Development of novel tumor-targeting nanoparticles for malignant brain tumor neutron capture therapy and diagnosis
| Project/Area Number |
20K07672
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 50020:Tumor diagnostics and therapeutics-related
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| Research Institution | University of Tsukuba |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
中井 啓 筑波大学, 医学医療系, 准教授 (50436284)
鶴淵 隆夫 筑波大学, 医学医療系, 講師 (70778901)
MATHIS BRYAN 筑波大学, 附属病院, 病院講師 (80794635)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | BNCT / glioma / nanoparticles / boron / gold / dosimetry / tumor targeting / liposomes |
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| Outline of Research at the Start |
Synthesis and application of complex boron nanoparticles superior to existing compounds for BNCT implemented by our research group will solve the problem of large boron amounts delivery to tumor cells needed for successful neutron capture reaction and dosimetry in cancer treatment using BNCT.
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| Outline of Final Research Achievements |
Novel complex boron nanoparticles (BNPs) for boron neutron capture therapy (BNCT) have been developed. BNPs showed low toxicity, more prolonged accumulation in the tumor cells, and a more prominent irradiation effect than currently used boronophenylalanine (BPA). Tumor-targeting ligand has also been synthesized. Using new calculation methods, the absorbed dose evaluation based on gold activation after neutron irradiation was done. Due to difficulties in the covalent binding of boron and gold, a liposome-based structure was used to couple both critical elements. Irradiation of larger animals (cats and dogs) with spontaneous tumors was also done to study the technical aspects of BNCT close to actual clinical conditions.
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| Academic Significance and Societal Importance of the Research Achievements |
With the development of accelerators for BNCT, there is a need for new, more effective boron compounds with absorbed dose estimation to improve cancer therapy. Our complex nanoparticles providing therapy and diagnosis will help further BNCT development and clinical application worldwide.
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Report
(4 results)
Research Products
(17 results)
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[Journal Article] Gold Nanoparticles Permit In Situ Absorbed Dose Evaluation in Boron Neutron Capture Therapy for Malignant Tumors2021
Author(s)
Zaboronok A., Taskaev S., Volkova O., Mechetina L., Kasatova A., Sycheva T., Nakai K., Kasatov D., Makarov A., Kolesnikov I., Shchudlo I., Bykov T., Sokolova E., Koshkarev A., Kanygin V., Kichigin A., Mathis B.J., Ishikawa E., Matsumura A.
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Journal Title
Pharmaceutics
Volume: 13
Issue: 9
Pages: 1490-1490
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Presentation] 元素状ホウ素ナノ粒子を用いた加速器型BNCT実験2022
Author(s)
Zaboronok A、Khaptakhanova P、Uspenskii S、Bekarevich R、Mechetina L、Volkova O、Kanygin V、石川 栄一、Kasatova A、 Kasatov D、Shchudlo I、Sycheva T、Taskaev S、鶴淵 隆夫、松村 明
Organizer
第18回日本中性子捕捉療法学会学術大会, 2022-10-29 (茨城, つくば市)
Related Report
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[Presentation] Polymer-stabilized elemental boron nanoparticles for BNCT: cell irradiation experiments.2021
Author(s)
Zaboronok A, Uspenskii S.A., Khaptakhanova P.A., Bekarevich R., Mechetina L.A., Volkova O.Yu., Kasatov D.A., Shchudlo I.M., Taskaev S.Yu., Mathis B.J., Kanygin V.V., Matsumura A.
Organizer
19th International Congress on Neutron Capture Therapy, Granada, Spain, 5-10 September, 2021. (Web開催). 口頭発表 (Oral presentation).
Related Report
Int'l Joint Research
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