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Drug development for motor neuron diseases utilizing neuronal excitability testing

Research Project

Project/Area Number 20K07754
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 51030:Pathophysiologic neuroscience-related
Research InstitutionChiba University

Principal Investigator

Shibuya Kazumoto  千葉大学, 医学部附属病院, 助教 (90507360)

Co-Investigator(Kenkyū-buntansha) 桑原 聡  千葉大学, 大学院医学研究院, 教授 (70282481)
鈴木 陽一  千葉大学, 医学部附属病院, 医員 (80818485)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords運動ニューロン疾患 / 神経興奮性 / イオンチャネル修飾薬 / 臨床試験
Outline of Research at the Start

研究計画1:運動ニューロン・軸索興奮性測定システムの確立
研究計画2: 運動ニューロン疾患患者を対象として、イオンチャネル修飾薬を投与。内服前後で神経興奮性を測定し、その変化を検討する。それぞれの薬剤について筋萎縮性側索硬化症患者、球脊髄性筋萎縮症患者30名を対象とする。内服前・開始2週間後に、神経興奮性検査を実施し比較検討する。
研究計画3:上記で最も興奮を抑制できたイオンチャネル修飾薬を
用いて、症状の進行抑制を検討する。運動ニューロン疾患患者60名を対象とする。標準的治療薬に加えて上記イオンチャネル修飾薬を加えて、6か月間の症状進行抑制、神経興奮性変化の推移を検討する。

Outline of Final Research Achievements

To develop drugs for motor neuron diseases, researches for neuronal excitability were performed. Threshold tracking transcranial magnetic stimulation did not find significant differences on motor cortical function among Japanese, Chinese and Australian (Caucasian). Motor nerve hyperexcitability was found in spinal and bulbar muscular atrophy (SBMA), and this hyperexcitability is assumed to be related to motor neuron death in SBMA. Motor cortical and nerve hyperexcitability was disclosed in amyotrophic lateral sclerosis (ALS). Additionally, cortical hyperexcitability was prominent from the early disease stage, and nerve hyperexcitability got apparent along disease progression.

Academic Significance and Societal Importance of the Research Achievements

筋萎縮性側索硬化症や球脊髄性筋萎縮症といった運動ニューロン疾患において、神経興奮性増大がその病態と密接に結びついていること、病期と共にこれらが変化していくことを明らかにした。また、これまで欧州や豪州において多くなされてきた神経興奮性検査データが、日本人においても同様に活用できる可能性を示した。
これらのデータは、運動ニューロン疾患の新規治療薬開発において、今後基盤的データとして活用できる可能性が考えられる。これまで神経興奮性と言う観点から運動ニューロン疾患の治療薬開発を目指した研究は少なく、新たな観点からの治療薬開発に繋がる可能性がある。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (39 results)

All 2022 2021 2020

All Journal Article (24 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 24 results,  Open Access: 7 results) Presentation (13 results) (of which Int'l Joint Research: 3 results,  Invited: 4 results) Book (2 results)

  • [Journal Article] Fasciculation intensity and limb dominance in amyotrophic lateral sclerosis: a muscle ultrasonographic study2022

    • Author(s)
      Suzuki Yo-ichi、Shibuya Kazumoto、Misawa Sonoko、Suichi Tomoki、Tsuneyama Atsuko、Kojima Yuta、Nakamura Keigo、Kano Hiroki、Prado Mario、Kuwabara Satoshi
    • Journal Title

      BMC Neurology

      Volume: 22 Issue: 1 Pages: 85-85

    • DOI

      10.1186/s12883-022-02617-1

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuronal Hyperexcitability and Free Radical Toxicity in Amyotrophic Lateral Sclerosis: Established and Future Targets2022

    • Author(s)
      Shibuya Kazumoto、Otani Ryo、Suzuki Yo-ichi、Kuwabara Satoshi、Kiernan Matthew C.
    • Journal Title

      Pharmaceuticals

      Volume: 15 Issue: 4 Pages: 433-433

    • DOI

      10.3390/ph15040433

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Efficacy and Safety of Ultrahigh-Dose Methylcobalamin in Early-Stage Amyotrophic Lateral Sclerosis2022

