Effects of longitudinal magnetic field on biological effectiveness of charged-particle therapy

• Project/Area Number: 20K08123
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 52040:Radiological sciences-related
• Research Institution: National Institutes for Quantum Science and Technology
• Principal Investigator: Inaniwa Taku 国立研究開発法人量子科学技術研究開発機構, 量子医科学研究所 物理工学部, グループリーダー (10446536)
• Co-Investigator(Kenkyū-buntansha): 松本 謙一郎 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線障害治療研究部, グループリーダー (10297046) ; 鈴木 雅雄 国立研究開発法人量子科学技術研究開発機構, 放射線医学総合研究所 放射線障害治療研究部, 上席研究員 (70281673)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2021: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
• Keywords: 粒子線治療 / 生物効果 / 外部磁場 / 平行磁場 / 細胞殺傷効果

Outline of Research at the Start

研究代表者等は、粒子線照射時に粒子線の進行方向と平行に外部磁場を掛けると粒子線の細胞殺傷効果が有意に増強される、粒子線の進行方向と直交する方向に外部磁場を掛けても細胞殺傷効果に変化がない、ことを世界で初めて確認した。しかしながら、この現象のメカニズムについては解明されていないのが現状である。本研究では、そのメカニズムを、物理的、生物的、化学的な側面から実験とシミュレーションにより解明する。本研究により、メカニズムが明らかになり、この現象が生体内など様々な条件下でも起こることが確認されれば、粒子線治療と平行磁場を組み合わせた、全く新しい効果的な粒子線治療の実現につながる可能性がある。

Outline of Final Research Achievements

We have investigated the effect of external magnetic fields on biological effectiveness of charged-particle beams. Exposure of human cancer and normal cells to the longitudinal magnetic fields of BL = 0.3 and 0.6 T significantly increased the biological effectiveness of carbon-ion beams, while exposure to the perpendicular magnetic fields of the same strengths did not alter significantly the biological effectiveness. These phenomenon can be used to increase the tumor control probability of radioresistant tumors in the future. However, the underlying mechanisms for the findings have been still unclear. In this study, we conducted physical, chemical, and biological experiments to explore the underlying mechanisms and to investigate the feasibility of the treatments using the observed phenomenon, namely a magneto-particle therapy. We have found additional biological and chemical phenomenon under longitudinal magnetic field. However, the mechanism has not yet been elucidated.

Academic Significance and Societal Importance of the Research Achievements

平行磁場により粒子線の細胞殺傷効果が増強し、直交磁場ではそれが変化しないことは、研究代表者等が初めて確認した現象であり、その機序を解明する本研究テーマは、学術的独自性に富むものである。本現象の機序が明らかになり、この現象が生体内など様々な条件下でも起こることが確認されれば、粒子線治療と平行磁場を組み合わせた、全く新しい効果的な粒子線治療の実現につながる可能性がある。
本研究期間内に、磁場方向によって現れる効果が異なることを含め、平行磁場効果の機序解明には至らなかった。しかしながら、本研究により確認された新たな生物・化学・物理的な実験結果は、平行磁場効果の機序解明に資するものである。

