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子どもの視空間注意の神経基盤の解明~縦断的コホート研究~

Research Project

Project/Area Number 20K08182
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionSaga University (2022-2023)
Kyushu University (2020-2021)

Principal Investigator

實藤 雅文  佐賀大学, 医学部, 准教授 (50467940)

Co-Investigator(Kenkyū-buntansha) 伊良皆 啓治  九州大学, システム情報科学研究院, 教授 (20211758)
Project Period (FY) 2020-04-01 – 2025-03-31
Project Status Granted (Fiscal Year 2023)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2023: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords発達 / 視空間注意機能 / 眼球運動追跡装置 / 視空間注意
Outline of Research at the Start

我々は、小児のコホート集団を対象として視空間注意を惹起するタスクについて、アイトラッカー(視線追跡装置)を用いて行動学的指標の収集を継続している。本研究では、その蓄積されたデータを縦断的に解析することで視空間注意の発達の軌跡を描出し、子どもの認知行動のみならず、注意欠如・多動性障害などの発達障害についても、その神経基盤を明らかにする。さらに8歳ではアイトラッカーと近赤外線スペクトロスコピー(NIRS)の同時計測を実施することにより、子どもの学習法について脳科学的な裏付けを与える。

Outline of Annual Research Achievements

注意の持続困難は、注意欠如多動症だけでなく自閉スペクトラム症でもしばしば観察され、神経発達症に合併する代表的な症状の一つである。また連続的な形質を持つため定型発達児にも程度の差はあれ認められることが多く、子どもが日常生活を送るうえで重要な問題となっている。しかしこれを司る視空間注意機構のメカニズムは、小児では十分に明らかにされていない。我々は、2015年より200人以上のコホート集団を対象として視空間注意を惹起するタスクを使用して、2・4・6・8歳時と縦断的にアイトラッカー(視線追跡装置)を用いてデータ収集を継続した。本研究の主な目的は、その蓄積されたデータを縦断的に解析することで視空間注意の発達の軌跡を描出し、子どもの認知行動との関連を明らかにすることである。令和3年度から2年間かけて、以前からの課題に加えて8歳のための課題を、および線2分法・利き手の調査など認知面を評価する様々な検査を実施し、2年間で計163人のデータを取得した。
令和5年度は参加者が10歳となり、時間的な制約もありアイトラッカー検査については見送ったが、線2分法・利き手の調査を実施することに加えてWISC-IVによる知能検査を、このコホートの参加者92名に対して実施することができた。この知能検査は、言語理解指標、知覚推理指標、ワーキングメモリー指標、処理速度指標と4つの下位項目からなり、これまで集積したアイトラッカー検査の結果との関連を、この下位項目と詳細に検討することで、本研究の目的を達成できると考えられる。

Current Status of Research Progress
Current Status of Research Progress

4: Progress in research has been delayed.

Reason

アイトラッカー解析の基本的なプラットフォームを作成するのに時間がかかっていることと、知能検査の結果を含めての解析を計画しているため。

Strategy for Future Research Activity

令和6年度も引き続き、残りの参加者の10歳のデータ収集を継続し、知能検査も含めた詳細な認知プロフィールのデータの取得を完了したい。そして、これまで収集したデータとの関連を検証していく予定である。

Report

(4 results)
  • 2023 Research-status Report
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (27 results)

All 2024 2023 2022 2021 2020

All Journal Article (23 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 23 results,  Open Access: 20 results) Presentation (4 results)

  • [Journal Article] Pediatric leukemia and maternal occupational exposure to anticancer drugs: the Japan Environment and Children’s Study2024

    • Author(s)
      Yamamoto Shunsuke、Sanefuji Masafumi、Suzuki Maya、Sonoda Yuri、Hamada Norio、Kato Wakako、Ono Hiroaki、Oba Utako、Nakashima Kentaro、Ochiai Masayuki、Kusuhara Koichi、Koga Yuhki、Ohga Shouichi
    • Journal Title

      Blood

      Volume: 143 Issue: 4 Pages: 311-319

    • DOI

      10.1182/blood.2023021008

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gestational Weight Gain Growth Charts Adapted to Japanese Pregnancies Using a Bayesian Approach in a Longitudinal Study: The Japan Environment and Children’s Study2023

