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Texture analysis of MRI and PET imaging for cardiac sarcoidosis

Research Project

Project/Area Number 20K08042
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionJichi Medical University

Principal Investigator

Oyama-Manabe Noriko  自治医科大学, 医学部, 教授 (70463742)

Co-Investigator(Kenkyū-buntansha) 大平 洋  北海道大学, 大学病院, 助教 (20528301)
平田 健司  北海道大学, 医学研究院, 准教授 (30431365)
真鍋 治  自治医科大学, 医学部, 准教授 (40443957)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Keywords心臓サルコイドーシス / 心臓MRI / FDG PET / 定量評価 / PET / ストレイン / テクスチャ解析 / MRI / 心サルコイドーシス
Outline of Research at the Start

心臓MRIとPETはそれぞれが心サルコイドーシス診療ガイドラインの主徴候として、臨床でもちいられているが、それぞれが独立して評価されており、二つの空間分解能も異常閾値も異なるモダリティの画像を半自動的に統合するプログラム作成及びその有用性の検証は、まだ報告されていない。これらの統合画像により、心サルコイドーシス活動性病変と非活動性の線維化病変の同時描出が可能となる。
心臓サルコイドーシスの病態を的確に示すPETとMRI画像を最新の画像融合技術を利用して統合し、テクスチャ解析を用いることで、病態評価、重症度判定、治療戦略のための最適な包括的評価法の確立を目指す。

Outline of Final Research Achievements

Cardiac MRI and PET are used clinically as the main diagnostic criteria for the 2016 edition of the Japanese Circulation Society's cardiac sarcoidosis treatment guidelines, but each is evaluated independently, and the creation and verification of the usefulness of a program that integrates images of modalities with different spatial resolution and abnormal threshold values has not yet been reported. These integrated images enable simultaneous depiction of active cardiac sarcoidosis lesions and inactive fibrotic lesions.
This study aims to establish an optimal comprehensive evaluation method for disease evaluation, severity determination, and treatment strategy by integrating PET and MRI images that accurately demonstrate the pathology of cardiac sarcoidosis using the latest image fusion technology and quantitatively visualizing the characteristic distribution of lesions using texture analysis.

Academic Significance and Societal Importance of the Research Achievements

心臓サルコイドーシス診療において、従来の定性的評価法ではFDGPETおよび心臓MRI所見の乖離や検者間の陽性率の不一致による、偽陽性・偽陰性といった病院間の不均衡が正診率の低下につながり、適切なタイミングで患者が治療を受けられず病変が進行してしまうことが社会的問題であった。欧米諸国に比して、日本では頻度が高い心臓サルコイドーシスによる致死性不整脈はペースメーカー植え込みといった介入を必要とし、本研究により客観的で再現性の高い解析法を確立することができれば、治療対象患者に対してより早期のステロイド投与等の介入が可能となり、致死的不整脈の予防が可能となり、結果医療費削減につながることが期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (28 results)

All 2023 2022 2021 2020 Other

All Journal Article (9 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 9 results,  Open Access: 5 results) Presentation (13 results) (of which Int'l Joint Research: 2 results,  Invited: 13 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Serial assessment of cardiac involvement in sarcoidosis by delayed 18F-fluorodeoxyglucose PET/CT2023

    • Author(s)
      Aikawa Tadao、Manabe Osamu、Ibe Tatsuro、Oyama-Manabe Noriko
    • Journal Title

      Journal of Nuclear Cardiology

      Volume: 未定 Issue: 5 Pages: 2225-2228

    • DOI

      10.1007/s12350-022-03151-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Underdiagnosis of cardiac sarcoidosis by ECG and echocardiography in cases of extracardiac sarcoidosis2022

    • Author(s)
      Ohira H, Sato T, Manabe O, Oyama-Manabe N, et al.
    • Journal Title

      ERJ Open Res

      Volume: 8 Issue: 2 Pages: 00516-2021

    • DOI

      10.1183/23120541.00516-2021

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Right ventricular involvement of cardiac sarcoidosis: A comprehensive evaluation using cardiovascular magnetic resonance imaging and positron emission tomography2022

    • Author(s)
      Aikawa Tadao、Ibe Tatsuro、Manabe Osamu、Oyama-Manabe Noriko
    • Journal Title

      Journal of Nuclear Cardiology

      Volume: 29 Issue: 6 Pages: 3593-3595

    • DOI

      10.1007/s12350-021-02655-1

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Delayed 18F-fluorodeoxyglucose PET/CT imaging improves detection of cardiac involvement in sarcoidosis2021

    • Author(s)
      Kato Sakura、Aikawa Tadao、Ibe Tatsuro、Manabe Osamu、Oyama-Manabe Noriko
    • Journal Title

      Journal of Nuclear Cardiology

      Volume: - Issue: 1 Pages: 417-419

    • DOI

      10.1007/s12350-021-02815-3

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] T2-weighted short-tau-inversion-recovery imaging reflects disease activity of cardiac sarcoidosis2021

    • Author(s)
      Tonegawa R, Oyama-Manabe N*, et al.
    • Journal Title

      Open Heart

      Volume: 8 Issue: 2 Pages: e001728-e001728

    • DOI

      10.1136/openhrt-2021-001728

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Role of Multimodality Imaging in Cardiac Sarcoidosis2021

    • Author(s)
      Oyama-Manabe Noriko、Manabe Osamu、Aikawa Tadao、Tsuneta Satonori
    • Journal Title

