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Biological activity and potential role of laminin-gamma2 as a novel biomarker for pancreatic ductal carcinoma

Research Project

Project/Area Number 20K07812
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionSt. Marianna University School of Medicine

Principal Investigator

Yasuda Hiroshi  聖マリアンナ医科大学, 医学部, 教授 (80262129)

Co-Investigator(Kenkyū-buntansha) 山本 博幸  聖マリアンナ医科大学, 医学研究科, 教授 (40332910)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords膵癌 / 胆道癌 / バイオマーカー / ラミニン / 膵臓癌 / 胆管癌 / Ln-γ2
Outline of Research at the Start

新規消化器系腫瘍マーカー候補であるLn-γ2の膵癌診断での有用性を検討する。膵癌由来Ln-γ2含有エクソソームの癌微小環境における膵星細胞の活性化における役割を検討し、desmoplasiaの制御による膵癌の新たな治療法の開発の一助となることを目的とする。悪性胆道閉塞時に内視鏡的経乳頭的経鼻ドレナージ法により採取した胆汁を用いて、胆汁中Ln-γ2の胆道癌診断への有用性を検討する。

Outline of Final Research Achievements

Laminin (Ln)-332 consists of α3, β3, and γ2 chains, which mediates epithelial cell adhesion to the basement membrane. Ln-γ2, a component of Ln-332, is frequently expressed as a monomer in the invasion front of several types of gastrointestinal cancers without simultaneous expression of Ln-α3 and/or Ln-β3 chains. Monomeric Ln-γ2 induces tumor cell proliferation and migration in vitro. We investigated the usefulness of Ln-γ2 as a biomarker in diagnosing pancreatic cancer and biliary tract cancer. IHC of Ln-γ2, serum Ln-γ2 ELISA measurement, and WB analysis of Ln-γ2 in bile were performed in 14 surgically treated biliary tract cancer cases in which endoscopically bile collection was pperformed before surgery. IHC (38%), ELISA (43%), and WB (64%) were positive for Ln-γ2, respectively, and may be useful as biomarkers for pancreatobiliary tract neoplasia.

Academic Significance and Societal Importance of the Research Achievements

難治癌である膵胆道癌の罹患率は特に高齢者で増加しており、2018年の死亡数は5万人であり新たなスクリーニング法の確立が急務である。ラミニン332 の構成成分であるラミニンγ2(Ln-γ2)単鎖は、様々な消化器癌の先進部分で特異的に発現することが報告されており、本研究は膵胆道癌の早期発見の一助となる可能性がある。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (16 results)

All 2023 2022 2021 2020

All Journal Article (10 results) (of which Peer Reviewed: 8 results,  Open Access: 8 results) Presentation (2 results) Book (4 results)

  • [Journal Article] Clinical characteristics and long‐term prognosis of type 1 gastric neuroendocrine tumors in a large Japanese national cohort2023

    • Author(s)
      Namikawa Ken、Kamada Tomoari、Fujisaki Junko、Sato Yuichi、Murao Takahisa、Chiba Tsutomu、Collaborators (Hiroshi Imamura , Hiroshi Yasuda, Hiroyuki Kobayashi, Hiroyuki Okada, Joji Syunto, Junichi Nishimura, Kazuhiko Oho, Keiji Ozeki, et al)
    • Journal Title

      Digestive Endoscopy

      Volume: 35 Issue: 6 Pages: 1-10

    • DOI

      10.1111/den.14529

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Successful Switch to Adalimumab after Long-Term Thalidomide-Based Maintenance Therapy for Juvenile Onset Intestinal Behçet's Disease: A Case Report2022

    • Author(s)
      Yamashita Masaki、Yasuda Hiroshi、Kato Masaki、Kiyokawa Hirofumi、Sato Yoshinori、Maehata Tadateru、Kimura Satoko、Tateishi Keisuke
    • Journal Title

      Journal of St. Marianna University

      Volume: 13 Issue: 2 Pages: 149-154

    • DOI

      10.17264/stmarieng.13.149

    • ISSN
      2185-1336, 2189-0277
    • URL

      https://marianna-u.repo.nii.ac.jp/records/2000173

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Updates in the Field of Submucosal Endoscopy2022

    • Author(s)
      Maehata Tadateru、Sato Yoshinori、Nakamoto Yusuke、Kato Masaki、Kawashima Akiyo、Kiyokawa Hirofumi、Yasuda Hiroshi、Yamamoto Hiroyuki、Tateishi Keisuke
    • Journal Title

      Life

      Volume: 13 Issue: 1 Pages: 104-104

    • DOI

      10.3390/life13010104

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Risk factors for liver‐related mortality of patients with hepatitis C virus after sustained virologic response to direct‐acting antiviral agents2022

    • Author(s)
      Hattori Nobuhiro、Ikeda Hiroki、Watanabe Tsunamasa、Satta Yosuke、Ehira Takuya、Suzuki Tatsuya、Kiyokawa Hirofumi、Nakahara Kazunari、Takahashi Hideaki、Matsunaga Kotaro、Matsumoto Nobuyuki、Yasuda Hiroshi、Suzuki Michihiro、Itoh Fumio、Tateishi Keisuke
    • Journal Title

      JGH Open

      Volume: 6 Issue: 10 Pages: 685-691

    • DOI

      10.1002/jgh3.12805

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Clinical usefulness of red dichromatic imaging in hemostatic treatment during endoscopic submucosal dissection: First report from a multicenter, open‐label, randomized controlled trial2021

