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Role of cGAS in bacterial virulence and antimicrobial resistance.

Research Project

Project/Area Number 20K07509
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 49050:Bacteriology-related
Research InstitutionNational Institute of Infectious Diseases

Principal Investigator

Suzuki Masato  国立感染症研究所, 薬剤耐性研究センター, 主任研究官 (70444073)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords薬剤耐性 / cGAS / 病原性 / Acinetobacter baummannii / 細菌
Outline of Research at the Start

cGAS (cyclic GMP-AMP synthase) から合成されるcGAMP (cyclic GMP-AMP) は、原核細胞と真核細胞、即ち分類学上の生物界を超えてクロスキングダムな生物活性を有するセカンドメッセンジャーであることが明らかとなってきた。本研究では、細菌cGASと薬剤耐性・病原性との関連性に焦点を置き、Acinetobacter baumannii流行株にてcGAMP標的因子の網羅的同定と機能解析を行い、細菌cGASを介した生命現象の分子機構を明らかにすることを企図した。

Outline of Final Research Achievements

Under the global concern regarding antimicrobial resistance in gram-negative bacterial pathogens, our objective was to investigate the underlying biological mechanisms regulated by the cyclic GMP-AMP synthase (cGAS) gene, which is encoded on an antimicrobial resistance plasmid found in the epidemic strain of Acinetobacter baumannii clinically isolated in Japan. Using wild-type, cGAS-deficient, and cGAS-complemented strains of A. baumannii, we conducted comparative analyses to evaluate the impact of cGAS on antimicrobial resistance and virulence. Considering the strain-specific preservation of cGAS among strains, it is regarded as a potential factor contributing to variations in phenotypes and regional/ethnic specificities among strains. This study successfully integrated the fields of fundamental bacteriology and molecular epidemiology of clinically significant bacterial species, resulting in novel insights.

Academic Significance and Societal Importance of the Research Achievements

病原細菌において菌株毎に保存性が異なるcGASは、菌株間の表現系の差違や菌株の地域・人種特異性などを説明することが可能な因子と考えられ、本研究から基礎細菌学と感染症起因菌の分子疫学の知見を結び付ける成果を得られた。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (52 results)

All 2023 2022 2021 2020

All Journal Article (52 results) (of which Int'l Joint Research: 24 results,  Peer Reviewed: 52 results,  Open Access: 46 results)

  • [Journal Article] Development of serological assays to identify Helicobacter suis and H. pylori infections2023

    • Author(s)
      Matsui Hidenori、Rimbara Emiko、Suzuki Masato、Tokunaga Kengo、Suzuki Hidekazu、Sano Masaya、Ueda Takashi、Tsugawa Hitoshi、Nanjo Sohachi、Takeda Akira、Sasaki Makoto、Terao Shuichi、Suda Tsuyoshi、Aoki Sae、Shibayama Keigo、Ota Hiroyoshi、Mabe Katsuhiro
    • Journal Title

      iScience

      Volume: 26 Issue: 4 Pages: 106522-106522

    • DOI

      10.1016/j.isci.2023.106522

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Enterococcal Linear Plasmids Adapt to Enterococcus faecium and Spread within Multidrug-Resistant Clades2023

    • Author(s)
      Hashimoto Yusuke、Suzuki Masato、Kobayashi Sae、Hirahara Yuki、Kurushima Jun、Hirakawa Hidetada、Nomura Takahiro、Tanimoto Koichi、Tomita Haruyoshi
    • Journal Title

      Antimicrobial Agents and Chemotherapy

      Volume: 67 Issue: 4 Pages: 67-67

    • DOI

      10.1128/aac.01619-22

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Helicobacter ailurogastricus in Patient with Multiple Refractory Gastric Ulcers, Japan2023

    • Author(s)
      Sano Masaya、Rimbara Emiko、Suzuki Masato、Matsui Hidenori、Hirai Miwa、Aoki Sae、Kenri Tsuyoshi、Shibayama Keigo、Suzuki Hidekazu
    • Journal Title

