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Study of neural circuits generating smooth muscle contraction patterns

Research Project

Project/Area Number 20K06908
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionThe University of Electro-Communications (2021-2022)
The University of Tokyo (2020)

Principal Investigator

Kohsaka Hiroshi  電気通信大学, 大学院情報理工学研究科, 准教授 (20431900)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords運動制御 / 神経回路 / ショウジョウバエ / カルシウムイメージング / コネクトミクス / オプトジェネティクス / 同期活動 / 遺伝学 / 体節間制御
Outline of Research at the Start

動物の躍動的でスムーズな運動は、体全体に配置された筋細胞が適切な時空間パターンで収縮することで実現します。このパターンを巧妙に制御しているのが、膨大な数の神経細胞からなる神経回路です。いかにして神経回路が動物のスムーズな動きを生み出すのかは、神経科学における謎の一つでしたが、近年神経回路を解析する手法が大きく発達したので、この問いに挑むことが可能になりました。本研究では、多彩な遺伝学的手法が使えるショウジョウバエ幼虫を用いて、動物のスムーズな動きの背後にある神経回路機構を解明することを目指します。

Outline of Final Research Achievements

The bodies of many animals are shaped in a series of connected units called segments, extending from the head to the tail. In order for segmented animals to move their bodies smoothly, it is necessary to coordinate the timing of the contraction of individual segments. By using Drosophila larvae as a model animal, this study investigated the neuromechanical mechanisms of movement in segmented animals. The results show that the timing of movement is controlled by a gap period between consecutive locomotion cycles. This phenomenon helps regulate the movement timing and adjust the speed of locomotion.

Academic Significance and Societal Importance of the Research Achievements

動物の動く速さは、その動物が生きていく上で重要な性能ですが、それを制御する神経回路のしくみはまだ完全には明らかになっていません。この研究では、運動していないときの時間幅が神経回路によって調整されているという新しい発見ができました。これは、進化の過程で動物がどのように巧妙な運動性能を獲得していったのかについての理解につながることに加えて、動物の動きを模した高性能なソフトロボットの開発にも貢献できると期待できます。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (42 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (4 results) Journal Article (11 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 7 results,  Open Access: 10 results) Presentation (19 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results) Book (1 results) Remarks (7 results)

  • [Int'l Joint Research] ジャネリア研究所(米国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] セントアンドリュース大学(英国)

    • Related Report
      2021 Research-status Report
  • [Int'l Joint Research] セントアンドリュース大学(英国)

    • Related Report
      2020 Research-status Report
  • [Int'l Joint Research] ジャネリア研究所(米国)

    • Related Report
      2020 Research-status Report
  • [Journal Article] A vacuum-actuated soft robot inspired by Drosophila larvae to study kinetics of crawling behaviour2023

    • Author(s)
      Sun Xiyang、Nose Akinao、Kohsaka Hiroshi
    • Journal Title

      PLOS ONE

      Volume: 18 Issue: 4 Pages: 1-18

    • DOI

      10.1371/journal.pone.0283316

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Extraction of bouton-like structures from neuropil calcium imaging data2022

    • Author(s)
      Fukumasu Kazushi、Nose Akinao、Kohsaka Hiroshi
    • Journal Title

      Neural Networks

      Volume: 156 Pages: 218-238

    • DOI

      10.1016/j.neunet.2022.09.033

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electrophysiological Validation of Monosynaptic Connectivity between Premotor Interneurons and the aCC Motoneuron in the Drosophila Larval CNS2022

    • Author(s)
      Giachello Carlo N. G.、Hunter Iain、Pettini Tom、Coulson Bramwell、Knufer Athene、Cachero Sebastian、Winding Michael、Arzan Zarin Aref、Kohsaka Hiroshi、Fan Yuen Ngan、Nose Akinao、Landgraf Matthias、Baines Richard A.
    • Journal Title

      The Journal of Neuroscience

      Volume: 42 Issue: 35 Pages: 6724-6738

    • DOI

      10.1523/jneurosci.2463-21.2022

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A neuromechanical model for Drosophila larval crawling based on physical measurements2022

    • Author(s)
      Sun Xiyang、Liu Yingtao、Liu Chang、Mayumi Koichi、Ito Kohzo、Nose Akinao、Kohsaka Hiroshi
    • Journal Title

      BMC Biology

      Volume: 20 Issue: 1 Pages: 130-130

    • DOI

      10.1186/s12915-022-01336-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 複数の運動出力パターンを生み出す神経ネットワーク構造2022

