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Neuronal circuit mechanisms in the cortical taste area

Research Project

Project/Area Number 20K06926
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionOsaka University

Principal Investigator

Toyoda Hiroki  大阪大学, 大学院歯学研究科, 准教授 (00432451)

Co-Investigator(Kenkyū-buntansha) 佐藤 元  明海大学, 歯学部, 講師 (10432452)
加藤 隆史  大阪大学, 大学院歯学研究科, 教授 (50367520)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords島皮質 / ニコチン受容体 / 局所神経回路 / シナプス可塑性 / 錐体細胞 / EPSC / IPSC / dopamine / ニコチン性受容体 / ドーパミン / LTP / 神経回路 / シナプス長期増強 / シナプス長期抑制 / GABA / 味覚 / アセチルコリン / シナプス / 興奮性シナプス伝達 / ニコチン / シナプス伝達 / GABAニューロン / 情報処理
Outline of Research at the Start

島皮質は味覚の受容において非常に重要な脳部位であるが、局所神経回路がどのように動作し、味覚の受容が行われているかについては未解明な点が多い。本研究では、島皮質ニューロンにおけるニコチン性アセチルコリン受容体(nicotinic ACh receptor: nAChR)の発現分布、島皮質ニューロンにおけるnAChRの電気生理学的性質、島皮質局所神経回路の動作機構(情報処理機構)におけるnAChRの役割、および島皮質が味覚刺激に応答する際のnAChRの役割を明らかにすることにより、島皮質における味覚情報処理の神経基盤を明らかにする。

Outline of Final Research Achievements

In this study, we examined how nicotine modulates synaptic activities in pyramidal neurons of the mouse insular cortex. We found that activation of nAChRs differentially modulates synaptic activities in layer III, V and VI pyramidal neurons of the insular cortex. In layer III and V pyramidal neurons, activation of nAChRs depressed synaptic potentiation while in layer 6 pyramidal neurons, activation of nAChRs enhanced synaptic potentiation. Thus, activation of nAChRs layer-specifically modulates synaptic activities in the mouse insular cortex, which may be important to perform physiological functions such as learning, memory and pain.

Academic Significance and Societal Importance of the Research Achievements

本研究では、島皮質に発現しているニコチン性受容体が、層特異的にシナプス活動を制御していることを明らかにした。ニコチン性受容体が、島皮質局所神経回路の動作に及ぼす影響については不明な点が多く残されており、これまで層特異的に検討した研究はなかったため、学術的意義が高いといえる。本研究により、島皮質により媒介される高次脳機能の発現メカニズムの一端が明らかになるものと期待される。また、島皮質が関与するニコチン性受容体を介して生じる疾患、例えばニコチン依存症の発症機構の解明に繋がることが期待される。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (21 results)

All 2023 2022 2021 2020 Other

All Int'l Joint Research (2 results) Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 6 results) Presentation (10 results) (of which Int'l Joint Research: 2 results,  Invited: 5 results)

  • [Int'l Joint Research] Seoul National University(韓国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Seoul National University(韓国)

    • Related Report
      2022 Research-status Report
  • [Journal Article] Increased vertical dimension of occlusion for varying periods differentially impairs learning and memory in guinea pigs2023

    • Author(s)
      Toyoda Hiroki、Fujinami Yozo、Saito Mitsuru、Maeda Yoshinobu、Kang Youngnam
    • Journal Title

      Behavioural Brain Research

      Volume: 452 Pages: 114547-114547

    • DOI

      10.1016/j.bbr.2023.114547

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The mechanism for regulating the isometric contraction of masseter muscles is involved in determining the vertical dimension of occlusion.2023

    • Author(s)
      Tanaka Y, Sato H, Toyoda H, Saito M, Maeda Y, Kang Y.
    • Journal Title

      Journal of Neurophysiology

      Volume: 129 Issue: 1 Pages: 211-219

    • DOI

      10.1152/jn.00301.2022

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Nature of Noradrenergic Volume Transmission From Locus Coeruleus to Brainstem Mesencephalic Trigeminal Sensory Neurons2022

    • Author(s)
      Hiroki Toyoda, Jonghwa Won, Wheedong Kim, Hayun Kim, Oscar Davy, Mitsuru Saito, Doyun Kim, Takuma Tanaka, Youngnam Kang*, Seog Bae Oh*
    • Journal Title

      Frontiers in Cellular Neuroscience

      Volume: 16 Pages: 1-16

    • DOI

      10.3389/fncel.2022.841239

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Subcellular Localization of Homomeric TASK3 Channels and Its Presumed Functional Significances in Trigeminal Motoneurons2022