      Emerging Infectious Diseases

      Volume: 29 Issue: 4 Pages: 833-835

    • DOI

      10.3201/eid2904.221807

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Reconsideration of the previously classified incompatibility groups of plasmids, IncP-1 and IncP-112023

    • Author(s)
      Shintani Masaki、Suzuki Haruo、Nojiri Hideaki、Suzuki Masato
    • Journal Title

      Environmental Microbiology

      Volume: - Issue: 6 Pages: 1071-1076

    • DOI

      10.1111/1462-2920.16345

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomic Epidemiological Analysis of Antimicrobial-Resistant Bacteria with Nanopore Sequencing2023

    • Author(s)
      Suzuki Masato、Hashimoto Yusuke、Hirabayashi Aki、Yahara Koji、Yoshida Mitsunori、Fukano Hanako、Hoshino Yoshihiko、Shibayama Keigo、Tomita Haruyoshi
    • Journal Title

      Methods in molecular biology

      Volume: 2632 Pages: 227-246

    • DOI

      10.1007/978-1-0716-2996-3_16

    • ISBN
      9781071629956, 9781071629963
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Plasmids harboring a tandem duplicate of blaVIM-24 in carbapenem-resistant ST1816 Pseudomonas aeruginosa in Japan2023

    • Author(s)
      Hishinuma Tomomi、Tada Tatsuya、Tohya Mari、Shintani Masaki、Suzuki Masato、Shimojima Masahiro、Kirikae Teruo
    • Journal Title

      Microbial Drug Resistance

      Volume: 29 Issue: 1 Pages: 10-17

    • DOI

      10.1089/mdr.2022.0168

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Klebsiella Species and Enterobacter cloacae Isolates Harboring <i>bla</i> <sub>OXA-181</sub> and <i>bla</i> <sub>OXA-48</sub> : Resistome, Fitness Cost, and Plasmid Stability2022

    • Author(s)
      Mahazu Samiratu、Prah Isaac、Ota Yusuke、Hayashi Takaya、Nukui Yoko、Suzuki Masato、Hoshino Yoshihiko、Akeda Yukihiro、Suzuki Toshihiko、Ishino Tomoko、Ablordey Anthony、Saito Ryoichi
    • Journal Title

      Microbiology Spectrum

      Volume: 10 Issue: 6

    • DOI

      10.1128/spectrum.03320-22

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A Nationwide Plasmidome Surveillance in Thailand Reveals a Limited Variety of New Delhi Metallo-β-Lactamase-Producing Carbapenem-Resistant <i>Enterobacteriaceae</i> Clones and Spreading Plasmids2022

    • Author(s)
      Abe Ryuichiro、Akeda Yukihiro、Sakamoto Noriko、Takeuchi Dan、Sugawara Yo、Yamamoto Norihisa、Kerdsin Anusak、Matsumoto Yuki、Motooka Daisuke、Laolerd Warawut、Santanirand Pitak、Suzuki Masato、Shibayama Keigo、Tomono Kazunori、Iida Tetsuya、Hamada Shigeyuki
    • Journal Title

      Journal of Clinical Microbiology

      Volume: 60 Issue: 12

    • DOI

      10.1128/jcm.01080-22

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Genomic epidemiological analysis of mcr-1-harboring Escherichia coli collected from livestock settings in Vietnam2022

    • Author(s)
      Nguyen Phuong Thi Lan、Ngo Thi Hong Hanh、Tran Thi Mai Hung、Vu Thi Ngoc Bich、Le Viet Thanh、Tran Hai Anh、Pham Duy Thai、Nguyen Ha Thanh、Tran Dieu Linh、Nguyen Thi Phuong Lien、Nguyen Thi Thi Tho、Tran Nhu Duong、Dang Duc Anh、Ba?uls Anne-Laure、Choisy Marc、van Doorn H. Rogier、Suzuki Masato、Tran Huy Hoang
    • Journal Title

      Frontiers in Veterinary Science

      Volume: 9 Pages: 1034610-1034610

    • DOI

      10.3389/fvets.2022.1034610

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Bcr4 Is a Chaperone for the Inner Rod Protein in the Bordetella Type III Secretion System2022