      Korean Circulation Journal

      Volume: 51 Issue: 7 Pages: 561-561

    • DOI

      10.4070/kcj.2021.0104

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Texture analysis of delayed contrast-enhanced computed tomography to diagnose cardiac sarcoidosis2021

    • Author(s)
      Tsuneta Satonori、Oyama-Manabe Noriko、Hirata Kenji、Harada Taisuke、Aikawa Tadao、Manabe Osamu、Ohira Hiroshi、Koyanagawa Kazuhiro、Naya Masanao、Kudo Kohsuke
    • Journal Title

      Japanese Journal of Radiology

      Volume: 39 Issue: 5 Pages: 442-450

    • DOI

      10.1007/s11604-020-01086-1

    • NAID

      210000186857

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Positron emission tomography/MRI for cardiac diseases assessment2020

    • Author(s)
      Manabe Osamu、Oyama-Manabe Noriko、Tamaki Nagara
    • Journal Title

      The British Journal of Radiology

      Volume: - Issue: 1113 Pages: 20190836-20190836

    • DOI

      10.1259/bjr.20190836

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prognostic Value of 18F-FDG PET Using Texture Analysis in Cardiac Sarcoidosis2020

    • Author(s)
      2)Manabe O, Koyanagawa K, Hirata K, Oyama-Manabe N, Ohira H, Aikawa T, Furuya S, Naya M, Tsujino I, Tomiyama Y, Otaki Y, Anzai T, Tamaki N
    • Journal Title

      JACC Cardiovasc Imaging

      Volume: 13 Issue: 4 Pages: 1096-1097

    • DOI

      10.1016/j.jcmg.2019.11.021

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] 左室だけじゃない!右室と心房から見えてくる心疾患2022

    • Author(s)
      真鍋徳子
    • Organizer
      AIMS Cardiac Imaging
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 循環器画像診断における放射線医の相棒2022

    • Author(s)
      真鍋徳子
    • Organizer
      Philips Radiology Workflow Solutions
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 心臓MRIが変わった!より診える機能画像へ2022

    • Author(s)
      真鍋徳子
    • Organizer
      第50回日本磁気共鳴医学会大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 心臓MRIを極めつくす!~実臨床で使えるノウハウ2022

    • Author(s)
      真鍋徳子
    • Organizer
      第50回日本磁気共鳴医学会大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 心臓MRIがマッピングでこんなに簡単に!2022

    • Author(s)
      真鍋徳子
    • Organizer
      第17回Imaging Now in Kanagawa
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] サルコイドーシス2022

    • Author(s)
      真鍋徳子
    • Organizer
      第26回MR実践・先端講座
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 虚血および非虚血性心筋症に対する心臓MRIの現在2021

    • Author(s)
      真鍋徳子
    • Organizer
      第61回日本核医学会学術総会 IAEA心臓核医学ワークショップ
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] 心臓機能画像のアップデート2021

    • Author(s)
      真鍋徳子
    • Organizer
      第61回日本核医学学術総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 心臓核医学の最新の話題2021

    • Author(s)
      真鍋徳子
    • Organizer
      Womens Cardiologist Conference
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] MRIのマッピング技術による循環器画像診断の新たな潮流2021

    • Author(s)
      真鍋徳子
    • Organizer
      第1回関東心臓MRI研究会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] Cardiomyoapthies2020

    • Author(s)
      Noriko Oyama-Manabe
    • Organizer
      Society of cardiovascular computed tomography annual meeting
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] アップデートしよう!心臓MRI のイロハ2020

    • Author(s)
      真鍋徳子
    • Organizer
      第30回日本心臓核医学会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 心臓MRIのシネ画像でここまでわかる!-ストレイン評価があとから可能に2020

    • Author(s)
      真鍋徳子
    • Organizer
      第6回東海循環器マルチモダリティセミナー
    • Related Report
      2020 Research-status Report
    • Invited
  • [Book] カレントテラピー2023

    • Author(s)
      相川忠夫、真鍋徳子
    • Total Pages
      4
    • Publisher
      ライフメディコム
    • Related Report
      2022 Annual Research Report
  • [Book] 循環器内科2022

    • Author(s)
      真鍋治、真鍋徳子
    • Total Pages
      6
    • Publisher
      科学評論社
    • Related Report
      2022 Annual Research Report
  • [Book] Hospitalist2020

    • Author(s)
      真鍋徳子
    • Publisher
      メディカルサイエンスインターナショル
    • Related Report
      2020 Research-status Report
  • [Book] 臨床放射線臨時増刊号2020

    • Author(s)
      真鍋治、小梁川和宏、納谷昌直、相川忠夫、平田健司、小林健太郎、古家翔、真鍋徳子、立石宇貴秀
    • Publisher
      金原出版
    • Related Report
      2020 Research-status Report
  • [Book] 循環器内科2020

    • Author(s)
      平田健司、真鍋治、真鍋徳子
    • Publisher
      画像診断におけるAI:texture解析とdeep learningを中心に
    • Related Report
      2020 Research-status Report
  • [Remarks] 自治医大教員データベース

    • URL

      http://kyouingyousekidb.jichi.ac.jp/profile/ja.2fa7d8721a2bac63.html

    • Related Report
      2022 Annual Research Report

URL: 

Published: 2020-04-28   Modified: 2024-01-30  

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