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Gadolinium neutron capture therapy as a new treatment for head and neck cancer

Research Project

Project/Area Number 20K08094
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionKobe Gakuin University

Principal Investigator

Andoh Tooru  神戸学院大学, 薬学部, 助教 (50639226)

Co-Investigator(Kenkyū-buntansha) 市川 秀喜  神戸学院大学, 薬学部, 教授 (00248105)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords中性子捕捉療法 / ガドリニウム / 頭頸部腫瘍 / キトサン / ナノ粒子 / がん中性子捕捉療法 / 頭頸部がん
Outline of Research at the Start

本研究は,再発の頭頸部がんに対して,優れた治療効果を有するホウ素中性子捕捉療法においても治療が困難な巨大化する頭頸部がんに対して,申請者らが開発してきたガドリニウム中性子捕捉療法用製剤であるガドリニウム含有キトサンナノ粒子(Gd-nanoCP)を用いることが可能かを検討する.Gd-nanoCPが担がん動物において,腫瘍組織に蓄積し,治療効果を発揮しうるかを試みる.さらに腫瘍組織内への蓄積とその分布の改善を目指して,粒子径の変化,ゼータ電位の変化,投与方法の変化による影響を明らかにする.

Outline of Final Research Achievements

Neutron-capture therapy using nonradioactive 157Gd (Gd-NCT) is currently under development as a potential radiation therapy option for cancer. γ-rays emitted by the 157Gd (n, γ) 158Gd reaction offer deep tissue penetration (100 μm), expected to provide tu-mor-killing efficacy within bulky tumors such as head and neck cancers. We have previously developed gadolinium-loaded chitosan nanoparticles (Gd-nanoCPs) for controlled Gd delivery in Gd-NCT. Here, we investigated in vivo the antitumor effects of NCT for bulky tumors by intratumoral injection of these nanoparticles.
Remarkable tumor growth was observed in HOT control groups, while the NCT groups showed a suppression of tumor growth. The tumor mass was selectively suppressed without damage to the normal surrounding mucosa because Gd-nanoCP would not be penetrated into the surrounding tissue. Gd-NCT using Gd-nanoCPs could thus be a promising therapeutic option to shrink tumors close to the mucosa.

Academic Significance and Societal Importance of the Research Achievements

巨大化する腫瘍に対する治療方法は確立された方法があるものの効果が乏しい場合において,治療やQOLの維持に難渋する場合もある.
本研究ではGd-NCTが巨大腫瘍の腫瘍成長を抑制することを明らかとし,さらに同種の治療法であるホウ素中性子捕捉療法では,効果的であるものの承認薬のステボロニンが正常組織である粘膜組織に集積し,治療後に副作用がみられることが課題となっているのに対し,本研究で用いられたGd含有キトサンナノ粒子は腫瘍組織に対して付着・親和性を示すことで腫瘍組織内に滞留し,副作用がみられなかった.よって本粒子を使用したGd-NCTは,粘膜に近い腫瘍を縮小させる有望な治療選択肢となる可能性を持つ.

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (27 results)

All 2023 2022 2021 2020

All Journal Article (10 results) (of which Peer Reviewed: 4 results,  Open Access: 1 results) Presentation (17 results) (of which Int'l Joint Research: 4 results,  Invited: 2 results)

  • [Journal Article] Proposal of recommended experimental protocols for <i>in vitro</i> and <i>in vivo</i> evaluation methods of boron agents for neutron capture therapy2023

    • Author(s)
      Hattori Yoshihide、Andoh Tooru、Kawabata Shinji、Hu Naonori、Michiue Hiroyuki、Nakamura Hiroyuki、Nomoto Takahiro、Suzuki Minoru、Takata Takushi、Tanaka Hiroki、Watanabe Tsubasa、Ono Koji
    • Journal Title

      Journal of Radiation Research

      Volume: 64 Issue: 6 Pages: 859-869

    • DOI

      10.1093/jrr/rrad064

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gadolinium neutron capture therapy as a new treatment for head and neck cancer: tumor-killing effects on a masseter muscle invasion model2022

    • Author(s)
      T. Andoh, T. Fujimoto, M. Suzuki, T. Takata, Y. Sakurai and H. Ichikawa
    • Journal Title

      KURRI Progress Report 2021

      Volume: 1 Pages: 13-13

    • Related Report
      2022 Research-status Report
  • [Journal Article] Development of New Treatment Method for Epithelioid Sarcoma by BNCT2022

    • Author(s)
      T. Fujimoto, T. Andoh, Y. Sakurai, M. Suzuki
    • Journal Title

      KURRI Progress Report 2021

      Volume: 1 Pages: 179-179

    • Related Report
      2022 Research-status Report
  • [Journal Article] Mathematical modeling of coating time in dry particulate coating using mild vibration field with bead media described by DEM simulation2022

