Multi-omix analyses of gastric intramucosal neoplasia based on histological subtypes.

• Project/Area Number: 20K07412
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 49020:Human pathology-related
• Research Institution: Iwate Medical University
• Principal Investigator: Sugai Tamotsu 岩手医科大学, 医学部, 教授 (20187628)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 胃粘膜内腫瘍 / 組織型 / オミックス解析 / 腺窩上皮型癌 / 手繋ぎ型癌 / 組織グレード / 腫瘍発生学 / 分子異常 / 胃癌 / 粘膜内癌 / 粘膜下層浸潤癌 / ゲノムワイド解析 / パネル変異解析 / マイクロサテライト解析 / 免疫染色 / 早期胃癌 / 分子解析 / 胃型癌 / 腸型癌

Outline of Research at the Start

我々は分化型粘膜内癌の組織型を腸型、胃型、分類困難型（特殊型）に類型化し、これらの粘膜内癌の組織型に基づいた分子プロファイルを明らかにする。腸型は低グレード上皮内癌、高グレード上皮内癌、粘膜内浸潤癌（粘膜内癌）に分類し、前二者は互いに独立した組織型であることを示す。更に粘膜内癌は高グレード上皮内癌より進展することを示す。胃型は腺窩上皮型、幽門腺型、胃底腺型に分類できるが、特に腺窩上皮型の分子プロファイルを明らかにする。特殊型では手繋ぎ型が独立した分子病型であることを示す。粘膜下層浸潤についても同様の解析を行い各粘膜内癌との関係性を明らかにし、新しい胃癌の分子腫瘍発生仮説の確立を目指す。

Outline of Final Research Achievements

We attempted to identify the molecular profiles of gastric intramucosal neoplasia (IMN; low-grade dysplasia, LGD; high-grade dysplasia, HGD; intramucosal cancer, IMC) by assessing somatic copy number alterations (SCNAs) stratified by microsatellite status (microsatellite stable, MSS; microsatellite instable, MSI). In addition, we aimed to identify the clinicopathological characteristics and molecular alterations contributing to the development of gastric foveolar neoplasia/dysplasia, and crawling type gastric adenocarcinoma. The SCNA pattern of LGD was different from that of HGD and IMC. Moreover, IMNs with the MSI phenotype could be categorized into two subtypes: high frequency of SCNAs and low frequency of SCNAs. Second, foveolar and crawling types were characterized by SCNAs at multiple foci relative to conventional type gastric adenocarcinoma. Molecular profiles may be useful for elucidation of the mechanisms of early gastric carcinogenesis.

Academic Significance and Societal Importance of the Research Achievements

これまで分化型粘膜内腫瘍の組織像との対応関係をゲノムワイドな網羅的解析によって明らかにした報告は皆無に近い。本研究は類型化された粘膜内腫瘍の組織像とマルチオミックス解析による分子解析との関連性を明らかにした。粘膜内腫瘍の組織像と分子異常との相関性、を明らかにすることは胃癌発生の初期の形態像に基づいた分子腫瘍発生の機序を解明し、胃癌の多様な組織発生の個別的な理解を深化させることに貢献できた。現在の胃粘膜内癌の治療は内視鏡的に行われているが、組織型に基づいたより個別的な治療の可能性について貢献できる研究であった。

Research Products

• [Journal Article] Attenuated Familial Adenomatous Polyposis (2023)
  • Author(s): Eizuka Makoto、Toya Yosuke、Kosaka Takashi、Oizumi Tomofumi、Morishita Toshifumi、Kasugai Satoshi、Yanai Shunichi、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Internal Medicine Volume: 62 Issue: 18 Pages: 2651-2654
  • DOI: 10.2169/internalmedicine.1101-22
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2023-09-15
  • Peer Reviewed / Open Access
• [Journal Article] Surgical treatment for lung metastasis of inflammatory myofibroblastic tumor of the lung: A case report (2023)
  • Author(s): Iwai Hidenobu、Yanagawa Naoki、Deguchi Hiroyuki、Tomoyasu Makoto、Shigeeda Wataru、Kaneko Yuka、Yoshimura Ryuichi、Kanno Hironaga、Sugai Mayu、Shikanai Shunsuke、Sugai Tamotsu、Saito Hajime
  • Journal Title: Thoracic Cancer Volume: - Issue: 17 Pages: 1644-1647
  • DOI: 10.1111/1759-7714.14914
  • Peer Reviewed / Open Access
• [Journal Article] Continuous use of antithrombotic medications during peri‐endoscopic submucosal dissection period for colorectal lesions: A propensity score matched study (2023)
  • Author(s): Kawasaki Keisuke、Torisu Takehiro、Esaki Motohiro、Eizuka Makoto、Kawatoko Shinichiro、Kumei Tomo、Hirai Minami、Kondo Masahiro、Fujioka Shin、Fuyuno Yuta、Matsuno Yuichi、Umeno Junji、Moriyama Tomohiko、Kitazono Takanari、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: - Issue: 6 Pages: 955-961
  • DOI: 10.1111/jgh.16149
  • Peer Reviewed / Open Access
• [Journal Article] Gastroblastoma mimics the embryonic mesenchyme of the foregut: a case report (2023)
  • Author(s): Sugimoto Ryo、Uesugi Noriyuki、Yamada Noriyuki、Osakabe Mitsumasa、Baba Shigeaki、Yanagawa Naoki、Akiyama Yuji、Habano Wataru、Sasaki Akira、Oda Yoshinao、Sugai Tamotsu
  • Journal Title: Diagnostic Pathology Volume: 18 Issue: 1 Pages: 24-24
  • DOI: 10.1186/s13000-023-01310-2
  • Peer Reviewed / Open Access
• [Journal Article] Nomogram as a novel predictive tool for lymph node metastasis in T1 colorectal cancer treated with endoscopic resection: a nationwide, multicenter study (2023)
  • Author(s): Kajiwara Yoshiki、Oka Shiro、Tanaka Shinji、Nakamura Takahiro、Saito Shoichi、Fukunaga Yosuke、Takamatsu Manabu、Kawachi Hiroshi、Hotta Kinichi、Ikematsu Hiroaki、Kojima Motohiro、Saito Yutaka、Yamada Masayoshi、Kanemitsu Yukihide、Sugai Tamotsu、etc
  • Journal Title: Gastrointestinal Endoscopy Volume: 97 Issue: 6 Pages: 1119-1128
  • DOI: 10.1016/j.gie.2023.01.022
  • Peer Reviewed / Open Access
• [Journal Article] Current status and perspectives for endoscopic diagnosis of superficial nonampullary duodenal epithelial tumors (2023)
  • Author(s): Toya Yosuke、Endo Masaki、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Digestive Endoscopy Volume: - Issue: 5 Pages: 574-583
  • DOI: 10.1111/den.14514
  • Peer Reviewed
• [Journal Article] Pathological Complete Response to Preoperative Nivolumab Plus Cabozantinib for Renal Cell Carcinoma With Inferior Vena Cava Thrombus: A Case Report (2022)
  • Author(s): MACHIDA ARISA、IKARASHI DAIKI、YANAGAWA NAOKI、SUZUK MASAMICHI、KAWAMURA TATSUYA、SEKIGUCHI KIE、TAKAHASHI KENTA、KATO RENPEI、MATSURA TOMOHIKO、MAEKAWA SHIGEKATSU、KANEHIRA MITSUGU、TAKATA RYO、SUGAI TAMOTSU、OBARA WATARU
  • Journal Title: Cancer Diagnosis & Prognosis Volume: 3 Issue: 1 Pages: 124-129
  • DOI: 10.21873/cdp.10189
  • Peer Reviewed / Open Access
• [Journal Article] Immune Checkpoint Inhibitor-Related Pneumonia in Unresectable Hepatocellular Carcinoma: Two Fatal Cases under Atezolizumab plus Bevacizumab (2022)
  • Author(s): Endo Kei、Kuroda Hidekatsu、Oikawa Takayoshi、Ito Yuma、Abe Tamami、Kooka Youhei、Kakisaka Keisuke、Miyasaka Akio、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Liver Cancer Volume: 11 Issue: 6 Pages: 572-575
  • DOI: 10.1159/000526388
  • Peer Reviewed / Open Access
• [Journal Article] Identification of a Fatty Acid for Diagnosing Non-Alcoholic Steatohepatitis in Patients with Severe Obesity Undergoing Metabolic Surgery. (2022)
  • Author(s): Takahashi N, Sasaki A, Umemura A, Sugai T, Kakisaka K, Ishigaki Y.