    • Author(s)
      Goto M, Abe A, Hanawa T, Suzuki M, Kuwae A.
    • Journal Title

      Microbiology Spectrum

      Volume: 10 Issue: 5

    • DOI

      10.1128/spectrum.01443-22

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clonal dissemination of carbapenem-resistant <i>Klebsiella pneumoniae</i> ST16 co-producing NDM-1 and OXA-232 in Thailand2022

    • Author(s)
      Abe Ryuichiro、Akeda Yukihiro、Takeuchi Dan、Sakamoto Noriko、Sugawara Yo、Yamamoto Norihisa、Kerdsin Anusak、Matsumoto Yuki、Motooka Daisuke、Leolerd Warawut、Santanirand Pitak、Suzuki Masato、Shibayama Keigo、Tomono Kazunori、Iida Tetsuya、Hamada Shigeyuki
    • Journal Title

      JAC-Antimicrobial Resistance

      Volume: 4 Issue: 4

    • DOI

      10.1093/jacamr/dlac084

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Multicenter survey for carbapenemase-producing Enterobacterales in central Japan2022

    • Author(s)
      Hara Y, Iguchi M, Tetsuka N, Morioka H, Hirabayashi A, Suzuki M, Tomita Y, Oka K, Yagi T.
    • Journal Title

      Nagoya Journal of Medical Science

      Volume: 84 Issue: 3 Pages: 630-639

    • DOI

      10.18999/nagjms.84.3.630

    • ISSN
      0027-7622
    • URL

      https://nagoya.repo.nii.ac.jp/records/2003754

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Carriage of Plasmid-Mediated Colistin Resistance-1-Positive Escherichia coli in Humans, Animals, and Environment on Farms in Vietnam2022

    • Author(s)
      Nguyen Phuong Thi Lan、Tran Hung Thi Mai、Tran Hai Anh、Pham Thai Duy、Luong Tan Minh、Nguyen Thanh Ha、Nguyen Lien Thi Phuong、Nguyen Tho Thi Thi、Hoang Ha Thi An、Nguyen Chi、Tran Duong Nhu、Dang Anh Duc、Suzuki Masato、Le Thanh Viet、Ba?uls Anne-Laure、Choisy Marc、Van Doorn Rogier H.、Tran Huy Hoang
    • Journal Title

      The American Journal of Tropical Medicine and Hygiene

      Volume: 107 Issue: 1 Pages: 65-71

    • DOI

      10.4269/ajtmh.21-1203

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Total synthesis and antimicrobial evaluation of (+)-hygrophorone B12 and its analogues2022

    • Author(s)
      Kamishima Takaaki、Suzuki Masato、Narita Koichi、Koseki Yoshitaka、Nonaka Toshiyuki、Nakatsuji Hirotaka、Hattori Hideo、Kasai Hitoshi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 7471-7471

    • DOI

      10.1038/s41598-022-11608-8

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomic epidemiology and temperature dependency of hypermucoviscous Klebsiella pneumoniae in Japan2022

    • Author(s)
      Le Mi Nguyen-Tra、Kayama Shizuo、Wyres Kelly L.、Yu Liansheng、Hisatsune Junzo、Suzuki Masato、Yahara Koji、Terachi Tsuneko、Sawa Kana、Takahashi Shin、Okuhara Toshihiko、Kohama Kunihiko、Holt Kathryn E.、Mizutani Tetsu、Ohge Hiroki、Sugai Motoyuki
    • Journal Title

      Microbial Genomics

      Volume: 8 Issue: 5 Pages: 1-1

    • DOI

      10.1099/mgen.0.000827

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Complete Genome Sequence of Mycobacterium fortuitum subsp. fortuitum JCM 6387, a Type Strain of Human-Pathogenic Mycobacteria Showing Inducible Macrolide Resistance2022

    • Author(s)
      Yoshida M, Fukano H, Suzuki M, Hoshino Y
    • Journal Title

      Microbiology Resource Announcements

      Volume: 11 Issue: 4

    • DOI

      10.1128/mra.00060-22

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Precise classification of antimicrobial resistance-associated IncP-2 megaplasmids for molecular epidemiological studies on <i>Pseudomonas</i> species2022

