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Precision medicine based on real-world clinical pharmacogenomics database

Research Project

Project/Area Number 20K07211
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 47060:Clinical pharmacy-related
Research InstitutionKyoto University (2021-2022)
Ritsumeikan University (2020)

Principal Investigator

Hira Daiki  京都大学, 医学研究科, 講師 (50636959)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords個別医療 / 薬物動態 / 薬力学 / 遺伝子多型 / ファーマコゲノミクス
Outline of Research at the Start

薬物の治療効果や副作用の個人差の一部は、薬物を分解する酵素の遺伝子変異が原因となることが知られている。このような遺伝子変異に基づいて薬物の種類や投与量を決定するファーマコゲノミクス (PGx) に関して数多くの臨床研究が行われているものの、臨床での応用は十分に進んでいるとは言い難い。本研究では、鎮痛薬トラマドールや免疫抑制薬アザチオプリンを対象として、実臨床の患者を対象としたPGx検査データベースを用いた解析を行い、日本人における個々の患者に合わせた投与方法の確立を目指す。

Outline of Final Research Achievements

Pharmacogenomic (PGx) testing can predict therapeutic responses or adverse effects based on genetic variants and is expected to be an effective clinical test for precision medicine patient management. The number of drugs recommended for PGx testing by regulatory agencies or consortiums are increasing, and the Food and Drug Administration and the European Medicines Agency provided distinct guidelines for conducting PGx tests. On the other hand, in Japan, only 3 PGx tests are clinically available with insurance coverage. In our retrospective clinical studies based on the PGx database, the clinical utilities of PGx tests for tramadol and thiopurine drugs were analyzed.

Academic Significance and Societal Importance of the Research Achievements

本研究では、薬物の治療効果や副作用の個人差の要因となる薬物代謝酵素の遺伝子多型を解析する事により、個々の患者に最適な薬物療法を提案できるファーマコゲノミクス (PGx) 検査の臨床的有用性を検証した。
実際の臨床現場での鎮痛薬や免疫抑制薬での解析事例を通じて、多様な患者背景を有する患者群であっても、PGx検査により治療効果や副作用発現の先制的な予測が可能となる可能性が示された。これらの研究を更に発展させることにより、副作用発現を制御しながら良好な効果を期待できる薬物療法の確立につながり、副作用に対する治療や過剰投与を回避することによる医療費低減にも繋がる可能性が期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (9 results)

All 2023 2022 2021

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 3 results)

  • [Journal Article] Single-Nucleotide Polymorphisms, c.415C &gt; T (Arg139Cys) and c.416G &gt; A (Arg139His), in the <i>NUDT15</i> Gene Are Associated with Thiopurine-Induced Leukopenia2023

    • Author(s)
      Isono Tetsuichiro、Hira Daiki、Ikeda Yoshito、Kawahara Masahiro、Noda Satoshi、Nishida Atsushi、Inatomi Osamu、Fujimoto Noriki、Andoh Akira、Terada Tomohiro、Morita Shin-ya
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 46 Issue: 3 Pages: 412-418

    • DOI

      10.1248/bpb.b22-00686

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2023-03-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impact of silicone oil tamponade on intravitreally injected vancomycin pharmacokinetics in cynomolgus monkey eyes2021

    • Author(s)
      Hira Daiki、Kitagawa Tomoya、Imamura Taku、Kakinoki Masashi、Ueshima Satoshi、Okano Tomonobu、Ohji Masahito、Kakumoto Mikio、Terada Tomohiro
    • Journal Title

      International Journal of Pharmaceutics

      Volume: 609 Pages: 121185-121185

    • DOI

      10.1016/j.ijpharm.2021.121185

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Urine volume to hydration volume ratio is associated with pharmacokinetics of high‐dose methotrexate in patients with primary central nervous system lymphoma2021

    • Author(s)
      Isono Tetsuichiro、Hira Daiki、Morikochi Aya、Fukami Tadateru、Ueshima Satoshi、Nozaki Kazuhiko、Terada Tomohiro、Morita Shin‐ya
    • Journal Title

      Pharmacology Research & Perspectives

      Volume: 9 Issue: 6

    • DOI

      10.1002/prp2.883

    • NAID

      120007174617

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Incorrect holding angle of dry powder inhaler during the drug-loading step significantly decreases output efficiency2021

    • Author(s)
      Kana Suenaga, Daiki Hira, Eri Ishido, Hiroyoshi Koide, Satoshi Ueshima, Tomoyuki Okuda, Masafumi Yamaguchi, Shin-ya Morita, Hirokazu Okamoto, Tomonobu Okano, Yasutaka Nakano, Tomohiro Terada, and Mikio Kakumoto
    • Journal Title

      Biol. Pharm. Bull.

      Volume: 44 (6) Pages: 1-9

    • NAID

      130008046714

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of antiepileptic drugs’ administration during pregnancy on the nerve cell proliferation and axonal outgrowth of human neuroblastoma SH-SY5Y nerve cells2021

    • Author(s)
      Mikio Kakumoto, Kosuke Shimokawa, Satoshi Ueshima, Daiki Hira,Tomonobu Okano
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 554 Pages: 151-157

    • DOI

      10.1016/j.bbrc.2021.03.107

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] 腎を主軸とした臨床研究の経験と期待.2022

    • Author(s)
      平 大樹, 國津侑貴, 幾田慧子, 中川俊作, 森田真也, 寺田智祐
    • Organizer
      第16回日本腎臓病薬物療法学会学術集会・総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Simultaneous quantification of 15 inhalants in exhaled breath for confirmation of adequate inhalation.2022

    • Author(s)
      Daiki Hira, Shunsaku Nakagawa, Kotaro Itohara, Sakiko Hatazoe, Satoshi Imai, Satoshi Ueshima, Atsushi Yonezawa, Takayuki Nakagawa, Tomonobu Okano, Mikio Kakumoto, Tomohiro Terada
    • Organizer
      20th International Congress of Therapeutic Drug Monitoring and Clinical Toxicology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 抗凝固薬内服者の消化器診療とPharmacogenomicsの重要性.2022

    • Author(s)
      平 大樹, 上島 智, 桂 敏也, 寺田智祐
    • Organizer
      JPW2022 (第96回日本薬理学会年会/第43回日本臨床薬理学会学術総会)
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 実臨床における薬物動態関連遺伝子多型検査の活用事例2021

    • Author(s)
      平 大樹, 森田真也, 寺田智祐
    • Organizer
      第61回日本臨床化学会年次学術集会
    • Related Report
      2021 Research-status Report
    • Invited

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Published: 2020-04-28   Modified: 2024-01-30  

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