  • Journal Title: Biomedicines Volume: 10 Issue: 11 Pages: 2920-2920
  • DOI: 10.3390/biomedicines10112920
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Prognostic impact of tumor microenvironment-related markers in patients with adenocarcinoma of the lung (2022)
  • Author(s): Sugai Mayu、Yanagawa Naoki、Shikanai Shunsuke、Osakabe Mitsumasa、Maemondo Makoto、Saito Hajime、Sugai Tamotsu
  • Journal Title: International Journal of Clinical Oncology Volume: 28 Issue: 2 Pages: 229-239
  • DOI: 10.1007/s10147-022-02271-0
  • Peer Reviewed / Open Access
• [Journal Article] Intraoperative rapid immunohistochemistry with noncontact antibody mixing for undiagnosed pulmonary tumors (2022)
  • Author(s): Imai Kazuhiro、Nanjo Hiroshi、Shigeeda Wataru、Sugai Tamotsu、Ito Tomoo、Maniwa Yoshimasa、Takashima Shinogu、Saito Hajime、Yanagawa Naoki、Tanaka Yugo、Doi Takefumi、Hiroshima Yuko、Nomura Kyoko、Tanino Mishie、Tanaka Shinya、Minamiya Yoshihiro、the R‐IHC Study Group
  • Journal Title: Cancer Science Volume: 114 Issue: 2 Pages: 702-711
  • DOI: 10.1111/cas.15616
  • Peer Reviewed / Open Access
• [Journal Article] Differential Expression in the Tumor Microenvironment of mRNAs Closely Associated with Colorectal Cancer Metastasis (2022)
  • Author(s): Ito Kazuhiro、Osakabe Mitsumasa、Sugimoto Ryo、Yamada Shun、Sato Ayaka、Uesugi Noriyuki、Yanagawa Naoki、Suzuki Hiromu、Sugai Tamotsu
  • Journal Title: Annals of Surgical Oncology Volume: 30 Issue: 2 Pages: 1255-1266
  • DOI: 10.1245/s10434-022-12574-1
  • Peer Reviewed / Open Access
• [Journal Article] A case of pathological complete response with liposomal irinotecan?+?5-FU/LV for unresectable locally advanced pancreatic cancer (2022)
  • Author(s): Kikuchi Koji、Umemura Akira、Nitta Hiroyuki、Katagiri Hirokatsu、Nishiya Masao、Uesugi Noriyuki、Sugai Tamotsu、Imanari Keisuke、Sasaki Akira
  • Journal Title: Surgical Case Reports Volume: 8 Issue: 1 Pages: 192-192
  • DOI: 10.1186/s40792-022-01549-9
  • Peer Reviewed / Open Access
• [Journal Article] An autopsy case of hyperimmunoglobulin E syndrome with coronary fibrinoid necrotizing arteritis and an aneurysm (2022)
  • Author(s): Sugimoto Ryo、Yanagawa Naoki、Osakabe Mitsumasa、Uesugi Noriyuki、Yamada Noriyuki、Kitada Yuriko、Yamashita Rina、Saito Hidenori、Sugai Tamotsu
  • Journal Title: Pathology International Volume: 72 Issue: 12 Pages: 631-636
  • DOI: 10.1111/pin.13278
  • Peer Reviewed / Open Access
• [Journal Article] ASO Visual Abstract: Differential Expression in the Tumor Microenvironment of mRNAs Closely Associated with Colorectal Cancer Metastasis (2022)
  • Author(s): Ito Kazuhiro、Osakabe Mitsumasa、Sugimoto Ryo、Yamada Shun、Sato Ayaka、Uesugi Noriyuki、Yanagawa Naoki、Suzuki Hiromu、Sugai Tamotsu
  • Journal Title: Annals of Surgical Oncology Volume: 30 Issue: 2 Pages: 1267-1268
  • DOI: 10.1245/s10434-022-12629-3
  • Peer Reviewed / Open Access
• [Journal Article] Primary extraovarian granulosa cell tumor of the mesentery (2022)
  • Author(s): Yanagawa Naoki、Ito Kazuhiro、Ito Yuma、Sugimoto Ryo、Osakabe Mitsumasa、Matsuo Teppei、Uesugi Noriyuki、Suto Takayuki、Sugai Tamotsu
  • Journal Title: Pathology International Volume: 72 Issue: 11 Pages: 566-568
  • DOI: 10.1111/pin.13273
  • Peer Reviewed / Open Access
• [Journal Article] New application of endocytoscope for histopathological diagnosis of colorectal lesions (2022)
  • Author(s): Inoue Fumihiro、Hirata Daizen、Iwatate Mineo、Hattori Santa、Fujita Mikio、Sano Wataru、Sugai Tamotsu、Kawachi Hiroshi、Ichikawa Kazuhito、Sano Yasushi
  • Journal Title: World Journal of Gastrointestinal Endoscopy Volume: 14 Issue: 8 Pages: 495-501
  • DOI: 10.4253/wjge.v14.i8.495
  • Peer Reviewed / Open Access
• [Journal Article] The new IASLC grading system for invasive non‐mucinous lung adenocarcinoma is a more useful indicator of patient survival compared with previous grading systems (2022)
  • Author(s): Yanagawa Naoki、Sugai Mayu、Shikanai Shunsuke、Sugimoto Ryo、Osakabe Mitsumasa、Uesugi Noriyuki、Saito Hajime、Maemondo Makoto、Sugai Tamotsu
  • Journal Title: Journal of Surgical Oncology Volume: 127 Issue: 1 Pages: 174-182
  • DOI: 10.1002/jso.27091
  • Peer Reviewed / Open Access
• [Journal Article] Genome‐wide analysis of colorectal cancer based on gene‐based somatic copy number alterations during neoplastic progression within the same tumor (2022)
  • Author(s): Yamada Shun、Osakabe Mitsumasa、Uesugi Noriyuki、Yanagawa Naoki、Matsumoto Takayuki、Suzuki Hiromu、Sugai Tamotsu
  • Journal Title: Cancer Medicine Volume: 12 Issue: 4 Pages: 4446-4454
  • DOI: 10.1002/cam4.5117
  • Peer Reviewed / Open Access
• [Journal Article] Genome-Wide Analysis of microRNA and mRNA Expression in Colorectal Intramucosal Neoplasia and Colorectal Cancer With a Microsatellite-Stable Phenotype Based on Adenoma-Carcinoma Sequences (2022)
  • Author(s): Sugai Tamotsu、Osakabe Mitsumasa、Niinuma Takeshi、Sugimoto Ryo、Eizuka Makoto、Tanaka Yoshihito、Yanagawa Naoki、Otsuka Koki、Sasaki Akira、Matsumoto Takayuki、Suzuki Hiromu
  • Journal Title: Frontiers in Oncology Volume: 12 Pages: 831100-831100
  • DOI: 10.3389/fonc.2022.831100
  • Peer Reviewed / Open Access
• [Journal Article] Correlation of tumor microenvironment-related markers with clinical outcomes in patients with squamous cell carcinoma of the lung (2022)
  • Author(s): Sugai Mayu、Yanagawa Naoki、Shikanai Shunsuke、Hashimoto Mai、Saikawa Hirotaka、Osakabe Mitsumasa、Saito Hajime、Maemondo Makoto、Sugai Tamotsu
  • Journal Title: Translational Lung Cancer Research Volume: 11 Issue: 6 Pages: 975-990
  • DOI: 10.21037/tlcr-22-10
  • Peer Reviewed / Open Access
• [Journal Article] High expression of fibroblast‐activating protein is a prognostic marker in non‐small cell lung carcinoma (2022)
  • Author(s): Yanagawa Naoki、Sugai Mayu、Shikanai Shunsuke、Sugimoto Ryo、Osakabe Mitsumasa、Uesugi Noriyuki、Saito Hajime、Maemondo Makoto、Sugai Tamotsu
  • Journal Title: Thoracic Cancer Volume: 13 Issue: 16 Pages: 2377-2384
  • DOI: 10.1111/1759-7714.14579
  • Peer Reviewed / Open Access
• [Journal Article] Pure Laparoscopic Left Hepatectomy for Regrowth of Mucinous Cystic Neoplasm of the Liver after Laparoscopic Deroofing (2022)
  • Author(s): Kumagai Hideki、Umemura Akira、Nitta Hiroyuki、Katagiri Hirokatsu、Kanno Shoji、Takeda Daiki、Amano Satoshi、Kikuchi Koji、Takashimizu Kiyoharu、Nishiya Masao、Uesugi Noriyuki、Sugai Tamotsu、Sasaki Akira
  • Journal Title: Case Reports in Surgery Volume: 2022 Pages: 1-6
  • DOI: 10.1155/2022/4829153
  • Peer Reviewed / Open Access
• [Journal Article] Clinical, histopathological, and molecular features of IDH-wildtype indolent diffuse glioma: comparison with typical glioblastoma (2022)
  • Author(s): Suzuki Hayato、Ono Takahiro、Koyota Souichi、Takahashi Masataka、Sugai Tamotsu、Nanjo Hiroshi、Shimizu Hiroaki
  • Journal Title: Journal of Neuro-Oncology Volume: 159 Issue: 2 Pages: 397-408
  • DOI: 10.1007/s11060-022-04074-9
  • Peer Reviewed / Open Access
• [Journal Article] A novel second-stage surgical strategy for severely obese patient with pancreatic neuroendocrine tumor: a case report (2022)
  • Author(s): Umemura Akira、Sasaki Akira、Nitta Hiroyuki、Katagiri Hirokatsu、Kanno Shoji、Takeda Daiki、Ando Taro、Amano Satoshi、Nishiya Masao、Uesugi Noriyuki、Sugai Tamotsu
  • Journal Title: Surgical Case Reports Volume: 8 Issue: 1 Pages: 125-125
  • DOI: 10.1186/s40792-022-01484-9
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide analysis of mRNA expression identified the involvement of trefoil factor 1 in the development of sessile serrated lesions (2022)
  • Author(s): Sugai Tamotsu、Osakabe Mitsumasa、Eizuka Makoto、Tanaka Yoshihito、Yamada Shun、Yanagawa Naoki、Matsumoto Takayuki、Suzuki Hiromu
  • Journal Title: Pathology - Research and Practice Volume: 236 Pages: 153987-153987
  • DOI: 10.1016/j.prp.2022.153987
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive Analysis of microRNA Expression During the Progression of Colorectal Tumors (2022)
  • Author(s): Sugai Tamotsu、Sugimoto Ryo、Eizuka Makoto、Osakabe Mitsumasa、Yamada Shun、Yanagawa Naoki、Matsumoto Takayuki、Suzuki Hiromu
  • Journal Title: Digestive Diseases and Sciences Volume: 68 Issue: 3 Pages: 813-823
  • DOI: 10.1007/s10620-022-07576-8
  • Peer Reviewed / Open Access
• [Journal Article] Positron emission tomography with 11C-methyl-L-methionine as a predictor of consequential outcomes at the time of discontinuing temozolomide-adjuvant chemotherapy in patients with residual IDH-mutant lower-grade glioma (2022)
  • Author(s): Beppu T, Iwaya T, Sato Y, Nomura J, Terasaki K, Sasaki T, Yamada N, Fujiwara S, Sugai T, Ogasawara K
  • Journal Title: Clin Nucl Med Volume: in press Issue: 7 Pages: 569-574
  • DOI: 10.1097/rlu.0000000000004221
  • Peer Reviewed / Open Access
• [Journal Article] <i>Helicobacter pylori</i> Modulated Host Immunity in Gastric Cancer Patients With S-1 Adjuvant Chemotherapy (2022)
  • Author(s): Koizumi Yuka、Ahmad Sheny、Ikeda Miyuki、Yashima-Abo Akiko、Espina Ginny、Sugimoto Ryo、Sugai Tamotsu、Iwaya Takeshi、Tamura Gen、Koeda Keisuke、Liotta Lance A、Takahashi Fumiaki、Nishizuka Satoshi S、the Northern Japan Gastric Cancer Study Consortium
  • Journal Title: JNCI: Journal of the National Cancer Institute Volume: 114 Issue: 8 Pages: 1149-1158
  • DOI: 10.1093/jnci/djac085
  • Peer Reviewed / Open Access
• [Journal Article] Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells. (2022)
  • Author(s): Mise Y, Hamanishi J, Daikoku T, Takamatsu S, Miyamoto T, Taki M, Yamanoi K, Yamaguchi K, Ukita M, Horikawa N, Abiko K, Murakami R, Furutake Y, Hosoe Y, Terakawa J, Kagabu M, Sugai T, Osakabe M, Fujiwara H, Matsumura N, Mandai M, Baba T.
