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Development of cancer-targeted radiotheranostics drugs based on smart polymers

Research Project

Project/Area Number 20K08062
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKobe Pharmaceutical University

Principal Investigator

Sano Kohei  神戸薬科大学, 薬学部, 准教授 (00546476)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywordsセラノスティクス / イメージング / がん治療 / ポリマー / 放射性医薬品 / 核医学
Outline of Research at the Start

医薬品の可溶化剤等として臨床利用される生体適合水溶性ポリマーは、それ自体ががん組織に集積するか否かについて殆ど明らかにされていない。本研究では、種々の分子構造的特徴を有する水溶性ポリマーが如何なる機構でがん組織内に取り込まれるか、また、その放射性標識体ががんの核医学診断用薬剤になりうるかについて検証する。また、水溶性ポリマーが持つ熱応答凝集作用に着目し、熱をトリガーとしたがん組織へのポリマー送達量の改善ならびに、治療用放射性標識体を用いるがん治療の可能性を検証する。

Outline of Final Research Achievements

The purpose of this study was to develop polymer-based drugs that contribute to both highly accurate nuclear medicine diagnosis and therapy of cancers, known as radiotheranostics. We synthesized novel radiolabeled polymers that exhibits thermoresponsive aggregation as a smart polymer. The uptake by cancer cells and biodistributions were evaluated to select the optimal molecular structure as a diagnostic drug carrier targeting cancers. By combining it with hyperthermia treatment, we successfully achieved high accumulation of radiolabeled polymers in cancer tissues. Some of the polymers demonstrated a significant therapeutic effect against cancers, indicating the potential of using thermoresponsive polymer-based radiopharmaceuticals in cancer-targeted radiotheranostics.

Academic Significance and Societal Importance of the Research Achievements

近年、次世代ドラッグデリバリーシステム製剤の開発に対する期待は高く、がんの化学療法において、抗がん剤の生体内分布を量的かつ時空間的に制御し、がん特異的な治療効果を達成することは、がんの根治に繋がるのみならず、正常組織における副作用を低減し、患者の苦痛の軽減と療養生活の質の維持向上に貢献するものと考えられている。実際、本研究課題において、ポリマーを基盤とする放射性薬剤開発を推進し、温熱療法との組み合わせにより、高いがん集積性および高い治療効果を示す可能性を明らかとした。ポリマーに対する化学修飾の容易性の観点から、今後様々な抗がん剤を導入し、より高いがん治療効果を示す薬剤開発へと繋げていきたい。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (14 results)

All 2023 2022 2021 2020 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (8 results) (of which Int'l Joint Research: 2 results,  Invited: 1 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Development of Seed-type Radiopharmaceuticals Based on In Vivo Aggregation of Water-soluble Polymer for Cancer-targeted Radiotherapy2023

    • Author(s)
      Sano Kohei
    • Journal Title

      RADIOISOTOPES

      Volume: 72 Issue: 1 Pages: 43-47

    • DOI

      10.3769/radioisotopes.72.43

    • ISSN
      0033-8303, 1884-4111
    • Year and Date
      2023-03-15
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Feasibility of Using Poly[oligo(ethylene glycol) Methyl Ether Methacrylate] as Tumor-Targeted Carriers of Diagnostic Drugs2022

    • Author(s)
      Sano Kohei、Umemoto Koki、Miura Haruka、Ohno Satoshi、Iwata Kyohei、Kawakami Rin、Munekane Masayuki、Yamasaki Toshihide、Citterio Daniel、Hiruta Yuki、Mukai Takahiro
    • Journal Title

      ACS Applied Polymer Materials

      Volume: 4 Issue: 7 Pages: 4734-4740

    • DOI

      10.1021/acsapm.2c00312

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of a Poly(2-ethyl-2-oxazoline)-Based Fluorescence Imaging Probe Targeting the Folate Receptor in Tumor Tissues2021

    • Author(s)
      Sano Kohei、Suzuno Natsuka、Bao Ling、Haratake Yoshie、Kijima Kohei、Munekane Masayuki、Yamasaki Toshihide、Mukai Takahiro
    • Journal Title

