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Novel hyperthermia using high-precision electromagnetic field simulation technology

Research Project

Project/Area Number 20K08146
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52040:Radiological sciences-related
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

Takayuki Ohguri  産業医科大学, 医学部, 准教授 (80469395)

Co-Investigator(Kenkyū-buntansha) 黒田 輝  東海大学, 情報理工学部, 教授 (70205243)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2020: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Keywords温熱療法 / ハイパーサーミア / サーマル ドーズ / 温熱治療計画 / 高精度放射線治療 / がん集学的治療 / 温度シミュレーション / 温度分布 / IMRT / SAR分布 / 電磁界シミュレーション / 強度変調放射線治療 / 数値シミュレーション / 放射線治療
Outline of Research at the Start

がんに対する温熱療法は直接的な殺細胞効果、放射線治療や抗がん剤の効果を増感することが基礎研究において広く証明されている。しかし、温熱療法が広く普及しない大きな理由は以下の2点に集約される。1) 多くの癌が存在する深部領域への加温集中性が不良である点、2) 腫瘍温度と加温時間から算出される”Thermal dose”の客観性が低い点である。本研究では、高精度な電磁界シミュレーションにより深部領域の加温集中性やThermal doseの信頼性を担保し、高精度放射線治療や免疫チェックポイント阻害薬をも含めた近年の癌集学的治療の中における温熱療法の貢献をより科学的に探索するものである。

Outline of Final Research Achievements

The major reasons for the lack of widespread use of hyperthermia can be summarized into the following three points: 1) poor concentration of heating in deep areas where many cancers exist, 2) delay in the development of a heating method (capacity-coupled heating) that takes advantage of the advantage of the Japanese, who tend to have thin body types, and 3) large differences in the achieved thermal dose, an objective measure of thermal dosage, among patients. 3) The achievement value of thermal dose, which is an objective measure of thermal dosage, varies widely among patients, resulting in individual differences in therapeutic effects.
This study is to plan hyperthermia according to patient body shape and target by using electromagnetic field simulation. Furthermore, it is to select more effective heating methods, predict the thermal dose that can be administered, and explore more scientifically the contribution of thermal therapy in the recent multidisciplinary treatment of cancer.

Academic Significance and Societal Importance of the Research Achievements

Compared to molecular targeted drugs and immunotherapy, hyperthermia has high potential in terms of health economic benefits as an inexpensive method to improve anti-cancer efficacy. This is a valuable study for the use of hyperthermia as a further step toward multidisciplinary treatment.

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (8 results)

All 2022 2021 2020

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 3 results) Presentation (5 results) (of which Int'l Joint Research: 3 results,  Invited: 2 results)

  • [Journal Article] Intensity-Modulated Radiotherapy with Regional Hyperthermia for High-Risk Localized Prostate Carcinoma2022

    • Author(s)
      Nakahara Sota、Ohguri Takayuki、Kakinouchi Sho、Itamura Hirohide、Morisaki Takahiro、Tani Subaru、Yahara Katuya、Fujimoto Naohiro
    • Journal Title

      Cancers

      Volume: 14 Issue: 2 Pages: 400-400

    • DOI

      10.3390/cancers14020400

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Optimization of the Clinical Setting Using Numerical Simulations of the Electromagnetic Field in an Obese Patient Model for Deep Regional Hyperthermia of an 8 MHz Radiofrequency Capacitively Coupled Device in the Pelvis2021

    • Author(s)
      Ohguri Takayuki、Kuroda Kagayaki、Yahara Katsuya、Nakahara Sota、Kakinouchi Sho、Itamura Hirohide、Morisaki Takahiro、Korogi Yukunori
    • Journal Title

      Cancers

      Volume: 13 Issue: 5 Pages: 979-979

    • DOI

      10.3390/cancers13050979

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Salvage re-irradiation with intensity-modulated radiotherapy, chemotherapy combined with hyperthermia for local recurrence of nasopharyngeal carcinoma after chemoradiotherapy2021

    • Author(s)
      Takahiro MORISAKI、Takayuki OHGURI、Katsuya YAHARA 、Sota NAKAHARA 1 , Sho KAKINOUCHI 1 , Hirohide ITAMURA ,Tetsuro WAKASUGI , Hideaki SUZUKI、Yukunori KOROGI
    • Journal Title

      Journal of UOEH

      Volume: -

    • NAID

      130008084893

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 血液灌流量の温度依存性ならびに加温領域の導電性を考慮した 前立腺がん加温に関する基礎検討2022

    • Author(s)
      円道大貴、大栗隆行、小山豪雄 、黒田輝
    • Organizer
      日本ハイパーサーミア学会第39回大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Numerical simulation analyses of 8MHz capacitive coupled heating for a patient with a bile duct metallic stent2022

    • Author(s)
      Takahiro Morisaki, Takayuki Ohguri, Sota Nakahara, Sho Kakinouchi, Subaru Tani , Kagayaki Kuroda
    • Organizer
      13th International Congress of Hyperthermic Oncology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Feasibility and new developments in radiofrequency capacitive hyperthermia 2022

    • Author(s)
      Takayuki Ohguri
    • Organizer
      13th International Congress of Hyperthermic Oncology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Optimisation for deep regional hyperthermia using 8 MHz radiofrequency capacitively coupled device for a female obese patient with lung cancer – numerical simulation analyses if the subcutaneous fat located near the lung cancer was excised2022

    • Author(s)
      Hirohide Itamura, Takayuki Ohguri, Sota Nakahara, Sho Kakinouchi, Takahiro Morisaki, Subaru Tani
    • Organizer
      13th International Congress of Hyperthermic Oncology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 深部領域加温の最適化とThermal doseの重要性2020

    • Author(s)
      大栗隆行
    • Organizer
      日本ハイパーサーミア学会 第38回大会
    • Related Report
      2020 Research-status Report
    • Invited

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Published: 2020-04-28   Modified: 2024-01-30  

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