  • Journal Title: Carcinogenesis Volume: na Issue: 7 Pages: 647-658
  • DOI: 10.1093/carcin/bgac032
  • Peer Reviewed / Open Access
• [Journal Article] Genome-wide analysis of mRNA and microRNA expression in colorectal cancer and adjacent normal mucosa (2022)
  • Author(s): Ito Yuma、Osakabe Mitsumasa、Niinuma Takeshi、Uesugi Noriyuki、Sugimoto Ryo、Yanagawa Naoki、Otsuka Koki、Sasaki Akira、Matsumoto Takayuki、Suzuki Hiromu、Sugai Tamotsu
  • Journal Title: The Journal of Pathology: Clinical Research Volume: - Issue: 4 Pages: 313-326
  • DOI: 10.1002/cjp2.268
  • Peer Reviewed / Open Access
• [Journal Article] Cribriform type adenocarcinoma of the colorectum: comprehensive molecular analyses of a distinctive histologic subtype of colorectal cancer (2022)
  • Author(s): Yamada Shun、Osakabe Mitsumasa、Eizuka Makoto、Hashimoto Mai、Uesugi Noriyuki、Yanagawa Naoki、Otsuka Koki、Suzuki Hiromu、Takayuki Matsumoto、Sugai Tamotsu
  • Journal Title: Carcinogenesis Volume: - Issue: 6 Pages: 601-610
  • DOI: 10.1093/carcin/bgac029
  • Peer Reviewed / Open Access
• [Journal Article] The Concept of Indeterminable NASH Inducted by Preoperative Diet and Metabolic Surgery: Analyses of Histopathological and Clinical Features (2022)
  • Author(s): Sasaki Akira、Umemura Akira、Ishida Kazuyuki、Takahashi Naoto、Nikai Haruka、Nitta Hiroyuki、Takikawa Yasuhiro、Kakisaka Keisuke、Abe Tamami、Nishiya Masao、Sugai Tamotsu
  • Journal Title: Biomedicines Volume: 10 Issue: 2 Pages: 453-453
  • DOI: 10.3390/biomedicines10020453
  • Peer Reviewed / Open Access
• [Journal Article] Morphological and Molecular Characteristics in Low Grade Fetal Adenocarcinoma of the Lung: Two Case Reports and Literature Review (2022)
  • Author(s): Yanagawa Naoki、Uesugi Noriyuki、Nishiya Masao、Sugimoto Ryo、Osakabe Mitsumasa、Saitoh Hajime、Maemondo Makoto、Sugai Tamotsu
  • Journal Title: International Journal of Surgical Pathology Volume: - Issue: 7 Pages: 797-803
  • DOI: 10.1177/10668969221081741
  • Peer Reviewed
• [Journal Article] Decidualization of Stromal Cells Promotes Involvement of Mast Cells in Successful Human Pregnancy by Increasing Stem Cell Factor Expression (2022)
  • Author(s): Ueshima Chiyuki、Kataoka Tatsuki R.、Osakabe Mitsumasa、Sugimoto Akihiko、Ushirokawa Akihiko、Shibata Yuji、Nakamura Hiroya、Shibuya Rintaro、Minamiguchi Sachiko、Sugai Tamotsu、Haga Hironori
  • Journal Title: Frontiers in Immunology Volume: 13 Pages: 779574-779574
  • DOI: 10.3389/fimmu.2022.779574
  • Peer Reviewed / Open Access
• [Journal Article] Desmoplastic reactions and epithelial-mesenchymal transition proteins in stages II and III colorectal cancer: association with and prognostic value for disease-free survival (2022)
  • Author(s): Hashimoto Mai、Uesugi Noriyuki、Sugai Mayu、Ito Kazuhiro、Yanagawa Naoki、Otsuka Koki、Kajiwara Yoshiki、Ueno Hideki、Sasaki Akira、Sugai Tamotsu
  • Journal Title: Virchows Archiv Volume: 480 Issue: 4 Pages: 793-805
  • DOI: 10.1007/s00428-021-03266-4
  • Peer Reviewed / Open Access
• [Journal Article] A case of hepatic intraductal papillary neoplasm of the bile duct (2022)
  • Author(s): Mukaida Eisuke、Tamura Akio、Nishiya Masao、Katoh Kenichi、Sugai Tamotsu、Yoshioka Kunihiro
  • Journal Title: BJR|case reports Volume: 8 Issue: 1
  • DOI: 10.1259/bjrcr.20210172
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of somatic copy number alterations in biliary tract carcinoma using a single nucleotide polymorphism array (2022)
  • Author(s): Shioi Yoshihiro、Osakabe Mitsumasa、Yanagawa Naoki、Nitta Hiroyuki、Sasaki Akira、Sugai Tamotsu
  • Journal Title: Future Science OA Volume: 8 Issue: 1
  • DOI: 10.2144/fsoa-2021-0057
  • Peer Reviewed / Open Access
• [Journal Article] Laparoscopic distal pancreatectomy for metastatic melanoma originating from the choroidal membrane: a case report (2021)
  • Author(s): Baba Shigeaki、Akiyama Yuji、Endo Fumitaka、Nikai Haruka、Sugimoto Ryo、Umemura Akira、Katagiri Hirokatsu、Hasegawa Yasushi、Iwaya Takeshi、Nitta Hiroyuki、Koeda Keisuke、Sugai Tamotsu、Sasaki Akira
  • Journal Title: Surgical Case Reports Volume: 7 Issue: 1
  • DOI: 10.1186/s40792-021-01345-x
  • Peer Reviewed / Open Access
• [Journal Article] Role of barium enema examination for the diagnosis of submucosal invasion depth in T1 colorectal cancers. (2021)
  • Author(s): Kawasaki K, Torisu T, Nagahata T, Esaki M, Kurahara K, Eizuka M, Tanaka Y, Fujiwara M, Kawatoko S, Oshiro Y, Yamada S, Ikegami K, Fujioka S, Fuyuno Y, Matsuno Y, Umeno J, Moriyama T, Kitazono T, Sugai T, Matsumoto T
  • Journal Title: Cancer Imaging Volume: 21 Issue: 1 Pages: 66-66
  • DOI: 10.1186/s40644-021-00437-z
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive analyses of microRNA and mRNA expression in colorectal serrated lesions and colorectal cancer with a microsatellite instability phenotype (2021)
  • Author(s): Sugai Tamotsu、Osakabe Mitsumasa、Niinuma Takeshi、Eizuka Makoto、Tanaka Yoshihito、Yamada Shun、Yanagawa Naoki、Otsuka Koki、Sasaki Akira、Matsumoto Takayuki、Suzuki Hiromu
  • Journal Title: Genes, Chromosomes and Cancer Volume: 61 Issue: 3 Pages: 161-171
  • DOI: 10.1002/gcc.23016
  • Peer Reviewed / Open Access
• [Journal Article] Clinicopathological and molecular analyses of hyperplastic lesions including microvesicular variant and goblet cell rich variant hyperplastic polyps and hyperplastic nodules?Hyperplastic nodule is an independent histological entity (2021)
  • Author(s): Uesugi Noriyuki、Ajioka Yoichi、Arai Tomio、Tanaka Yoshihito、Sugai Tamotsu
  • Journal Title: Pathology International Volume: 72 Issue: 2 Pages: 128-137
  • DOI: 10.1111/pin.13187
  • Peer Reviewed / Open Access
• [Journal Article] Combination treatment with bevacizumab plus erlotinib for meningeal carcinomatosis of afatinib-resistant EGFR mutated lung cancer without T790M mutation: a case report (2021)
  • Author(s): Chiba Shinji、Akiyama Masachika、Yakuwa Kazuhiro、Sato Hideomi、Hirano Kunio、Utsumi Yu、Nagashima Hiromi、Sugai Tamotsu、Maemondo Makoto
  • Journal Title: Annals of Palliative Medicine Volume: 0 Issue: 8 Pages: 0-0
  • DOI: 10.21037/apm-21-1885
  • Peer Reviewed / Open Access
• [Journal Article] Pretreatment tumour immune microenvironment predicts clinical response and prognosis of muscle-invasive bladder cancer in the neoadjuvant chemotherapy setting (2021)
  • Author(s): Ikarashi Daiki、Kitano Shigehisa、Tsuyukubo Takashi、Takenouchi Kazumasa、Nakayama Takayuki、Onagi Hiroko、Sakaguchi Asumi、Yamashita Makiko、Mizugaki Hidenori、Maekawa Shigekatsu、Kato Renpei、Kato Yoichiro、Sugai Tamotsu、Nakatsura Tetsuya、Obara Wataru
  • Journal Title: British Journal of Cancer Volume: 126 Issue: 4 Pages: 606-614
  • DOI: 10.1038/s41416-021-01628-y
  • Peer Reviewed / Open Access
• [Journal Article] Primary cutaneous adenoid cystic carcinoma of the skin with regional lymph node metastasis (2021)
  • Author(s): Sato Yuri、Tsunoda Kanako、Sugai Tamotsu、Amano Hiroo
  • Journal Title: European Journal of Dermatology Volume: 31 Issue: 5 Pages: 647-649
  • DOI: 10.1684/ejd.2021.4125
  • Peer Reviewed
• [Journal Article] The Frequency of DNA Mismatch Repair Deficiency Is Very Low in Surgically Resected Lung Carcinoma (2021)
  • Author(s): Yanagawa Naoki、Yamada Noriyuki、Sugimoto Ryo、Osakabe Mitsumasa、Uesugi Noriyuki、Shiono Satoshi、Endoh Makoto、Ogata Shin-ya、Saito Hajime、Maemondo Makoto、Sugai Tamotsu
  • Journal Title: Frontiers in Oncology Volume: 11
  • DOI: 10.3389/fonc.2021.752005
  • Peer Reviewed / Open Access
• [Journal Article] Gastrointestinal Adverse Events Induced by Immune-Checkpoint Inhibitors (2021)
  • Author(s): Yanai Shunichi、Toya Yosuke、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Digestion Volume: 102 Issue: 6 Pages: 965-973
  • DOI: 10.1159/000518543
  • Peer Reviewed
• [Journal Article] Expression Patterns of Microenvironmental Factors and Tenascin-C at the Invasive Front of Stage II and III Colorectal Cancer: Novel Tumor Prognostic Markers (2021)
  • Author(s): Hashimoto Mai、Uesugi Noriyuki、Osakabe Mitsumasa、Yanagawa Naoki、Otsuka Koki、Kajiwara Yoshiki、Ueno Hideki、Sasaki Akira、Sugai Tamotsu
  • Journal Title: Frontiers in Oncology Volume: 11
  • DOI: 10.3389/fonc.2021.690816
  • Peer Reviewed / Open Access
• [Journal Article] The mucin phenotype does not affect the endoscopic resection outcome of non-ampullary duodenal epithelial tumors (2021)
  • Author(s): Toya Yosuke、Endo Masaki、Yamada Shun、Oizumi Tomofumi、Morishita Toshifumi、Akasaka Risaburo、Yanai Shunichi、Nakamura Shotaro、Eizuka Makoto、Uesugi Noriyuki、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Endoscopy International Open Volume: 09 Issue: 09 Pages: E1297-E1302
  • DOI: 10.1055/a-1477-3186
  • Peer Reviewed / Open Access
• [Journal Article] VEGF-C/VEGFR-3 signalling in macrophages ameliorates acute lung injury. (2021)
  • Author(s): Yamashita M, Niisato M, Kawasaki Y, Karaman S, Robciuc MR, Shibata Y, Ishida Y, Nishio R, Masuda T, Sugai T, Ono M, Tuder RM, Alitalo K, Yamauchi K.
