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Investigation of neuropsychological examination and speech-language activity for agrammatism in patients with dementia

Research Project

Project/Area Number 20K07979
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52030:Psychiatry-related
Research InstitutionTokyo Medical University

Principal Investigator

Higashi Shinji  東京医科大学, 医学部, 教授 (30365647)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords進行性失語症 / アルツハイマー病 / 前頭側頭葉変性症 / 失文法 / 神経心理 / 認知症 / 原発性進行性失語症
Outline of Research at the Start

認知症には言語障害から発症する群があり、原発性進行性失語症と総称される。その多くはアルツハイマー病や前頭側頭葉変性症の亜型や非典型例である。
原発性進行性失語症には下位分類があり、診断には失語症状の把握が不可欠である。その中でも文を構造化できない失文法症状は特にその把握が難しい症状であるが、現在統一された検査手順はない。
本研究は失文法型の認知症の診断検査法の開発を目的とする。日本人における文の形成・理解に必要な高次脳機能とその関連脳領域を調査し、効果的な認知訓練方法の開発を検証する。

Outline of Final Research Achievements

Language impairment is one of the major cognitive dysfunctions of dementia. We focused on grammatical impairment among them, and conducted research on psychological tests to detect grammatical impairment, neurodegenerative sites of each aphasic symptom, and therapeutic strategies that can be implemented inexpensively and in large numbers of patients.
In this study, we examined the usefulness of the neuropsychiatric test using stimulus picture and word cards, language functions involving the cerebral cortex and subcortical gray matter/white matter, respectively, and the rate of continuation of speech-language activities using Internet videos at home.

Academic Significance and Societal Importance of the Research Achievements

現在の高齢化社会において認知症の理解・治療・介護は重要な課題となっている。認知症の症状は記憶障害と見当識障害が注目される傾向にあるが、言語機能は人と人とのつながりを促すコミュニケーションツールであり、高齢者の心理・人格の安定に欠かすことのできない機能であり、文法機能はその基本となるものである。本研究はこの言語機能の中でも最も理解や把握が難しい文法機能に焦点を当てた研究である。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (33 results)

All 2023 2022 2021 2020

All Journal Article (19 results) (of which Peer Reviewed: 19 results,  Open Access: 12 results) Presentation (12 results) Book (2 results)

  • [Journal Article] Screening of Mild Cognitive Impairment Through Conversations With Humanoid Robots: Exploratory Pilot Study2023

    • Author(s)
      Yoshii Kenta、Kimura Daiki、Kosugi Akihiro、Shinkawa Kaoru、Takase Toshiro、Kobayashi Masatomo、Yamada Yasunori、Nemoto Miyuki、Watanabe Ryohei、Ota Miho、Higashi Shinji、Nemoto Kiyotaka、Arai Tetsuaki、Nishimura Masafumi
    • Journal Title

      JMIR Formative Research

      Volume: 7 Pages: e42792-e42792

    • DOI

      10.2196/42792

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The mediating role of depressive symptoms and subjective cognitive dysfunction in the relationship between stressful life events and functional disability in adult community volunteers2023

    • Author(s)
      Toyoshima Kuniyoshi、Inoue Takeshi、Masuya Jiro、Fujimura Yota、Higashi Shinji、Kusumi Ichiro
    • Journal Title

      Journal of Affective Disorders

      Volume: 330 Pages: 110-116

    • DOI

      10.1016/j.jad.2023.02.144

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mediating effects of trait anxiety and state anxiety on the effects of physical activity on depressive symptoms2023

    • Author(s)
      Kikkawa M, *Shimura A, Nakajima K, Morishita C, Honyashiki M, Tamada Y, Higashi S, Ichiki M, Inoue T, Masuya J
    • Journal Title

      Int J Environ Res Public Health

      Volume: 20 Issue: 7 Pages: 5319-5319

    • DOI

      10.3390/ijerph20075319

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On workdays, earlier sleep for morningness and later wakeup for eveningness are associated with better work productivity2022