    • Author(s)
      T. Yasunaga, M. Yoshida, A. Shimosaka, Y. Shirakawa, T. Andoh, H. Ichikawa, N. Ogawa, H. Yamamoto
    • Journal Title

      Advanced Powder Technology

      Volume: 33 Issue: 11 Pages: 103779-103779

    • DOI

      10.1016/j.apt.2022.103779

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Design and preparation of nanocomposite acrylate coating agents for binder-free dry coating of 100 &#181;m-sized drug-containing particles and their coating performance2022

    • Author(s)
      T. Yasunaga, T. Andoh, N. Ogawa, H. Yamamoto, H. Ichikawa
    • Journal Title

      Eur J Pharm Biopharm

      Volume: 170 Pages: 133-143

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gadolinium neutron capture therapy as new treatment for head and neck cancer2021

    • Author(s)
      T. Andoh, T. Fujimoto, M. Suzuki, T. Takata, Y. Sakurai, H. Ichikawa
    • Journal Title

      KURRI Progress Report 2020

      Volume: 1 Pages: 30-30

    • Related Report
      2021 Research-status Report
  • [Journal Article] Preclinical study of boron neutron capture therapy for clear cell sarcoma using three human cell lines2020

    • Author(s)
      安藤 徹
    • Journal Title

      Drug Delivery System

      Volume: 35 Issue: 3 Pages: 262-263

    • DOI

      10.2745/dds.35.262

    • NAID

      130007930448

    • ISSN
      0913-5006, 1881-2732
    • Year and Date
      2020-07-25
    • Related Report
      2020 Research-status Report
  • [Journal Article] Influence of the particle size of gadolinium-loaded chitosan nanoparticles on their tumor-killing effect in neutron capture therapy in vitro2020

    • Author(s)
      T. Andoh, Y. Nakatani, M. Suzuki, Y. Sakurai, T. Fujimoto, H. Ichikawa
    • Journal Title

      Appl Radiat Isot.

      Volume: 164 Pages: 109270-109270

    • DOI

      10.1016/j.apradiso.2020.109270

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] 悪性腫瘍に対する中性子捕捉療法のためのガドリニウム製剤の創製2020

    • Author(s)
      市川 秀喜, 安藤 徹
    • Journal Title

      ファルマシア

      Volume: 56(5) Pages: 396-400

    • NAID

      130007841816

    • Related Report
      2020 Research-status Report
  • [Journal Article] Nanoparticulate formulations for neutron capture therapy: Evaluation of anti-tumor effect after intratumor injection2020

    • Author(s)
      T. Andoh, T. Fujimoto, M. Suzuki, T. Takata, Y. Sakurai, H. Ichikawa
    • Journal Title

      KURRI Progress Report 2019

      Volume: 1 Pages: 100-100

    • Related Report
      2020 Research-status Report
  • [Presentation] がん中性子捕捉療法用 Gd 含有キトサンナノ粒子の表面修飾が腫瘍内滞留性と抗腫瘍効果に与える影響2023

    • Author(s)
      安藤 徹,濵田夏帆,東 凌平,永繁佑亮,鶴迫聖華,鈴木 実,髙田卓志,櫻井良憲,松本 まり絵,市川秀喜
    • Organizer
      第40回 製剤と粒子設計シンポジウム
    • Related Report
      2023 Annual Research Report
  • [Presentation] 生分解性高分子のキトサンナノ粒子を提供します!2023

    • Author(s)
      安藤 徹,市川秀喜
    • Organizer
      APPIE産学官連携フェア2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] 肉腫に対するホウ素中性子捕捉療法(BNCT)適応の可能性と課題2023

    • Author(s)
      藤本卓也,安藤 徹,櫻井良憲,田中浩基,須藤 保,二瓶圭二,藤田郁夫,佐久間 淑子,市川秀喜,竹森俊幸,河本旭哉,秋末敏宏,黒田良祐,小野公二,鈴木 実
    • Organizer
      第6回日本サルコーマ治療研究学会学術集会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] がん中性子捕捉療法用Gd含有キトサンナノ粒子の開発:粒子表面修飾が及ぼす腫瘍内直接投与後の腫瘍殺傷効果への影響2023

    • Author(s)
      安藤 徹, 鶴迫聖華,東 凌平,永繁佑亮,松本 まり絵,鈴木 実,髙田卓志,櫻井良憲,市川秀喜
    • Organizer
      日本薬学会第143年会
    • Related Report
      2022 Research-status Report
  • [Presentation] がん中性子捕捉療法用Gd含有キトサンナノ粒子の開発:腫瘍内直接投与後の腫瘍滞留性に及ぼす粒子表面修飾の影響2022