  • Journal Title: Eur Respir J. Volume: 59 Issue: 4 Pages: 2100880-2100880
  • DOI: 10.1183/13993003.00880-2021
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Pancreatic ductal adenocarcinoma in a patient with pancreas divisum and gastrointestinal duplication cyst: a case report (2021)
  • Author(s): Takahashi Naoto、Nitta Hiroyuki、Umemura Akira、Katagiri Hirokatsu、Kanno Shoji、Takeda Daiki、Makabe Kenji、Amano Satoshi、Nishiya Masao、Uesugi Noriyuki、Sugai Tamotsu、Sasaki Akira
  • Journal Title: Surgical Case Reports Volume: 7 Issue: 1
  • DOI: 10.1186/s40792-021-01279-4
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic nutritional index is an independent prognostic factor for older patients aged???85?years treated by gastric endoscopic submucosal dissection (2021)
  • Author(s): Toya Yosuke、Endo Masaki、Akasaka Risaburo、Morishita Toshifumi、Yanai Shunichi、Nakamura Shotaro、Eizuka Makoto、Sugimoto Ryo、Uesugi Noriyuki、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: BMC Gastroenterology Volume: 21 Issue: 1
  • DOI: 10.1186/s12876-021-01896-1
  • Peer Reviewed / Open Access
• [Journal Article] Primary Cranial Vault Lymphoma Extending between Subcutaneous Tissue and Brain Parenchyma without Skull Destruction after Mild Head Trauma: A Case Report and Literature Review (2021)
  • Author(s): Setta Kengo、Beppu Takaaki、Sato Yuichi、Saura Hiroaki、Nomura Junichi、Sugai Tamotsu、Ogasawara Kuniaki
  • Journal Title: Case Reports in Oncology Volume: 14 Issue: 2 Pages: 1118-1123
  • DOI: 10.1159/000516272
  • Peer Reviewed / Open Access
• [Journal Article] Low‐grade fibromyxoid sarcoma arising from the lung: A case report (2021)
  • Author(s): Yoshimura Ryuichi、Nishiya Masao、Yanagawa Naoki、Deguchi Hiroyuki、Tomoyasu Makoto、Kudo Satoshi、Shigeeda Wataru、Kaneko Yuka、Kanno Hironaga、Sugai Mayu、Shikanai Shunsuke、Sugai Tamotsu、Saito Hajime
  • Journal Title: Thoracic Cancer Volume: 12 Issue: 18 Pages: 2517-2520
  • DOI: 10.1111/1759-7714.14107
  • Peer Reviewed / Open Access
• [Journal Article] NLRP3 Inflammasome Inhibitor OLT1177 Suppresses Onset of Inflammation in Mice with Dextran Sulfate Sodium-Induced Colitis (2021)
  • Author(s): Oizumi Tomofumi、Mayanagi Taira、Toya Yosuke、Sugai Tamotsu、Matsumoto Takayuki、Sobue Kenji
  • Journal Title: Digestive Diseases and Sciences Volume: - Issue: 7 Pages: 2912-2921
  • DOI: 10.1007/s10620-021-07184-y
  • Peer Reviewed / Open Access
• [Journal Article] High frequency and long persistency of ballooning hepatocyte were associated with glucose intolerance in patients with severe obesity (2021)
  • Author(s): Kakisaka Keisuke、Sasaki Akira、Umemura Akira、Nikai Haruka、Suzuki Yuji、Nishiya Masao、Sugai Tamotsu、Nitta Hiroyuki、Takikawa Yasuhiro
  • Journal Title: Scientific Reports Volume: 11 Issue: 1
  • DOI: 10.1038/s41598-021-94937-4
  • Peer Reviewed / Open Access
• [Journal Article] Resectability of underwater endoscopic mucosal resection for duodenal tumor: A single‐center, retrospective pilot study (2021)
  • Author(s): Toya Yosuke、Endo Masaki、Yamazato Masanao、Yamada Shun、Kumei Tomo、Hirai Minami、Eizuka Makoto、Morishita Toshifumi、Akasaka Risaburo、Yanai Shunichi、Uesugi Noriyuki、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Journal of Gastroenterology and Hepatology Volume: 36 Issue: 11 Pages: 3191-3195
  • DOI: 10.1111/jgh.15638
  • Peer Reviewed / Open Access
• [Journal Article] A genome‐wide analysis of the molecular alterations occurring in the adenomatous and carcinomatous components of the same tumor based on the adenoma?carcinoma sequence (2021)
  • Author(s): Sugai Tamotsu、Osakabe Mitsumasa、Habano Wataru、Tanaka Yoshihito、Eizuka Makoto、Sugimoto Ryo、Yanagawa Naoki、Matsumoto Takayuki、Suzuki Hiromu
  • Journal Title: Pathology International Volume: 71 Issue: 9 Pages: 582-593
  • DOI: 10.1111/pin.13129
  • Peer Reviewed / Open Access
• [Journal Article] Case report of meningeal carcinomatosis in advanced cutaneous apocrine carcinoma (2021)
  • Author(s): Watanabe Ayano、Tsunoda Kanako、Watabe Daisuke、Sugai Tamotsu、Amano Hiroo
  • Journal Title: The Journal of Dermatology Volume: 48 Issue: 10
  • DOI: 10.1111/1346-8138.16055
  • Peer Reviewed / Open Access
• [Journal Article] Is barium enema examination negligible for the management of colorectal cancer? Comparison with conventional colonoscopy and magnifying colonoscopy (2021)
  • Author(s): Kawasaki Keisuke、Nakamura Shotaro、Eizuka Makoto、Tanaka Yoshihito、Kumei Tomo、Yanai Shunichi、Toya Yosuke、Urushikubo Jun、Torisu Takehiro、Moriyama Tomohiko、Umeno Junji、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Japanese Journal of Radiology Volume: 39 Issue: 12 Pages: 1159-1167
  • DOI: 10.1007/s11604-021-01157-x
  • NAID: 210000169837
  • Peer Reviewed / Open Access
• [Journal Article] Coexistence of salivary duct, myoepithelial and epithelial-myoepithelial carcinomas in the parotid gland: a case report and literature review (2021)
  • Author(s): Yanagawa Naoki、Suzuki Masamichi、Saito Daisuke、Sugimoto Ryo、Osakabe Mitsumasa、Uesugi Noriyuki、Shiga Kiyoto、Sugai Tamotsu
  • Journal Title: Journal of Surgical Case Reports Volume: 2021 Issue: 6
  • DOI: 10.1093/jscr/rjab230
  • Peer Reviewed / Open Access
• [Journal Article] An Integrated Epigenome and Transcriptome Analysis to Clarify the Effect of Epigenetic Inhibitors on GIST (2021)
  • Author(s): NIINUMA TAKESHI、KITAJIMA HIROSHI、YAMAMOTO EIICHIRO、MARUYAMA REO、AOKI HIRONORI、HARADA TAKU、ISHIGURO KAZUYA、SUDO GOTA、TOYOTA MUTSUMI、YOSHIDO AYANO、KAI MASAHIRO、NAKASE HIROSHI、SUGAI TAMOTSU、SUZUKI HIROMU
  • Journal Title: Anticancer Research Volume: 41 Issue: 6 Pages: 2817-2828
  • DOI: 10.21873/anticanres.15062
  • Peer Reviewed / Open Access
• [Journal Article] Two hepatectomy cases for initially unresectable hepatocellular carcinoma after achieving a radiological complete response to sequential therapy with lenvatinib and transcatheter arterial chemoembolization (2021)
  • Author(s): Endo Kei、Kuroda Hidekatsu、Abe Tamami、Sato Hiroki、Kooka Youhei、Oikawa Takayoshi、Sato Ayaka、Nishiya Masao、Sugai Tamotsu、Takikawa Yasuhiro
  • Journal Title: Hepatology Research Volume: 51 Issue: 10 Pages: 1082-1086
  • DOI: 10.1111/hepr.13665
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between miR‐155 expression and clear cell papillary renal cell carcinoma in the dialyzed kidney (2021)
  • Author(s): Shiomi Ei、Kato Renpei、Matsuura Tomohiko、Maekawa Shigekatsu、Kato Yoichiro、Kanehira Mitsugu、Takata Ryo、Sugimura Jun、Ishida Kazuyuki、Abe Takaya、Sugai Tamotsu、Obara Wataru
  • Journal Title: IJU Case Reports Volume: 4 Issue: 3 Pages: 127-131
  • DOI: 10.1002/iju5.12258
  • Peer Reviewed / Open Access
• [Journal Article] Unclassified serrated lesion of the colon observed by magnifying endoscopy (2021)
  • Author(s): Kawasaki Keisuke、Eizuka Makoto、Torisu Takehiro、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Gastrointestinal Endoscopy Volume: 94 Issue: 3 Pages: 659-660
  • DOI: 10.1016/j.gie.2021.05.001
  • Peer Reviewed
• [Journal Article] SMARCB1-deficient sinonasal carcinoma: a case report and literature review (2021)
  • Author(s): Yanagawa Naoki、Suzuki Masamichi、Sugimoto Ryo、Osakabe Mitsumasa、Uesugi Noriyuki、Shiga Kiyoto、Sugai Tamotsu
  • Journal Title: Journal of Surgical Case Reports Volume: 2021 Issue: 4
  • DOI: 10.1093/jscr/rjab161
  • Peer Reviewed / Open Access
• [Journal Article] Microenvironmental markers are correlated with lymph node metastasis in invasive submucosal colorectal cancer (2021)
  • Author(s): Sugai Tamotsu、Yamada Noriyuki、Osakabe Mitsumasa、Hashimoto Mai、Uesugi Noriyuki、Eizuka Makoto、Tanaka Yoshihito、Sugimoto Ryo、Yanagawa Naoki、Matsumoto Takayuki
  • Journal Title: Histopathology Volume: 79 Issue: 4 Pages: 584-598
  • DOI: 10.1111/his.14388
  • Peer Reviewed / Open Access
• [Journal Article] Histopathological atlas of desmoplastic reaction characterization in colorectal cancer (2021)
  • Author(s): Ueno Hideki、Kajiwara Yoshiki、Ajioka Yoich、Sugai Tamotsu、Sekine Shigeki、Ishiguro Megumi、Takashima Atsuo、Kanemitsu Yukihide
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 51 Issue: 6 Pages: 1004-1012
  • DOI: 10.1093/jjco/hyab040
  • Peer Reviewed / Open Access
• [Journal Article] Protective effect of proton pump inhibitors and potassium competitive acid blockers against post-gastric endoscopic submucosal dissection bleeding: a single-center, propensity score-matched analysis (2021)
  • Author(s): Toya Yosuke、Endo Masaki、Sugai Kyohei、Yamada Shun、Oizumi Tomofumi、Morishita Toshifumi、Akasaka Risaburo、Yanai Shunichi、Nakamura Shotaro、Eizuka Makoto、Uesugi Noriyuki、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Scandinavian Journal of Gastroenterology Volume: 56 Issue: 2 Pages: 199-204
  • DOI: 10.1080/00365521.2020.1862906
  • Peer Reviewed
• [Journal Article] Prognostic value of desmoplastic reaction characterisation in stage II colon cancer: prospective validation in a Phase 3 study (SACURA Trial) (2021)
  • Author(s): Ueno Hideki、Ishiguro Megumi、Nakatani Eiji、Ishikawa Toshiaki、Uetake Hiroyuki、Murotani Kenta、Matsui Shigeyuki、Teramukai Satoshi、Sugai Tamotsu、Ajioka Yoichi、Maruo Hirotoshi、Kotaka Masahito、Tsujie Masaki、Munemoto Yoshinori、Yamaguchi Takashi、Kuroda Hisashi、Fukunaga Mutsumi、Tomita Naohiro、Sugihara Kenichi
  • Journal Title: British Journal of Cancer Volume: 124 Issue: 6 Pages: 1088-1097
  • DOI: 10.1038/s41416-020-01222-8
  • Peer Reviewed / Open Access
• [Journal Article] Loss of CD38 expression in myelomatous pleural effusion in a patient with myeloma treated with daratumumab: Report of a case (2021)
  • Author(s): Sasaki Natsuki、Ishida Kazuyuki、Yanagawa Naoki、Nishiya Masao、Yashima‐Abo Akiko、Kikuchi Inako、Yamada Noriyuki、Ambo Junichi、Kiyohara Kazuki、Osakabe Mitsumasa、Uesugi Noriyuki、Ito Shigeki、Sugai Tamotsu
  • Journal Title: Diagnostic Cytopathology Volume: 49 Issue: 1 Pages: 168-170
  • DOI: 10.1002/dc.24630
  • Peer Reviewed / Open Access
• [Journal Article] Undifferentiated carcinoma arising from intracranial epidermoid cyst (2021)
  • Author(s): Yanagawa Naoki、Nishiya Masao、Sato Yuichi、Sugimoto Ryo、Osakabe Mitsumasa、Uesugi Noriyuki、Beppu Takaaki、Ogasawara Kuniaki、Sugai Tamotsu
  • Journal Title: Pathology International Volume: 71 Issue: 4 Pages: 281-283
  • DOI: 10.1111/pin.13071
  • Peer Reviewed / Open Access
• [Journal Article] Cutaneous metastasis from esophageal basaloid squamous cell carcinoma: A case report (2021)
  • Author(s): Endo F, Akiyama Y, Onishi M, Uesugi N, Sugai T, Sasaki A.
  • Journal Title: International Journal of Surgery Case Reports Volume: 80 Pages: 105621-105621
  • DOI: 10.1016/j.ijscr.2021.02.007
  • Peer Reviewed / Open Access
• [Journal Article] Laparoscopic Left Hepatectomy with Middle Hepatic Vein Resection for Hepatocellular Carcinoma with Extrahepatic Portal Vein Obstruction (2021)
  • Author(s): Umemura A, Nitta H, Takahara T, Hasegawa Y, Katagiri H, Kanno S, Kobayashi M, Ando T, Sato A, Uesugi N, Sugai T, Sasaki A.