    • Author(s)
      Oki Ryosuke et al.
    • Journal Title

      JAMA Neurology

      Volume: 79 Issue: 6 Pages: 575-575

    • DOI

      10.1001/jamaneurol.2022.0901

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between motor cortical and peripheral axonal hyperexcitability in amyotrophic lateral sclerosis2022

    • Author(s)
      Suzuki Yo-Ichi、Shibuya Kazumoto、Misawa Sonoko、Suichi Tomoki、Tsuneyama Atsuko、Kojima Yuta、Nakamura Keigo、Kano Hiroki、Prado Mario、Aotsuka Yuya、Otani Ryo、Morooka Marie、Kuwabara Satoshi
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry

      Volume: 93 Issue: 10 Pages: 1074-1079

    • DOI

      10.1136/jnnp-2021-328550

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fatigue and activity-dependent conduction block in neuromuscular disorders2022

    • Author(s)
      Tsuneyama Atsuko、Shibuya Kazumoto、Misawa Sonoko、Suzuki Yo-ichi、Suichi Tomoki、Kojima Yuta、Nakamura Keigo、Kano Hiroki、Prado Mario J.、Kuwabara Satoshi
    • Journal Title

      Clinical Neurophysiology Practice

      Volume: 7 Pages: 71-77

    • DOI

      10.1016/j.cnp.2022.02.003

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Different patterns of sensory nerve involvement in chronic inflammatory demyelinating polyneuropathy subtypes2022

    • Author(s)
      Shibuya Kazumoto、Tsuneyama Atsuko、Misawa Sonoko、Suzuki Yo‐ichi、Suichi Tomoki、Kojima Yuta、Nakamura Keigo、Kano Hiroki、Ohtani Ryo、Aotsuka Yuya、Morooka Marie、Prado Mario、Kuwabara Satoshi
    • Journal Title

      Muscle & Nerve

      Volume: In press Issue: 2 Pages: 131-135

    • DOI

      10.1002/mus.27530

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Impaired neuromuscular transmission in facial muscles of amyotrophic lateral sclerosis: A single‐fiber electromyography study2022

    • Author(s)
      Watanabe Keisuke、Shibuya Kazumoto、Misawa Sonoko、Nagashima Kengo、Suzuki Yo‐ichi、Suichi Tomoki、Kojima Yuta、Nakamura Keigo、Kano Hiroki、Prado Mario、Uzawa Akiyuki、Kuwabara Satoshi
    • Journal Title

      Neurology and Clinical Neuroscience

      Volume: 10 Issue: 2 Pages: 78-82

    • DOI

      10.1111/ncn3.12580

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Marked Respiratory Failure in an Ambulant Patient with Immune-mediated Necrotizing Myopathy and Anti-Kv1.4 and Anti-titin Antibodies2021

    • Author(s)
      Sugiyama Atsuhiko、Onishi Yosuke、Ito Kimiko、Shibuya Kazumoto、Nakamura Keigo、Oda Fumiko、Nishino Ichizo、Suzuki Shigeaki、Kuwabara Satoshi
    • Journal Title

      Internal Medicine

      Volume: 60 Issue: 16 Pages: 2671-2675

    • DOI

      10.2169/internalmedicine.6834-20

    • NAID

      130008074642

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2021-08-15
    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of racial background on motor cortical function as measured by threshold tracking transcranial magnetic stimulation2021

    • Author(s)
      Suzuki Yo-Ichi、Ma Yan、Shibuya Kazumoto、Misawa Sonoko、Suichi Tomoki、Tsuneyama Atsuko、Nakamura Keigo、Matamala Jos? Manuel、Dharmadasa Thanuja、Vucic Steve、Fan Dongsheng、Kiernan Matthew C.、Kuwabara Satoshi
    • Journal Title

      Journal of Neurophysiology

      Volume: 126 Issue: 3 Pages: 840-844

    • DOI

      10.1152/jn.00083.2021

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Coexistence of neuronal intranuclear inclusion disease and amyotrophic lateral sclerosis: an autopsy case2021

    • Author(s)
      Sugiyama Atsuhiko、Takeda Takahiro、Koide Mizuho、Yokota Hajime、Mukai Hiroki、Kitayama Yoshihisa、Shibuya Kazumoto、Araki Nobuyuki、Ishikawa Ai、Isose Sagiri、Ito Kimiko、Honda Kazuhiro、Yamanaka Yoshitaka、Sano Terunori、Saito Yuko、Arai Kimihito、Kuwabara Satoshi
    • Journal Title

      BMC Neurology

      Volume: 21 Issue: 1 Pages: 239-239

    • DOI

      10.1186/s12883-021-02306-5

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Novel serum autoantibodies against ß-actin (ACTB) in amyotrophic lateral sclerosis.2021

    • Author(s)
      Sugimoto K, Mori M, Liu J, Shibuya K, Isose S, Koide M, Hiwasa T, Kuwabara S.
    • Journal Title

      Amyotroph Lateral Scler Frontotemporal Degener.