    • Author(s)
      Shintani Masaki、Suzuki Haruo、Nojiri Hideaki、Suzuki Masato
    • Journal Title

      Journal of Antimicrobial Chemotherapy

      Volume: 77 Issue: 4 Pages: 1202-1204

    • DOI

      10.1093/jac/dkac006

    • NAID

      120007188390

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Emergence of mobile tigecycline resistance gene tet(X4)-harbouring Shewanella xiamenensis in a water environment2022

    • Author(s)
      Dao Trung Duc、Kasuga Ikuro、Hirabayashi Aki、Nguyen Dong Tu、Tran Hien Thi、Vu Hieu、Pham Linh Tuyet Ngoc、Vu Thi My Hanh、Hasebe Futoshi、Nguyen Ha Thanh、Thi Trang Le、Tran Hoang Huy、Shibayama Keigo、Takemura Taichiro、Suzuki Masato
    • Journal Title

      Journal of Global Antimicrobial Resistance

      Volume: 28 Pages: 140-142

    • DOI

      10.1016/j.jgar.2021.12.022

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] High-Throughput Screening of Antimicrobial Resistance Genes and Their Association With Class 1 Integrons in Urban Rivers in Japan2022

    • Author(s)
      I. Kasuga, K. Nagasawa, M. Suzuki, F. Kurisu and H. Furumai
    • Journal Title

      Frontiers in Environmental Science

      Volume: 10 Pages: 825372-825372

    • DOI

      10.3389/fenvs.2022.825372

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elucidation of host diversity of the VanD-carrying genomic islands in enterococci and anaerobes2022

    • Author(s)
      Hashimoto Yusuke、Hisatsune Junzo、Suzuki Masato、Kurushima Jun、Nomura Takahiro、Hirakawa Hidetada、Kojima Naoko、Ono Yuichi、Hasegawa Yutaka、Tanimoto Koichi、Sugai Motoyuki、Tomita Haruyoshi
    • Journal Title

      JAC-Antimicrobial Resistance

      Volume: 4 Issue: 1 Pages: 189-189

    • DOI

      10.1093/jacamr/dlab189

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genomic characterization of triple-carbapenemase-producing <i>Acinetobacter baumannii</i>2021

    • Author(s)
      Oinuma Ken-Ichi、Suzuki Masato、Sakiyama Arata、Tsubouchi Taishi、Saeki Kozo、Sato Kanako、Niki Mamiko、Yamada Koichi、Shibayama Keigo、Kakeya Hiroshi、Kaneko Yukihiro
    • Journal Title

      JAC-Antimicrobial Resistance

      Volume: 3 Issue: 4

    • DOI

      10.1093/jacamr/dlab191

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Potential spread of mcr-9-carrying IncHI2 plasmids in Enterobacter hormaechei in Vietnam2021

    • Author(s)
      Ha Van Thi Thu、Tran Linh Dieu、Mai Nguyen Thi Tuyet、Hirabayashi Aki、Nguyen Son Thai、Tran Hoang Huy、Shibayama Keigo、Suzuki Masato
    • Journal Title

      Journal of Global Antimicrobial Resistance

      Volume: 27 Pages: 332-334

    • DOI

      10.1016/j.jgar.2021.09.012

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expansion of KPC-producing Enterobacterales in four large hospitals in Hanoi, Vietnam2021

    • Author(s)
      Linh Tran Dieu、Thu Nguyen Hoai、Shibayama Keigo、Suzuki Masato、Yoshida LayMint、Thai Pham Duy、Anh Dang Duc、Duong Tran Nhu、Trinh Hong Son、Thom Vu Phuong、Nga Luu Thi Vu、Phuong Nguyen Thi Kim、Thuyet Bui Thanh、Walsh Timothy R.、Thanh Le Viet、Ba?uls Anne-Laure、van Doorn H. Rogier、Van Anh Tran、Hoang Tran Huy
    • Journal Title

      Journal of Global Antimicrobial Resistance

      Volume: 27 Pages: 200-211

    • DOI

      10.1016/j.jgar.2021.09.007

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Human pathogenic Mycobacterium kansasii (former subtype I) with zoonotic potential isolated from a diseased indoor pet cat, Japan2021

