Abdominal organ blood flow and intestinal bacterial flora in heart failure

• Project/Area Number: 20K07828
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52010:General internal medicine-related
• Research Institution: Fukushima Medical University
• Principal Investigator: Akiomi Yoshihisa 福島県立医科大学, 保健科学部, 教授 (40448642)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 心不全 / 肝障害 / 腎障害 / 消化管障害 / 腹部臓器血流 / 腹部臓器機能

Outline of Research at the Start

心不全では、低心拍出による臓器低灌流や臓器うっ血および多臓器機能低下など多様な病態が関与しており、心不全を全身疾患ととらえた包括的な病態評価および管理が重要であるものと考えられる。心不全における肝機能障害の病態および実地臨床における評価方法は確立されていない。また、心不全における肝臓および腸管の血行動態と腸内細菌叢の関係は明らかではない。そこで本研究では、腹部エコーの新たな指標や近赤外線分光法を用いて、心不全患者における肝臓の血行動態および腸管血流の評価を行い、併せて栄養状態および腸内細菌叢との関連（心-腸-肝連関）について検討することを骨子としている。

Outline of Final Research Achievements

We established technique to evaluate congestion and the hypoperfusion in liver and the kidney using abdominal echography. Furthermore, we showed that prognosis was exacerbated by gastrointestinal disturbance.

Academic Significance and Societal Importance of the Research Achievements

心不全に伴ううっ血や低潅流による肝臓、腎臓、消化管の障害機序および予後への影響に関して明らかにした。これらへの介入が増加する心不全の予後を改善する可能性が示唆された。

