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development of a neurofeedback methd for depression by recovering cognitive and emotional dysfunction

Research Project

Project/Area Number 20K07920
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionYamaguchi University

Principal Investigator

Matsubara Toshio  山口大学, 大学院医学系研究科, 准教授 (60526896)

Co-Investigator(Kenkyū-buntansha) 原田 健一郎  山口大学, 大学院医学系研究科, 助教 (50761011)
中川 伸  山口大学, 大学院医学系研究科, 教授 (60360905)
陳 冲  山口大学, 大学院医学系研究科, 助教 (70783067)
藤田 悠介  山口大学, 大学院創成科学研究科, 准教授 (40509527)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywordsうつ病 / ニューロフィードバック / 情動調整障害 / 認知機能障害 / 光トポグラフィー / ニューフィードバック / 情動 / 認知機能
Outline of Research at the Start

われわれは、情動・認知相関の知見をもとに、陽性情動刺激課題を用いた前頭部ニューロフィードバック(NF)を用いて、うつ病患者の認知機能回復も目指した情動調整法とその脳病態を明らかにする。具体的には、うつ病患者をRCTにて、NF介入群と非介入群に分け、光トポグラフィー装置を用いて、NFを介入群、sham-NFを非介入群に、週1回6ヶ月間行い、0ヶ月、3ヶ月、6ヶ月後の情動・認知機能検査および0ヶ月、6ヶ月後のDTIを測定する。またNF終了6ヶ月後に、情動認知機能が維持されていることを確認する目的で、もう一度情動・認知機能検査を行う。

Outline of Final Research Achievements

We summarised previous Japanese clinical studies using functional near-infrared spectroscopy in depression (Mood Disorders. Cambridge University Press. 2021). To clarify the brain basis of cognitive dysfunction or emotional dysregulation in depression, we compared frontal function during emotional words and verbal fluency tasks using functional near-infrared spectroscopy in a group of depressed patients and the healthy controls, and found a significant reduction in frontal blood flow during the verbal fluency task in the patients with depression, while frontal blood flow during the emotional words task was significantly activated (Matsubara T et al.: J Affect Disord. 2022).

Academic Significance and Societal Importance of the Research Achievements

本研究の結果の意義は、うつ病患者では健常群に比し、認知課題中は充分に前頭部が賦活されず、情動調整課題中は前頭部が過賦活されるという、うつ病の神経基盤を明らかにしたことである。うつ状態の患者の鑑別補助手法として、認知機能課題や情動調整課題中の脳機能変化の差が役立つ可能性が示唆された。またニューロフィードバックを用いて改善すべきうつ病の前頭部の神経基盤が明らかになり、血流調整課題として認知機能課題を用いるか、情動調整課題を用いるかで異なる脳血流の方向性を被験者に指示する必要があることも明らかになった。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (20 results)

All 2023 2022 2021 2020

All Journal Article (13 results) (of which Peer Reviewed: 12 results,  Open Access: 9 results) Presentation (6 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] Prefrontal activity during the emotional go/no-go task and computational markers of risk-based decision-making predict future relapse in alcohol use disorder2023

    • Author(s)
      Sasaki Jun、Matsubara Toshio、Chen Chong、Fujii Yuko、Fujita Yoko、Nakamuta Masako、Nitta Kumiko、Egashira Kazuteru、Hashimoto Takashi、Nakagawa Shin
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13

    • DOI

      10.3389/fpsyt.2022.1048152

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prefrontal cortex activities during verbal fluency and emotional words tasks in major depressive, adjustment, and bipolar disorders with depressive states2022

    • Author(s)
      Matsubara Toshio、Chen Chong、Hirotsu Masako、Watanuki Toshio、Harada Kenichiro、Watanabe Yoshifumi、Matsuo Koji、Nakagawa Shin
    • Journal Title

      Journal of Affective Disorders

      Volume: 316 Pages: 109-117

    • DOI

      10.1016/j.jad.2022.08.025

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computational markers of experience- but not description-based decision-making are associated with future depressive symptoms in young adults2022

    • Author(s)
      Chen Chong、Mochizuki Yasuhiro、Hagiwara Kosuke、Hirotsu Masako、Matsubara Toshio、Nakagawa Shin
    • Journal Title

      Journal of Psychiatric Research

      Volume: 154 Pages: 307-314

    • DOI

      10.1016/j.jpsychires.2022.08.003

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of positive autobiographical memory retrieval on decision-making under risk: A computational model-based analysis2022

    • Author(s)
      Shimizu Natsumi、Mochizuki Yasuhiro、Chen Chong、Hagiwara Kosuke、Matsumoto Karin、Oda Yusuke、Hirotsu Masako、Okabe Emi、Matsubara Toshio、Nakagawa Shin
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13

    • DOI

      10.3389/fpsyt.2022.930466

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nonlinear Probability Weighting in Depression and Anxiety: Insights From Healthy Young Adults2022

    • Author(s)
      Hagiwara Kosuke、Mochizuki Yasuhiro、Chen Chong、Lei Huijie、Hirotsu Masako、Matsubara Toshio、Nakagawa Shin
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 810867-810867

    • DOI

      10.3389/fpsyt.2022.810867

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Brief, manualised and semistructured individual psychotherapy programme for patients with advanced cancer in Japan: study protocol for Managing Cancer and Living Meaningfully (CALM) phase 2 trial2022

    • Author(s)
      Seraki Miyamoto, Tadahiro Yamazaki, Ken Shimizu, Toshio Matsubara, Hidenori Kage, Kousuke Watanabe, Hiroshi Kobo, Yutaka Matsuyama, Gary Rodin, Kazuhiro Yoshiuchi
    • Journal Title

