Investigation of brain aging and cardiac functions in healthy and disease populations

• Project/Area Number: 20K07776
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Tohoku University
• Principal Investigator: 鈴木 秀明 東北大学, 大学病院, 助教 (20705462)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 心脳連関 / 心不全 / バイオバンク / 慢性血栓塞栓性肺高血圧症 / MRI / SPECT / 認知機能 / 脳科学 / 脳 / UKバイオバンク / 心機能 / 加齢

Outline of Research at the Start

心疾患・脳疾患は経年的に増加しているが、「心機能低下が脳の老化を促進するのか」、その点については明らかでは無い。本研究は、①心疾患患者での脳の老化、②心疾患に対する治療的介入による脳の老化の改善、③心疾患の無い中高齢者における心機能低下と脳の老化の関連、という三つの仮説を検証し、心機能低下と脳の老化の関係について明らかにすることで、急激に高齢化しつつある日本社会においても高齢者が健康な脳を維持し得る方法を模索することを目的とする。

Outline of Annual Research Achievements

研究1.ナショナルデータベースを用いた心疾患が脳の老化に及ぼす影響の研究について、経皮的大動脈弁置換術後のせん妄における狭心症と脳血流の関連・意義に関し、責任著者として発表した(Takeuchi M, Suzuki H, et al. Angina, a preoperative clinical sign for the development of delirium after transcatheter aortic valve implantation. Geriatrics & Gerontology International 2023)。また、新規新規心保護薬であるベルイシグアトの血行動態に及ぼす影響に関し、第一・責任著者として発表した(Suzuki H, Inoue T, et al. Evaluating hemodynamic changes: vericiguat in patients with heart failure with reduced ejection fraction. ESC Heart Failure 2024 in press)。
研究2.心疾患に対する治療的な介入による脳の老化の可逆性の研究について、各群12例(計24例)の慢性血栓塞栓性肺高血圧症治療前・後の症例の登録・フォローを完了し、解析結果に関し2024年度日本心臓病学会学術集会に抄録を投稿した。
研究3.心疾患の無い中高齢者における心機能が脳の老化に及ぼす影響の研究について、脳の老化に関係する脳画像指標として、頭部MRI画像から計測される大脳白質病変の解析結果に関し、2023年度日本循環器学会学術集会で発表を行った。
以上、2023年度における発表原著論文として、上記2本を含む原著論文5本が採択された。

Research Products

• [Int'l Joint Research] Imperial College London(英国)
• [Int'l Joint Research] The University of Bordeaux(フランス)
• [Int'l Joint Research] Imperial College London(英国)
• [Int'l Joint Research] University of Bordeaux(フランス)
• [Int'l Joint Research] Imperial College London(英国)
• [Int'l Joint Research] University of Bordeaux(フランス)
• [Int'l Joint Research] Imperial College London(英国)
• [Int'l Joint Research] University of Bordeaux(フランス)
• [Journal Article] Intractable Ventricular Tachycardia Prior to an Overt Cardiac Tumor Mass of Metastatic Cardiac Rhabdomyosarcoma (Spindle-cell Type) (2024)
  • Author(s): Terui Yosuke, Suzuki Hideaki, Chikata Akio, Hanaki Yuichi, Komatsu Yuki, Ota Hideki, Fujishima Fumiyoshi, Umezawa Rei, Ouchi Kota, Sato Haruka. Satoh Taijyu, Miyamichi-Yamamoto Saori, Yaoita Nobuhiro, Hayashi Hideka, Nochioka Kotaro, Takahama Hiroyuki, Nogami Akihiko, Saiki Yoshikatsu, Yasuda Satoshi
  • Journal Title: Internal Medicine Volume: 63 Issue: 12 Pages: 1725-1731
  • DOI: 10.2169/internalmedicine.2568-23
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2024-06-15
  • Peer Reviewed
• [Journal Article] Evaluating hemodynamic changes: vericiguat in patients with heart failure with reduced ejection fraction. (2024)
  • Author(s): Hideaki Suzuki, Takumi Inoue, Yousuke Terui, Kouki Takeuchi, Kai Susukita, Marina Arai, Haruka Sato, Taijyu Satoh, Saori Yamamoto, Nobuhiro Yaoita, Shunsuke Tatebe, Hideka Hayashi, Kotaro Nochioka, Hiroyuki Takahama, Satoshi Yasuda
  • Journal Title: ESC Heart Failure Volume: - Issue: 4 Pages: 2451-2454
  • DOI: 10.1002/ehf2.14802
  • Peer Reviewed / Open Access
• [Journal Article] Chronic effects of adaptive servo-ventilation therapy on mortality and the urgent rehospitalization rate in patients experiencing recurrent admissions for HF: a multicenter, prospective, observational study (SAVIOR-L). (2024)
  • Author(s): Yoshihiro Fukumoto, Takeshi Tada, Hideaki Suzuki, et al.