      Volume: 1 Issue: 5-6 Pages: 1-7

    • DOI

      10.1080/21678421.2021.1885448

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dispersion of mean consecutive differences in single‐fiber electromyography increases diagnostic sensitivity for myasthenia gravis2021

    • Author(s)
      Kojima Yuta、Shibuya Kazumoto、Uzawa Akiyuki、Kano Hiroki、Nakamura Keigo、Yasuda Manato、Suzuki Yo‐ichi、Tsuneyama Atsuko、Suichi Tomoki、Ozawa Yukiko、Misawa Sonoko、Noto Yu‐ichi、Mizuno Toshiki、Kuwabara Satoshi
    • Journal Title

      Muscle & Nerve

      Volume: 63 Issue: 6 Pages: 885-889

    • DOI

      10.1002/mus.27236

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Magnetic resonance neurography in diagnosing childhood chronic inflammatory demyelinating polyradiculoneuropathy2021

    • Author(s)
      Yoshii Shoko、Shibuya Kazumoto、Yokota Hajime、Ikehara Hajime、Shiohama Tadashi、Sawada Daisuke、Kuwabara Satoshi、Fujii Katsunori
    • Journal Title

      Brain and Development

      Volume: 43 Issue: 2 Pages: 352-356

    • DOI

      10.1016/j.braindev.2020.10.001

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Motor cortical excitability predicts cognitive phenotypes in amyotrophic lateral sclerosis2021

    • Author(s)
      Agarwal Smriti、Highton-Williamson Elizabeth、Caga Jashelle、Howells James、Dharmadasa Thanuja、Matamala Jos? M.、Ma Yan、Shibuya Kazumoto、Hodges John R.、Ahmed Rebekah M.、Vucic Steve、Kiernan Matthew C.
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 2172-2172

    • DOI

      10.1038/s41598-021-81612-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Long‐Term Safety and Efficacy of Eculizumab in Aquaporin‐4 IgG‐Positive NMOSD2021

    • Author(s)
      Wingerchuk Dean M., PREVENT Study Group (Kazumoto Shibuya)
    • Journal Title

      Annals of Neurology

      Volume: In press Issue: 6 Pages: 1088-1098

    • DOI

      10.1002/ana.26049

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Lenalidomide Treatment for Thalidomide-refractory POEMS Syndrome: A Prospective Single-arm Clinical Trial2020

    • Author(s)
      Suichi T, Misawa S, Nagashima K, Sato Y, Iwai Y, Katayama K, Sekiguchi Y, Shibuya K, Amino H, Suzuki YI, Tsuneyama A, Nakamura K, Kuwabara S.
    • Journal Title

      Internal Medicine

      Volume: 59 Issue: 9 Pages: 1149-1153

    • DOI

      10.2169/internalmedicine.3800-19

    • NAID

      130007839456

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2020-05-01
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Different distribution of demyelination in chronic inflammatory demyelinating polyneuropathy subtypes2020

    • Author(s)
      Shibuya Kazumoto、Tsuneyama Atsuko、Misawa Sonoko、Sekiguchi Yukari、Beppu Minako、Suichi Tomoki、Suzuki Yo-ichi、Nakamura Keigo、Kano Hiroki、Kuwabara Satoshi
    • Journal Title

      Journal of Neuroimmunology

      Volume: 341 Pages: 577170-577170

    • DOI

      10.1016/j.jneuroim.2020.577170

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Treatment response and prognosis of POEMS syndrome coexisting with Castleman disease.2020

    • Author(s)
      Suichi T, Misawa S, Sekiguchi Y, Shibuya K, Tsuneyama A, Suzuki YI, Nakamura K, Kano H, Kuwabara S.
    • Journal Title

      J Neurol Sci.

