-6

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human-scale Brain Simulation via Supercomputer: A Case Study on the Cerebellum2021

    • Author(s)
      Yamazaki Tadashi、Igarashi Jun、Yamaura Hiroshi
    • Journal Title

      Neuroscience

      Volume: 462 Pages: 235-246

    • DOI

      10.1016/j.neuroscience.2021.01.014

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Real-Time Simulation of a Cerebellar Scaffold Model on Graphics Processing Units2021

    • Author(s)
      Kuriyama Rin、Casellato Claudia、D'Angelo Egidio、Yamazaki Tadashi
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 15 Pages: 623552-623552

    • DOI

      10.3389/fncel.2021.623552

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Simulation neuroscience: a new kind of neuroscience?2022

    • Author(s)
      Tadashi Yamazaki
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Learning sequences of parallel fiber stimulation by a cerebellar Purkinje cell model with dendrites2022

    • Author(s)
      Kaaya Tamura, Yuki Yamamoto, Taira Kobayashi, Tadashi Yamazaki
    • Organizer
      NEURO2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] earning to discriminate stimulus sequences by dendritic computation of a single cerebellar Purkinje cell model2022

    • Author(s)
      Kaaya Tamura, Yuki Yamaoto, Taira Kobayashi, Tadashi Yamazaki
    • Organizer
      Neuroscience2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] An explicit method to accelerate simulation of a cerebellar multi-compartment network model2021

    • Author(s)
      Taira Kobayashi, Tadashi Yamazaki
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] igh-performance simulation of multi-compartment models using an explicit method2021

    • Author(s)
      Taira Kobayashi, Rin Kuriyama, Tadashi Yamazaki
    • Organizer
      第31回日本神経回路学会全国大会 (JNNS2021)
    • Related Report
      2021 Research-status Report
  • [Presentation] Discrimination of stimulus sequences by dendritic computation2021

    • Author(s)
      Kaaya Tamura, Taira Kobayashi, Tadashi Yamazaki
    • Organizer
      第31回日本神経回路学会全国大会 (JNNS2021)
    • Related Report
      2021 Research-status Report
  • [Presentation] A new acceleration method for multi-compartment neuron model simulation2020

    • Author(s)
      Taira Kobayashi, Tadashi Yamazaki
    • Organizer
      第43回日本神経科学学会全国大会
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Simulation of multicompartment neuron models using an explicit PDE solver2020

    • Author(s)
      Taira Kobayashi, Tadashi Yamazaki
    • Organizer
      第30回日本神経回路学会全国大会
    • Related Report
      2020 Research-status Report
  • [Book] はじめての神経回路シミュレーション2021

    • Author(s)
      山﨑 匡、五十嵐 潤
    • Total Pages
      224
    • Publisher
      森北出版
    • ISBN
      9784627856318
    • Related Report
      2021 Research-status Report
  • [Remarks] Cerebellum-neuron-model-simulation-using-RKC

    • URL

      https://github.com/numericalbrainorg/Cerebellum-neuron-model-simulation-using-RKC

    • Related Report
      2021 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

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