  • Journal Title: Circulation Journal Volume: -
  • Peer Reviewed
• [Journal Article] Adult-onset Leigh Syndrome with a m.9176T>C Mutation Manifested As Reversible Cerebral Vasoconstriction Syndrome (2023)
  • Author(s): Ohyama-Tamagake Ayane, Kaneko Kimihiko, Itami Ryo, Nakano Masatsugu, Namioka Yasuhiro, Izumi Rumiko, Sato Haruka, Suzuki Hideaki, Takeda Atsuhito, Okazaki Yasushi, Yatsuka Yukiko, Abe Takaaki, Murayama Kei, Sugeno Naoto, Misu Tatsuro, Aoki Masashi
  • Journal Title: Internal Medicine Volume: 62 Issue: 13 Pages: 1995-1998
  • DOI: 10.2169/internalmedicine.0773-22
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2023-07-01
  • Peer Reviewed
• [Journal Article] Angina, a preoperative clinical sign for the development of delirium after transcatheter aortic valve implantation (2023)
  • Author(s): Takeuchi Masashi、Suzuki Hideaki、Miyata Satoshi、Ebihara Satoru、Satoshi Yasuda
  • Journal Title: Geriatrics & Gerontology International Volume: 23 Issue: 12 Pages: 971-972
  • DOI: 10.1111/ggi.14707
  • Peer Reviewed / Open Access
• [Journal Article] Inhaled nitric oxide testing in predicting prognosis in pulmonary hypertension due to left‐sided heart diseases (2023)
  • Author(s): Satoh Taijyu、Yaoita Nobuhiro、Nochioka Kotaro、Tatebe Shunsuke、Hayashi Hideka、Yamamoto Saori、Sato Haruka、Takahama Hiroyuki、Suzuki Hideaki、Terui Yosuke、Yamada Kaito、Yamada Yusuke、Inoue Takumi、Aoki Tatsuo、Satoh Kimio、Sugimura Koichiro、Miyata Satoshi、Yasuda Satoshi
  • Journal Title: ESC Heart Failure Volume: 10 Issue: 6 Pages: 3592-3603
  • DOI: 10.1002/ehf2.14515
  • Peer Reviewed / Open Access
• [Journal Article] A teenage boy with acute myocarditis and reversible microvascular angina: A case report (2023)
  • Author(s): Aota Hiroto, Suzuki Hideaki, Godo Shigeo, Kuniyoshi Shimpei, Fujishima Fumiyoshi, Tahakashi Jun, Yasuda Satoshi
  • Journal Title: Journal of Cardiology Cases Volume: － Issue: 6 Pages: 254-257
  • DOI: 10.1016/j.jccase.2023.02.007
  • Peer Reviewed / Open Access
• [Journal Article] Usefulness of cardiac magnetic resonance for early detection of cancer therapeutics-related cardiac dysfunction in breast cancer patients (2023)
  • Author(s): Terui Yosuke、Sugimura Koichiro、Miyata Satoshi、Shimokawa Hiroaki、et al.
  • Journal Title: International Journal of Cardiology Volume: 371 Pages: 472-479
  • DOI: 10.1016/j.ijcard.2022.09.025
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of the development of delirium after transcatheter aortic valve implantation using preoperative brain perfusion SPECT (2022)
  • Author(s): Takeuchi Masashi, Suzuki Hideaki, Matsumoto Yasuharu, Kikuchi Yoku, Takanami Kentaro, Wagatsuma Toshihiro, Sugisawa Jun, Tsuchiya Satoshi, Nishimiya Kensuke, Hao Kiyotaka, Godo Shigeo, Shindo Tomohiko, Shiroto Takashi, Takahashi Jun, Kumagai Kiichiro, Kohzuki Masahiro, et al.
  • Journal Title: PLOS ONE Volume: 17 Issue: 11 Pages: e0276447-e0276447
  • DOI: 10.1371/journal.pone.0276447
  • Peer Reviewed / Open Access
• [Journal Article] Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate (2022)
  • Author(s): Mishra Aniket,* Duplaa Cecile,* Vojinovic Dina,* Suzuki Hideaki,* Sargurupremraj Muralidharan,* Zilhao Nuno R.,* et al *These authors contributed equally to this work.