      Volume: 413 Pages: 116771-116771

    • DOI

      10.1016/j.jns.2020.116771

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Association of Dermatomyositis Sine Dermatitis With Anti-Nuclear Matrix Protein 2 Autoantibodies2020

    • Author(s)
      Michio Inoue, Kazumoto Shibuya (11th) et al.
    • Journal Title

      JAMA Neurology

      Volume: 77 Issue: 7 Pages: 872-872

    • DOI

      10.1001/jamaneurol.2020.0673

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Homozygous nonsense variant in LRIF1 associated with facioscapulohumeral muscular dystrophy2020

    • Author(s)
      Hamanaka Kohei、Sikrova Darina、Mitsuhashi Satomi、Masuda Hiroki、Sekiguchi Yukari、Sugiyama Atsuhiko、Shibuya Kazumoto、Lemmers Richard J.L.F.、Goossens Remko、Ogawa Megumu、Nagao Koji、Obuse Chikashi、Noguchi Satoru、Hayashi Yukiko K.、Kuwabara Satoshi、Balog Judit、Nishino Ichizo、van der Maarel Silvere M.
    • Journal Title

      Neurology

      Volume: 94 Issue: 23

    • DOI

      10.1212/wnl.0000000000009617

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Facial onset amyotrophic lateral sclerosis with K3E variant in the Cu/Zn superoxide dismutase gene2020

    • Author(s)
      Shibuya Kazumoto、Sawai Setsu、Sugiyama Atsuhiko、Koide Mizuho、Nishiyama Ayumi、Aoki Masashi、Kuwabara Satoshi
    • Journal Title

      Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

      Volume: 22 Issue: 1-2 Pages: 144-146

    • DOI

      10.1080/21678421.2020.1797092

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Split hand and motor axonal hyperexcitability in spinal and bulbar muscular atrophy2020

    • Author(s)
      Shibuya Kazumoto, Misawa Sonoko, Uzawa Akiyuki, Sawai Setsu, Tsuneyama Atsuko, Suzuki Yo-Ichi, Suichi Tomoki, Kojima Yuta, Nakamura Keigo, Kano Hiroki, Prado Mario, Kuwabara Satoshi
    • Journal Title

      Journal of Neurology, Neurosurgery & Psychiatry

      Volume: 91 Issue: 11 Pages: 1189-1194

    • DOI

      10.1136/jnnp-2020-324026

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] A multi-ethnic meta-analysis identifies novel genes, including ACSL5, associated with amyotrophic lateral sclerosis.2020

    • Author(s)
      Nakamura R, Misawa K, Tohnai G, Nakatochi M, Furuhashi S, Atsuta N, Hayashi N, Yokoi D, Watanabe H, Watanabe H, Katsuno M, Izumi Y, Kanai K, Hattori N, Morita M, Taniguchi A, Kano O, Oda M, Shibuya K, Kuwabara S, Suzuki N, Aoki M, Ohta Y, Yamashita T, Abe K, Hashimoto R, Aiba I, Okada Y, Nagasaki M, Sobue G. et al.,
    • Journal Title

      Commun Biol.

      Volume: 23 Issue: 1 Pages: 526-526

    • DOI

      10.1038/s42003-020-01251-2

    • NAID

      120007178464

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dysfunction of the left angular gyrus may be associated with writing errors in ALS2020

    • Author(s)
      Sakurai Toru、Hirano Shigeki、Abe Midori、Uji Yuriko、Shimizu Keisuke、Suzuki Masahide、Nakano Yoshikazu、Ishikawa Ai、Kojima Kazuho、Shibuya Kazumoto、Murata Atsushi、Kuwabara Satoshi
    • Journal Title

      Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration

      Volume: In press Issue: 3-4 Pages: 1-9

    • DOI

      10.1080/21678421.2020.1861021

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] 筋萎縮性側索硬化症における上位運動ニューロン徴候と運動野興奮性増大の関係2022

    • Author(s)
      澁谷和幹、大谷亮、水地智基、中村圭吾、諸岡茉里恵 、青墳佑弥 、三澤園子、桑原聡
    • Organizer
      第63回日本神経学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Facial onset sensory and motor neuronopathyにおける末梢神経軸索興奮性変化2022