Research Products

• [Journal Article] Persistent Hypochloremia Is Associated with Adverse Prognosis in Patients Repeatedly Hospitalized for Heart Failure (2023)
  • Author(s): Nozaki Yuji、Yoshihisa Akiomi、Sato Yu、Ohara Himika、Sugawara Yukiko、Abe Satoshi、Misaka Tomofumi、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Nakazato Kazuhiko、Takeishi Yasuchika
  • Journal Title: Journal of Clinical Medicine Volume: 12 Issue: 4 Pages: 1257-1257
  • DOI: 10.3390/jcm12041257
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic significance of spleen shear wave elastography and dispersion in patients with heart failure: the crucial role of cardio-splenic axis (2023)
  • Author(s): Tomofumi Misaka, Akiomi Yoshihisa, Yasuhiro Ichijo, Shinji Ishibashi, Mitsuko Matsuda, Yukio Yamadera, Himika Ohara, Yukiko Sugawara, Fumiya Anzai, Yu Sato, Satoshi Abe, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi, Yasuchika Takeishi
  • Journal Title: Clin Res Cardiol Volume: N.A. Issue: 7 Pages: 942-953
  • DOI: 10.1007/s00392-023-02183-7
  • Peer Reviewed
• [Journal Article] Prognostic Effects of Changes in Right Ventricular Fractional Area Change in Patients With Heart Failure (2022)
  • Author(s): Yukiko Sugawara, Akiomi Yoshihisa, Ryohei Takeishi, Himika Ohara, Fumiya Anzai, Yu Hotsuki, Koichiro Watanabe, Yu Sato, Satoshi Abe, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atushi Kobayashi, Kazuhiko Nakazato, Yasuhicka Takeishi
  • Journal Title: Circulation Journal Volume: 86 Issue: 12 Pages: 1982-1989
  • DOI: 10.1253/circj.CJ-22-0212
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2022-11-25
  • Peer Reviewed / Open Access
• [Journal Article] Increases in Hepatokine Selenoprotein P Levels Are Associated With Hepatic Hypoperfusion and Predict Adverse Prognosis in Patients With Heart Failure (2022)
  • Author(s): Takeishi Ryohei、Misaka Tomofumi、Ichijo Yasuhiro、Ishibashi Shinji、Matsuda Mitsuko、Yamadera Yukio、Ohara Himika、Sugawara Yukiko、Hotsuki Yu、Watanabe Koichiro、Anzai Fumiya、Sato Yu、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Yamaki Takayoshi、Nakazato Kazuhiko、Yoshihisa Akiomi、Takeishi Yasuchika
  • Journal Title: Journal of the American Heart Association Volume: 11 Issue: 11
  • DOI: 10.1161/jaha.121.024901
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Decreases in hepatokine Fetuin-A levels are associated with hepatic hypoperfusion and predict cardiac outcomes in patients with heart failure. (In press) (2022)
  • Author(s): Tomita Yusuke、Misaka Tomofumi、Yoshihisa Akiomi、Ichijo Yasuhiro、Ishibashi Shinji、Matsuda Mitsuko、Yamadera Yukio、Ohara Himika、Sugawara Yukiko、Hotsuki Yu、Watanabe Koichiro、Anzai Fumiya、Sato Yu、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Takeishi Yasuchika
  • Journal Title: Clinical Research in Cardiology Volume: - Issue: 10 Pages: 1104-1112
  • DOI: 10.1007/s00392-022-02023-0
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Impaired brain activity in patients with persistent atrial fibrillation assessed by near-infrared spectroscopy and its changes after catheter ablation (2022)
  • Author(s): Yoshihisa Akiomi、Kono Soichi、Kaneshiro Takashi、Ichijo Yasuhiro、Misaka Tomofumi、Yamada Shinya、Oikawa Masayoshi、Miura Itaru、Yabe Hirooki、Takeishi Yasuchika
  • Journal Title: Scientific Reports Volume: 12 Issue: 1 Pages: 7866-7866
  • DOI: 10.1038/s41598-022-12097-5
• [Journal Article] Renal Venous Stasis Index Reflects Renal Congestion and Predicts Adverse Outcomes in Patients With Heart Failure (2022)
  • Author(s): Ohara Himika、Yoshihisa Akiomi、Horikoshi Yuko、Ishibashi Shinji、Matsuda Mitsuko、Yamadera Yukio、Sugawara Yukiko、Ichijo Yasuhiro、Hotsuki Yu、Watanabe Koichiro、Sato Yu、Misaka Tomofumi、Kaneshiro Takashi、Oikawa Masayoshi、Kobayashi Atsushi、Takeishi Yasuchika
  • Journal Title: Frontiers in Cardiovascular Medicine Volume: 9 Pages: 772466-772466
  • DOI: 10.3389/fcvm.2022.772466
  • Open Access
• [Journal Article] B-type natriuretic peptide is associated with the occurrence of bleeding events in heart failure patients with a history of coronary artery disease (2022)
  • Author(s): Sato Yu、Yoshihisa Akiomi、Takeishi Ryohei、Ohara Himika、Sugawara Yukiko、Ichijo Yasuhiro、Hotsuki Yu、Watanabe Koichiro、Abe Satoshi、Misaka Tomofumi、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Nakazato Kazuhiko、Takeishi Yasuchika
  • Journal Title: Journal of Cardiology Volume: 80 Issue: 1 Pages: 88-93
  • DOI: 10.1016/j.jjcc.2022.02.003
• [Journal Article] Liver Congestion Assessed by Hepatic Vein Waveforms in Patients With Heart Failure (2021)
  • Author(s): Sugawara Yukiko、Yoshihisa Akiomi、Takeishi Yasuchika
  • Journal Title: CJC Open Volume: 3 Issue: 6 Pages: 778-786
  • DOI: 10.1016/j.cjco.2021.02.004
  • Peer Reviewed / Open Access
• [Journal Article] Serum TRACP5b, a Marker of Bone Resorption, Is Associated With Adverse Cardiac Prognosis in Hospitalized Patients With Heart Failure (2021)