      ACS Applied Polymer Materials

      Volume: 3 Issue: 10 Pages: 4889-4895

    • DOI

      10.1021/acsapm.1c00670

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Enhanced Delivery of Thermoresponsive Polymer-Based Medicine into Tumors by Using Heat Produced from Gold Nanorods Irradiated with Near-Infrared Light2021

    • Author(s)
      Sano Kohei、Ishida Yumi、Tanaka Toshie、Mizukami Tatsuya、Nagayama Tomono、Haratake Yoshie、Munekane Masayuki、Yamasaki Toshihide、Mukai Takahiro
    • Journal Title

      Cancers

      Volume: 13 Issue: 19 Pages: 5005-5005

    • DOI

      10.3390/cancers13195005

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 水溶性ポリマーを基盤とするがんのラジオセラノスティクス薬剤の開発2022

    • Author(s)
      佐野 紘平
    • Organizer
      第59回アイソトープ・放射線研究発表会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Internal radiotherapy of tumors using radiolabeled thermoresponsive polymers via self-aggregation under hyperthermic conditions2021

    • Author(s)
      Kohei Sano, Tatsuya Mizukami, Toshie Tanaka, Katsushi Takahashi, Yoshie Haratake, Masayuki Munekane, Toshihide Yamasaki, Takahiro Mukai
    • Organizer
      SNMMI 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Internal radiotherapy of tumors using radiolabeled polymers that thermoresponsively self-aggregate under hyperthermic conditions2021

    • Author(s)
      Kohei Sano, Tatsuya Mizukami, Toshie Tanaka, Katsushi Takahashi, Yoshie Haratake, Masayuki Munekane, Toshihide Yamasaki, Takahiro Mukai
    • Organizer
      CJKSRS2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 水溶性ポリマーPOEGMAのがん診断用薬剤キャリアとしての有効性評価:ポリマーの物理化学的特性が体内動態に与える影響2021

    • Author(s)
      梅本 晃暉、佐野 紘平、三浦 悠、大野 哲史、岩田 匡平、田中 寿枝、宗兼 将之、山﨑 俊栄、チッテリオ ダニエル、蛭田 勇樹、向 高弘
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Research-status Report
  • [Presentation] Poly[oligo(ethylene glycol) methyl ether methacrylate]を母体とするがんの蛍光イメージングプローブの開発2020

    • Author(s)
      三浦 悠、佐野 紘平、山﨑 俊栄、宗兼 将之、澤田 和紀、チッテリオ ダニエル、蛭田 勇樹、向 高弘
    • Organizer
      第36回日本DDS学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] がんのセラノスティクスを目指した水溶性ポリマーを基盤とするDDS製剤の開発2020

    • Author(s)
      佐野 紘平
    • Organizer
      第36回日本DDS学会学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] Polyoxazoline-based fluorescence imaging probe targeting folate receptor in cancers2020

    • Author(s)
      Kohei Sano, Masayuki Munekane, Toshihide Yamasaki, Takahiro Mukai
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 放射性標識熱応答凝集性ポリマーと光応答性金ナノロッドを組み合わせたがん治療法の開発2020

    • Author(s)
      佐野 紘平、石田 有美、水上 達也、田中 寿枝、原武 芳江、宗兼 将之、山﨑 俊栄、向 高弘
    • Organizer
      第60回日本核医学会学術総会
    • Related Report
      2020 Research-status Report
  • [Book] 中分子創薬に向けたDDS開発の新展開2022

    • Author(s)
      杉林堅次、佐野紘平 他(分担執筆)
    • Total Pages
      239
    • Publisher
      シーエムシー出版
    • ISBN
      9784781316598
    • Related Report
      2021 Research-status Report
  • [Remarks] 神戸薬科大学 薬品物理化学研究室 ホームページ

    • URL

      https://www.kobepharma-u.ac.jp/biophys/index.html

    • Related Report
      2022 Annual Research Report 2021 Research-status Report 2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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