    • Author(s)
      Fukano Hanako、Terazono Tsukasa、Hirabayashi Aki、Yoshida Mitsunori、Suzuki Masato、Wada Shinpei、Ishii Norihisa、Hoshino Yoshihiko
    • Journal Title

      Emerging Microbes & Infections

      Volume: 10 Issue: 1 Pages: 220-222

    • DOI

      10.1080/22221751.2021.1878935

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete Genome Sequence of a Clinical Isolate of Acinetobacter baumannii Harboring 11 Plasmids2021

    • Author(s)
      Sakiyama Arata、Matsumoto Yuki、Tsubouchi Taishi、Suzuki Masato、Niki Makoto、Niki Mamiko、Oinuma Ken-Ich、Kakeya Hiroshi、Kaneko Yukihiro
    • Journal Title

      Microbiology Resource Announcements

      Volume: 10 Issue: 39

    • DOI

      10.1128/mra.00695-21

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Complete Genome Sequence of Acinetobacter pittii OCU_Ac17, Isolated from Human Venous Blood2021

    • Author(s)
      Matsumoto Yuki、Sakiyama Arata、Tsubouchi Taishi、Suzuki Masato、Niki Makoto、Niki Mamiko、Kakeya Hiroshi、Kaneko Yukihiro
    • Journal Title

      Microbiology Resource Announcements

      Volume: 10 Issue: 39

    • DOI

      10.1128/mra.00696-21

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome Sequence of Acinetobacter towneri Strain DSM 16313, Previously Known as the Proposed Type Strain of Acinetobacter seohaensis2021

    • Author(s)
      Maehana Shotaro、Kitasato Hidero、Suzuki Masato
    • Journal Title

      Microbiology Resource Announcements

      Volume: 10 Issue: 35

    • DOI

      10.1128/mra.00690-21

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Transferable IncC-IncX3 Hybrid Plasmid Cocarrying <i>bla</i> <sub>NDM-4</sub> , <i>tet</i> (X), and <i>tmexCD3-toprJ3</i> Confers Resistance to Carbapenem and Tigecycline2021

    • Author(s)
      Hirabayashi Aki、Dao Trung Duc、Takemura Taichiro、Hasebe Futoshi、Trang Le Thi、Thanh Nguyen Ha、Tran Hoang Huy、Shibayama Keigo、Kasuga Ikuro、Suzuki Masato
    • Journal Title

      mSphere

      Volume: 6 Issue: 4 Pages: 00592-21

    • DOI

      10.1128/msphere.00592-21

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Plasmid analysis of NDM metallo-β-lactamase-producing Enterobacterales isolated in Vietnam2021

    • Author(s)
      Hirabayashi Aki、Yahara Koji、Mitsuhashi Satomi、Nakagawa So、Imanishi Tadashi、Ha Van Thi Thu、Nguyen An Van、Nguyen Son Thai、Shibayama Keigo、Suzuki Masato
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 7 Pages: e0231119-e0231119

    • DOI

      10.1371/journal.pone.0231119

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Resistance mechanisms and genetic relatedness among carbapenem-resistant <i>Pseudomonas aeruginosa</i> isolates from three major hospitals in Hanoi, Vietnam (2011?15)2021

    • Author(s)
      Tran Anh、Vu Bich、Trinh Tung、Tran Linh、Pham My、Ngo Hanh、Nguyen Thao、Tran Duong、Pham Thai、Dang Anh、Shibayama Keigo、Suzuki Masato、Yoshida Lay-Myint、Trinh Son、Le Thanh、Vu Thom、Luu Nga、Banuls Anne-Laure、Trinh Linh、Tran Anh、Tran Hoang、van Doorn Rogier
    • Journal Title

      JAC-Antimicrobial Resistance

      Volume: 3 Issue: 3

    • DOI

      10.1093/jacamr/dlab103

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Protected but not from Contamination: Antimicrobial Resistance Profiles of Bacteria from Birds in a Ghanaian Forest Protected Area2021

