Inflammation imaging of coronary plaque and perivascular adipose tissue by digital PET/CT
Project/Area Number |
20K08052
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Review Section |
Basic Section 52040:Radiological sciences-related
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Research Institution | Ehime University |
Principal Investigator |
Miyagawa Masao 愛媛大学, 医学部附属病院, 教授 (90346685)
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Co-Investigator(Kenkyū-buntansha) |
川口 直人 愛媛大学, 医学部附属病院, 助教 (40837259)
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Project Period (FY) |
2020-04-01 – 2023-03-31
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Project Status |
Completed (Fiscal Year 2022)
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Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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Keywords | デジタル PET/CT / FDG / デジタルPET/CT / 血管炎 / FDG PET / PET/CT |
Outline of Research at the Start |
人体の局所の活動性炎症を非侵襲的に検出する方法として、F-18 fluorodeoxyglucose (FDG)を用いたポジトロン放出断層撮影(PET)をX線CTと重ね合わせるFDG PET/CTがある。半導体検出器: silicon photo-multiplierを搭載した最新型デジタルPET/CT装置を用いて、冠動脈硬化プラークおよび血管周囲脂肪組織の活動性炎症を可視化して心血管イベントのハイリスクグループを拾い上げ、イベントに至る前に予防・治療に結び付けることを目的とする。従来型PETに比べて解像度が約2倍、呼吸同期により空間分解能の劣化が67%改善する。心電図同期も併せて行う。
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Outline of Final Research Achievements |
Digital PET/CT with semiconductor detectors has excellent sensitivity and spacial resolution. We investigated its clinical usefulness in 150 patients with cardiovascular inflammatory diseases. For the evaluation of the activity of large vessel inflammation (outer diameter> 2-3 cm) such as Takayasu's arteritis and giant cell arteritis, the FDG accumulation in the vessel wall was a highly useful indicator by imaging analysis. The detection of periarteritis nodosa, which is inflammation of moderate vessels (outer diameter; 5-8 mm), was also improved. On the other hand, detection of FDG accumulation in coronary arteries and surrounding fat tissue was difficult due to lack of enough spatial resolution. FDG accumulation in peri-coronary fat was detected in IgG4-related diseases and atrial fibrillation, but the detection rate was low in coronary artery lesions with severe calcification.
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Academic Significance and Societal Importance of the Research Achievements |
原発性血管炎は,診断に難渋する症例が多く,その多くが難病に指定されている. 確定診断には血管から組織を採取し組織学的に活動性炎症を確認する. 代わりに動脈造影, CTおよびMR血管造影などが行われるが,活動性の評価は困難である. FDGは活動性炎症細胞浸潤部に集積するので活動性を評価でき, 免疫抑制剤等の治療適応の決定や効果判定の指標となる. 空間分解能に優れる半導体デジタルPET/CTを用いて高安動脈炎や巨細胞性動脈炎などの大血管炎, 中等度血管炎である結節性多発動脈炎について検出能の向上が確認され, IgG4関連疾患や心房細動などでは冠動脈周囲脂肪へのFDG集積が検出された.
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Report
(4 results)
Research Products
(33 results)
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[Journal Article] Clinical features and prognosis of isolated cardiac sarcoidosis diagnosed using new guidelines with dedicated FDG PET/CT.2023
Author(s)
Tomohisa Okada, Naoto Kawaguchi, Masao Miyagawa, Marika Matsuoka, Rami Tashiro, Yuki Tanabe, Tomoyuki Kido, Toru Miyoshi, Haruhiko Higashi, Takeshi Inoue, Hideki Okayama, Osamu Yamaguchi, Teruhito Kido.
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Journal Title
J Nuclear Cardiology
Volume: 30
Issue: 1
Pages: 280-289
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Quantitative Assessment Using the Compartment Model for Detecting Regional Coronary Artery Disease by Dynamic Myocardial Perfusion Single-Photon Emission Computed Tomography2022
Author(s)
Kawaguchi N, Miyagawa M, Okada T, Onishi K, Ishimura H, Tsuruoka K, Tanabe Y, Nakamura M, Kido T, Mochizuki T, Miyoshi T, Yamaguchi O, Kido T.
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Journal Title
Circulation Journal
Volume: 86
Issue: 5
Pages: 857-865
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2022-04-25
Related Report
Peer Reviewed / Open Access
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[Journal Article] JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases2021
Author(s)
Yamagishi Masakazu、Tamaki Nagara、Akasaka Takashi、Ikeda Takanori、Ueshima Kenji、Uemura Shiro、----------------、Kurata Akira、---、Yasuda Satoshi、Yoshino Hideaki、on behalf of the Japanese Circulation Society Working Group
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Journal Title
Circulation Journal
Volume: 85
Issue: 4
Pages: 402-572
DOI
NAID
ISSN
1346-9843, 1347-4820
Year and Date
2021-03-25
Related Report
Peer Reviewed / Open Access
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[Journal Article] Usefulness of albumin-globulin ratio as a clinical prognostic factor in patients with thyroid cancer treated with radioiodine.2021
Author(s)
Takata N, Miyagawa M, Matsuda T, Takakado M, Okada T, Kawaguchi N, Makita K, Ishikawa H, Tsuruoka S, Uwatsu K, Kido T.
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Journal Title
Ann Nucl Med
Volume: 35
Issue: 9
Pages: 1015-1021
DOI
Related Report
Peer Reviewed
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[Journal Article] Clinical significance of corrected relative flow reserve derived from 13N-ammonia positron emission tomography combined with coronary computed tomography angiography.2020
Author(s)
1.Kawaguchi N, Okayama H, Kido T, Fukuyama N, Shigematsu T, Kawamura G, Hiasa G, Kazatani Y, Inoue T, Miki H, Miyagawa M, Mochizuki T.
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Journal Title
J Nucl Cardiol.
Volume: 3
Issue: 5
Pages: 1851-1860
DOI
Related Report
Peer Reviewed
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[Presentation] Multicenter study of early versus delayed myocardial perfusion imaging with a CZT cardiac SPECT camera.2022
Author(s)
Kelly A, Bengel F, Camoni L, Cerudelli E, Diekmann J, Han L, Kawaguchi N, Keng F, Miyagawa M, Ratner H, Ruddy T, Wells RG.
Organizer
Society of Nuclear Medicine and Molecular Imaging 69th Annual Meeting
Related Report
Int'l Joint Research
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[Presentation] Multi-center evaluation of inter-site variability in SPECT myocardial blood flow measurement.2021
Author(s)
Wells RG, Bengel F, Camoni L, Cerudelli E, Cuddy-Walsh SG, Han L, Kawaguchi N, Felix Keng YJ, Miyagawa M, Ratner H, Romsa J, Ruddy TD.
Organizer
AHA Scientific Sessions
Related Report
Int'l Joint Research
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[Book] Chapter 7; FDG PET/CT for Sarcoidosis. In: Toyama H., Li Y., Hatazawa J., Huang G., Kubota K. (eds) PET/CT for Inflammatory Diseases.2020
Author(s)
Miyagawa M, Watanabe E, Kawaguchi N, Tashiro R, Sarai M, Manabe O, Oyama-Manabe N, Watanabe A, Toyama H.
Total Pages
25
Publisher
Springer, Singapore
ISBN
9789811508097
Related Report