    • Author(s)
      Saito Mitsuru、Tanaka Chie、Toyoda Hiroki、Kang Youngnam
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 1 Pages: 344-344

    • DOI

      10.3390/ijms24010344

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nicotine Exposure during Adolescence Leads to Changes of Synaptic Plasticity and Intrinsic Excitability of Mice Insular Pyramidal Cells at Later Life2021

    • Author(s)
      Toyoda Hiroki、Koga Kohei
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 1 Pages: 34-34

    • DOI

      10.3390/ijms23010034

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synaptic and Genetic Bases of Impaired Motor Learning Associated with Modified Experience-Dependent Cortical Plasticity in Heterozygous <i>Reeler</i> Mutants2021

    • Author(s)
      Nishibe Mariko、Toyoda Hiroki、Hiraga Shin-ichiro、Yamashita Toshihide、Katsuyama Yu
    • Journal Title

      Cerebral Cortex

      Volume: 32 Issue: 3 Pages: 504-519

    • DOI

      10.1093/cercor/bhab227

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Intranasal Administration of Rotenone Reduces GABAergic Inhibition in the Mouse Insular Cortex Leading to Impairment of LTD and Conditioned Taste Aversion Memory2021

    • Author(s)
      Toyoda H, Katagari A, Kato T, Sato H
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 22・1 Issue: 1 Pages: 259-259

    • DOI

      10.3390/ijms22010259

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CB1 cannabinoid receptor-mediated plasticity of GABAergic synapses in the mouse insular cortex2020

    • Author(s)
      Toyoda H
    • Journal Title

      Scientific Reports

      Volume: 10・1 Issue: 1 Pages: 7187-7187

    • DOI

      10.1038/s41598-020-64236-5

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cellular mechanisms underlying the rapid depolarization caused by oxygen and glucose deprivation in layer III pyramidal cells of the somatosensory cortex2020

    • Author(s)
      Toyoda H, Kawano T, Sato H, Kato T
    • Journal Title

      Neurosci Res.

      Volume: - Pages: 1-9

    • DOI

      10.1016/j.neures.2020.03.003

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Impairment of autoinhibition in locus coeruleus neurons is involved in the pathogenesis of Alzheimer’s disease2023

    • Author(s)
      Hiroki Toyoda, Seog Bae Oh, Youngnam Kang
    • Organizer
      The 10th Federation of the Asian and Oceanian Physiological Societies Congress
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 島皮質神経回路の機能調節を担うニコチン性受容体の役割2023

    • Author(s)
      豊田博紀
    • Organizer
      第65回歯科基礎医学会学術大会サテライトシンポジウム
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] ストレスによる青斑核ニューロンの細胞変性メカニズムとアルツハイマー病への関与2023

    • Author(s)
      豊田博紀, 姜英男
    • Organizer
      認知症と口腔機能研究会第4回学術集会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 発達期大脳皮質体性感覚野ニューロンにおいて間歇的低酸素負荷がシナプス活動に与える影響2023

    • Author(s)
      豊田博紀, 早田敦子, 片桐綾乃,山田雅治,田熊一敞,加藤隆史
    • Organizer
      第100回日本生理学会大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 間歇的低酸素負荷が発達期の大脳皮質体性感覚野ニューロンの神経活動に及ぼす影響2022

    • Author(s)
      豊田博紀, 早田敦子, 片桐綾乃,山田雅治,田熊一敞,加藤隆史
    • Organizer
      第64回歯科基礎医学会学術大会
    • Related Report
      2022 Research-status Report
  • [Presentation] 島皮質局所神経回路の活動制御におけるニコチン性アセチルコリン受容体の役割2022

    • Author(s)
      豊田博紀
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 青斑核ニューロンの自己抑制障害による過興奮がアルツハイマー病を誘引する 可能性と咀嚼によるその緩和2021

    • Author(s)
      豊田博紀,姜英男
    • Organizer
      認知症と口腔機能研究会第2回学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] マウス大脳皮質ニューロンおいて虚血により誘導される急速脱分極のメカニズム2021

    • Author(s)
      豊田博紀、河野奨、佐藤元、加藤隆史
    • Organizer
      第44回日本神経科学大会/第1回CJK国際会議
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] マウス島皮質シナプス長期増強におけるニコチンおよびドーパミン受容体の役割2020

    • Author(s)
      豊田博紀,佐藤元,加藤隆史
    • Organizer
      第62回歯科基礎医学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] マウス島皮質シナプス可塑性におけるニコチンおよびドーパミン受容体の役割2020

    • Author(s)
      豊田博紀,佐藤元,加藤隆史
    • Organizer
      第43回日本神経科学大回
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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