  • Journal Title: Am J Case Rep. Volume: 22
  • DOI: 10.12659/ajcr.928801
  • Peer Reviewed / Open Access
• [Journal Article] Relationship between Trace Element in Tumor and Prognosis in Lung Cancer Patients (2021)
  • Author(s): Saikawa Hirotaka、Nagashima Hiromi、Cho Katsuya、Chiba Ryosuke、Sera Koichiro、Shigeeda Wataru、Tomoyasu Makoto、Deguchi Hiroyuki、Takahashi Fumiaki、Saito Hajime、Sugai Tamotsu、Maemondo Makoto
  • Journal Title: Medicina Volume: 57 Issue: 3 Pages: 209-209
  • DOI: 10.3390/medicina57030209
  • Peer Reviewed / Open Access
• [Journal Article] Frequent post-operative monitoring of colorectal cancer using individualised ctDNA validated by multiregional molecular profiling (2021)
  • Author(s): Yaegashi Mizunori、Iwaya Takeshi、Sasaki Noriyuki、Fujita Masashi、Ju Zhenlin、Siwak Doris、Hachiya Tsuyoshi、Sato Kei、Endo Fumitaka、Kimura Toshimoto、Otsuka Koki、Sugimoto Ryo、Sugai Tamotsu、Liotta Lance、Lu Yiling、Mills Gordon B.、Nakagawa Hidewaki、Nishizuka Satoshi S.
  • Journal Title: British Journal of Cancer Volume: 124 Issue: 9 Pages: 1556-1565
  • DOI: 10.1038/s41416-021-01266-4
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Central hepatic bisectionectomy with hepatic artery and biliary tracts reconstruction for the patient with nodular type intrahepatic hilar cholangiocarcinoma: A case report (2021)
  • Author(s): Umemura Akira、Nitta Hiroyuki、Takahara Takeshi、Hasegawa Yasushi、Sugai Tamotsu、Sasaki Akira
  • Journal Title: International Journal of Surgery Case Reports Volume: 82 Pages: 105868-105868
  • DOI: 10.1016/j.ijscr.2021.105868
  • Peer Reviewed / Open Access
• [Journal Article] Molecular alterations in gastric cancer and the surrounding intestinal metaplastic mucosa: an analysis of isolated glands (2021)
  • Author(s): Sugimoto Ryo、Habano Wataru、Yanagawa Naoki、Akasaka Risaburo、Toya Yosuke、Sasaki Akira、Matsumoto Takayuki、Sugai Tamotsu
  • Journal Title: Gastric Cancer Volume: 24 Issue: 2 Pages: 382-391
  • DOI: 10.1007/s10120-020-01130-z
  • NAID: 40022501538
  • Peer Reviewed / Open Access
• [Journal Article] IgA vasculitis in a patient with ulcerative colitis under infliximab: drug-induced or genetic? (2021)
  • Author(s): Urushikubo Jun、Yanai Shunichi、Nakamura Shotaro、Toya Yosuke、Asakura Kensuke、Gonai Takahiro、Eizuka Makoto、Uesugi Noriyuki、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Clinical Journal of Gastroenterology Volume: 14 Issue: 1 Pages: 198-203
  • DOI: 10.1007/s12328-020-01280-8
  • Peer Reviewed / Open Access
• [Journal Article] Programmed death ligand 1 protein expression is positively correlated with the solid predominant subtype, high MIB-1 labeling index, and p53 expression and negatively correlated with epidermal growth factor receptor mutations in lung adenocarcinoma (2021)
  • Author(s): Yanagawa Naoki、Shiono Satoshi、Endo Makoto、Ogata Shin-ya、Yamada Noriyuki、Sugimoto Ryo、Osakabe Mitsumasa、Uesugi Noriyuki、Sugai Tamotsu
  • Journal Title: Human Pathology Volume: 108 Pages: 12-21
  • DOI: 10.1016/j.humpath.2020.10.014
  • Peer Reviewed
• [Journal Article] A genome‐wide study of the relationship between chromosomal abnormalities and gene expression in colorectal tumors (2020)
  • Author(s): Sugai Tamotsu、Osakabe Mitsumasa、Sugimoto Ryo、Eizuka Makoto、Tanaka Yoshihito、Yanagawa Naoki、Otsuka Koki、Sasaki Akira、Matsumoto Takayuki、Suzuki Hiromu
  • Journal Title: Genes, Chromosomes and Cancer Volume: 60 Issue: 4 Pages: 250-262
  • DOI: 10.1002/gcc.22924
  • Peer Reviewed / Open Access
• [Journal Article] Multi-institutional re-evaluation of prognostic factors in chromophobe renal cell carcinoma: proposal of a novel two-tiered grading (2020)
  • Author(s): Ohashi, R. Martignoni, G. Hartmann, A. Calio, A. Segala, D. Stohr, C. Wach, S. Erlmeier, F. Weichert, W. Autenrieth, M. Schraml, P. Rupp, N. J. Ohe, C. Otsuki, Y. Kawasaki, T. Kobayashi, H. Kobayashi, K. Miyazaki, T. Shibuya, H. Tsuzuki, T. Nagashima, Y. Ajioka, Y. Moch, H. et al.
  • Journal Title: Virchows Arch Volume: 476 Issue: 3 Pages: 409-418
  • DOI: 10.1007/s00428-019-02710-w
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microvascular density under magnifying narrow-band imaging endoscopy in colorectal epithelial neoplasms. (2020)
  • Author(s): Gonai T, Kawasaki K, Nakamura S, Yanai S, Akasaka R, Sato K, Toya Y, Asakura K, Urushikubo J, Fujita Y, Eizuka M, Uesugi N, Sugai T, Matsumoto T.
  • Journal Title: Intest Res Volume: 18 Issue: 1 Pages: 107-114
  • DOI: 10.5217/ir.2019.00061
  • Peer Reviewed / Open Access
• [Journal Article] Differential expression of microRNAs in colorectal cancer: Different patterns between isolated cancer gland and stromal cells. (2020)
  • Author(s): Sato A, Fujita Y, Otsuka K, Sasaki A, Suzuki H, Matsumoto T, Sugai T.
  • Journal Title: Pathol Int Volume: 70 Issue: 1 Pages: 21-30
  • DOI: 10.1111/pin.12872
  • Peer Reviewed / Open Access
• [Journal Article] A diagnostic algorithm of magnifying endoscopy with crystal violet staining for non-ampullary duodenal epithelial tumors. (2020)
  • Author(s): Toya Y, Endo M, Oizumi T, Akasaka R, Yanai S, Kawasaki K, Nakamura S, Eizuka M, Fujita Y, Uesugi N, Ishida K, Sugai T, Matsumoto T.
  • Journal Title: Dig Endosc Volume: - Issue: 7 Pages: 1066-1073
  • DOI: 10.1111/den.13640
  • Peer Reviewed / Open Access
• [Journal Article] Comprehensive analysis of somatic copy number alterations in clear cell renal cell carcinoma. (2020)
  • Author(s): Tsuyukubo T, Ishida K, Osakabe M, Shiomi E, Kato R, Takata R, Obara W, Sugai T.
  • Journal Title: Mol Carcinog Volume: 59 Issue: 4 Pages: 412-424
  • DOI: 10.1002/mc.23164
  • Peer Reviewed / Open Access
• [Journal Article] Upregulation of AEBP1 in endothelial cells promotes tumor angiogenesis in colorectal cancer (2020)
  • Author(s): Yorozu Akira、Yamamoto Eiichiro、Niinuma Takeshi、Tsuyada Akihiro、Maruyama Reo、Kitajima Hiroshi、Numata Yuto、Kai Masahiro、Sudo Gota、Kubo Toshiyuki、Nishidate Toshihiko、Okita Kenji、Takemasa Ichiro、Nakase Hiroshi、Sugai Tamotsu、Takano Kenichi、Suzuki Hiromu
  • Journal Title: Cancer Science Volume: － Issue: 5 Pages: 1631-1644
  • DOI: 10.1111/cas.14360
  • Peer Reviewed / Open Access
• [Journal Article] Significance of gene mutations in the Wnt signaling pathway in traditional serrated adenomas of the colon and rectum (2020)
  • Author(s): Nakanishi, H. Sawada, T. Kaizaki, Y. Ota, R. Suzuki, H. Yamamoto, E. Aoki, H. Eizuka, M. Hasatani, K. Takahashi, N. Inagaki, S. Ebi, M. Kato, H. Kubota, E. Kataoka, H. Takahashi, S. Tokino, T. Minamoto, T. Sugai, T. Sasaki, Y.
  • Journal Title: PLoS One Volume: 15 Issue: 2 Pages: e0229262-e0229262
  • DOI: 10.1371/journal.pone.0229262
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Laparoscopic Sleeve Gastrectomy on Non-Alcoholic Steatohepatitis and Liver Fibrosis in Japanese Patients with Severe Obesity. (2020)
  • Author(s): Nikai H, Ishida K, Umemura A, Baba S, Nitta H, Sugai T, Sasaki A.
  • Journal Title: Obes Surg Volume: - Issue: 7 Pages: 2579-2587
  • DOI: 10.1007/s11695-020-04515-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] White Opaque Substance Under Narrow-Band Imaging Colonoscopy May Hinder Microvascular Pattern Recognition in Colorectal Tumors. (2020)
  • Author(s): Kawasaki K, Sugai T, Matsumoto T.