  • Journal Title: Brain Volume: 145 Issue: 6 Pages: 1992-2007
  • DOI: 10.1093/brain/awab432
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Gene-mapping study of extremes of cerebral small vessel disease reveals TRIM47 as a strong candidate (2022)
  • Author(s): Mishra Aniket,* Duplaa Cecile,* Vojinovic Dina,* Suzuki Hideaki,* Sargurupremraj Muralidharan,* Zilhao Nuno R.,* et al *These authors contributed equally to this work.
  • Journal Title: Brain Volume: in press
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Reversible increase in stress-associated neurobiological activity in the acute phase of Takotsubo syndrome; a brain 18F-FDG-PET study (2021)
  • Author(s): Suzuki Hideaki, Takanami Kentaro, Takase Kei, Shimokawa Hiroaki, Yasuda Satoshi
  • Journal Title: International Journal of Cardiology Volume: 344 Pages: 31-33
  • DOI: 10.1016/j.ijcard.2021.09.057
  • Peer Reviewed
• [Journal Article] Alcohol consumption in the general population is associated with structural changes in multiple organ systems (2021)
  • Author(s): Evangelou Evangelos, Suzuki Hideaki,* Bai Wenjia,* Pazoki Raha, Gao He, Matthews Paul M., Elliott Paul *These authors contributed equally to this work.
  • Journal Title: eLife Volume: 10
  • DOI: 10.7554/elife.65325
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Detection of intracellular histological abnormalities using cardiac magnetic resonance T1 mapping in patients with Danon disease: a case series (2021)
  • Author(s): Suzuki Hideaki、Morita Yoshiaki、Saito Ryoko、Tatebe Shunsuke、Niihori Tetsuya、Saiki Yoshikatsu、Yasuda Satoshi、Shimokawa Hiroaki
  • Journal Title: European Heart Journal - Case Reports Volume: 5 Issue: 5
  • DOI: 10.1093/ehjcr/ytab145
  • Peer Reviewed
• [Journal Article] Brain-heart connection in Takotsubo syndrome before onset (2021)
  • Author(s): Suzuki Hideaki, Yasuda Satoshi, Shimokawa Hiroaki
  • Journal Title: European Heart Journal Volume: 42 Issue: 19 Pages: 1909-1911
  • DOI: 10.1093/eurheartj/ehab026
  • Peer Reviewed
• [Journal Article] A population-based phenome-wide association study of cardiac and aortic structure and function (2020)
  • Author(s): Bai Wenjia、Suzuki Hideaki、Huang Jian、Francis Catherine、Wang Shuo、Tarroni Giacomo、Guitton Florian、Aung Nay、Fung Kenneth、Petersen Steffen E.、Piechnik Stefan K.、Neubauer Stefan、Evangelou Evangelos、Dehghan Abbas、O’Regan Declan P.、Wilkins Martin R.、Guo Yike、Matthews Paul M.、Rueckert Daniel
  • Journal Title: Nature Medicine Volume: 26 Issue: 10 Pages: 1654-1662
  • DOI: 10.1038/s41591-020-1009-y
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cerebral small vessel disease genomics and its implications across the lifespan (2020)
  • Author(s): Sargurupremraj Muralidharan、Suzuki Hideaki、eet al、International Headache Genomics Consortium (IHGC)
  • Journal Title: Nature Communications Volume: 11 Issue: 1 Pages: 6285-6285
  • DOI: 10.1038/s41467-020-19111-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Beneficial effects of riociguat on hemodynamic responses to exercise in CTEPH patients after balloon pulmonary angioplasty - A randomized controlled study (2020)
  • Author(s): Aoki T, Tatebe S, Shimokawa H et al.
  • Journal Title: Int J Cardiol Heart Vasc . Volume: 29 Pages: 100579-100579
  • DOI: 10.1016/j.ijcha.2020.100579
  • Peer Reviewed / Open Access
• [Journal Article] Impacts of hippocampal blood flow on changes in left ventricular wall thickness in patients with chronic heart failure (2020)
  • Author(s): Suzuki Hideaki, Matsumoto Yasuharu, Sugimura Koichiro, Takahashi Jun, Miyata Satoshi, Fukumoto Yoshihiro, Taki Yasuyuki, Shimokawa Hiroaki
  • Journal Title: International Journal of Cardiology Volume: in press Pages: 103-107
  • DOI: 10.1016/j.ijcard.2020.01.019
  • Peer Reviewed / Open Access
• [Journal Article] Transcatheter aortic valve implantation and cognitive function in elderly patients with severe aortic stenosis. (2020)
  • Author(s): Tsuchiya S, Matsumoto Y, Suzuki H, Takanami K, Kikuchi Y, Takahashi J, Miyata S, Tomita N, Kumagai K, Taki Y, Saiki Y, Arai H, Shimokawa H.
