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Investigation of repair mechanisms of tissue injury based on macrophage-triggered innate immune response

Research Project

Project/Area Number 20K07824
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionNagoya University

Principal Investigator

Kawabe Tsutomu  名古屋大学, 医学系研究科(保健), 教授 (20378219)

Co-Investigator(Kenkyū-buntansha) 松島 充代子  名古屋大学, 医学系研究科(保健), 講師 (10509665)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsマクロファージ / エフェロサイトーシス / 組織修復 / 2型免疫応答 / 自然リンパ球
Outline of Research at the Start

マクロファージの組織の修復機転、特に死細胞を貪食処理するエフェロサイトーシスに自然免疫の環境がどのような意義を持つのか、マクロファージの他、修復機構に重要な働きをすると考えられる、傷害部位の組織構成細胞や自然リンパ球がどのように協働しているかを解明する。本研究により解明される有効な修復機構を誘導することで、組織傷害に対してより完全な修復・治癒機転の招来をもたらす。

Outline of Final Research Achievements

Phagocytic clearance of apoptotic cells by macrophages, termed efferocytosis, is one of the important functions for tissue repair and resolution of inflammation. It has been reported that impaired efferocytosis was observed in airway diseases such as asthma. In the present study, we investigated the involvement of efferocytosis in type 2 immune responses. NC/Nga mice, which exhibit a type 2-prone immune response, showed decreased phagocytosis of latex beads and efferocytosis of apoptotic cells in bone marrow-derived macrophages compared to BALB/c mice. The clearance rate of apoptotic cells by alveolar macrophages in NC/Nga mice was decreased compared to that in BALB/c mice under normal and inflammatory conditions. These results suggested that impaired efferocytosis might promote type 2 immune responses.

Academic Significance and Societal Importance of the Research Achievements

組織修復には多くの組織の傷害に共通な機構と、肺や肝臓など、その組織に特異的な機構が必要となる。マクロファージは自然免疫応答の基軸となる細胞で、修復機転の最初の段階においてエフェロサイトーシスと呼ばれる死細胞を含む異物処理を行う。本研究により修復機構で活躍するマクロファージの機能や修復機転の効果的な発動機構、さらには自然免疫に関わるその他の細胞との関連が明らかになり、統合的に理解することができれば、多くの組織の傷害に共通な修復機構を効果的に誘導することが可能となる。また、現行の治療法に補完的に組み合わせることにより、より効果的な治療成績が期待できる。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (28 results)

All 2023 2022 2021 2020

All Journal Article (8 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 8 results) Presentation (19 results) (of which Int'l Joint Research: 2 results) Book (1 results)

  • [Journal Article] Analysis of Airstream Inside the Slip Joint of Tracheal Intubation Tube for Breathing Measurement2023

    • Author(s)
      Tsukada Tsuyoshi、Hasegawa Yoshihiro、Farisi Muhammad Salman Al、Matsushima Miyoko、Kawabe Tsutomu、Shikida Mitsuhiro
    • Journal Title

      IEEJ Transactions on Sensors and Micromachines

      Volume: 143 Issue: 1 Pages: 6-12

    • DOI

      10.1541/ieejsmas.143.6

    • ISSN
      1341-8939, 1347-5525
    • Year and Date
      2023-01-01
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Decrease in cholesterol in the cell membrane is essential for Nrf2 activation by quercetin2023

    • Author(s)
      Matsushima Miyoko、Nose Haruka、Tsuzuki Hikaru、Takekoshi Masahiro、Kusatsugu Yuto、Taniguchi Hinata、Ohdachi Tomoko、Hashimoto Naozumi、Sato Mitsuo、Kawabe Tsutomu
    • Journal Title

      The Journal of Nutritional Biochemistry

      Volume: 116 Pages: 109329-109329

    • DOI

      10.1016/j.jnutbio.2023.109329

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Correlation of theophylline levels in rat exhaled breath and lung tissue after its intravenous injection2022

    • Author(s)
      Matsushima Miyoko、Tanihata Souma、Kusakabe Junpei、Okahira Momoha、Ito Hiroshi、Yamamoto Atsushi、Yamamoto Masanori、Yamamoto Ryohei、Kawabe Tsutomu
    • Journal Title

      Journal of Breath Research

      Volume: 16 Issue: 3 Pages: 036003-036003

    • DOI

      10.1088/1752-7163/ac6b4b

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of MEMS Flow and Pressure Sensor Device for Detection of Extravasation at an Early Stage2022

    • Author(s)
      Hasegawa Yoshihiro、Shimohira Chihiro、Matsushima Miyoko、Sugiyama Tomoshi、Kawabe Tsutomu、Shikida Mitsuhiro
    • Journal Title

      IEEJ Transactions on Electrical and Electronic Engineering

      Volume: 18 Issue: 1 Pages: 139-146

    • DOI

      10.1002/tee.23706

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Resistance to mutant KRAS V12-induced senescence in an hTERT/Cdk4-immortalized normal human bronchial epithelial cell line2022

    • Author(s)
      Muraki N, Yamada M, Doki H, Nakai R, Komeda K, Goto D, Kawabe N, Matsuoka K, Matsushima M, Kawabe T, Tanaka I, Morise M, Shay JW, Minna JD, Sato M.
    • Journal Title

      Exp Cell Res .