  • Journal Title: Dig Endosc Volume: - Issue: 5 Pages: 826-826
  • DOI: 10.1111/den.13667
  • Peer Reviewed / Open Access
• [Journal Article] Eosinophilic esophagitis with a severe stenosis: report of a Japanese case (2020)
  • Author(s): Toya Yosuke、Kumei Tomo、Yamada Shun、Akasaka Risaburo、Yanai Shunichi、Nakamura Shotaro、Osakabe Mitsumasa、Uesugi Noriyuki、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Clinical Journal of Gastroenterology Volume: 13 Issue: 5 Pages: 708-712
  • DOI: 10.1007/s12328-020-01145-0
  • Peer Reviewed / Open Access
• [Journal Article] The clinicopathological and molecular features of sporadic gastric foveolar type neoplasia (2020)
  • Author(s): Sugai Tamotsu、Uesugi Noriyuki、Habano Wataru、Sugimoto Ryo、Eizuka Makoto、Fujita Yasuko、Osakabe Mitsumasa、Toya Yosuke、Suzuki Hiromu、Matsumoto Takayuki
  • Journal Title: Virchows Archiv Volume: 477 Issue: 6 Pages: 835-844
  • DOI: 10.1007/s00428-020-02846-0
  • Peer Reviewed / Open Access
• [Journal Article] Super-late pulmonary recurrence after radical esophagectomy for esophageal squamous cell carcinoma (2020)
  • Author(s): Umemura Akira、Akiyama Yuji、Iwaya Takeshi、Koeda Keisuke、Sugimoto Ryo、Sugai Tamotsu、Endo Fumitaka、Baba Shigeaki、Nikai Haruka、Nitta Hiroyuki、Takahara Takeshi、Otuska Koki、Kimura Toshimoto、Saito Hajime、Deguchi Hiroyuki、Tomoyasu Makoto、Sasaki Akira
  • Journal Title: International Journal of Surgery Case Reports Volume: 72 Pages: 166-171
  • DOI: 10.1016/j.ijscr.2020.05.068
  • Peer Reviewed / Open Access
• [Journal Article] Endoscopic submucosal dissection for adenocarcinoma arising from ectopic gastric mucosa in the cervical esophagus (2020)
  • Author(s): Toya Yosuke、Fujita Yasuko、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Digestive and Liver Disease Volume: 52 Issue: 9 Pages: 1053-1053
  • DOI: 10.1016/j.dld.2020.03.028
  • Peer Reviewed
• [Journal Article] Traditional serrated adenoma has two distinct genetic pathways for molecular tumorigenesis with potential neoplastic progression (2020)
  • Author(s): Tanaka Yoshihito、Eizuka Makoto、Uesugi Noriyuki、Kawasaki Keisuke、Yamano Hiroo、Suzuki Hiromu、Matsumoto Takayuki、Sugai Tamotsu
  • Journal Title: Journal of Gastroenterology Volume: 55 Issue: 9 Pages: 846-857
  • DOI: 10.1007/s00535-020-01697-5
  • Peer Reviewed / Open Access
• [Journal Article] Dysregulation of microRNA expression during the progression of colorectal tumors (2020)
  • Author(s): Eizuka Makoto、Osakabe Mitsumasa、Sato Ayaka、Fujita Yasuko、Tanaka Yoshihito、Otsuka Koki、Sasaki Akira、Matsumoto Takayuki、Suzuki Hiromu、Sugai Tamotsu
  • Journal Title: Pathology International Volume: 70 Issue: 9 Pages: 633-643
  • DOI: 10.1111/pin.12975
  • Peer Reviewed / Open Access
• [Journal Article] Esophageal carcinosarcoma in which the sarcomatous element has sloughed off: A case report (2020)
  • Author(s): Sasaki Noriyuki、Iwaya Takeshi、Akiyama Yuji、Baba Shigeaki、Endo Fumitaka、Nikai Haruka、Fujisawa Ryosuke、Kimura Toshimoto、Takahara Takeshi、Otsuka Koki、Nitta Hiroyuki、Kimura Yusuke、Koeda Keisuke、Sugimoto Ryo、Uesugi Noriyuki、Sugai Tamotsu、Sasaki Akira
  • Journal Title: International Journal of Surgery Case Reports Volume: 74 Pages: 27-31
  • DOI: 10.1016/j.ijscr.2020.07.064
  • Peer Reviewed / Open Access
• [Journal Article] Mesenteric phlebosclerosis complicating colonic cancer treated by endoscopic submucosal dissection (2020)
  • Author(s): Kawasaki Keisuke、Eizuka Makoto、Kudara Norihiko、Yanai Shunichi、Toya Yosuke、Torisu Takehiro、Umeno Junji、Nakamura Shotaro、Sugai Tamotsu、Matsumoto Takayuki
  • Journal Title: Clinical Journal of Gastroenterology Volume: 13 Issue: 6 Pages: 1183-1188
  • DOI: 10.1007/s12328-020-01205-5
  • Peer Reviewed / Open Access
• [Journal Article] Risk for lymph node metastasis in Epstein?Barr virus‐associated gastric carcinoma with submucosal invasion (2020)
  • Author(s): Tsuji Yosuke、Ushiku Tetsuo、Shinozaki Tomohiro、Yamashita Hiroharu、Seto Yasuyuki、Fukayama Masashi、Fujishiro Mitsuhiro、Oda Ichiro、Katai Hitoshi、Taniguchi Hirokazu、Hasatani Kenkei、Kaizaki Yasuharu、Oga Atsunori、Nishikawa Jun、Akasaka Risaburo、Endo Masaki、Sugai Tamotsu、Matsumoto Takayuki、Koike Kazuhiko
  • Journal Title: Digestive Endoscopy Volume: ー Issue: 4 Pages: 592-597
  • DOI: 10.1111/den.13823
  • Peer Reviewed / Open Access
• [Journal Article] Epiploic appendage infarction of the sigmoid colon (2020)
  • Author(s): Sugimoto Ryo、Yanagawa Naoki、Osakabe Mitsumasa、Uesugi Noriyuki、Ito Yuma、Fukagawa Daisuke、Baba Tsukasa、Sugai Tamotsu
  • Journal Title: Pathology International Volume: 70 Issue: 11 Pages: 918-919
  • DOI: 10.1111/pin.13019
  • Peer Reviewed / Open Access
• [Journal Article] Pulmonary epithelial-myoepithelial carcinoma without AKT1, HRAS or PIK3CA mutations: a case report (2020)
  • Author(s): Yanagawa Naoki、Sato Ayaka、Nishiya Masao、Suzuki Masamichi、Sugimoto Ryo、Osakabe Mitsumasa、Uesugi Noriyuki、Saito Hajime、Sugai Tamotsu
  • Journal Title: Diagnostic Pathology Volume: 15 Issue: 1
  • DOI: 10.1186/s13000-020-01020-z
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of clinicopathological and molecular features of crawling-type gastric adenocarcinoma (2020)
  • Author(s): Fujita Yasuko、Uesugi Noriyuki、Sugimoto Ryo、Eizuka Makoto、Toya Yosuke、Akasaka Risaburo、Matsumoto Takayuki、Sugai Tamotsu
  • Journal Title: Diagnostic Pathology Volume: 15 Issue: 1
  • DOI: 10.1186/s13000-020-01026-7
  • Peer Reviewed / Open Access
• [Journal Article] A case of bone marrow involvement in sarcoidosis with crescentic glomerular lesions (2020)
  • Author(s): Sugai M, Murata O, Oikawa H, Katagiri H, Matsumoto A, Nagashima H, Sugai T, Maemondo M.
  • Journal Title: Respir Med Case Rep. Volume: 31 Pages: 101202-101202
  • DOI: 10.1016/j.rmcr.2020.101202
  • Peer Reviewed / Open Access
• [Journal Article] Primary esophageal malignant melanoma successfully treated with anti-PD-1 antibody for retroperitoneal recurrence after esophagectomy: A case report (2020)
  • Author(s): Endo Fumitaka、Akiyama Yuji、Onishi Masazumi、Fujisawa Ryosuke、Sasaki Noriyuki、Nikai Haruka、Baba Shigeaki、Sugimoto Ryo、Kimura Toshimoto、Takahara Takeshi、Iwaya Takeshi、Otsuka Koki、Nitta Hiroyuki、Koeda Keisuke、Sugai Tamotsu、Sasaki Akira
  • Journal Title: International Journal of Surgery Case Reports Volume: 75 Pages: 152-156
  • DOI: 10.1016/j.ijscr.2020.09.034
  • Peer Reviewed / Open Access
• [Journal Article] Two-stage laparoscopic surgery for incarcerated umbilical Littre’s hernia in severely obese patient: a case report (2020)
  • Author(s): Ariyoshi Yu、Suto Takayuki、Umemura Akira、Fujiwara Hisataka、Yanari Shingo、Uesugi Noriyuki、Sugai Tamotsu、Sasaki Akira
  • Journal Title: Surgical Case Reports Volume: 6 Issue: 1
  • DOI: 10.1186/s40792-020-01008-3
  • Peer Reviewed / Open Access
• [Journal Article] Immunohistochemical Analysis of Mismatch Repair Gene Proteins in Early Gastric Cancer Based on Microsatellite Status (2020)
  • Author(s): Sugimoto Ryo、Endo Masaki、Osakabe Mitsumasa、Toya Yosuke、Yanagawa Naoki、Matsumoto Takayuki、Sugai Tamotsu
  • Journal Title: Digestion Volume: ー Issue: 5 Pages: 1-10
  • DOI: 10.1159/000510679
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Complete Pathological Response to Neoadjuvant Pembrolizumab in a Patient With Chemoresistant Upper Urinary Tract Urothelial Carcinoma: A Case Report (2020)
  • Author(s): Ikarashi Daiki、Kitano Shigehisa、Ishida Kazuyuki、Nakatsura Tetsuya、Shimodate Hitoshi、Tsuyukubo Takashi、Tamura Daichi、Kato Renpei、Sugai Tamotsu、Obara Wataru
  • Journal Title: Frontiers in Oncology Volume: 10
  • DOI: 10.3389/fonc.2020.564714
  • Peer Reviewed / Open Access
• [Journal Article] Genome?wide analysis of microRNA to evaluate prognostic markers in isolated cancer glands and surrounding stroma in high?grade serous ovarian carcinoma (2020)
  • Author(s): Sato Chie、Osakabe Mitsumasa、Nagasawa Takayuki、Suzuki Hiromu?、Itamochi Hiroaki、Baba Tsukasa、Sugai Tamotsu
  • Journal Title: Oncology Letters Volume: 20 Issue: 6 Pages: 1-1
  • DOI: 10.3892/ol.2020.12198
  • Peer Reviewed / Open Access
• [Journal Article] Pleomorphic carcinoma of the trachea after chemoradiotherapy for laryngeal cancer (2020)
  • Author(s): Saikawa Hirotaka、Uesugi Noriyuki、Sugai Tamotsu、Maemondo Makoto
  • Journal Title: BMJ Case Reports Volume: 13 Issue: 10 Pages: e236819-e236819
  • DOI: 10.1136/bcr-2020-236819
  • Peer Reviewed / Open Access
• [Journal Article] Immunohistochemical Examination is Highly Sensitive and Specific for Detection of the V600E BRAF Mutation in Colorectal Serrated Lesions (2020)
  • Author(s): Yamada Noriyuki、Eizuka Makoto、Sugimoto Ryo、Tanaka Yoshihito、Yanagawa Naoki、Yamano Hiroo、Suzuki Hiromu、Matsumoto Takayuki、Sugai Tamotsu
  • Journal Title: Applied Immunohistochemistry & Molecular Morphology Volume: Publish Ahead of Print Issue: 6 Pages: 446-453
  • DOI: 10.1097/pai.0000000000000890
  • Peer Reviewed
• [Journal Article] Clinicopathological and Molecular Findings of Differentiated-Type Minute Gastric Intramucosal Neoplasia. (2019)
  • Author(s): Uesugi N, Sugai T, Sugimoto R, Eizuka M, Fujita Y, Sato A, Osakabe M, Ishida K, Shiomi E, Toya Y, Akasaka R, Matsumoto T.
  • Journal Title: Digestion. Volume: 印刷中 Issue: 3 Pages: 287-297
  • DOI: 10.1159/000499464
  • Peer Reviewed
• [Journal Article] Primary plasmacytoma in the cerebellum: A case report and literature review. (2019)
  • Author(s): Yanagihara W, Beppu T, Ogasawara Y, Ito S, Sato Y, Sugai T, Ogasawara K.
  • Journal Title: World Neurosurg. Volume: 134 Pages: 10-13
  • DOI: 10.1016/j.wneu.2019.10.036
  • Peer Reviewed / Open Access
• [Journal Article] Immune checkpoint inhibitor-induced diarrhea: A clinicopathological study of eleven patients. (2019)
  • Author(s): Yanai S, Nakamura S, Kawasaki K, Toya Y, Akasaka R, Oizumi T, Ishida K, Sugai T, Matsumoto T.
