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Development of detecting assay for anti-myelin oligodendrocyte glycoprotein antibody

Research Project

Project/Area Number 20K07892
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52020:Neurology-related
Research InstitutionTohoku Medical and Pharmaceutical University

Principal Investigator

NAKASHIMA Ichiro  東北医科薬科大学, 医学部, 教授 (50333810)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2022: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000)
Fiscal Year 2020: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Keywords脱髄疾患 / 自己抗体 / 検査法 / MOG抗体関連疾患 / 多発性硬化症 / 視神経脊髄炎
Outline of Research at the Start

近年、中枢神経の炎症性脱髄疾患の中に抗ミエリンオリゴデンドロサイト糖蛋白(MOG)抗体が関与する病態が存在することが明らかになってきており、多発性硬化症や視神経脊髄炎とは異なる新たな疾患概念として確立しつつある。診断には抗MOG抗体の測定が必須であるが、現在の測定法は煩雑かつコストが高く、検査の普及を妨げており、保険適用に至っていない。本研究は診断マーカーとしての抗MOG抗体の新たな測定法の開発を目的とする。

Outline of Final Research Achievements

It is becoming clear that myelin oligodendrocyte glycoprotein (MOG) antibodies are involved in inflammatory demyelinating diseases of the central nervous system, and this is being established as a new disease concept distinct from multiple sclerosis and neuromyelitis optica. Measurement of MOG antibodies is essential for diagnosis, but the current measurement method is complicated and costly, preventing widespread use of the test, and has not yet been covered by insurance. In this study, we developed a new assay for MOG antibodies as a diagnostic marker and analyzed the clinical significance of MOG antibodies in relation to cytokines and other substances in serum and cerebrospinal fluid while conducting a nationwide epidemiological survey.

Academic Significance and Societal Importance of the Research Achievements

MOG抗体関連疾患はMOGADとよばれ、当科において初の全国疫学調査を実施した。これにより全国に1700人程度の患者が存在していることがあきらかになった。また、国際的なMOGADの診断基準が提唱され、今後独立した疾患概念として確立していく疾患である。一方でMOG抗体の測定は保険適用になっておらず、測定法のキット化が必要であり、感度および特異度の高い検査法の確立が求められている。今回の研究により開発を進めているMOG抗体測定法を今後キット化することにより、疾患の診断が容易になるため、臨床的な意義が大きい。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (23 results)

All 2023 2022 2021 2020

All Journal Article (23 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 23 results,  Open Access: 11 results)

  • [Journal Article] Complement-dependent cytotoxicity of human autoantibodies against myelin oligodendrocyte glycoprotein2023

    • Author(s)
      Kohyama Kuniko、Nishida Hiroya、Kaneko Kimihiko、Misu Tatsuro、Nakashima Ichiro、Sakuma Hiroshi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 17 Pages: 1014071-1014071

    • DOI

      10.3389/fnins.2023.1014071

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epidemiological and clinical characteristics of myelin oligodendrocyte glycoprotein antibody-associated disease in a nationwide survey2023

    • Author(s)
      Nakamura Masashi、Ogawa Ryo、Fujimori Juichi、Uzawa Akiyuki、Sato Yasunori、Nagashima Kengo、Kuriyama Nagato、Kuwabara Satoshi、Nakashima Ichiro
    • Journal Title

      Multiple Sclerosis Journal

      Volume: - Issue: 4-5 Pages: 530-539

    • DOI

      10.1177/13524585231156736

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] White blood cell count profiles in anti-aquaporin-4 antibody seropositive neuromyelitis optica spectrum disorder and anti-myelin oligodendrocyte glycoprotein antibody-associated disease2023

    • Author(s)
      Akaishi Tetsuya、Misu Tatsuro、Fujihara Kazuo、Nakaya Kumi、Nakaya Naoki、Nakamura Tomohiro、Kogure Mana、Hatanaka Rieko、Itabashi Fumi、Kanno Ikumi、Kaneko Kimihiko、Takahashi Toshiyuki、Fujimori Juichi、Takai Yoshiki、Nishiyama Shuhei、Ishii Tadashi、Aoki Masashi、Nakashima Ichiro、Hozawa Atsushi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 6481-6481

    • DOI

      10.1038/s41598-023-33827-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Follow-up of retinal thickness and optic MRI after optic neuritis in anti-MOG antibody-associated disease and anti-AQP4 antibody-positive NMOSD2022

    • Author(s)
      Akaishi Tetsuya、Himori Noriko、Takeshita Takayuki、Misu Tatsuro、Takahashi Toshiyuki、Takai Yoshiki、Nishiyama Shuhei、Kaneko Kimihiko、Fujimori Juichi、Ishii Tadashi、Aoki Masashi、Fujihara Kazuo、Nakazawa Toru、Nakashima Ichiro
    • Journal Title

      Journal of the Neurological Sciences

      Volume: 437 Pages: 120269-120269

    • DOI

      10.1016/j.jns.2022.120269

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] GRP78 Antibodies Are Associated With Blood-Brain Barrier Breakdown in Anti-Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disorder2021