Research Products

• [Journal Article] Microdosimetric investigation for multi-ion therapy by means of silicon on insulator (SOI) microdosimeter (2022)
  • Author(s): Sakata Dousatsu、Lee Sung Hyun、Tran Linh T、Pan Vladimir、Nakaji Taku、Mizuno Hideyuki、Kok Angela、Povoli Marco、Rosenfeld Anatoly、Inaniwa Taku
  • Journal Title: Physics in Medicine & Biology Volume: 67 Issue: 21 Pages: 215010-215010
  • DOI: 10.1088/1361-6560/ac8968
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Performance Evaluation for Repair of HSGc-C5 Carcinoma Cell Using Geant4-DNA (2021)
  • Author(s): Sakata Dousatsu、Suzuki Masao、Hirayama Ryoichi、Abe Yasushi、Muramatsu Masayuki、Sato Shinji、Belov Oleg、Kyriakou Ioanna、Emfietzoglou Dimitris、Guatelli Susanna、Incerti Sebastien、Inaniwa Taku
  • Journal Title: Cancers Volume: 13 Issue: 23 Pages: 6046-6046
  • DOI: 10.3390/cancers13236046
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Adaptation of stochastic microdosimetric kinetic model to hypoxia for hypo-fractionated multi-ion therapy treatment planning (2021)
  • Author(s): Inaniwa Taku、Kanematsu Nobuyuki、Shinoto Makoto、Koto Masashi、Yamada Shigeru
  • Journal Title: Physics in Medicine & Biology Volume: 66 Issue: 20 Pages: 205007-205007
  • DOI: 10.1088/1361-6560/ac29cc
  • Peer Reviewed
• [Journal Article] Application of lung substitute material as ripple filter for multi-ion therapy with helium-, carbon-, oxygen-, and neon-ion beams. (2021)
  • Author(s): Taku Inaniwa, Yasushi Abe, Masao Suzuki, Sung Hyun Lee, Kota Mizushima, Taku Nakaji, Dousatsu Sakata, Shinji Sato, Yoshiyuki Iwata, Nobuyuki Kanematsu, Toshiyuki Shirai
  • Journal Title: Physics in Medicine and Biology Volume: 66 Issue: 5 Pages: 1-10
  • DOI: 10.1088/1361-6560/abde99
  • Peer Reviewed / Open Access
• [Journal Article] Effects of loading a magnetic field longitudinal to the linear particle-beam track on yields of reactive oxygen species in water (2021)
  • Author(s): Matsumoto Ken-ichiro、Nakanishi Ikuo、Abe Yasushi、Sato Shinji、Kohno Ryosuke、Sakata Dousatsu、Mizushima Kota、Lee Sung Hyun、Inaniwa Taku
  • Journal Title: Free Radical Research Volume: 55 Issue: 5 Pages: 547-555
  • DOI: 10.1080/10715762.2021.1970151
  • Peer Reviewed / Open Access
• [Journal Article] Effect of external magnetic fields on biological effectiveness of proton beams (2020)
  • Author(s): T. Inaniwa, M. Suzuki, S. Sato, M. Muramatsu, A. Noda, Y. Iwata, N. Kanematsu, T. Shirai, K. Noda
  • Journal Title: Int. J. Radiat. Oncol. Biol. Phys. Volume: 106 Issue: 3 Pages: 597-603
  • DOI: 10.1016/j.ijrobp.2019.10.040
  • Peer Reviewed
• [Journal Article] Biomedical research program at present and future high-energy particle accelerators. (2020)
  • Author(s): V. Patera, Y. Prezado, F. Azaiez, G. Battistoni, D. Bettoni, S. Brandenburg, A. Bugay, G. Cuttone, D. Dauvergne, G. France, C. Graeff, T. Haberer, T. Inaniwa, S. Incerti, E. Nasonova, A. Navin, M. Pullia, S. Rossi, C. Vandevoorde, M. Durante
  • Journal Title: Frontiers in Physics Volume: 8
  • DOI: 10.3389/fphy.2020.00380
  • Peer Reviewed
• [Journal Article] Fully integrated Monte Carlo simulation for evaluating radiation induced DNA damage and subsequent repair using Geant4-DNA (2020)
  • Author(s): D. Sakata, O. Belov, M-C. Bordage, D. Emfietzoglou, S. Guatelli, T. Inaniwa, V. Ivanchenko, M. Karamitros, I. Kyriakou, N. Lampe, I. Petrovic, A. Ristic-Fira, W-G. Shin, S. Incerti
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 20788-20788
  • DOI: 10.1038/s41598-020-75982-x
  • Peer Reviewed / Open Access
• [Presentation] Development of a Quantum Scalpel (2023)
  • Author(s): Taku Inaniwa
  • Organizer: MMND & ITRO 2023
  • Int'l Joint Research / Invited
• [Presentation] Radiation biology and biological modeling for ion beam therapy (2022)
  • Author(s): Taku Inaniwa
  • Organizer: IUPESM WC2022
  • Int'l Joint Research / Invited
• [Presentation] Biological model for carbon-ion radiotherapy treatment planning (2022)
  • Author(s): Taku Inaniwa
  • Organizer: Carbon Therapy Grand Rounds 2022
  • Int'l Joint Research / Invited
• [Presentation] Mechanistic biological model for charged-particle therapy treatment planning (2022)
  • Author(s): Taku Inaniwa
  • Organizer: AOCMP 2022
  • Int'l Joint Research / Invited
• [Presentation] Radiation Biology for Particle Therapy Treatment Planning (2022)
  • Author(s): Taku Inaniwa
  • Organizer: PTCOG-AO 2022
  • Int'l Joint Research / Invited
• [Presentation] Developments of hypo-fractionated multi-ion therapy at QST (2022)
  • Author(s): Taku Inaniwa
  • Organizer: 3rdRAON School of Bio-Medical Research
  • Int'l Joint Research / Invited
• [Presentation] Michrodosimetric Kinetic Model for carbon-ion radiotherapy treatment planning (2022)
  • Author(s): Taku Inaniwa
  • Organizer: 27th International Symposium of Yonsei Song-dang Institute for Cancer Research
  • Int'l Joint Research / Invited
• [Presentation] Physical and biological models for carbon-ion radiotherapy treatment planning (2021)
  • Author(s): Taku Inaniwa
  • Organizer: Carbon Ion Therapy Symposium
  • Int'l Joint Research / Invited
• [Presentation] Current status and future perspective of heavy-ion therapy at NIRS, QST (2021)
  • Author(s): Taku Inaniwa
  • Organizer: GSI biophysics seminar
  • Int'l Joint Research / Invited
• [Presentation] Effect of longitudinal magnetic field to the linear particle beam track on yields of hydroxyl radical and hydrogen peroxide in water (2021)
  • Author(s): K. Matsumoto
  • Organizer: 20th Biennial Meeting of SFRR international
  • Int'l Joint Research
• [Presentation] Stochastic microdosimetric kinetic model for hypo-fractionated multi-ion therapy (2020)
  • Author(s): T. Inaniwa
  • Organizer: MMND 2020
  • Int'l Joint Research / Invited
• [Presentation] Nuclear applied physics and biophysics at HIMAC (2020)
  • Author(s): T. Inaniwa
  • Organizer: IBC 2020
  • Int'l Joint Research / Invited