    • Author(s)
      高坂洋史
    • Journal Title

      月刊細胞

      Volume: 54 (2) Pages: 47-49

    • Related Report
      2021 Research-status Report
  • [Journal Article] Interspecies variation of larval locomotion kinematics in the genus Drosophila and its relation to habitat temperature2021

    • Author(s)
      Matsuo Yuji、Nose Akinao、Kohsaka Hiroshi
    • Journal Title

      BMC Biology

      Volume: 19 Issue: 1 Pages: 1-21

    • DOI

      10.1186/s12915-021-01110-4

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Regulation of coordinated muscular relaxation in Drosophila larvae by a pattern-regulating intersegmental circuit2021

    • Author(s)
      Hiramoto Atsuki、Jonaitis Julius、Niki Sawako、Kohsaka Hiroshi、Fetter Richard D.、Cardona Albert、Pulver Stefan R.、Nose Akinao
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1-14

    • DOI

      10.1038/s41467-021-23273-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of coordinated muscular relaxation by a pattern-generating intersegmental circuit2021

    • Author(s)
      Hiramoto Atsuki、Jonaitis Julius、Niki Sawako、Kohsaka Hiroshi、Fetter Richard、Cardona Albert、Pulver Stefan、Nose Akinao
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2021.03.08.434356

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Electrophysiological validation of premotor interneurons monosynaptically connected to the aCC motoneuron in the Drosophila larval CNS2020

    • Author(s)
      Giachello Carlo N. G.、Zarin Aref Arzan、Kohsaka Hiroshi、Fan Yuen Ngan、Nose Akinao、Landgraf Matthias、Baines Richard A.
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2020.06.17.156430

    • Related Report
      2020 Research-status Report
    • Open Access / Int'l Joint Research
  • [Journal Article] A neuromechanical model and kinematic analyses for Drosophila larval crawling based on physical measurements2020

    • Author(s)
      Sun Xiyang、Liu Yingtao、Liu Chang、Mayumi Koichi、Ito Kohzo、Nose Akinao、Kohsaka Hiroshi
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2020.07.17.208611

    • Related Report
      2020 Research-status Report
    • Open Access
  • [Journal Article] Interspecies variation of larval locomotion kinematics in the genusDrosophilaand its relation to habitat temperature2020

    • Author(s)
      Matsuo Yuji、Nose Akinao、Kohsaka Hiroshi
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2020.11.06.371120

    • Related Report
      2020 Research-status Report
    • Open Access
  • [Presentation] Synchronous multi-segmental activity between metachronal waves controls the crawling speed in fly larvae.2022

    • Author(s)
      Liu Y., Nose A., Zwart M.F. and Kohsaka H.
    • Organizer
      第45回日本分子生物学会年会 (MBSJ2022)
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Synchronous multi-segmental activity controls the speed of axial locomotion by modulating the interval between peristaltic waves in Drosophila larvae.2022

    • Author(s)
      Liu Y., Nose A., Zwart M.F. and Kohsaka H.
    • Organizer
      Neuroscience 2022, 51st Annual Meeting of the Society for Neuroscience
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Comprehensive characterization of the axon bundles in the Drosophila larval motor circuits with expansion microscopy.2022

    • Author(s)
      Date T., Nose A. and Kohsaka H.
    • Organizer
      第15 回日本ショウジョウバエ研究会 (JDRC15)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Automated real-time quantitative analysis of behavior in Drosophila larvae.2022

    • Author(s)
      Zhang X., Nose A. and Kohsaka H.
    • Organizer
      第15 回日本ショウジョウバエ研究会 (JDRC15)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Module structures in spatial distribution of activity timing and transmitters of synapse population in motor generating circuits.2022

    • Author(s)
      Fukumasu K., Nose A. and Kohsaka H.
    • Organizer
      第45回日本神経科学大会 (NEURO2022)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Automated real-time quantitative analysis of behavior in Drosophila larvae2022

    • Author(s)
      Zhang X., Nose A. and Kohsaka H.
    • Organizer
      第45回日本神経科学大会 (NEURO2022)
    • Related Report
      2022 Annual Research Report
  • [Presentation] RNAi-based screening of neuromodulators involved in motor patterns of foraging behavior in Drosophila larvae2022

    • Author(s)
      Aoki A., Zhang X., Nose A. and Kohsaka H.
    • Organizer
      第45回日本神経科学大会 (NEURO2022)
    • Related Report
      2022 Annual Research Report
  • [Presentation] ショウジョウバエ近縁種における幼虫運動制御の種間比較2021

