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Neuronal mechanism for subjective duration perception and generation

Research Project

Project/Area Number 20K07728
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 51020:Cognitive and brain science-related
Research InstitutionKindai University

Principal Investigator

Inase Masahiko  近畿大学, 医学部, 教授 (80249961)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords時間認知 / 前頭連合野 / 内側運動前野 / 神経細胞活動 / 運動前野 / 時間再生 / 大脳皮質 / 主観的時間 / 大脳基底核
Outline of Research at the Start

本研究の目的は、時間知覚と時間再生に関わる神経機構を、神経細胞活動レベルで解明することである。視覚刺激の時間知覚と運動待機中の時間再生の双方の時間計測過程を含有する課題を用いて、前頭連合野や線条体などの神経細胞活動を解析する。さらに、視覚刺激を変化させたり薬物を投与することにより主観的な時間を操作し、時間計測に関わる神経細胞活動がどう変化するかを検討し、主観的な時間の神経機構を明らかにする。

Outline of Final Research Achievements

To clarify the neuronal mechanism for duration perception and generation, neuronal activity was investigated in the dorsolateral prefrontal cortex (PFC) and the medial premotor areas (MPA) of monkeys during the task containing duration estimation of the visual cue stimulus and duration production based on the cue duration. In the PFC phasic activity related to cue duration estimation was found during the cue presentation and the following delay periods. In the MPA build-up activity was found during the retention period of waiting the response start time. These results suggest that the PFC may engage in duration estimation of the cue with the filtering mechanism and the MPA may engage in duration production in motor preparation with the build-up activity.

Academic Significance and Societal Importance of the Research Achievements

脳内における時間計測過程、特に秒単位の時間情報処理過程は未だ明らかにされていない。本研究では、外部からの感覚刺激の時間計測と自ら定めた待機時間の計測とが、同じしくみで同じ神経細胞群によって実行されるのか、それともしくみや神経回路は異なるのか、について検討した。その結果、大脳皮質の異なる領域の神経細胞が、異なる様式で、2つの時間計測過程に関わることが明らかとなった。この結果は、時間知覚と時間再生とが、異なる神経細胞群により、異なるしくみによって実現されていることを示す。脳内の時間情報処理機構の解明に大いに貢献する結果である。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (8 results)

All 2023 2022 2021 2020

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (6 results)

  • [Journal Article] Sphingosine-1-Phosphate Induces ATP Release via Volume-Regulated Anion Channels in Breast Cell Lines2022

    • Author(s)
      Furuya K, Takahashi Y, Hirata H, Kobayashi T, Sokabe M
    • Journal Title

      J Physiol Sci

      Volume: 72 (suppl 1) Pages: 109-109

    • DOI

      10.1186/s12576-022-00851-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal activity in the monkey prefrontal cortex during a duration discrimination task with visual and auditory cues2021

    • Author(s)
      Atsushi Chiba, Kazunori Morita, Ken-ichi Oshio, Masahiko Inase
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 17520-17520

    • DOI

      10.1038/s41598-021-97094-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Information processing for time estimation and production in prefrontal cortex and medial premotor areas of the monkey2023

    • Author(s)
      Atsushi Chiba, Kazunori Morita, Ken-ichi Oshio, Masahiko Inase
    • Organizer
      第100回日本生理学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Functional linkage between prefrontal cortex and medial premotor areas of the monkey in time estimation and production2022

    • Author(s)
      Atsushi Chiba, Kazunori Morita, Sayuki Takara, Ken-ichi Oshio, Masahiko Inase
    • Organizer
      第45回日本神経科学大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Integration of temporal information on auditory and visual stimuli in monkey prefrontal neurons2022

    • Author(s)
      Atsushi Chiba, Kazunori Morita, Ken-ichi Oshio, Masahiko Inase
    • Organizer
      第99回日本神生理学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Neuronal activity related to duration perception and generation in the medial premotor areas of the monkey2021

    • Author(s)
      Atsushi Chiba, Kazunori Morita, Sayuki Takara, Ken-ichi Oshio, Masahiko Inase
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Neuronal activity of the monkey medial premotor areas in a duration estimation and production task2021

    • Author(s)
      Chiba A, Morita K, Takara S, Oshio K-I, Inase M
    • Organizer
      第98回日本生理学会大会
    • Related Report
      2020 Research-status Report
  • [Presentation] Prefrontal neuronal activity related to duration perception and generation in the monkey2020

    • Author(s)
      Chiba A, Morita K, Takara S, Oshio K-I, Inase M
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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