    • Author(s)
      Shimizu F, Ogawa R, Mizukami Y, Watanabe K, Hara K, Kadono C, Takahashi T, Misu T, Takeshita Y, Sano Y, Fujisawa M, Maeda T, Nakashima I, Fujihara K, Kanda T.
    • Journal Title

      Neurol Neuroimmunol Neuroinflamm

      Volume: 9 Issue: 1

    • DOI

      10.1212/nxi.0000000000001038

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A nation-wide survey of Japanese pediatric MOG antibody-associated diseases2021

    • Author(s)
      Azumagawa Kohji、Nakashima Ichiro、Kaneko Kimihiko、Torisu Hiroyuki、Sakai Yasunari、Kira Ryutaro、Sakuma Hiroshi、Tanaka Keiko、Shigeri Yasushi、Tanaka Yoshie、Nakajima Hideto、Shimakawa Shuichi、Tamai Hiroshi
    • Journal Title

      Brain and Development

      Volume: 43 Issue: 6 Pages: 705-713

    • DOI

      10.1016/j.braindev.2021.01.008

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Difference in the Source of Anti-AQP4-IgG and Anti-MOG-IgG Antibodies in CSF in Patients With Neuromyelitis Optica Spectrum Disorder.2021

    • Author(s)
      Akaishi T, Takahashi T, Misu T, Kaneko K, Takai Y, Nishiyama S, Ogawa R, Fujimori J, Ishii T, Aoki M, Fujihara K, Nakashima I.
    • Journal Title

      Neurology.

      Volume: 97 Issue: 1

    • DOI

      10.1212/wnl.0000000000012175

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Five-year visual outcomes after optic neuritis in anti-MOG antibody-associated disease.2021

    • Author(s)
      Akaishi T, Himori N, Takeshita T, Misu T, Takahashi T, Takai Y, Nishiyama S, Fujimori J, Ishii T, Aoki M, Fujihara K, Nakazawa T, Nakashima I.
    • Journal Title

      Mult Scler Relat Disord

      Volume: 56 Pages: 103222-103222

    • DOI

      10.1016/j.msard.2021.103222

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Myelin oligodendrocyte glycoprotein-IgG-positive, steroid-responsive combined central and peripheral demyelination with recurrent peripheral neuropathy.2021

    • Author(s)
      Nakamura T, Kaneko K, Watanabe G, Harashima S, Kawasaki E, Tsukita K, Takahashi T, Nakashima I, Misu T, Suzuki Y.
    • Journal Title

      Neurol Sci

      Volume: 42 Issue: 3 Pages: 1135-1138

    • DOI

      10.1007/s10072-020-04822-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Anti-NMDAR encephalitis may develop concurrently with anti-MOG antibody-associated bilateral medial frontal cerebral cortical encephalitis and relapse with elevated CSF IL-6 and CXCL132021

    • Author(s)
      Fujimori Juichi、Takahashi Toshiyuki、Kaneko Kimihiko、Atobe Yuri、Nakashima Ichiro
    • Journal Title

      Multiple Sclerosis and Related Disorders

      Volume: 47 Pages: 102611-102611

    • DOI

      10.1016/j.msard.2020.102611

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Recent advances in the understanding of myelin oligodendrocyte glycoprotein antibody?associated disorders2021

    • Author(s)
      Nakashima Ichiro
    • Journal Title

      Clinical and Experimental Neuroimmunology

      Volume: 12 Issue: 1 Pages: 4-4

    • DOI

      10.1111/cen3.12629

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Progression pattern of neurological disability with respect to clinical attacks in anti-MOG antibody-associated disorders2021

    • Author(s)
      Akaishi Tetsuya、Misu Tatsuro、Takahashi Toshiyuki、Takai Yoshiki、Nishiyama Shuhei、Fujimori Juichi、Ishii Tadashi、Aoki Masashi、Fujihara Kazuo、Nakashima Ichiro
    • Journal Title

      Journal of Neuroimmunology

      Volume: 351 Pages: 577467-577467

    • DOI

      10.1016/j.jneuroim.2020.577467

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osmotic pressure of serum and cerebrospinal fluid in patients with suspected neurological conditions2020

    • Author(s)
      Akaishi Tetsuya、Takahashi Toshiyuki、Nakashima Ichiro、Abe Michiaki、Aoki Masashi、Ishii Tadashi
    • Journal Title

      Neural Regeneration Research

      Volume: 15 Issue: 5 Pages: 944-944

    • DOI

      10.4103/1673-5374.268906

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study2020

    • Author(s)
      Takai Y, Misu T, Kaneko K, Chihara N, Narikawa K, Tsuchida S, Nishida H, Komori T, Seki M, Komatsu T, Nakamagoe K, Ikeda T, Yoshida M, Takahashi T, Ono H, Nishiyama S, Kuroda H, Nakashima I, Suzuki H, Bradl M, Lassmann H, Fujihara K, Aoki M
    • Journal Title

      Brain

      Volume: 143 Issue: 5 Pages: 1431-1446

    • DOI

      10.1093/brain/awaa102

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CSF levels of glutamine synthetase and GFAP to explore astrocytic damage in seronegative NMOSD2020