  • Journal Title: EuroIntervention Volume: 15 Issue: 18 Pages: e1580-e1587
  • DOI: 10.4244/eij-d-19-00489
  • Peer Reviewed / Open Access
• [Journal Article] Large-scale Quality Control of Cardiac Imaging in Population Studies: Application to UK Biobank (2020)
  • Author(s): Tarroni Giacomo, Bai Wenjia, Oktay Ozan, Schuh Andreas, Suzuki Hideaki, Glocker Ben, Matthews Paul M, Rueckert Daniel
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 2408-2408
  • DOI: 10.1038/s41598-020-58212-2
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cyclophilin A as a biomarker for the therapeutic effect of balloon angioplasty in chronic thromboembolic pulmonary hypertension. (2020)
  • Author(s): Kozu K, Satoh K, Aoki T, Tatebe S, Miura M, Yamamoto S, Yaoita N, Suzuki H, Shimizu T, Sato H, Konno R, Terui Y, Nochioka K, Kikuchi N, Satoh T, Sugimura K, Miyata S, Shimokawa H.
  • Journal Title: J Cardiol Volume: 75 Issue: 4 Pages: 415-423
  • DOI: 10.1016/j.jjcc.2019.09.010
  • Peer Reviewed / Open Access
• [Presentation] The Impact of Heart Failure on Longitudinal Changes in White Matter Hyperintensities: Insights from B-HeFT 2 Study (2023)
  • Author(s): Ai Sugano, Hideaki Suzuki, Ryo Kurosawa, Koki Takeuchi, Takumi Inoue, Marina Arai, Hideka Hayashi, Kotaro Nochioka, Hiroyuki Takahama, Toru Nakazawa, Kaoru Ito, Satoshi Yasuda
  • Organizer: 第88回日本循環器学会学術集会
• [Presentation] Cardiac Uptake of 18F-fluorodeoxyglucose Positron Emission Tomography and Fatal Ventricular Arrhythmic Events in Patients with Cardiac Sarcoidosis (2023)
  • Author(s): Kouki Takeuchi, Hideaki Suzuki, Kentaro Takanami, Yoshitaka Tanaka, Kai Susukita, Takumi Inoue, Marina Arai, Hideka Hayashi, Kotaro Nochioka, Hiroyuki Takahama, Kei Takase, Satoshi Yasuda
  • Organizer: 第88回日本循環器学会学術集会
• [Presentation] 心サルコイドーシスに対するステロイド治療により、急速に糖尿病が増悪した一例 (2023)
  • Author(s): 木下英尊、鈴木秀明、高濱博幸、後岡広太郎、林秀華、新井真理奈、井上巧、薄田海、武内広樹、矢尾板信裕、山本沙織、佐藤大樹、佐藤遥、建部俊介、安田聡
  • Organizer: 第178回日本循環器学会東北地方会
• [Presentation] 心不全による大脳白質病変の変化：縦断観察脳MRI研究 (2023)
  • Author(s): 菅野愛、鈴木秀明、林秀華、後岡広太郎、高濱博幸、佐藤遥、佐藤大樹、山本沙織、矢尾板信裕、安田聡
  • Organizer: 第229回日本内科学会東北地方会
• [Presentation] Bi-directional algorithms predicting blood pressure and its-associated brain damage based on brain MRI (2023)
  • Author(s): Suzuki Hideaki, Thyreau Benjamin, Higuchi Akira, Taki Yasuyuki, Yasuda Satoshi
  • Organizer: 第87回 日本循環器学会学術集会
  • Int'l Joint Research
• [Presentation] 低心機能・心尖部の菲薄化を伴う持続性心室頻拍の一例 (2023)
  • Author(s): 石塚充、鈴木秀明、照井洋輔、後岡広太郎、高濱博幸、佐藤宏行、千葉貴彦、長谷部雄飛、中野誠、野田崇、安田聡
  • Organizer: 第228回 日本内科学会東北地方会
• [Presentation] 難治性心室頻拍が心臓腫瘍の顕在化に先行して認められた紡錘細胞型転移性横紋筋肉腫の一例 (2022)