      Volume: 414 Issue: 1 Pages: 113053-113053

    • DOI

      10.1016/j.yexcr.2022.113053

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Miniaturization of Respiratory Measurement System in Artificial Ventilator for Small Animal Experiments to Reduce Dead Space and Its Application to Lung Elasticity Evaluation2021

    • Author(s)
      Yoshida Homare、Hasegawa Yoshihiro、Matsushima Miyoko、Sugiyama Tomoshi、Kawabe Tsutomu、Shikida Mitsuhiro
    • Journal Title

      Sensors

      Volume: 21 Issue: 15 Pages: 5123-5123

    • DOI

      10.3390/s21155123

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fibroblasts positive for meflin have anti-fibrotic properties in pulmonary fibrosis2021

    • Author(s)
      Nakahara Y, Hashimoto N, Sakamoto K, Enomoto A, Adams TS, Yokoi T, Omote N, Poli S, Ando A, Wakahara K, Suzuki A, Inoue M, Hara A, Mizutani Y, Imaizumi K, Kawabe T, Rosas IO, Takahashi M, Kaminski N, Hasegawa Y.
    • Journal Title

      European Respiratory Journal

      Volume: 58 Issue: 6 Pages: 2003397-2003397

    • DOI

      10.1183/13993003.03397-2020

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Involvement of heme oxygenase-1 in suppression of T cell activation by quercetin2020

    • Author(s)
      Sugiyama Tomoshi、Matsushima Miyoko、Ohdachi Tomoko、Hashimoto Naozumi、Hasegawa Yoshinori、Yokoi Kohei、Kawabe Tsutomu
    • Journal Title

      Immunopharmacology and Immunotoxicology

      Volume: 42 Issue: 4 Pages: 295-305

    • DOI

      10.1080/08923973.2020.1759623

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] Wireless MEMS Thermal Flow Sensor System Integrated on Medical Mask for Emergency Medical Treatment2022

    • Author(s)
      Tsuyoshi Tsukada, Yoshihiro Hasegawa, Farisi Muhammad Salman Al, Shin Hasegawa, Miyoko Matsushima, Tsutomu Kawabe, Mitsuhiro Shikida
    • Organizer
      Asia-Pacific Conference of Transducers and Micro-Nano Technology 2022 (APCOT2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of localization changes of caveolin-1 on Nrf2-HO-1 activation induced by quercetin2022

    • Author(s)
      Fuzuki Hayashi, Miyoko Matsushima, Hikaru Tsuzuki, Moeko Ohara, Nodoka Shimasaki, Ayumi Tajima, Hinata Taniguchi, Hina Kawashima, Sayaka Takagi, Nanami Yoshida, Tsutomu Kawabe
    • Organizer
      第51回日本免疫学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Positive effects on selective autophagy by quercetin-induced heme oxygenase-12022

    • Author(s)
      Hinata Taniguchi, Miyoko Matsushima, Sayaka Takagi, Moeko Ohara, Hikaru Tsuzuki, Nodoka Shimasaki, Ayumi Tajima, Hina Kawashima, Fuzuki Hayashi, Nanami Yoshida, Tsutomu Kawabe
    • Organizer
      第51回日本免疫学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Synergistic effects of Toll-like receptor signaling on inflammation induced by silica nanoparticles2022

    • Author(s)
      Nanami Yoshida, Miyoko Matsushima, Moeko, Ohara, Hikaru Tsuzuki, Nodoka Shimasaki, Ayumi Tajima, Hinata Taniguchi, Hina Kawashima, Sayaka Takagi, Fuzuki Hayashi, Tsutomu Kawabe
    • Organizer
      第51回日本免疫学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Analysis of lymphocyte differentiation and proliferation in NC/Nga mice2022

    • Author(s)
      Hikaru Tsuzuki, Miyoko Matsushima, Ayumi Tajima, Moeko Ohara, Nodoka Shimasaki, Hinata Taniguchi, Hina Kawashima, Sayaka Takagi, Fuzuki Hayashi, Nanami Yoshida, Tsutomu Kawabe
    • Organizer
      第51回日本免疫学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Modulation of proinflammatory responses by diazinon in mast cells2022

    • Author(s)
      Moeko Ohara, Miyoko Matsushima, Hina Kawashima, Hikaru Tsuzuki, Nodoka Shimasaki, Ayumi Tajima, Hinata Taniguchi, Sayaka Takagi, Fuzuki Hayashi, Nanami Yoshida, Tsutomu Kawabe
    • Organizer
      第51回日本免疫学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 症状発現に関わるアレルゲンエピトープの探索2022