  • Journal Title: Dig Endosc. Volume: - Issue: 4 Pages: 616-620
  • DOI: 10.1111/den.13555
  • Peer Reviewed / Open Access
• [Presentation] SSLDにおけるdysplasia成分の組織亜型分類に基づく臨床病理学的および分子病理学的検討 (2023)
  • Author(s): 上杉憲幸，田中義人，杉本 亮，河内 洋，八尾隆史，味岡洋一，菅井 有
  • Organizer: 第98回大腸癌研究会
• [Presentation] Superficially serrated adenoma(SuSA)の臨床病理学的および分子生物学的検討 (2023)
  • Author(s): 田中義人，上杉憲幸，永塚 真，刑部光正，栁川直樹，松下弘雄，山本英一郎，鈴木 拓，松本主之，菅井 有
  • Organizer: 第98回大腸癌研究会
• [Presentation] Traditional serrated adenoma(TSA)の臨床病理学的，分子生物学的検討 (2023)
  • Author(s): 田中義人，永塚 真，松本主之，菅井 有
  • Organizer: 第19回日本消管学会総会学術集会
• [Presentation] 現代の病理診断学とは - 35年間の私の実践 - (2023)
  • Author(s): 菅井 有
  • Organizer: 第39回岩手県臨床細胞学会集団会
  • Invited
• [Presentation] 胃癌における組織像と分子異常との関連性 (2023)
  • Author(s): 菅井 有
  • Organizer: 第95回日本病理学会東北支部学術集会
  • Invited
• [Presentation] Gastroblastomaの１例 (2023)
  • Author(s): 杉本 亮，上杉憲幸，菅井 有
  • Organizer: 第95回日本胃癌学会総会
• [Presentation] 消化管内視鏡診療と消化管病理診断の連携―正確な診断，適切な治療のために― (2023)
  • Author(s): 菅井 有
  • Organizer: 第132回日本消化器病学会北海道支部例会・第126回日本消化器内視鏡学会北海道支部例会
  • Invited
• [Presentation] Cold snare polypectomyにおける病理学的な視点 (2023)
  • Author(s): 菅井 有
  • Organizer: 第109回日本消化器病学会総会
  • Invited
• [Presentation] Gastroblastoma の 1 例 (2023)
  • Author(s): 杉本 亮，上杉憲幸，刑部光正，鈴木正通，伊藤勇馬，伊藤一洋，秋山有史，栁川直樹，佐々木 章，小田義直，佐藤 孝，菅井 有
  • Organizer: 第112回日本病理学会総会
• [Presentation] 胃粘膜内腫瘍におけるコピー数異常解析と遺伝子パネルを用いた変異解析 (2023)
  • Author(s): 小池吉彦, 刑部光正, 栁川直樹, 菅井 有
  • Organizer: 第112回日本病理学会総会
• [Presentation] 脾臓 littoral cell angiosarcoma の一例 (2023)
  • Author(s): 伊藤勇馬, 佐藤 孝, 栁川直樹, 藤原久貴, 鈴木正通, 杉本 亮, 刑部光正, 上杉憲幸, 菅井 有
  • Organizer: 第112回日本病理学会総会
• [Presentation] 進行非扁平上皮非小細胞肺癌の化学療法における治療効果予測因子としての TTF-1 免疫染色の有用性 (2023)
  • Author(s): 菅井万優，栁川直樹，鹿内俊輔，伊藤一洋，伊藤勇馬，鈴木正通，杉本 亮，刑部光正，上杉憲幸，佐藤 孝，菅井 有
  • Organizer: 第112回日本病理学会総会
• [Presentation] 散発性 MSI-H 型大腸癌の臨床・分子病理学的特徴 -MSS 型大腸癌との比較検討 - (2023)
  • Author(s): 山田 峻，上杉憲幸，伊藤勇馬，鈴木正通，杉本 亮，刑部光正，栁川直樹，佐藤 孝，松本主之，菅井 有
  • Organizer: 第112回日本病理学会総会
• [Presentation] 原発性肺腺癌における腫瘍関連マクロファージの臨床病理学的意義 (2023)
  • Author(s): 鹿内俊介，栁川直樹，菅井万優，伊藤一洋，伊藤勇馬，鈴木正通，杉本 亮，刑部光正，上杉憲幸，佐藤 孝，菅井 有
  • Organizer: 第112回日本病理学会総会
• [Presentation] 多形腺腫由来と考えられた唾液腺癌肉腫の一例 (2023)
  • Author(s): 都鳥未来也，栁川直樹，小池吉彦，伊藤一洋，伊藤勇馬，鈴木正通，杉本 亮，刑部光正，上杉憲幸，菅井 有
  • Organizer: 第112回日本病理学会総会
• [Presentation] 治療成績向上のための大腸癌の基礎知識―臨床医が知っておくべき病理組織学的知識 (2023)
  • Author(s): 菅井 有
  • Organizer: 第32回日本大腸肛門病学会教育セミナー
  • Invited
• [Presentation] 大腸腫瘍の病理診断と分子異常―診断病理学から治療病理学へ (2023)
  • Author(s): 菅井 有
  • Organizer: 第105回日本消化器内視鏡学会総会
  • Invited
• [Presentation] Superficially serrated adenoma(SuSA)の臨床病理学的および分子生物学的検討 (2022)
  • Author(s): 田中義人, 松下弘雄, 吉川健二郎, 田口愛弓, 萬 春花, 加藤文一朗, 山本英一郎, 鈴木 拓, 松本主之, 菅井 有
  • Organizer: 第103回日本消化器内視鏡学会総会
• [Presentation] MSI型大腸癌の臨床病理学的・分子病理学的特徴 -MSS型大腸癌との分子病理学的比較検討- (2022)
  • Author(s): 山田 峻，上杉憲幸，杉本 亮，刑部光正，栁川直樹，佐々木 章，菅井有
  • Organizer: 第97回大腸癌研究会
• [Presentation] 組織型に基づいた胃粘膜内癌の分子異常 (2022)
  • Author(s): 菅井 有
  • Organizer: 第81回日本癌学会総会
  • Invited
• [Presentation] 消化管腫瘍の病理組織像と分子プロファイルとの関連性 (2022)
  • Author(s): 菅井 有
  • Organizer: 第61回日本臨床細胞学会秋期大会
  • Invited
• [Presentation] 病院業務と研究活動の両立について経験を踏まえての現状と課題 (2022)
  • Author(s): 山田範幸，杉本 亮，刑部光正，上杉憲幸，栁川直樹，菅井 有
  • Organizer: 第61回日本臨床細胞学会秋期大会
• [Presentation] 肺癌新報告様式の導入に向けて―現時点における報告様式の実態― (2022)
  • Author(s): 栁川直樹，山田範幸，伊藤勇馬，鈴木正通，杉本 亮，刑部光正，上杉憲幸，菅井 有
  • Organizer: 第61回日本臨床細胞学会秋期大会
• [Presentation] HPV関連・非関連子宮頸部腺癌の病理組織学的特徴と細胞像 (2022)
  • Author(s): 刑部光正，山田範幸，杉本 亮，上杉憲幸，栁川直樹，菅井 有
  • Organizer: 第61回日本臨床細胞学会秋期大会
• [Presentation] 多形腺腫との鑑別が困難であった結節性筋膜炎の一例 (2022)
  • Author(s): 高橋静子，栁川直樹，佐々木奈都紀，上田奈央子，肥田野靖史，柴田祐二，菊池いな子，山田範幸，安保淳一，鈴木正通，杉本 亮，刑部光正，上杉憲幸，佐藤 孝，菅井 有
  • Organizer: 第61回日本臨床細胞学会秋期大会
• [Presentation] 超音波内視鏡下穿刺吸引細胞診で診断しえた悪性黒色腫膵転移の一例 (2022)
  • Author(s): 肥田野靖史，栁川直樹，佐々木奈都紀，上田奈央子，柴田祐二，高橋静子，菊池いな子，山田範幸，安保淳一，伊藤勇馬，西谷匡央，鈴木正通，杉本 亮，刑部光正，上杉憲幸，佐藤 孝，菅井 有
  • Organizer: 第61回日本臨床細胞学会秋期大会
• [Presentation] Ⅱ，Ⅲ期進行胃癌における癌周囲間質の免疫組織化学的特徴および予後との関連性の検討 (2022)
  • Author(s): 杉本 亮，山田 峻，上杉憲幸，菅井 有
  • Organizer: 第33回日本消化器癌発生学会総会
• [Presentation] 腺管分離法を用いた大腸cribriform-type adenocarcinomaの網羅的分子解析 (2022)
  • Author(s): 山田 峻，上杉憲幸，刑部光正，伊藤一洋，伊藤勇馬，杉本 亮，栁川直樹，佐々木 章，佐藤 孝，菅井 有
  • Organizer: 第33回日本消化器癌発生学会総会
• [Presentation] 胃癌の病理診断とその分子背景 (2022)
  • Author(s): 菅井 有
  • Organizer: 第34回日本消化器内視鏡学会東北セミナー
  • Invited
• [Presentation] 胆膵系細胞診の検体処理方法 (2022)
  • Author(s): 山田範幸，伊藤勇馬，鈴木正通，杉本 亮，刑部光正，上杉憲幸，栁川直樹，菅井 有
  • Organizer: 第68回日本病理学会秋期特別総会
• [Presentation] KRAS遺伝子とTP53遺伝子の変異部位は稀であった直腸癌肉腫の１例 (2022)
  • Author(s): 都鳥未来也，栁川直樹，伊藤一洋，伊藤勇馬，杉本 亮，刑部光正，上杉憲幸，菅井 有
  • Organizer: 第68回日本病理学会秋期特別総会
• [Presentation] Deficient mismatch repair(dMMR)型胃癌の切除および生検検体の臨床病理学的，組織学的検討 (2022)
  • Author(s): 杉本 亮，上杉憲幸，永塚 真，刑部光正，山田範幸，秋山有史，栁川直樹，佐々木 章，松本主之，菅井 有
  • Organizer: 第68回日本病理学会秋期特別総会
• [Presentation] 同一腫瘍内で癌浸潤に伴うコピー数変化に基づいた大腸癌のゲノムワイド解析について (2022)
  • Author(s): 山田 峻，上杉憲幸，刑部光正，伊藤一洋，伊藤勇馬，鈴木正通，杉本 亮，栁川直樹，菅井 有
  • Organizer: 第68回日本病理学会秋期特別総会
• [Presentation] 大腸癌および癌近傍正常粘膜のmessenger RNA とmicro RNAの網羅的解析 (2022)
  • Author(s): 伊藤勇馬，刑部光正，杉本 亮，上杉憲幸，栁川直樹，新沼 猛，大塚幸喜，佐々木 章，松本主之，鈴木 拓，菅井 有
  • Organizer: 第68回日本病理学会秋期特別総会
• [Presentation] 肺腺癌における癌微小環境関連マーカーと臨床転帰の検討 (2022)
  • Author(s): 菅井万優，栁川直樹，鹿内俊介，伊藤一洋，伊藤勇馬，杉本 亮，刑部光正，上杉憲幸，前門戸 任，菅井 有
  • Organizer: 第68回日本病理学会秋期特別総会
• [Presentation] 心臓腫瘍の1例 (2022)
  • Author(s): 伊藤一洋，杉本 亮，栁川直樹，上杉憲幸，刑部光正，田林 東，金 一，小田義直，菅井 有
  • Organizer: 第68回日本病理学会秋期特別総会
• [Presentation] 組織型に基づいた異腫瘍の臨床病理像と分子異常 (2022)
  • Author(s): 菅井 有
  • Organizer: 第42回北海道臨床細胞学会総会・学術集会
  • Invited
• [Presentation] Stage Ⅱ大腸癌浸潤先進部癌間質におけるCAFおよびEMT関連蛋白発現に関する病理学的検討 (2022)
  • Author(s): 橋元麻生，上杉憲幸，刑部光正，栁川直樹，大塚幸喜，梶原由規，上野秀樹，佐々木 章，菅井 有
  • Organizer: 第96回大腸癌研究会
• [Presentation] Somatic copy number alterations in gastric intramucosal neoplasias based on microsatellite status (2022)
  • Author(s): 菅井 有
  • Organizer: 第94回日本胃癌学会総会
  • Invited
• [Presentation] Ⅱ，Ⅲ期進行胃癌における癌周囲間質の免疫組織化学的特徴および予後との関連性の検討 (2022)
  • Author(s): 杉本 亮，上杉憲幸，菅井 有
  • Organizer: 第94回日本胃癌学会総会
• [Presentation] Isolated gland/stroma-based multi omics解析に基づいた大腸腫瘍の発生進展過程の解明 -Elucidation of colorectal carcinogenesis based on multi-omics analyses of isolated gland/stromal tissue (2022)
  • Author(s): 菅井 有
  • Organizer: 第111回日本病理学会総会
  • Invited
• [Presentation] 線維芽細胞活性化蛋白の発現は非小細胞肺癌の予後因子となる (2022)
  • Author(s): 栁川直樹，菅井万優，鹿内俊介，鈴木正通，杉本 亮，刑部光正，上杉憲幸，菅井 有
  • Organizer: 第111回日本病理学会総会
• [Presentation] 大腸過形成性病変における臨床病理学的および分子病理学的検討 - 過形成結節は独立した疾患概念か？- (2022)