    • Author(s)
      大谷亮, 澁谷和幹, 三澤園子, 水地智基, 青墳佑弥, 狩野裕樹, 諸岡茉里恵, 大櫛萌子, 桑原聡
    • Organizer
      第33回日本末梢神経学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Different patterns of sensory nerve involvement in chronic inflammatory demyelinating polyneuropathy subtypes2021

    • Author(s)
      Kazumoto Shibuya, Atsuko Tsuneyama, Sonoko Misawa, Yo-ichi Suzuki, Tomoki Suichi, Yuta Kojima, Keigo Nakamura, Hiroki Kano, Ryo Ohtani, Yuya Aotsuka, Marie Morooka, Mario Prado and Satoshi Kuwabara
    • Organizer
      The Peripheral Nerve Society
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 球脊髄性筋萎縮症の症状進行速度における神経軸索興奮性の関与2021

    • Author(s)
      澁谷和幹、鈴木陽一、三澤園子、水地智基、常山篤子、中村圭吾、狩野裕樹、 大谷亮、諸岡茉里恵、青墳佑弥、Mario Prado、桑原聡
    • Organizer
      第62回日本神経学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 慢性炎症性脱髄性ニューロパチーにおける感覚神経障害の臨床病型による差異2021

    • Author(s)
      澁谷和幹、常山篤子、三澤園子、鈴木陽一、水地智基、小島雄太、狩野裕樹、大谷亮、青墳佑弥、諸岡茉里恵、Mario Prado、桑原聡
    • Organizer
      第32回日本末梢神経学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Overview of Axonal Excitability studies2021

    • Author(s)
      Kazumoto Shibuya
    • Organizer
      7th Asian Oceanian Congress on Clinical Neurophysiology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Assessment of upper motor neuron function utilizing threshold tracking transcranial magnetic stimulation in amyotrophic lateral sclerosis2021

    • Author(s)
      Kazumoto Shibuya, Yo-ichi Suzuki, Sonoko Misawa, Yukari Sekiguchi, Tomoki Suichi, Atsuko Tsuneyama, Keigo Nakamura and Satoshi Kuwabara
    • Organizer
      7th Asian Oceanian Congress on Clinical Neurophysiology
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 筋萎縮性側索硬化症の閾値追跡経頭蓋2連発磁気刺激検査による上位運動ニューロン評価2020

    • Author(s)
      澁谷和幹、鈴木陽一、三澤園子、水地智基、常山篤子、中村圭吾、狩野裕樹、桑原聡
    • Organizer
      第61回日本神経学会学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 慢性炎症性脱髄性多発ニューロパチーにおける脳神経麻痺の特徴と治療反応性2020

    • Author(s)
      澁谷和幹、常山篤子、三澤園子、水地智基、鈴木陽一、小島雄太、中村圭吾、狩野裕樹、Mario Prado、桑原聡
    • Organizer
      第38回日本神経治療学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 手根管症候群の圧迫・虚血によるイオンチャネルの変化2020

    • Author(s)
      澁谷和幹
    • Organizer
      第31回日本末梢神経学会学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] ALSの新たな展開 Gold Coast診断基準2020

    • Author(s)
      澁谷和幹
    • Organizer
      第 50回日本臨床神経生理学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] GBS/CIDPにおける生物学・免疫学と電気生理学の接点 血液神経関門と脱髄分布2020

    • Author(s)
      澁谷和幹
    • Organizer
      第 50回日本臨床神経生理学会学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 筋萎縮性側索硬化症における上位・下位運動神経興奮性増大の関与2020

    • Author(s)
      澁谷和幹、鈴木陽一、三澤園子、水地智基、常山篤子、小島雄太、中村圭吾、狩野裕樹、大谷亮、青墳佑弥、諸岡茉里恵、Mario Prado、桑原聡
    • Organizer
      第 50回日本臨床神経生理学会学術大会
    • Related Report
      2020 Research-status Report
  • [Book] Annual Review 神経 20222022

    • Author(s)
      鈴木則宏
    • Total Pages
      332
    • Publisher
      中外医学社
    • ISBN
      9784498328822
    • Related Report
      2022 Annual Research Report
  • [Book] 末梢神経障害2022

    • Author(s)
      神田 隆
    • Total Pages
      512
    • Publisher
      医学書院
    • ISBN
      9784260049399
    • Related Report
      2022 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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