    • Author(s)
      小原萌恵子、松島充代子、佐藤光夫、伊藤浩明、川部 勤
    • Organizer
      第71回日本アレルギー学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 環境からのストレスに備えるケルセチンによる細胞保護作用の新規機序の検討2022

    • Author(s)
      都築 光、松島充代子、竹腰正広、谷口ひなた、小原萌恵子、島崎温香、田島歩実、佐藤光夫、川部 勤
    • Organizer
      第52回日本職業・環境アレルギー学会総会・学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Involvement of p62 on Activation of Heme Oxygenase-1 Induced by Quercetin2021

    • Author(s)
      Yuki Hayashi, Miyoko Matsushima, Goki Inoue, Ko Iwaki, Teppei Yamashita, Moeko Ohara, Hikaru Tsuzuki and Tsutomu Kawabe
    • Organizer
      第50回日本免疫学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Effects of localization changes of caveolin-1 on cellular function induced by quercetin2021

    • Author(s)
      Hikaru Tsuzuki, Miyoko Matsushima, Goki Inoue, Ko Iwaki, Yuki Hayashi, Teppei Yamashita, Moeko Ohara, Tsutomu Kawabe
    • Organizer
      第50回日本免疫学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Investigation of B-cell differentiation on atopic dermatitis model mice2021

    • Author(s)
      Moeko Ohara, Miyoko Matsushima, Hikaru Tsuzuki, Goki Inoue, Ko Iwaki, Yuki Hayashi, Teppei Yamashita, Tsutomu Kawabe
    • Organizer
      第50回日本免疫学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Attenuation of signal transduction induced by diazinon in RBL-2H3 cells2021

    • Author(s)
      Goki Inoue, Miyoko Matsushima, Ko Iwaki, Yuki Hayashi, Teppei Yamashita, Moeko Ohara, Hikaru Tsuzuki, Tsutomu Kawabe
    • Organizer
      第50回日本免疫学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Effects on function of macrophages by diazinon-modified metabolic status2021

    • Author(s)
      Ko Iwaki, Miyoko Matsushima, Goki Inoue, Yuki Hayashi, Teppei Yamashita, Moeko Ohara, Hikaru Tsuzuki and Tsutomu Kawabe
    • Organizer
      第50回日本免疫学会
    • Related Report
      2021 Research-status Report
  • [Presentation] Analysis of efferocytosis on type 2-skewed immune responses in NC/Nga mice2021

    • Author(s)
      Teppei Yamashita, Miyoko Matsushima, Goki Inoue, Ko Iwaki, Yuki Hayashi, Moeko Ohara, Hikaru Tsuzuki and Tsutomu Kawabe
    • Organizer
      第50回日本免疫学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 呼吸の物理量情報をもとに評価する心肺機能2021

    • Author(s)
      川部 勤、松島充代子、長谷川 信、長谷川義大、式田光宏
    • Organizer
      第 58 回日本臨床生理学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Modulatory effects of diazinon on mast cell activation.2020

    • Author(s)
      Miyoko Matsushima, Kazuko Atsumi, Moeko Ohara, Masahiro Takekoshi, Yuka Tsubosaki, Goki Inoue, Ko Iwaki, Yuki Hayashi, Teppei Yamashita, Tsutomu Kawabe
    • Organizer
      JSA/WAO XXVII World Allergy Congress (WAC 2020) conjoint with the APAPARI 2020 Congress
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 肥満細胞の即時型および遅発型反応に対するダイアジノンの免疫修飾作用2020

    • Author(s)
      岩城 巧、松島充代子、坪﨑由夏、小原萌恵子、竹腰正広、井上剛希、川部 勤
    • Organizer
      第51回日本職業・環境アレルギー学会総会・学術大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 呼気分析を応用した非侵襲的治療薬物モニタリングシステムの検討2020

    • Author(s)
      川部 勤、松島充代子、橋本直純、佐藤光夫、長谷川好規、山本良平、山本 敦
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Related Report
      2020 Research-status Report
  • [Presentation] 呼吸に伴い変化する物理量の解析から得られる生体情報の意義についての検討2020

    • Author(s)
      川部 勤、松島充代子、橋本直純、佐藤光夫、長谷川好規、長谷川 信、長谷川義大、式田光宏
    • Organizer
      第60回日本呼吸器学会学術講演会
    • Related Report
      2020 Research-status Report
  • [Book] ポリイミドの高機能設計と応用技術2022

    • Author(s)
      執筆者 : 57名、技術情報協会
    • Total Pages
      566
    • Publisher
      技術情報協会
    • ISBN
      9784861048876
    • Related Report
      2022 Annual Research Report

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Published: 2020-04-28   Modified: 2024-01-30  

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