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Study on the assessment of odor identification as the screening test for early diagnosis of dementia

Research Project

Project/Area Number 20K07849
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52010:General internal medicine-related
Research InstitutionKochi University

Principal Investigator

Kashibayashi Tetsuo  高知大学, 医学部, 客員講師 (90403823)

Co-Investigator(Kenkyū-buntansha) 奥谷 文乃  高知大学, 教育研究部医療学系看護学部門, 教授 (10194490)
上村 直人  高知大学, 教育研究部医療学系臨床医学部門, 准教授 (10315004)
米田 哲也  熊本大学, 大学院生命科学研究部(保), 准教授 (20305022)
数井 裕光  高知大学, 教育研究部医療学系臨床医学部門, 教授 (30346217)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsアルツハイマー型認知症 / 軽度認知障害 / 嗅覚障害 / 統計画像解析 / 嗅覚検査 / 認知症移行率 / スクリーニング検査
Outline of Research at the Start

ADでは早期からの治療と診断が重要である。本研究では、ADの早期診断の指標として、簡易で非侵襲的な検査が可能な嗅覚認知障害に注目し、認知症前段階のMCIに対する嗅覚検査をベースラインとして、以下を検討する。
・ADによるMCIの嗅覚障害の特徴: MCIの嗅覚障害を解析する。
・嗅覚検査と神経基板との相関の解明: 頭部MRI・脳血流シンチを計測解析する。
・MCIからADへのコンバート率: 嗅覚障害の有無との関係を解析する。
本研究により、MCI段階のADの嗅覚障害の神経基盤とともに、AD早期診断に関する嗅覚検査の有用性が明らかになると期待できる。

Outline of Final Research Achievements

Alzheimer's disease (AD) has been shown to cause olfactory impairment from the early stages of the disease.
Mild cognitive impairment (MCI), which has been proposed as a precursor condition to AD, may include diseases other than AD, as some cases remain in MCI for a long time or recover normally. We hypothesized that the presence of olfactory impairment in MCI is a potential non-invasive biomarker for the development of AD. We investigated the neural basis of olfactory dysfunction in MCI to early AD and the transition from MCI to AD and olfactory dysfunction in MCI to AD. Statistical imaging analysis revealed that the olfactory detection and identification are correlated in MCI and AD, respectively, and that the detection zone is preserved in MCI, whereas the cognitive zone is injured, resulting in a high frequency of AD.

Academic Significance and Societal Importance of the Research Achievements

認知症に対する早期に治療介入、予防という観点から、MCIからADへの移行を予測できる因子の開発は重要である。MCIから初期ADにおける嗅覚低下の神経基盤を解明し、MCI段階での嗅覚障害パターンを明らかにすることで、嗅覚検査がAD 移行への非侵襲的バイオマーカーとして活用される展望が与えられる。我々の研究では、神経基盤に加え、嗅覚障害の程度による2年間のADへの移行率を示すことができ、学術的、社会的に有意義な研究であった。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (9 results)

All 2022 2021

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (4 results)

  • [Journal Article] Association of right precuneus compression with apathy in idiopathic normal pressure hydrocephalus: a pilot study2022

    • Author(s)
      Chadani Yoshihiro、Kashibayashi Tetsuo、Yamamoto Takahiro、Tsuda Atsushi、Fujito Ryoko、Akamatsu Masanori、Kamimura Naoto、Takahashi Ryuichi、Yamagami Takuji、Furuya Hirokazu、Ueba Tetsuya、Saito Motoaki、Inoue Keiji、Kazui Hiroaki
    • Journal Title

      Scientific Reports

      Volume: 12(1) Issue: 1 Pages: 20428-20428

    • DOI

      10.1038/s41598-022-23800-x

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation between cerebral blood flow and olfactory function in mild cognitive impairment and Alzheimer's disease2021

    • Author(s)
      Kashibayashi Tetsuo、Takahashi Ryuichi、Fujita Jun、Fujito Ryoko、Kamimura Naoto、Okutani Fumino、Kazui Hiroaki
    • Journal Title

      International Journal of Geriatric Psychiatry

      Volume: 36 Issue: 7 Pages: 1103-1109

    • DOI

      10.1002/gps.5527

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical profiles of people with dementia exhibiting with neuropsychiatric symptoms admitted to mental hospitals: A multicenter prospective survey in Japan2021

    • Author(s)
      Hozumi A, Tagai K, Shinagawa S, Kamimura N, Shigenobu K, Kashibayashi T, Azuma S, Yoshiyama K, Hashimoto M, Ikeda M, Shigeta M, Kazui H
    • Journal Title

      Geriatr Gerontol Int

      Volume: 21(9) Issue: 9 Pages: 825-829

    • DOI

      10.1111/ggi.14248

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distinctive regional asymmetry in dopaminergic and serotoninergic dysfunction in degenerative Parkinsonisms2021

    • Author(s)
      Takahashi Ryuichi、Ishii Kazunari、Sousa Kaoru、Marumoto Kohei、Kashibayashi Tetsuo、Fujita Jun、Yokoyama Kazumasa
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 423 Pages: 117363-117363

    • DOI

      10.1016/j.jns.2021.117363

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Olfactory-cognitive index distinguishes involvement of frontal lobe shrinkage, as in sarcopenia from shrinkage of medial temporal areas, and global brain, as in Kihon Checklist frailty/dependence, in older adults with progression of normal cognition to Alzheimer's disease.2021

    • Author(s)
      Iritani O, Okuno T, Miwa T, Makizako H, Okutani F, Kashibayashi T, Suzuki K, Hara H, Mori E, Omoto S, Suzuki H, Shibata M, Adachi H, Kondo K, Umeda-Kameyama Y, Kodera K, Morimoto S.
    • Journal Title

      Geriatr Gerontol Int

      Volume: 21 Issue: 3 Pages: 291-298

    • DOI

      10.1111/ggi.14128

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 嗅覚障害と認知症 アルツハイマー型認知症の嗅覚障害2021

    • Author(s)
      樫林哲雄、高橋竜一、數井裕光
    • Organizer
      第36回日本老年精神医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 特発性正常圧水頭症患者におけるアパシーと局所脳容積および局所脳血流の相関2021

    • Author(s)
      茶谷佳宏、樫林哲雄、津田敦、赤松正規、高橋竜一、數井裕光
    • Organizer
      第22回日本正常圧水頭症学会
    • Related Report
      2021 Research-status Report
  • [Presentation] V-Pシャント術後に軽躁状態が再燃した特発性正常圧水頭症の一例2021

    • Author(s)
      藤原維斗彦、赤松正規、津田敦、樫林哲雄、數井裕光
    • Organizer
      第22回日本正常圧水頭症学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 特発性正常圧水頭症に対する複数回歩行検査における時間変動率と歩行の特徴との関係2021

    • Author(s)
      山本貴裕、樫林哲雄、永倉和希、津田敦、赤松正規、細田里南、高谷将吾、永野靖典、池内昌彦、數井裕光
    • Organizer
      第22回日本正常圧水頭症学会
    • Related Report
      2021 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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