      BMJ open

      Volume: 12 Issue: 3 Pages: e056136-e056136

    • DOI

      10.1136/bmjopen-2021-056136

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sex difference in the weighting of expected uncertainty under chronic stress2021

    • Author(s)
      Lei Huijie、Mochizuki Yasuhiro、Chen Chong、Hagiwara Kosuke、Hirotsu Masako、Matsubara Toshio、Nakagawa Shin
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 8700-8700

    • DOI

      10.1038/s41598-021-88155-1

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Effect of Acute Aerobic Exercise on Divergent and Convergent Thinking and Its Influence by Mood2021

    • Author(s)
      Aga K, Inamura M, Chen C, Hagiwara K, Yamashita R, Hirotsu M, Seki T, Takao A, Fujii Y, Matsubara T, Nakagawa S
    • Journal Title

      Brain Sci

      Volume: 11 Issue: 5 Pages: 546-546

    • DOI

      10.3390/brainsci11050546

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Mood-Improving Effect of Viewing Images of Nature and Its Neural Substrate2021

    • Author(s)
      Yamashita Rikuto、Chen Chong、Matsubara Toshio、Hagiwara Kosuke、Inamura Masato、Aga Kohei、Hirotsu Masako、Seki Tomoe、Takao Akiyo、Nakagawa Erika、Kobayashi Ayumi、Fujii Yuko、Hirata Keiko、Ikei Harumi、Miyazaki Yoshifumi、Nakagawa Shin
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 10 Pages: 5500-5500

    • DOI

      10.3390/ijerph18105500

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] 自殺予防の簡易な介入法2021

    • Author(s)
      松原 敏郎、中川 伸
    • Journal Title

      精神科治療学

      Volume: 36 Pages: 997-1001

    • Related Report
      2021 Research-status Report
  • [Journal Article] The Negative Association Between Positive Psychological Wellbeing and Loss Aversion2021

    • Author(s)
      Koan Ibuki、Nakagawa Takumi、Chen Chong、Matsubara Toshio、Lei Huijie、Hagiwara Kosuke、Hirotsu Masako、Yamagata Hirotaka、Nakagawa Shin
    • Journal Title

      Frontiers in Psychology

      Volume: 12 Pages: 641340-641340

    • DOI

      10.3389/fpsyg.2021.641340

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A 26-year retrospective survey on suicide cases of students at Yamaguchi University (1992ー2017): Risk factors and the role of the health administration center2021

    • Author(s)
      Matsubara Toshio、Yamamoto Naoki、Chen Chong、Okuya Shigeru、Nakagawa Shin
    • Journal Title

      Psychiatry Research

      Volume: 295 Pages: 113566-113566

    • DOI

      10.1016/j.psychres.2020.113566

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Regular Moderate- to Vigorous-Intensity Physical Activity Rather Than Walking Is Associated with Enhanced Cognitive Functions and Mental Health in Young Adults2020

    • Author(s)
      Nakagawa Takumi、Koan Ibuki、Chen Chong、Matsubara Toshio、Hagiwara Kosuke、Lei Huijie、Hirotsu Masako、Yamagata Hirotaka、Nakagawa Shin
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 17 Issue: 2 Pages: 614-614

    • DOI

      10.3390/ijerph17020614

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Development of the Japanese Version of Death and Dying Distress Scale(DADDS-J)2022

    • Author(s)
      Seraki Miyamoto,Tadahiro Yamazaki, Toshio Matsubara, Hiroshi Yamagata, Kobo Hiroshi, Hiroaki Abe, Masahiko Sumitani, Ken Shimizu, Gary Rodin, Kazuhiro Yoshiuchi
    • Organizer
      23th IPOS
    • Related Report
      2022 Annual Research Report
  • [Presentation] 喉頭全摘術を拒否していたが音声合成アプリを利用して声を残すことで手術決意に繋がった進行がん患者の事例2022

    • Author(s)
      佐藤裕子、大野陽子、松原敏郎、野村さやか、乗安里佳、山縣裕史、松本美志也、中川伸.
    • Organizer
      第35回日本サイコオンコロジー学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 統合失調症・双極性障害・うつ病・自閉スペクトラム症の多施設大規模データによる疾患横断的な大脳皮質構造の類似度の解析2022

    • Author(s)
      松本 純弥、福永 雅喜、三浦 健一郎、根本 清貴、岡田 直大、橋本 直樹、松原 敏郎、尾崎 紀夫、笠井 清登、橋本 亮太ら
    • Organizer
      BPCNPNPPP4学会合同年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Cortical structural mega-analysis across four major psychiatric disorders in 5432 individuals.2021

    • Author(s)
      Junya Matsumoto, Masaki Fukunaga, Kenichiro Miura , Toshio Matsubara, Ryota Hashimoto et.al
    • Organizer
      71th AsCNP
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Using brain activations during cognitive and emotional tasks for the differential diagnosis of depressive states: A functional near-infrared spectroscopy study.2020

    • Author(s)
      T Matsubara, C Chen, M Hirotsu, T Watanuki, K Matsuo, Y Watanabe, S Nakagawa
    • Organizer
      75th Society of Biological Psychiatry
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Predicting the future relapse with alcohol use disorder using task of working memory and probability-based decision making.2020

    • Author(s)
      J Sasaki, T Matsubara, C Chen, Y Fujii, M Hirotsu, M Nakamuta, Y Fujita, T Hashimoto, S Nakagawa
    • Organizer
      75th Society of Biological Psychiatry
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Book] Mood Disorders: Brain imaging and Therapeutic Implications chapter13. Functional Near-Infrared Spectroscopy studies in Mood Disorders.2021

    • Author(s)
      Koji Matsuo, Toshio Matsubara.
    • Total Pages
      282
    • Publisher
      Cambridge University Press.
    • Related Report
      2020 Research-status Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

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