    • Author(s)
      Shimura Akiyoshi、Yokoi Katsunori、Sugiura Ko、Higashi Shinji、Inoue Takeshi
    • Journal Title

      Sleep Medicine

      Volume: 92 Pages: 73-80

    • DOI

      10.1016/j.sleep.2022.03.007

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Moderating and mediating effects of resilience together with neuroticism on depressive symptoms in adult volunteers2022

    • Author(s)
      Ito S, *Morishita C, Masuya J, Ono M, Honyashiki M, Higashi S, Tamada Y, Fujimura Y, Inoue T
    • Journal Title

      Neuropsychiatr Dis Treat

      Volume: 18 Pages: 1751-1761

    • DOI

      10.2147/ndt.s370201

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cognitive complaints mediate the influence of sleep disturbance and state anxiety on subjective well-being and ill-being in adult community volunteers: a cross sectional study2022

    • Author(s)
      Toyoshima Kuniyoshi、Ichiki Masahiko、Inoue Takeshi、Shimura Akiyoshi、Masuya Jiro、Fujimura Yota、Higashi Shinji、Kusumi Ichiro
    • Journal Title

      BMC Public Health

      Volume: 22 Issue: 1 Pages: 566-566

    • DOI

      10.1186/s12889-022-12936-0

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cognitive complaints mediate childhood parental bonding influence on presenteeism2022

    • Author(s)
      Toyoshima Kuniyoshi、Inoue Takeshi、Shimura Akiyoshi、Masuya Jiro、Fujimura Yota、Higashi Shinji、Kusumi Ichiro
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 3 Pages: 1-15

    • DOI

      10.1371/journal.pone.0266226

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The relationship among sleep reactivity, job-related stress, and subjective cognitive dysfunction: a cross-sectional study using path analysis2021

    • Author(s)
      TOYOSHIMA Kuniyoshi、INOUE Takeshi、SHIMURA Akiyoshi、MASUYA Jiro、FUJIMURA Yota、HIGASHI Shinji、KUSUMI Ichiro
    • Journal Title

      Industrial Health

      Volume: 59 Issue: 4 Pages: 229-238

    • DOI

      10.2486/indhealth.2020-0251

    • NAID

      130008086307

    • ISSN
      0019-8366, 1880-8026
    • Year and Date
      2021-07-14
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mediating Roles of Cognitive Complaints on Relationships between Insomnia, State Anxiety, and Presenteeism in Japanese Adult Workers2021

    • Author(s)
      Toyoshima Kuniyoshi、Inoue Takeshi、Shimura Akiyoshi、Uchida Yoshihiro、Masuya Jiro、Fujimura Yota、Higashi Shinji、Kusumi Ichiro
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 18 Issue: 9 Pages: 4516-4516

    • DOI

      10.3390/ijerph18094516

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of Cognitive Complaints in the Relationship Between Trait Anxiety, Depressive Symptoms, and Subjective Well-Being and Ill-Being in Adult Community Volunteers2021

    • Author(s)
      Toyoshima Kuniyoshi、Ichiki Masahiko、Inoue Takeshi、Masuya Jiro、Fujimura Yota、Higashi Shinji、Kusumi Ichiro
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: Volume 17 Pages: 1299-1309

    • DOI

      10.2147/ndt.s303751

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Subjective cognitive impairment and presenteeism mediate the associations of rumination with subjective well-being and ill-being in Japanese adult workers from the community2021

    • Author(s)
      Toyoshima Kuniyoshi、Ichiki Masahiko、Inoue Takeshi、Shimura Akiyoshi、Masuya Jiro、Fujimura Yota、Higashi Shinji、Kusumi Ichiro
    • Journal Title

      BioPsychoSocial Medicine

      Volume: 15 Issue: 1 Pages: 15-15

    • DOI

      10.1186/s13030-021-00218-x

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] TEMPS‐A (short version) plays a supplementary role in the differential diagnosis between major depressive disorder and bipolar disorder2021

