The nature and roles of cellular metabolism and energy in the regulation of neuronal chain migration
| Project/Area Number |
20K06865
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 46010:Neuroscience-general-related
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| Research Institution | National Institute of Genetics |
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Principal Investigator |
ZHU YAN 国立遺伝学研究所, 遺伝形質研究系, 助教 (50464235)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
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| Keywords | chain migration / precerebellar neurons / OXPHOS / tangential / radial / adhesion / protease / Chain migration / Precerebellar neurons / Metabolic pathways / metabolic pathway / neuronal migration / bioenergetics / ATP sensor / Bioenergetics / metabolic pathways / Neuronal migration / energy status / energy sensor |
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| Outline of Research at the Start |
All cellular activities consume energy which is supplied by metabolic pathways. Status of energy consumption both reflects and controls cell behaviors. This research investigates the dynamics of energy status and the metabolic pathways during the development of mammalian brains.
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| Outline of Annual Research Achievements |
Our objective is to understand characteristics of chain migrating neurons, in particular its energy expenditure and metabolic sources. We generated a knockout mice line deficient in a transcription factor known to promote OXPHOS pathway and found that the chain migrating precerebellar neurons showed defect in switching from tangential to radial migration. In a separate approach, we have found that fine-tuning the level of a key adhesion molecule, possibly by a protease system, also contribute to this process.
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Report
(4 results)
Research Products
(5 results)