    • Author(s)
      松尾悠司、真中美穂、福益一司、能瀬聡直、高坂洋史
    • Organizer
      日本遺伝学会 第93回大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Spatial configuration of synaptic population activities underlying the generation of larval motor patterns.2021

    • Author(s)
      Fukumasu K., Nose A. and Kohsaka H.
    • Organizer
      Cold Spring Harbor laboratory, meeting on Neurobiology of Drosophila
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Dissecting the central nervous system in Drosophila larvae with expansion microscopy.2021

    • Author(s)
      Date T., Nose A. and Kohsaka H.
    • Organizer
      第14 回日本ショウジョウバエ研究会(JDRC14)
    • Related Report
      2021 Research-status Report
  • [Presentation] Spatial configuration of synapse population activities underlying the generation of larval motor patterns.2021

    • Author(s)
      Fukumasu K., Nose A. and Kohsaka H.
    • Organizer
      第14 回日本ショウジョウバエ研究会(JDRC14)
    • Related Report
      2021 Research-status Report
  • [Presentation] Dissecting the 3D structure of the Drosophila larval central nervous system with expansion microscopy.2021

    • Author(s)
      Date T., Nose A. and Kohsaka H.
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Spatially continuous propagation of synapse population activity and its geometric structure in motor pattern generating circuits.2021

    • Author(s)
      Fukumasu K., Nose A. and Kohsaka H.
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Quantitative analysis of Drosophila larval locomotion based on machine vision.2021

    • Author(s)
      Zhang X., Awasaki T., Nose A. and Kohsaka H.
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Spatially continuous propagation of synapse population activity and its geometric structure in motor pattern generating circuits.2021

    • Author(s)
      K. Fukumasu, A. Nose, H. Kohsaka.
    • Organizer
      第6回脳情報動態領域会議
    • Related Report
      2020 Research-status Report
  • [Presentation] A disinhibitory neural circuit for bending posterior segments in the initial phase of forward locomotion in Drosophila larvae2020

    • Author(s)
      Y. Liu, MF.Zwart, A. Nose, H. Kohsaka.
    • Organizer
      CSHL meeting ”Molecular Mechanisms of Neuronal Connectivity (Virtual)”
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] A neuromechanical model and kinematic analyses for Drosophila larval crawling based on physical measurements.2020

    • Author(s)
      X. Sun, C. Liu, K. Mayumi, K. Ito, A. Nose, H. Kohsaka
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report
  • [Presentation] A modular structure underlying generation of distinct motor patterns revealed by multi-synapse functional imaging and high-dimensional data analysis2020

    • Author(s)
      K. Fukumasu, A. Nose, H. Kohsaka.
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report
  • [Presentation] A neural circuit structure underlying generation of distinct motor patterns revealed by multi-synapse functional imaging and high-dimensional data analysis.2020

    • Author(s)
      K. Fukumasu, A. Nose, H. Kohsaka.
    • Organizer
      第20回東京大学生命科学シンポジウム
    • Related Report
      2020 Research-status Report
  • [Book] Optogenetics in Drosophila, "Optogenetics 2nd edition"2021

    • Author(s)
      Kohsaka H. and Nose A.
    • Total Pages
      12
    • Publisher
      Springer Verlag
    • Related Report
      2020 Research-status Report
  • [Remarks] しなやかな幼虫の動きを再現するソフトロボットの開発に成功 ー ぜん動運動の物理の解明に貢献 ー

    • URL

      https://www.k.u-tokyo.ac.jp/information/category/press/10158.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] しなやかな幼虫の動きを再現するソフトロボットの開発に成功 ー ぜん動運動の物理の解明に貢献 ー

    • URL

      https://www.uec.ac.jp/news/announcement/2023/20230406_5293.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] 密集したシナプス集団の活動データから統計力学的手法により単一シナプスを検出

    • URL

      https://www.k.u-tokyo.ac.jp/information/category/press/9828.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] 密集したシナプス集団の活動データから統計力学的手法により単一シナプスを検出

    • URL

      https://www.uec.ac.jp/news/announcement/2022/20221101_4907.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] 物性測定に基づいた虫の動きの高精度シミュレーション

    • URL

      https://www.k.u-tokyo.ac.jp/information/category/press/9551.html

    • Related Report
      2022 Annual Research Report
  • [Remarks] 虫が動く速さと環境温度との関係

    • URL

      https://www.uec.ac.jp/news/announcement/2021/20210902_3673.html

    • Related Report
      2021 Research-status Report
  • [Remarks] 虫が動く速さと環境温度との関係

    • URL

      https://www.k.u-tokyo.ac.jp/information/category/press/8643.html

    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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