Research Project
Grant-in-Aid for Scientific Research (C)
幹細胞マーカーを発現するがん細胞は、がん幹細胞と呼ばれ、化学療法や放射線療法に強い抵抗性を示す。また、がん幹細胞の特性としてスフェロイドの形成(足場非依存的増殖)が知られており、スフェロイド形成の制御が新たながんの治療法として期待されている。本研究では、がんのスフェロイド形成を制御する糖タンパク質に注目し、その作用機構を明らかにする。またその糖タンパク質が、がんの治療に効果があるかどうかを検証する。
Fetuin-A: α-2-HS-glycoprotein, is secreted from the liver and can be detected in human blood. The function of Fetuin-A against cancer is not clear to date. In this study, we found that Fetuin-A increased cell growth rate and resistance in lung cancer cells against anti-cancer drug treatment. Additionally, we clarified a part of its molecular mechanisms.
Fetuin-Aの癌に対する機能を世界に先駆けて明らかにした。またその作用メカニズムの一端を明らかにしたことから、Fetuin-Aを標的にした、新たな治療法の開発が期待される。
All 2023 2022 2021 2020 Other
All Journal Article (19 results) (of which Int'l Joint Research: 8 results, Peer Reviewed: 19 results, Open Access: 12 results) Presentation (15 results) (of which Int'l Joint Research: 2 results, Invited: 2 results) Book (2 results) Remarks (1 results)
Glycoconj. J
Volume: 40 Issue: 3 Pages: 1-10
10.1007/s10719-023-10108-9
Antioxid Redox Signal.
Volume: - Issue: 16-18 Pages: 227-234
10.1089/ars.2022.0010
Proceedings of the National Academy of Sciences
Volume: 119 Issue: 43 Pages: 1-12
10.1073/pnas.2205277119
Glycoconj. J.
Volume: 39 Issue: 2 Pages: 145-155
10.1007/s10719-022-10051-1
Biochemical and Biophysical Research Communications
Volume: 633 Pages: 68-71
10.1016/j.bbrc.2022.09.027
The Journal of Dermatology
Volume: 49 Issue: 10 Pages: 1027-1036
10.1111/1346-8138.16506
Int. J. Mol. Sci.
Volume: 22 Issue: 16 Pages: 8579-8579
10.3390/ijms22168579
Cancer Sci.
Volume: 112 Issue: 9 Pages: 3756-3768
10.1111/cas.15032
The FEBS Journal
Volume: Online ahead of print Issue: 22 Pages: 7147-7162
10.1111/febs.16185
The Role of Glycosylation in Health and Disease
Volume: 1325 Pages: 137-149
10.1007/978-3-030-70115-4_6
Volume: 23 Issue: 1 Pages: 423-442
10.3390/ijms23010423
Nagoya Journal of Medical Science
Volume: 83 Issue: 3 Pages: 535-549
10.18999/nagjms.83.3.535
120007147350
https://nagoya.repo.nii.ac.jp/records/2001444
Biochemical Society Transactions
Volume: 49 Issue: 1 Pages: 441-453
10.1042/bst20200780
Molecular Pharmaceutics
Volume: 18 Issue: 1 Pages: 451-460
10.1021/acs.molpharmaceut.0c00839
Cell Reports
Volume: 33 Issue: 2 Pages: 108261-108261
10.1016/j.celrep.2020.108261
Molecular Cancer Research
Volume: 19 Issue: 1 Pages: 150-161
10.1158/1541-7786.mcr-20-0420
Molecular Aspects of Medicine
Volume: in press Pages: 100905-100905
10.1016/j.mam.2020.100905
J Biochem.
Volume: 168 Issue: 2 Pages: 103-112
10.1093/jb/mvaa041
40022308727
Volume: 21 Issue: 6 Pages: 1906-1906
10.3390/ijms21061906
https://oici.jp/laboratory/department/tousa/