    • Author(s)
      Modupe Sawyerr Louisa、Yaa Ntiamoa-Baidu、Henaku Owusu Erasmus、Ohya Kenji、Masato Suzuki、Opare Odoi Justice、Baboreka Kayang Boniface
    • Journal Title

      Environmental Health Insights

      Volume: 15 Pages: 786302211017687-786302211017687

    • DOI

      10.1177/11786302211017687

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Natural factories that manufacture antimicrobial resistance genes: quadruple blaGES-carrying plasmids in Aeromonas and Pseudomonas species.2021

    • Author(s)
      Shotaro Maehana, Ryotaro Eda, Aki Hirabayashi, Nagi Niida, Masaki Nakamura, Takashi Furukawa, Shinsuke Ikeda, Fumiaki Kojima, Kouji Sakai, Kazunari Sei, Hidero Kitasato, Masato Suzuki.
    • Journal Title

      Int J Antimicrob Agents.

      Volume: 28 Issue: 5 Pages: 106327-106327

    • DOI

      10.1016/j.ijantimicag.2021.106327

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] On-Site Genomic Epidemiological Analysis of Antimicrobial-Resistant Bacteria in Cambodia With Portable Laboratory Equipment2021

    • Author(s)
      Hirabayashi Aki、Yanagisawa Hideji、Takahashi Hiromizu、Yahara Koji、Boeing Philipp、Wolfenden Bethan、Nov Vandarith、Lorn Vichet、Veng Mom、Ann Vuth、Darapheak Chau、Shibayama Keigo、Suzuki Masato
    • Journal Title

      Frontiers in Microbiology

      Volume: 12 Pages: 675463-675463

    • DOI

      10.3389/fmicb.2021.675463

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Long-read metagenomics using PromethION uncovers oral bacteriophages and their interaction with host bacteria2021

    • Author(s)
      Yahara Koji、Suzuki Masato、Hirabayashi Aki、Suda Wataru、Hattori Masahira、Suzuki Yutaka、Okazaki Yusuke
    • Journal Title

      Nature Communications

      Volume: 12 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41467-020-20199-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel DNA chromatography method to discriminate Mycobacterium abscessus subspecies and macrolide susceptibility2021

    • Author(s)
      Yoshida Mitsunori、Sano Sotaro、Chien Jung-Yien、Fukano Hanako、Suzuki Masato、Asakura Takanori、Morimoto Kozo、Murase Yoshiro、Miyamoto Shigehiko、Kurashima Atsuyuki、Hasegawa Naoki、Hsueh Po-Ren、Mitarai Satoshi、Ato Manabu、Hoshino Yoshihiko
    • Journal Title

      EBioMedicine

      Volume: 64 Pages: 103187-103187

    • DOI

      10.1016/j.ebiom.2020.103187

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Point mutation in the stop codon of MAV_RS14660 increases the growth rate of Mycobacterium avium subspecies hominissuis2021

    • Author(s)
      Kawakita Tomomi、Mukai Tetsu、Yoshida Mitsunori、Yamada Hiroyuki、Nakayama Masaaki、Miyamoto Yuji、Suzuki Masato、Nakata Noboru、Takii Takemasa、Ryo Akihide、Ohara Naoya、Ato Manabu
    • Journal Title

      Microbiology

      Volume: 167 Issue: 2 Pages: 1-14

    • DOI

      10.1099/mic.0.001007

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
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    • Author(s)
      Ryotaro Eda, Shotaro Maehana, Aki Hirabayashi, Masaki Nakamura, Takashi Furukawa, Shinsuke Ikeda, Kouji Sakai, Fumiaki Kojima, Kazunari Sei, Masato Suzuki, Hidero Kitasato.
    • Journal Title

      J Glob Antimicrob Resist.

