| Project/Area Number |
20K08066
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 52040:Radiological sciences-related
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| Research Institution | National Institutes for Quantum Science and Technology |
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Principal Investigator |
Mohammadi Akram 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 先進核医学基盤研究部, 主任研究員 (10554735)
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| Project Period (FY) |
2020-04-01 – 2024-03-31
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| Project Status |
Completed (Fiscal Year 2023)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2022: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000)
Fiscal Year 2021: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | Dose reconstruction / PET image / heavy ion therapy / dose reconstruction / ion therapy |
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| Outline of Research at the Start |
患者体内におけるビームの飛程確認は、粒子線治療の利点を最大化するために重要である。PETは、入射粒子と生体組織との反応から生成される陽電子放出核種を検出するために、最も広く研究されている方法であるが、実際に付与された線量を推定し、計画線量と直接比較する手法はまだ確立されていない。本研究では、PET画像から線量分布を再構成する手法を開発し、11Cを用いた治療前の飛程検証、及び計画線量との直接比較を可能にすることを目的とする。まず、均質なファントムや不均質なファントムに対して様々な分布の線量を照射し、推定手法の精度の評価を行う。そして、臨床相当のビームに対して適用し評価することで実現可能性を明らかにする。
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| Outline of Final Research Achievements |
It is desirable to verify the treatment during ion therapy. For this purpose, we developed a method for predicting the dose distributions from positron emission tomography (PET) images in ion therapy and demonstrated the validity of the method for 11C and 15O ion beams. The depth doses and PET images were measured in polymethyl methacrylate (PMMA) phantoms for both ion beams under the same conditions in the carbon therapy facility of the Heavy Ion Medical Accelerator in Chiba (HIMAC). The mono-energetic beams were used to reproduce the measured PET activity of the poly-energetic beams and then the depth doses were calculated using the proposed method. The predicted dose profiles were in overall good agreement with the measured ones and the distal fall-off positions at 80% of the Bragg peaks were also predicted within 0.2 mm for both 11C and 15O ion beams.
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| Academic Significance and Societal Importance of the Research Achievements |
Treatment verification is highly desirable in ion therapy to cover tumors with maximum dose and to spare normal tissues or organs at risk near the tumors. We developed a method to predict dose distribution from positron emission tomography (PET) images in ion therapy for treatment verification.
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