    • Author(s)
      Kleerekooper I, Herbert MK, Kuiperij HB, Sato DK, Fujihara K, Callegaro D, Marignier R, Saiz A, Senel M, Tumani H, de Jong BA, Trip SA, Nakashima I, Verbeek MM, Petzold A
    • Journal Title

      J Neurol Neurosurg Psychiatry

      Volume: 91 Issue: 6 Pages: 605-611

    • DOI

      10.1136/jnnp-2019-322286

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Steroid-responsive recurrent tumefactive demyelination with multiple petechial hemorrhages along non-displaced medullary veins2020

    • Author(s)
      Tsuboi Takashi、Harada Yumiko、Suzuki Masashi、Ando Takashi、Atsuta Naoki、Ohka Fumiharu、Takeuchi Kazuhito、Taoka Toshiaki、Ohba Shigeo、Nakaguro Masato、Abe Masato、Nakashima Ichiro、Yoshida Mari、Katsuno Masahisa
    • Journal Title

      Clinical Neurology and Neurosurgery

      Volume: 193 Pages: 105764-105764

    • DOI

      10.1016/j.clineuro.2020.105764

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Unilateral chronic pulsatile headache as the single manifestation of anti-MOG antibody-associated unilateral cerebral cortical encephalitis2020

    • Author(s)
      Fujimori Juichi、Ogawa Ryo、Murata Takaki、Jin Kazutaka、Yazawa Yukako、Nakashima Ichiro
    • Journal Title

      Journal of Neuroimmunology

      Volume: 346 Pages: 577322-577322

    • DOI

      10.1016/j.jneuroim.2020.577322

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Epidemiology of Neuromyelitis Optica Spectrum Disorder and Its Prevalence and Incidence Worldwide2020

    • Author(s)
      Hor Jyh Yung、Asgari Nasrin、Nakashima Ichiro、Broadley Simon A.、Leite M. Isabel、Kissani Najib、Jacob Anu、Marignier Romain、Weinshenker Brian G.、Paul Friedemann、Pittock Sean J.、Palace Jacqueline、Wingerchuk Dean M.、Behne Jacinta M.、Yeaman Michael R.、Fujihara Kazuo
    • Journal Title

      Frontiers in Neurology

      Volume: 11 Pages: 501-13

    • DOI

      10.3389/fneur.2020.00501

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Treatment of MOG-IgG-associated disorder with rituximab: An international study of 121 patients.2020

    • Author(s)
      Whittam DH, Cobo-Calvo A, Lopez-Chiriboga AS, Pardo S, E, Ciron J, Deschamps R, Biotti D, Rostasy K, Neuteboom R, HemingwaGornall M, Cicconi S, Brandt A, Berek K, Berger T, Jelcic I, Gombolay G, Oliveira LM, Callegaro D, Kaneko K, Misu T, et al.
    • Journal Title

      Mult Scler Relat Disord

      Volume: 44 Pages: 102251-102251

    • DOI

      10.1016/j.msard.2020.102251

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Differences in Clinical Features of Myelin Oligodendrocyte Glycoprotein Antibody-Associated Optic Neuritis in White and Asian Race2020

    • Author(s)
      Padungkiatsagul Tanyatuth、Chen John J.、Jindahra Panitha、Akaishi Tetsuya、Takahashi Toshiyuki、Nakashima Ichiro、Takeshita Takayuki、Moss Heather E.
    • Journal Title

      American Journal of Ophthalmology

      Volume: 219 Pages: 332-340

    • DOI

      10.1016/j.ajo.2020.07.008

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Treatment of MOG antibody associated disorders: results of an international survey2020

    • Author(s)
      Whittam Daniel H、Nakashima Ichiro、Fujihara Kazuo、Sato Douglas Kazutoshi、et al.
    • Journal Title

      Journal of Neurology

      Volume: 267 Issue: 12 Pages: 3565-3577

    • DOI

      10.1007/s00415-020-10026-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Seasonal variation of onset in patients with anti-aquaporin-4 antibodies and anti-myelin oligodendrocyte glycoprotein antibody2020

    • Author(s)
      Akaishi Tetsuya、Fujimori Juichi、Takahashi Toshiyuki、Misu Tatsuro、Takai Yoshiki、Nishiyama Shuhei、Kaneko Kimihiko、Ogawa Ryo、Abe Michiaki、Ishii Tadashi、Aoki Masashi、Fujihara Kazuo、Nakashima Ichiro
    • Journal Title

      Journal of Neuroimmunology

      Volume: 349 Pages: 577431-577431

    • DOI

      10.1016/j.jneuroim.2020.577431

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical and Radiological Features of Adult Onset Bilateral Medial Frontal Cerebral Cortical Encephalitis With Anti-myelin Oligodendrocyte Glycoprotein Antibody2020

    • Author(s)
      Fujimori Juichi、Nakamura Masashi、Yagihashi Takahito、Nakashima Ichiro
    • Journal Title

      Frontiers in Neurology

      Volume: 11 Pages: 1-5

    • DOI

      10.3389/fneur.2020.600169

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access

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Published: 2020-04-28   Modified: 2024-01-30  

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