Reconstruction of dose distributions using PET images in heavy ion therapy
| Project/Area Number |
20K08066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | National Institutes for Quantum Science and Technology |
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Principal Investigator |
Mohammadi Akram 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 先進核医学基盤研究部, 主任研究員 (10554735)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Project Status |
Granted (Fiscal Year 2022)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2021: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | dose reconstruction / PET image / ion therapy |
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| Outline of Research at the Start |
患者体内におけるビームの飛程確認は、粒子線治療の利点を最大化するために重要である。PETは、入射粒子と生体組織との反応から生成される陽電子放出核種を検出するために、最も広く研究されている方法であるが、実際に付与された線量を推定し、計画線量と直接比較する手法はまだ確立されていない。本研究では、PET画像から線量分布を再構成する手法を開発し、11Cを用いた治療前の飛程検証、及び計画線量との直接比較を可能にすることを目的とする。まず、均質なファントムや不均質なファントムに対して様々な分布の線量を照射し、推定手法の精度の評価を行う。そして、臨床相当のビームに対して適用し評価することで実現可能性を明らかにする。
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| Outline of Annual Research Achievements |
A method for prediction of dose profiles from PET images for 11C and 15O ion beams were developed. The depth dose was measured for both ion beams with mono-energetic and poly-energetic conditions in the carbon therapy facility of the Heavy Ion Medical Accelerator in Chiba (HIMAC). The PET images were obtained for an irradiated polymethyl methacrylate (PMMA) phantom with both beams under the same conditions using a prototype PET system. The results of the mono-energetic beams were used for prediction of the dose profiles for the poly-energetic beams and the predicted dose profiles were in overall good agreement with the measured ones.
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| Current Status of Research Progress |
Current Status of Research Progress
3: Progress in research has been slightly delayed.
Reason
For publication the accuracy and reproducibility of the data are essential. Therefore we are planning to perform more experiments. All experiments should be performed at the carbon therapy facility of the Heavy Ion Medical Accelerator in Chiba (HIMAC) using our prototype PET system and the number of experiments is so limited.
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| Strategy for Future Research Activity |
The development and optimization of the method for prediction of dose profiles are going to be carried out for the measured data of an irradiated PMMA phantom with 12C ion beam and radioactive ion beams of 11C with SOBP.
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Report
(3 results)
Research Products
(2 results)