    • Author(s)
      Morishita Chihiro、Kameyama Rie、Toda Hiroyuki、Masuya Jiro、Fujimura Yota、Higashi Shinji、Kusumi Ichiro、Inoue Takeshi
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 75 Issue: 5 Pages: 166-171

    • DOI

      10.1111/pcn.13198

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Affective temperaments moderate the effect of insomnia on depressive symptoms in adult community volunteers2021

    • Author(s)
      Toyoshima Kuniyoshi、Inoue Takeshi、Masuya Jiro、Fujimura Yota、Higashi Shinji、Kusumi Ichiro
    • Journal Title

      Journal of Affective Disorders

      Volume: 282 Pages: 726-731

    • DOI

      10.1016/j.jad.2020.12.138

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Does Subjective Cognitive Function Mediate the Effect of Affective Temperaments on Functional Disability in Japanese Adults?2020

    • Author(s)
      Toyoshima Kuniyoshi、Inoue Takeshi、Masuya Jiro、Fujimura Yota、Higashi Shinji、Kusumi Ichiro
    • Journal Title

      Neuropsychiatric Disease and Treatment

      Volume: Volume 16 Pages: 1675-1684

    • DOI

      10.2147/ndt.s256647

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural Brain Network Correlated with Reading Impairment in Alzheimer’s Disease2020

    • Author(s)
      Ota Miho、Koshibe Yuko、Higashi Shinji、Nemoto Kiyotaka、Tsukada Eriko、Tamura Masashi、Takahashi Takumi、Arai Tetsuaki
    • Journal Title

      Dementia and Geriatric Cognitive Disorders

      Volume: 49 Issue: 3 Pages: 264-269

    • DOI

      10.1159/000508406

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Associations among childhood parenting, affective temperaments, depressive symptoms, and cognitive complaints in adult community volunteers2020

    • Author(s)
      Toyoshima Kuniyoshi、Inoue Takeshi、Masuya Jiro、Fujimura Yota、Higashi Shinji、Kusumi Ichiro
    • Journal Title

      Journal of Affective Disorders

      Volume: 276 Pages: 361-368

    • DOI

      10.1016/j.jad.2020.07.107

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Structural equation modeling approach to explore the influence of childhood maltreatment in adults.2020

    • Author(s)
      Toyoshima,K., Inoue,T., Masuya,J., Fujimura,Y., Higashi,S., Tanabe,H., Kusumi,I.
    • Journal Title

      PLoS ONE

      Volume: 15(10) Issue: 10 Pages: 0239820-0239820

    • DOI

      10.1371/journal.pone.0239820

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Personality traits mediate the association between perceived parental bonding and well-being in adult volunteers from the community2020

    • Author(s)
      Murakoshi Akiko、Mitsui Nobuyuki、Masuya Jiro、Fujimura Yota、Higashi Shinji、Kusumi Ichiro、Inoue Takeshi
    • Journal Title

      BioPsychoSocial Medicine

      Volume: 14 Issue: 1 Pages: 28-28

    • DOI

      10.1186/s13030-020-00198-4

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intracellular dynamics of Ataxin-2 in the human brains with normal and frontotemporal lobar degeneration with TDP-43 inclusions2020

    • Author(s)
      Watanabe Ryohei、Higashi Shinji、Nonaka Takashi、Kawakami Ito、Oshima Kenichi、Niizato Kazuhiro、Akiyama Haruhiko、Yoshida Mari、Hasegawa Masato、Arai Tetsuaki
    • Journal Title

      Acta Neuropathologica Communications

      Volume: 8 Issue: 1 Pages: 176-176

    • DOI

      10.1186/s40478-020-01055-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Characterization of phosphorylated TDP-43 aggregates induced under several conditions2022

    • Author(s)
      勇亜衣子、大谷麗子、渡辺亮平、野中隆、東晋二、新井哲明、小野寺理、長谷川成人
    • Organizer
      第63回日本神経学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 認知症の改訂長谷川式簡易知能評価スケールにおける遅延再生と物品記憶に関連する障害脳領域の同定2022