    • Author(s)
      安藤 徹,鶴迫聖華,東 凌平,永繁佑亮,鈴木 実,髙田卓志,櫻井良憲,松本まり絵,市川秀喜
    • Organizer
      第18回日本中性子捕捉療法学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] BNCTを用いた類上皮肉腫に対する新たな治療方法の開発2022

    • Author(s)
      藤本卓也,安藤 徹,須藤 保,佐久間淑子,高田卓志,櫻井良憲,田中浩基,藤田郁夫,竹森俊幸,河本旭哉,黒田良祐,秋末敏宏,市川秀喜,廣瀬隆則,鈴木 実
    • Organizer
      第18回日本中性子捕捉療法学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] Gadolinium neutron capture therapy as a new treatment for head and neck cancer: tumor-killing effects on a masseter muscle invasion model2022

    • Author(s)
      T. Andoh, M. Matsumoto, R. Azuma, Y. Nagashige, T. Fujimoto, M. Suzuki, T. Takata, Y. Sakurai, H. Ichikawa
    • Organizer
      ICCCI2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] がんのホウ素中性子捕捉療法用p-borono-L-phenylalanine(L-BPA)ナノサスペンションの調製と体内動態評価2022

    • Author(s)
      安藤 徹,市川秀喜
    • Organizer
      第59回粉体に関する討論会
    • Related Report
      2022 Research-status Report
  • [Presentation] がん中性子捕捉療法のためのガドリニウム含有キトサンナノ粒子の開発:巨大腫瘍に対する抗腫瘍効果2022

    • Author(s)
      安藤 徹,藤本卓也,鈴木 実,高田卓志,櫻井良憲,市川秀喜
    • Organizer
      日本薬学会第141年会
    • Related Report
      2021 Research-status Report
  • [Presentation] がん中性子捕捉療法用Gd含有キトサンナノ粒子の開発と抗腫瘍効果の評価2021

    • Author(s)
      安藤 徹,鈴木 実,櫻井良憲,高田卓志,藤本卓也,市川秀喜
    • Organizer
      粉体工学会2021年度春期研究発表会
    • Related Report
      2021 Research-status Report
  • [Presentation] utaneous melanocytoma with CRTC1-TRIM11 fusionに対するBNCT2021

    • Author(s)
      藤本卓也,神谷伸彦,平塚純一,鈴木 実,森下雅之,櫻井良憲,藤田郁夫,佐久間淑子,後村大祐,渡部直史,田中了,藤田昌秀,安藤 徹,小野公二,廣瀬隆則
    • Organizer
      第17回日本中性子捕捉療法学会学術大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Evaluation of gadolinium neutron-capture therapy as a new therapeutic option for bulky tumors2021

    • Author(s)
      T. Andoh, T. Fujimoto, M. Suzuki, T. Takata, Y. Sakurai, H. Ichikawa
    • Organizer
      19th International Congress on Neutron Capture Therapy
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] T. Fujimotoa, N. Kamitani, J. Hiratsuka, M. Suzuki, M. Morishita, D. Atomura, T. Sudo, I. Fujita, Y. Sakurai, H. Tanaka, T. Takata, N. Kondo, K. Goto, T. Takai, T. Sakuma, T. Watabe, T. Kawamoto, R. Tanaka, H. Hara, M. Fujita, T. Andoh, T. Akisue, K. Ono, R. Kuroda, T. Hirose2021

    • Author(s)
      BNCT for cutaneous melanocytoma with CRTC1-TRIM11 fusion
    • Organizer
      19th International Congress on Neutron Capture Therapy
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Preparation of nanocrystal-coated microparticles to improve dissolution of poorly water-soluble drugs and their tableting2021

    • Author(s)
      T. Andoh, K. Fukushima, A. Fukuyama, H. Ichikawa
    • Organizer
      8th Asian Particle Technology Symposium APT2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 同所性腫瘍移植モデルを用いたBNCTの前臨床研究2020

    • Author(s)
      安藤 徹
    • Organizer
      令和2年度 京都大学複合原子力科学研究所 専門研究会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] がん中性子捕捉療法用Gd含有キトサンナノ粒子の開発:異なる粒子径を持つナノ粒子を用いた抗腫瘍効果の評価2020

    • Author(s)
      安藤 徹,鈴木 実,櫻井良憲,高田卓志,藤本卓也,市川秀喜
    • Organizer
      粉体工学会2020年度春期研究発表会
    • Related Report
      2020 Research-status Report
  • [Presentation] 明細胞肉腫(CCS)に対するホウ素中性子捕捉療法:CCSのLAT1の発現がp-borono-L-phenylalanineの腫瘍集積に与える影響2020

    • Author(s)
      安藤 徹,藤本卓也,和田 恵二郎,須藤 保,市川秀喜
    • Organizer
      日本薬学会 第141年会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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