| Project/Area Number |
20K07420
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 49030:Experimental pathology-related
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| Research Institution | Hokkaido University |
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Principal Investigator |
Elewa Yaser 北海道大学, 獣医学研究院, 助教 (30782221)
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| Co-Investigator(Kenkyū-buntansha) |
昆 泰寛 北海道大学, 獣医学研究院, 教授 (10178402)
市居 修 北海道大学, 獣医学研究院, 准教授 (60547769)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | lung injury / MFALCs / streptozoticin / Lung asthma / diabetes / Bleomycin / autoimmune diseases / immune cells / Lung Injury / Autoimmune Disease / lymphoproliferative / mouse models / lung / Dual effect / Lung Asthma / Streptozotocin / Lung injury / Respiratorty diseases / lung cancer / cardiovascular disease |
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| Outline of Research at the Start |
our study represents cutting-edge research to provide some innovative strategies through understanding the role of MFALCs “PlFALCs and PerFALCs” in the pathogenesis of devasting respiratory and cardiac diseases such as targeting some immune cells or silencing of some genes within such clusters using different mice models and the results thus obtained will help to update MFALCs immunity and suggest some innovative therapeutic approach of several respiratory and cardiac diseases in human that not respond to treatments
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| Outline of Final Research Achievements |
The pathological Alternations of mediastinal fat-associated lymphoid clusters (MFALCs) and lung injury following metabolic disorder (diabetes induction) (Elewa et al. 2021, Microscopy and microanalysis) and asthma induction (Elewa et al. 2021, Int. J. Mol. Sci.) were revealed. Furthermore, we could clarify the impact of either dexamethasone or bleomycin on the degree of lung injury and MFALCs development in autoimmune-induced lung lesions. From the data analysis of these experiments, I could publish in three high-impact Journals (Elewa et al. 2021, Front. Immunol.; Elewa et al. 2022, Microscopy and Microanalysis; Elewa et al. 2022, Int. J. Mol. Sci.). Also, through collaborative research with other researchers within my lab and other institutions inside Japan and outside Japan, and from this collaboration, I could publish the data in 30 high impacted Journals.
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| Academic Significance and Societal Importance of the Research Achievements |
We clarified the impact of MFALCs targeting in the revealing of lung injury in several mice models.Therefore, this study could open the bright future of human respiratory diseases by introducing innovative therapeutic strategies for respiratory diseases
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