  • Author(s): 上杉憲幸，田中義人，永塚 真，杉本 亮，刑部光正，柳川直樹，味岡洋一，新井冨生，菅井 有
  • Organizer: 第111回日本病理学会総会
• [Presentation] 遺伝子時代の子宮体癌の病理診断 (2022)
  • Author(s): 刑部光正，杉本 亮，上杉憲幸，栁川直樹，菅井 有
  • Organizer: 第111回日本病理学会総会
• [Presentation] ２，３期進行胃癌における癌周囲間質の免疫組織化学的特徴および予後との関連性の検討 (2022)
  • Author(s): 杉本 亮，上杉憲幸，刑部光正，伊藤一洋，橋元麻生，秋山有史，栁川直樹，佐々木 章，菅井 有
  • Organizer: 第111回日本病理学会総会
• [Presentation] 大腸癌および癌近傍正常粘膜のmessenger RNAとmicro RNAの網羅的解析 (2022)
  • Author(s): 伊藤勇馬，刑部光正，杉本 亮，栁川直樹，大塚幸喜，佐々木 章，松本主人之，鈴木 拓，菅井 有
  • Organizer: 第111回日本病理学会総会
• [Presentation] 大腸篩状腺癌のCAFおよびEMT関連蛋白発現解析に基づく予後についての検討 (2022)
  • Author(s): 橋元麻生，伊藤一洋，伊藤勇馬，山田 峻，山田範幸，杉本 亮，刑部光正，上杉憲幸，栁川直樹，菅井 有
  • Organizer: 第111回日本病理学会総会
• [Presentation] 肺扁平上皮癌における癌間質反応(Desmoplastic reaction)の臨床病理学的意義 (2022)
  • Author(s): 菅井万優，栁川直樹，鹿内俊介，伊藤一洋，伊藤勇馬，鈴木正通，杉本 亮，刑部光正，上杉憲幸，菅井 有
  • Organizer: 第111回日本病理学会総会
• [Presentation] 腺管分離法を用いた大腸cribriform type adenocarcinomaの網羅的分子解析 (2022)
  • Author(s): 山田 峻，上杉憲幸，刑部光正，永塚 真，橋元麻生，伊藤一洋，伊藤勇馬先生，杉本 亮，栁川直樹，菅井 有
  • Organizer: 第111回日本病理学会総会
• [Presentation] 転移及び非転移Microsatellite stable型大腸癌の癌と癌周囲間質の網羅的messenger RNA, micro RNA解析 (2022)
  • Author(s): 伊藤一洋，刑部光正，杉本 亮，橋元麻生，山田 峻，上杉憲幸，大塚幸喜，栁川直樹，佐々木 章，菅井 有
  • Organizer: 第111回日本病理学会総会
• [Presentation] ステージⅡおよびⅢ期大腸癌における浸潤先進部の微小環境因子の発現パターンとTenascin-C発現の有用性に関する解析 (2021)
  • Author(s): 橋元麻生，上杉憲幸，刑部光正，栁川直樹，梶原由規，上野秀樹，菅井 有
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 大腸癌の腫瘍近傍分離正常腺管と分離癌腺管におけるmiRNA/mRNA発現状態の網羅的解析 (2021)
  • Author(s): 刑部光正，伊藤勇馬，杉本 亮，上杉憲幸，栁川直樹，鈴木 拓，菅井 有
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] 大腸鋸歯状病変の病理診断と分子異常． (2021)
  • Author(s): 菅井 有
  • Organizer: 第101回日本消化器内視鏡学会総会
  • Invited
• [Presentation] ヘリコバクターピロリ除菌後/未感染胃癌の病理． (2021)
  • Author(s): 菅井 有
  • Organizer: 第15回日本消化管学会教育講演会
  • Invited
• [Presentation] 【New world of gastric cancer pathology】Comprehensive molecular analyses of gastric differentiated type intramucosal tumor． (2021)
  • Author(s): 菅井 有
  • Organizer: 第93回日本胃癌学会総会
  • Invited
• [Presentation] 分離腺管を用いた大腸粘膜内腫瘍と大腸癌のオミックス解析 ―Gland-based geneticsの提唱―． (2021)
  • Author(s): 菅井 有
  • Organizer: 第110回日本病理学会総会
  • Invited
• [Presentation] 消化管腫瘍の網羅的エピジェネテッィク異常． (2021)
  • Author(s): 菅井 有
  • Organizer: 第110回日本病理学会総会
  • Invited
• [Presentation] 進行大腸癌浸潤先進部の癌微小環境下における癌胞巣と癌間質の臨床病理学的および分子病理学的検討． (2021)
  • Author(s): 橋元麻生，上杉憲幸，杉本 亮，永塚 真，田中義人，佐藤綾香，西谷匡央，刑部光正，栁川直樹，菅井 有
  • Organizer: 第110回日本病理学会総会
• [Presentation] 大腸早期腫瘍性病変及び浸潤癌のマルチオミックス解析． (2020)
  • Author(s): 菅井 有，杉本 亮，刑部光正，永塚 真，田中義人，松本主之
  • Organizer: 第92回大腸癌研究会
  • Invited
• [Presentation] 大腸腫瘍（腺腫，粘膜内癌，進行癌）におけるmicro RNA 発現異常解析． (2020)
  • Author(s): 永塚 真，田中義人，佐藤綾香，杉本 亮，藤田泰子，上杉憲幸，菅井 有
  • Organizer: 第92回大腸癌研究会
• [Presentation] Traditional serrated adenoma(TSA)における臨床病理学的および分子生物学的検討． (2020)
  • Author(s): 田中義人，上杉憲幸，永塚 真，杉本 亮，藤田泰子，菅井 有
  • Organizer: 第92回大腸癌研究会
• [Presentation] 腺管分離法を用いた大腸腺腫，SSA/P，早期大腸癌および進行大腸癌の網羅的microRNA 解析（Comprehensive microRNA analysis of colorectal adenomas, SSA/P, early colorectal cancer and advanced colorectal cancer with crypt isolation technique）． (2020)
  • Author(s): 杉本 亮，刑部光正，上杉憲幸，藤田泰子，永塚 真，川崎啓祐，鈴木正通，佐藤綾香，伊藤勇馬，石田和之，大塚幸喜，佐々木 章，松本主之，菅井 有
  • Organizer: 第16回日本消化管学会総会学術集会
• [Presentation] SNP array を用いた早期胃癌，進行胃癌における染色体コピー数変化の網羅的解析． (2020)
  • Author(s): 永塚 真，荒川典之，田中義人，杉本 亮，藤田泰子，鳥谷洋右，赤坂理三郎，川崎啓祐，刑部光正，上杉憲幸，石田和之，松本主之，菅井 有
  • Organizer: 第16回日本消化管学会総会学術集会
• [Presentation] GNAS変異を伴う十二指腸内反性嚢胞性管状絨毛腺腫の一例． (2020)
  • Author(s): 藤田泰子，上杉憲幸，杉本 亮，伊藤勇馬，佐藤綾香，永塚 真，西谷匡央，刑部光正，石田和之，菅井 有
  • Organizer: 第109回日本病理学会総会
• [Presentation] Comprehensive miRNA analysis of isolated glands and the surrounding stromal cells in CRC．Comprehensive miRNA analysis of isolated glands and the surrounding stromal cells in CRC． (2020)
  • Author(s): Ryo Sugimoto, Mitsumasa Osakabe, Noriyuki Uesugi, Noriyuki Yamada, Makoto Eizuka, Ayaka Sato, Masamichi Suzuki, Kazuyuki Ishida, Koki Otsuka, Akira Sasaki, Tamotsu Sugai
  • Organizer: 第109回日本病理学会総会
• [Presentation] Molecular profiling and comprehensive genome-wide analysis of somatic copy number alterations in gastric intramucosal neoplasias based on microsatellite status． (2020)
  • Author(s): 永塚 真，田中義人，杉本 亮，藤田泰子，刑部光正，上杉憲幸，石田和之，菅井 有
  • Organizer: 第109回日本病理学会総会
• [Presentation] Traditional serrated adenoma（TSA）における臨床病理学的および分子生物学的検討． (2020)
  • Author(s): 田中義人，上杉憲幸，山田範幸，永塚 真，伊藤勇馬，杉本 亮，藤田泰子，刑部光正，石田和之，菅井 有
  • Organizer: 第109回日本病理学会総会
• [Presentation] 進行大腸癌先進部における分離癌腺管と分離癌間質のmicroRNA発現異常の検討． (2020)
  • Author(s): 佐藤綾香, 藤田泰子，杉本 亮, 永塚 真, 刑部光正, 上杉憲幸, 大塚幸喜, 石田和之, 佐々木 章, 菅井 有
  • Organizer: 第109回日本病理学会総会
• [Presentation] 卵巣高異型度漿液性癌の再発に関与するmicroRNA発現状態の網羅的解析． (2020)
  • Author(s): 佐藤千絵, 刑部光正, 鈴木正通, 杉本 亮, 藤田泰子, 上杉憲幸, 石田和之, 菅井 有
  • Organizer: 第109回日本病理学会総会
• [Presentation] 淡明細胞型腎細胞癌における somatic copy number alteration の網羅的解析． (2020)
  • Author(s): 露久保敬嗣,石田和之,刑部光正,塩見 叡,永塚 真,加藤廉平,高田 亮,小原 航,菅井 有
  • Organizer: 第109回日本病理学会総会
• [Presentation] 胸水貯留をきたした抗CD38抗体療法後の形質細胞骨髄腫の一例． (2020)
  • Author(s): 佐々木奈都紀,石田和之,西谷匡央,菊池いな子,山田範幸,安保淳一,刑部光正,阿保亜紀子,上杉憲幸,菅井 有
  • Organizer: 第109回日本病理学会総会
• [Presentation] Adenoma carcinoma Sequenceに基づいた大腸癌のマルチオミックス解析． (2020)
  • Author(s): 菅井 有，刑部光正，杉本 亮，鈴木 拓
  • Organizer: 第79回日本癌学会学術総会
  • Invited
• [Presentation] PD-L1蛋白発現は非小細胞肺癌において術後化学療法の効果を予測する因子である． (2020)
  • Author(s): 栁川直樹，菅井 有，上杉憲幸，刑部光正，杉本 亮
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 腺管分離法を用いた大腸癌における癌腺管および周囲の間質細胞の網羅的microRNA解析-第2法-． (2020)
  • Author(s): 杉本 亮，刑部光正，上杉憲幸，永塚 真，栁川直樹，菅井 有
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 腺管分離法を用いた大腸癌および大腸周囲粘膜の網羅的omics解析． (2020)
  • Author(s): 伊藤勇馬，杉本 亮，刑部光正，栁川直樹，大塚幸喜，佐々木 章，鈴木 拓，菅井 有
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 卵巣高異型度漿液性癌における分離癌腺管および癌周囲間質のmicroRNA発現状態． (2020)
  • Author(s): 佐藤千絵，刑部光正，鈴木 拓，板持広明，馬場 長，菅井 有
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 淡明細胞型腎細胞癌における体細胞コピー数変化の網羅的解析． (2020)
  • Author(s): 露久保敬嗣，刑部光正，塩見 叡，加藤廉平，高田 亮，栁川直樹，小原 航，菅井 有
  • Organizer: 第79回日本癌学会学術総会
• [Presentation] 大腸鋸歯状病変の病理診断と分子異常． (2020)
  • Author(s): 菅井 有
  • Organizer: JDDW 2020 KOBE
  • Invited
• [Presentation] Clinicopathological and molecular study of traditional serrated adenoma(TSA) ． (2020)
  • Author(s): 田中義人，菅井 有，松本主之
  • Organizer: JDDW 2020 KOBE
• [Presentation] 細胞診検体処理の工夫 -胆膵系細胞診の検体処理-． (2020)
  • Author(s): 山田範幸，小川七恵，佐々木奈都紀，上田奈央子，肥田野靖史，高橋静子，菊池いな子，安保淳一，西谷匡央，鈴木正通，杉本 亮，刑部光正，上杉憲幸，栁川直樹，菅井 有
  • Organizer: 第50回日本臨床細胞学会秋期大会
• [Remarks] 岩手医科大学 医学部 病理診断学講座
  • URL: https://pathology-iwate-med.jp