    • Author(s)
      Fujimoto Ai、Saito Yutaka、Abe Seiichiro、Hoteya Syu、Nomura Kosuke、Yasuda Hiroshi、Matsuo Yasumasa、Uraoka Toshio、Kuribayashi Shiko、Tsuji Yosuke、Ohki Daisuke、Maehata Tadateru、Kato Motohiko、Yahagi Naohisa
    • Journal Title

      Digestive Endoscopy

      Volume: 34 Issue: 2 Pages: 379-390

    • DOI

      10.1111/den.14191

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prediction of esophagogastric varices associated with oxaliplatin administration2021

    • Author(s)
      Satta Yosuke、Shigefuku Ryuta、Watanabe Tsunamasa、Mizukami Takuro、Tsuda Takashi、Suzuki Tatsuya、Ehira Takuya、Hattori Nobuhiro、Kiyokawa Hirofumi、Nakahara Kazunari、Ikeda Hiroki、Matsunaga Kotaro、Takahashi Hideaki、Matsumoto Nobuyuki、Okuse Chiaki、Suzuki Michihiro、Sunakawa Yu、Yasuda Hiroshi、Itoh Fumio
    • Journal Title

      JGH Open

      Volume: 5 Issue: 11 Pages: 1289-1297

    • DOI

      10.1002/jgh3.12668

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Risk factors of interventional radiology/surgery for colonic diverticular bleeding2021

    • Author(s)
      Sato Yoshinori、Yasuda Hiroshi、Nakamoto Yusuke、Kiyokawa Hirofumi、Yamashita Masaki、Matsuo Yasumasa、Maehata Tadateru、Yamamoto Hiroyuki、Mimura Hidefumi、Itoh Fumio
    • Journal Title

      JGH Open

      Volume: 5 Issue: 3 Pages: 343-349

    • DOI

      10.1002/jgh3.12499

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Non-tuberculous Mycobacterial Pseudo-outbreak of an Intestinal Culture Specimen Caused by a Water Tap in an Endoscopy Unit2020

    • Author(s)
      Satta Yusuke、Yamashita Masaki、Matsuo Yasumasa、Kiyokawa Hirofumi、Sato Yoshinori、Takemura Hiromu、Kunishima Hiroyuki、Yasuda Hiroshi、Itoh Fumio
    • Journal Title

      Internal Medicine

      Volume: 59 Issue: 22 Pages: 2811-2815

    • DOI

      10.2169/internalmedicine.5188-20

    • NAID

      130007939893

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2020-11-15
    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intra-abdominal bleeding as a rare complication after colonic endoscopic mucosal resection in a patient taking direct oral anticoagulants2020

    • Author(s)
      Sato Yoshinori、Satta Yusuke、Yasuda Hiroshi、Kiyokawa Hirofumi、Yamashita Masaki、Matsuo Yasumasa、Itoh Fumio
    • Journal Title

      Clinical Journal of Gastroenterology

      Volume: 13 Issue: 5 Pages: 794-798

    • DOI

      10.1007/s12328-020-01181-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tip-in endoscopic mucosal resection for large colorectal sessile polyps2020

    • Author(s)
      Sato Yoshinori、Ozawa Shun-ichiro、Yasuda Hiroshi、Kato Masaki、Kiyokawa Hirofumi、Yamashita Masaki、Matsuo Yasumasa、Yamamoto Hiroyuki、Itoh Fumio
    • Journal Title

      Surgical Endoscopy

      Volume: 35 Issue: 4 Pages: 1820-1826

    • DOI

      10.1007/s00464-020-07581-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 当院における食道PDT後の狭窄予防対策の工夫2021

    • Author(s)
      清川博史, 安田 宏, 佐藤義典,前畑忠輝, 伊東文生.
    • Organizer
      第112回日本消化器内視鏡学会関東支部例会
    • Related Report
      2021 Research-status Report
  • [Presentation] 治療効果予測マーカーの可能性を持つ肝細胞癌新規腫瘍マーカー・ラミニン関連分子2020

    • Author(s)
      安田 宏、清川博史、近江亮介、伊東文生
    • Organizer
      第71回日本電気泳動学会総会
    • Related Report
      2020 Research-status Report
  • [Book] カラー図解 人体の正常構造と機能 全10巻縮刷版2021

    • Author(s)
      安田宏(分担)、坂井建雄・河原克雅、総編集
    • Total Pages
      904
    • Publisher
      日本医事新報社
    • ISBN
      9784784931811
    • Related Report
      2021 Research-status Report
  • [Book] カラー図解 人体の正常構造と機能〈4〉肝・胆・膵2021

    • Author(s)
      泉井 亮、妹尾 春樹、金田 研司、池田 一雄、安田 宏、眞嶋 浩聡、大野 秀樹
    • Total Pages
      84
    • Publisher
      日本医事新報社
    • ISBN
      9784784932436
    • Related Report
      2021 Research-status Report
  • [Book] 分子腫瘍マーカー診療ガイドライン 第2版2021

    • Author(s)
      安田宏(分担)、日本分子腫瘍マーカー研究会編
    • Total Pages
      252
    • Publisher
      金原出版
    • ISBN
      9784307204385
    • Related Report
      2021 Research-status Report
  • [Book] 人体の成城構造と機能2021

    • Author(s)
      安田宏、坂井健雄、河原克雄、他
    • Total Pages
      904
    • Publisher
      日本医事新報社
    • ISBN
      9784784931811
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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