    • Author(s)
      東晋二、根本清貴、越部裕子、宮崎峻弘、渡辺亮平、内田由寛、庭瀬美智子、桜井礼二、朝田武、新井哲明、井上猛
    • Organizer
      第27回日本神経精神医学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 進行性失語症に対するオンライン動画を用いた言語療法の1年間の実施結果2022

    • Author(s)
      東晋二、越部裕子、宮崎峻弘、渡辺亮平、中目華子、井上猛、朝田隆、新井哲明
    • Organizer
      第41回日本認知症学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 認知症における遅延再生とシリアルセブンに関連する障害脳領域の同定2022

    • Author(s)
      東晋二、根本清貴、越部裕子、宮崎峻弘、渡辺亮平、内田由寛、庭瀬美智子、桜井礼二、朝田武、新井哲明、井上猛
    • Organizer
      第37回日本老年精神医学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 液-液相分離はTDP-43凝集体形成に関与するか?2022

    • Author(s)
      勇亜衣子、大谷麗子、渡辺亮平、野中隆、東晋二、新井哲明、小野寺理、長谷川成人
    • Organizer
      第41回日本認知症学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 進行性失語症に対するオンライン動画を用いた言語療法の参加継続に関わる要因の解析2021

    • Author(s)
      東晋二、越部裕子、渡辺亮平、中目華子、井上猛、朝田隆、新井哲明
    • Organizer
      第36回日本老年精神医学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 進行性失語症に対するオンライン動画を用いた言語療法の難易度と速度設定に関わる失語症状の解析2021

    • Author(s)
      東晋二、越部裕子、渡辺亮平、中目華子、井上猛、朝田隆、新井哲明
    • Organizer
      第26回日本神経精神医学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 進行性失語症に対するオンライン動画を用いた言語療法の治療意欲に関わる要因の解析2021

    • Author(s)
      東晋二、越部裕子、渡辺亮平、中目華子、井上猛、朝田隆、新井哲明
    • Organizer
      第40回日本認知症学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] Rey複雑図形を用いたアルツハイマー病とレビー小体型認知症の視覚認知障害の検討2021

    • Author(s)
      原田寛之、東晋二、渡辺亮平、越部裕子、中目華子、庭瀬美智子、内田由寛、桜井礼二、朝田武、片山成仁、新井哲明、井上猛
    • Organizer
      第40回日本認知症学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 一般成人における主観的健康感に及ぼす、特性不安、小児期虐待、成人期ライフイベントの影響2020

    • Author(s)
      内田由寛、東晋二、片山成仁、井上猛
    • Organizer
      第116回日本精神神経学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] アルツハイマー型認知症患者における居住形態に応じたBPSDの違い2020

    • Author(s)
      翠川晴彦、江湖山さおり、太刀川弘和、東晋二、新井哲明
    • Organizer
      第35回日本老年精神医学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 認知機能障害患者におけるバウムテストとレーヴン色彩マトリックス検査の相関性の検討2020

    • Author(s)
      越部裕子、東晋二、原田寛之、内田由寛、庭瀬美智子、桜井礼二、朝田武、新井哲明、井上猛
    • Organizer
      第39回日本認知症学会学術集会
    • Related Report
      2020 Research-status Report
  • [Book] 認知症ハンドブック 第2版 (第11章 前頭側頭葉変性症とその他の変性性認知症疾患 1 前頭側頭葉変性症)2020

    • Author(s)
      東 晋二
    • Total Pages
      946
    • Publisher
      医学書院
    • ISBN
      9784260041669
    • Related Report
      2020 Research-status Report
  • [Book] 認知症がわかる本2020

    • Author(s)
      東 晋二、松崎 朝樹
    • Total Pages
      200
    • Publisher
      メディカル・サイエンス・インターナショナル
    • ISBN
      9784815730062
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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