      Volume: 24 Pages: 180-182

    • DOI

      10.1016/j.jgar.2020.12.007

    • Related Report
      2020 Research-status Report
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  • [Journal Article] Complete Genome Sequence of Mycobacterium heckeshornense JCM 15655T, Closely Related to a Pathogenic Nontuberculous Mycobacterial Species, Mycobacterium xenopi2021

    • Author(s)
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      Microbiology Resource Announcements

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    • DOI

      10.1128/mra.00020-21

    • Related Report
      2020 Research-status Report
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  • [Journal Article] Emergence of a plasmid-borne tigecycline resistance in Klebsiella pneumoniae in Vietnam2021

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      Journal of Medical Microbiology

      Volume: 70 Issue: 3 Pages: 140-142

    • DOI

      10.1099/jmm.0.001320

    • Related Report
      2020 Research-status Report
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    • Author(s)
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      Genome Medicine

      Volume: 13 Issue: 1 Pages: 1-12

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      10.1186/s13073-021-00860-8

    • Related Report
      2020 Research-status Report
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    • Author(s)
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      Proceedings of the National Academy of Sciences

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      10.1073/pnas.2026337118

    • Related Report
      2020 Research-status Report
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    • Author(s)
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      The Journal of Antibiotics

      Volume: 74 Issue: 5 Pages: 291-299

    • DOI

      10.1038/s41429-020-00402-1

    • Related Report
      2020 Research-status Report
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  • [Journal Article] First Report of the Local Spread of Vancomycin-Resistant Enterococci Ascribed to the Interspecies Transmission of a vanA Gene Cluster-Carrying Linear Plasmid2020

    • Author(s)
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      mSphere

      Volume: 5 Issue: 2

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      10.1128/msphere.00102-20

    • Related Report
      2020 Research-status Report
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    • Author(s)
      Tsubouchi Taishi、Suzuki Masato、Niki Makoto、Oinuma Ken-Ichi、Niki Mamiko、Kakeya Hiroshi、Kaneko Yukihiro
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      Microbiology Resource Announcements

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      10.1128/mra.00289-20

    • Related Report
      2020 Research-status Report
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    • Author(s)
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    • Journal Title

      Journal of Global Antimicrobial Resistance

      Volume: 21 Pages: 272-274

    • DOI

      10.1016/j.jgar.2020.04.033

    • Related Report
      2020 Research-status Report
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      Nature Communications

      Volume: 11 Issue: 1 Pages: 2934-2934

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      10.1038/s41467-020-16731-6

    • Related Report
      2020 Research-status Report
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    • Author(s)
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    • Journal Title

      FEMS Microbiology Letters

      Volume: 367 Issue: 15

    • DOI

      10.1093/femsle/fnaa127

    • Related Report
      2020 Research-status Report
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    • Author(s)
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    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 10

    • DOI

      10.3389/fcimb.2020.00385

    • Related Report
      2020 Research-status Report
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    • Author(s)
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    • Journal Title

      Organic Letters

      Volume: 22 Issue: 15 Pages: 5876-5879

    • DOI

      10.1021/acs.orglett.0c01975

    • Related Report
      2020 Research-status Report
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    • Author(s)
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    • Journal Title

      Microbiology Resource Announcements

      Volume: 9 Issue: 36 Pages: 830-20

    • DOI

      10.1128/mra.00830-20

    • Related Report
      2020 Research-status Report
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  • [Journal Article] Prevalence and Characterization of Carbapenem-Hydrolyzing Class D β-Lactamase-Producing Acinetobacter Isolates From Ghana2020

    • Author(s)
      Ayibieke Alafate、Kobayashi Ayumi、Suzuki Masato、Sato Wakana、Mahazu Samiratu、Prah Isaac、Mizoguchi Miyuki、Moriya Kyoji、Hayashi Takaya、Suzuki Toshihiko、Iwanaga Shiroh、Ablordey Anthony、Saito Ryoichi
    • Journal Title

      Frontiers in Microbiology

      Volume: 11 Pages: 587398-587398

    • DOI

      10.3389/fmicb.2020.587398

    • Related Report
      2020 Research-status Report
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  • [Journal Article] Shotgun metagenome sequencing identification of a set of genes encoded by Actinomyces associated with medication-related osteonecrosis of the jaw2020

    • Author(s)
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    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 11 Pages: e0241676-e0241676

    • DOI

      10.1371/journal.pone.0241676

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2020-04-28   Modified: 2024-01-30  

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