  • Author(s): 照井洋輔、鈴木秀明、近田明男、花木裕一、小松雄樹、大田英揮、藤島史喜、梅澤玲、大内康太、佐藤遥、佐藤大樹、山本沙織、矢尾板信裕、林秀華、後岡広太郎、高濱博幸、野上昭彦、齋木佳克、安田聡
  • Organizer: 第175回 日本循環器学会東北地方会
• [Presentation] 経カテーテル大動脈弁留置術前における狭心痛と、術前脳血流量・術後せん妄の関連 (2022)
  • Author(s): 竹内雅史、鈴木秀明、羽尾清貴、高浪健太郎、西宮健介、神戸茂雄、進藤智彦、大山宗馬、相馬奨太、白戸崇、高橋潤、高瀬圭、齋木佳克、海老原覚、安田聡
  • Organizer: 第7回 日本心臓リハビリテーション学会東北支部地方会
• [Presentation] Datasets in Tohoku Medical Megabank Organization (ToMMo) in Japan: comparative brain MRI and genetic cohort with UK Biobank (2022)
  • Author(s): Suzuki Hideaki
  • Organizer: The International Stroke Genetics Consortium 2022 in Bordeaux
  • Int'l Joint Research / Invited
• [Presentation] 慢性心不全患者における脳由来成長因子(BDNF) と脳灰白質量との関連 -慢性心不全における脳の構造・機能に関する縦断研究(B-HeFT2)- (2022)
  • Author(s): 鈴木 秀明、松本泰治、大田英揮、杉村宏一郎、後岡広太郎、高橋潤、宮田敏、古川勝敏、福本義弘、瀧靖之、下川宏明、安田聡
  • Organizer: 第23回応用薬理シンポジウム「高齢者における循環器疾患に対する応用薬理」
  • Invited
• [Presentation] What we learn from 2021 ESC heart failure guidelines - Case-based discussion by JIYC - (2022)
  • Author(s): 鈴木 秀明
  • Organizer: 第86回 日本循環器学会学術集会
  • Invited
• [Presentation] Assessment of cerebral autonomic activity with Brain 18F-FDG-PET in Takotsubo syndrome (2022)
  • Author(s): Suzuki Hideaki , Takanami Kentaro, Takase Kei, Shimokawa Hiroaki, Yasuda Satoshi
  • Organizer: 第86回 日本循環器学会学術集会
• [Presentation] 抗ミトコンドリア陽性筋炎に伴う心筋症に対し、副腎皮質ステロイド・シクロフォスファミドが著効した一例 (2021)
  • Author(s): 石塚充, 鈴木秀明, 高濱博幸, 後岡広太郎, 照井洋輔, 迫田みく, 矢尾板信裕, 山本沙織, 佐藤大樹, 佐藤遥, 秋田佳奈恵, 保坂龍彦, 安田聡
  • Organizer: 第173回 日本循環器学会東北地方会
• [Presentation] UKバイオバンクにおける脳MRI画像表現型に基づいた動脈硬化性病変に関わるゲノム解析 (2021)
  • Author(s): 鈴木 秀明
  • Organizer: 日本人類遺伝学会第66回大会・第28回日本遺伝子診療学会大会 合同開催
  • Invited
• [Presentation] 海外留学ネットワーキングセミナー (2021)
  • Author(s): 鈴木秀明
  • Organizer: 第85会日本循環器学会学術集会
  • Invited
• [Presentation] Increased activity of cerebral autonomic center in Takotsubo syndrome (2021)
  • Author(s): Hideaki Suzuki, Yasuharu Matsumoto, Hiroaki Shimokawa, Satoshi Yasuda
  • Organizer: 第85会日本循環器学会学術集会
  • Invited
• [Presentation] Brain Associations with Cardiovascular Outcomes in Patients with Chronic Heart Failure (2021)
  • Author(s): Hideaki Suzuki, Yasuharu Matsumoto, Koichiro Sugimura, Jun Takahashi, Satoshi Miyata, Yoshihiro Fukumoto, Hiroyuki Arai, Yasuyuki Taki, Hiroaki Shimokawa
  • Organizer: 第85会日本循環器学会学術集会
• [Presentation] T1マッピングを用いたダノン病の非侵襲的診断法に関する報告 (2020)
  • Author(s): 青田宏人、鈴木秀明、森田佳明、齋藤涼子、建部俊介、奥山虎之、斎木佳克、下川宏明、安田聡
  • Organizer: 第170回日本循環器学会東北地方会
• [Patent(Industrial Property Rights)] 生活習慣予測装置、生活習慣予測システム、生活習慣予測方法、生活習慣予測プログラムおよび記録媒体 (2022)
  • Inventor(s): 鈴木秀明、安田聡、樋口彰、イマンクロヴァ アイジャン
  • Industrial Property Rights Holder: 鈴木秀明、安田聡、樋口彰、イマンクロヴァ アイジャン
  • Industrial Property Rights Type: 特許
  • Filing Date: 2022
  • Overseas