| Project/Area Number |
20K07775
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 51030:Pathophysiologic neuroscience-related
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
Raveney Benjamin 国立研究開発法人国立精神・神経医療研究センター, 神経研究所 免疫研究部, 科研費研究員 (70795385)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | Autoimmune disease / multiple sclerosis / neuroinflammation / Autoimmunity / Multiple sclerosis / Biomarker / T helper cells / autoimmunity / Multiple Sclerosis / cytotoxic Th cells / Eomes / Neuroimmunology / CD4 T cells / EAE |
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| Outline of Research at the Start |
Biomarkers indicating transition of multiple sclerosis (MS) to a secondary progressive form (SPMS) are lacking. Early data: a new Th cells subset could predict SPMS transition and disease status. Exploration and understanding of the functions and mechanisms of these pathogenic Th cells, should lead to novel targets for SPMS treatment and provide new biomarkers for diagnosis and disease monitoring. Hints at the possible involvement of similar cells in other diseases suggest knowledge gained in this study may provide insight into additional fields to inflammatory neurodegenerative diseases.
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| Outline of Final Research Achievements |
The autoimmune disease multiple sclerosis (MS) occurs when activated immune cells enter the brain and spine, causing tissue damage, which leads to peripheral and neurological disabilities. Previously, we found that a new type of T helper cell (Eomes+ Th cells) was associated with a model of chronic MS. In this study, we investigated how Eomes+ Th cells were associated with disease in patients with secondary progressive MS (SPMS), a chronic type of MS.
We found Eomes+ Th cells were increased in the blood of some patients with SPMS and these cells were infiltrating into patient brain tissue. Also, high levels of Eomes+ Th cells were associated with worsening clinical disease. This study highlights Eomes+ Th cell measurement as a biomarker for SPMS diagnosis and disease activity, allowing early treatment with efficacious drugs. As Eomes+ Th cells appear to be a pathogenic cell type associated with damage in SPMS, these cells are a candidate target for developing future SPMS treatments.
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| Academic Significance and Societal Importance of the Research Achievements |
This study provides new information about a type of damage-associated T cells in autoimmune disease. This will aid future study of the process involving these cells and increase understanding of cellular immunology in diseased tissues as well as providing new biomarkers and targets for treatment.
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