  • Author(s): Abe Satoshi、Yoshihisa Akiomi、Ichijo Yasuhiro、Kimishima Yusuke、Yokokawa Tetsuro、Misaka Tomofumi、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Kaneshiro Takashi、Nakazato Kazuhiko、Takeishi Yasuchika
  • Journal Title: CJC Open Volume: 3 Issue: 4 Pages: 470-478
  • DOI: 10.1016/j.cjco.2020.12.005
  • Peer Reviewed / Open Access
• [Journal Article] Cardio-Ankle Vascular Index Reflects Impaired Exercise Capacity and Predicts Adverse Prognosis in Patients With Heart Failure (2021)
  • Author(s): Watanabe Koichiro、Yoshihisa Akiomi、Sato Yu、Hotsuki Yu、Anzai Fumiya、Ichijo Yasuhiro、Kimishima Yusuke、Yokokawa Tetsuro、Misaka Tomofumi、Sato Takamasa、Kaneshiro Takashi、Oikawa Masayoshi、Kobayashi Atsushi、Takeishi Yasuchika
  • Journal Title: Frontiers in Cardiovascular Medicine Volume: 8 Pages: 631807-631807
  • DOI: 10.3389/fcvm.2021.631807
  • Peer Reviewed / Open Access
• [Journal Article] Soluble fibrin monomer complex is associated with cardio- and cerebrovascular events in patients with heart failure (2021)
  • Author(s): Yoshihisa Akiomi、Sato Yu、Kimishima Yusuke、Ichijo Yasuhiro、Yokokawa Tetsuro、Misaka Tomofumi、Sato Takamasa、Oikawa Masayoshi、Kobayashi Atsushi、Nakazato Kazuhiko、Takeishi Yasuchika
  • Journal Title: IJC Heart & Vasculature Volume: 32 Pages: 100697-100697
  • DOI: 10.1016/j.ijcha.2020.100697
  • Peer Reviewed / Open Access
• [Journal Article] Clinical implications of hepatic hemodynamic evaluation by abdominal ultrasonographic imaging in patients with heart failure. (2020)
  • Author(s): Yoshihisa A, Ishibashi S, Matsuda M, Yamadera Y, Ichijo Y, Sato Y, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Yamaki T, Kunii H, Takeishi Y.
  • Journal Title: Journal of American Heart Association Volume: 9 Issue: 15
  • DOI: 10.1161/jaha.120.016689
  • Peer Reviewed / Open Access
• [Journal Article] Intrarenal Doppler ultrasonography reflects hemodynamics and predicts prognosis in patients with heart failure. (2020)
  • Author(s): Yoshihisa A, Watanabe K, Sato Y, Ishibashi S, Matsuda M, Yamadera Y, Ichijo Y, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Takeishi Y.
  • Journal Title: Scientific Report Volume: 10 Issue: 1 Pages: 22257-22257
  • DOI: 10.1038/s41598-020-79351-6
  • Peer Reviewed / Open Access
• [Journal Article] Shear Wave Dispersion Predicts Liver Fibrosis and Adverse Outcomes in Patients with Heart Failure (2020)
  • Author(s): Himika Ohara, Akiomi Yoshihisa, Shinji Ishibashi, Mitsuko Matsuda, Yukio Yamadera, Yukiko Sugawara, Yasuhiro Ichijo, Yu Hotsuki, Koichiro Watanabe, Fumiya Anzai, Yu Sato, Yusuke Kimishima, Tetsuro Yokokawa, Tomofumi Misaka, Takamasa Sato, Masayoshi Oikawa, Atsushi Kobayashi and Yasuchika Takeishi.
  • Journal Title: J Clin Med Volume: 9 Issue: 12 Pages: 3953-3953
  • DOI: 10.3390/jcm9123953
  • Peer Reviewed / Open Access
• [Presentation] Clinical implications of hepatic hemodynamic evaluation by abdominal ultrasonographic imaging in patients with heart failure. (2020)
  • Author(s): Hotsuki Y, Yoshihisa A, Ichijo Y, Watanabe K, Sato Y, Kimishima Y, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Takeishi Y.
  • Organizer: American Heart Association Scientific Session 2020
  • Int'l Joint Research
• [Presentation] Intrarenal doppler ultrasonography reflects hemodynamics and predicts prognosis in patients with heart failure. (2020)
  • Author(s): Watanabe K, Yoshihisa A, Sato Y, Hotsuki Y, Ichijo Y, Kimishima Y, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Takeishi Y.
  • Organizer: American Heart Association Scientific Session 2020
  • Int'l Joint Research
• [Presentation] Liver dispersion predicts adverse outcomes in patients with heart failure. (2020)
  • Author(s): Hotsuki Y, Yoshihisa A, Watanabe K, Sato Y, Kimishima Y, Yokokawa T, Misaka T, Oikawa M, Kobayashi A, Takeishi Y.
  • Organizer: American Heart Association Scientific Session 2020
  • Int'l Joint Research
• [Presentation] 心不全患者の肝うっ血評価におけるshear wave elastographyの有用性に関する検討. (2020)
  • Author(s): 松田美津子, 山寺幸雄, 石橋伸治, 幕田倫子, 大沼秀知, 義久精臣, 志村浩己, 竹石恭知.
  • Organizer: 日本超音波医学会第93回学術集会
• [Presentation] Clinical implications of hepatic hemodynamic evaluation by ultrasonography in patients with heart failure. (2020)
  • Author(s): 寳槻 優, 義久精臣, 渡邊孝一郎, 佐藤 悠, 君島勇輔, 喜古崇豊, 菅野優紀, 横川哲朗, 阿部諭史, 三阪智史, 佐藤崇匡, 及川雅啓, 小林 淳, 竹石恭知.
  • Organizer: 第24回 日本心不全学会学術集会
• [Presentation] Intrarenal doppler ultrasonography reflects hemodynamics and predicts prognosis in patients with heart failure. (2020)
  • Author(s): 渡邊孝一郎, 佐藤 悠, 義久精臣, 一條靖洋, 寳槻 優, 横川哲朗, 三阪智史, 及川雅啓, 小林 淳, 竹石恭知.
  • Organizer: 第24回 日本心不全学会学術集会
• [Book] 令和の心不全治療ガイド (2022)
  • Author(s): 伊藤 浩
  • Total Pages: 314
  • Publisher: 文光堂
  • ISBN: 9784830619694
• [Remarks] 福島県立医科大学 研究者データベース 義久精臣
  • URL: https://www.fmu.ac.jp/kenkyu/html/725_ja.html
• [Remarks] 福島県立医科大学 循環器内科学講座 心不全臨床研究
  • URL: https://www.fmu.ac.jp/home/int-med1/reserch-c-hf.htm
• [Remarks] 福島県立医科大学 研究者データベース
  • URL: https://www.fmu.ac.jp/kenkyu/html/725_ja.html