    • Author(s)
      Naho Morisaki, Aurlie Piedvache, Seiichi Morokuma, Kazushige Nakahara, Masanobu Ogawa, Kiyoko Kato, Masafumi Sanefuji, Eiji Shibata, Mayumi Tsuji, Masayuki Shimono, Toshihiro Kawamoto, Shouichi Ohga, Koichi Kusuhara
    • Journal Title

      Journal of Epidemiology

      Volume: 33 Issue: 5 Pages: 217-226

    • DOI

      10.2188/jea.JE20210049

    • NAID

      130008079286

    • ISSN
      0917-5040, 1349-9092
    • Year and Date
      2023-05-05
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prenatal metal levels and congenital anomalies of the kidney and urinary tract: The Japan Environment and Children's Study2023

    • Author(s)
      Iwaya Yuka、Sanefuji Masafumi、Nishiyama Kei、Sonoda Yuri、Hamada Norio、Suga Reiko、Ochiai Masayuki、Shimono Masayuki、Kusuhara Koichi、Ohga Shouichi
    • Journal Title

      Science of The Total Environment

      Volume: 890 Pages: 164356-164356

    • DOI

      10.1016/j.scitotenv.2023.164356

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Poor response to methylphenidate is associated with a smaller dorsal attentive network in adult Attention-Deficit/Hyperactivity Disorder (ADHD)2023

    • Author(s)
      Parlatini Valeria、Radua Joaquim、Solanes Font Aleix、Wichers Rob、Maltezos Stefanos、Sanefuji Masafumi、Dell’Acqua Flavio、Catani Marco、Thiebaut de Schotten Michel、Murphy Declan
    • Journal Title

      Translational Psychiatry

      Volume: 13 Issue: 1 Pages: 303-303

    • DOI

      10.1038/s41398-023-02598-w

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Occupational exposure of pregnant women to refined oil and infant wheezing: Japan environment and children's study findings2023

    • Author(s)
      Kawamura Masaru、Shimono Masayuki、Suga Reiko、Yoshino Kiyoshi、Fujino Yoshihisa、Tsuji Mayumi、Sanefuji Masafumi、Ohga Shouichi、Hoshina Takayuki、Kusuhara Koichi、the Japan Environment and Children's Study (JECS) Group
    • Journal Title

      Clinical & Experimental Allergy

      Volume: 53 Issue: 12 Pages: 1302-1306

    • DOI

      10.1111/cea.14404

    • Related Report
      2023 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Longitudinal gut mycobiota changes in Japanese infants during first three years of life2023

    • Author(s)
      Mishima Riko、Tanaka Masaru、Momoda Rie、Sanefuji Masafumi、Morokuma Seiichi、Ogawa Masanobu、Kato Kiyoko、Nakayama Jiro
    • Journal Title

      Journal of Bioscience and Bioengineering

      Volume: 135 Issue: 4 Pages: 266-273

    • DOI

      10.1016/j.jbiosc.2023.01.007

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Shank3a/b isoforms regulate the susceptibility to seizures and thalamocortical development in the early postnatal period of mice2023

    • Author(s)
      Okuzono Sayaka、Fujii Fumihiko、Matsushita Yuki、Setoyama Daiki、Shinmyo Yohei、Taira Ryoji、Yonemoto Kousuke、Akamine Satoshi、Motomura Yoshitomo、Sanefuji Masafumi、Sakurai Takeshi、Kawasaki Hiroshi、Han Kihoon、Kato Takahiro A.、Torisu Hiroyuki、Kang Dongchon、Nakabeppu Yusaku、Sakai Yasunari、Ohga Shouichi
    • Journal Title

      Neuroscience Research

      Volume: in press Pages: 13-19

    • DOI

      10.1016/j.neures.2023.03.001

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Two differential cavities in syringomyelia of pediatric Chiari I malformation presenting with unilateral foot drop2023

    • Author(s)
      Higuchi Naoya、Nakamura Takuji、Yoshioka Fumitaka、Sanefuji Masafumi、Matsuo Muneaki
    • Journal Title

      Brain and Development

      Volume: 45 Issue: 3 Pages: 191-195

    • DOI

      10.1016/j.braindev.2022.11.007

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Fluctuations of aeroallergen-specific immunoglobulins and children's allergic profiles: Japan Environment & Children's Study of a pilot cohort2022

    • Author(s)
      Irahara Makoto、Yamamoto-Hanada Kiwako、Saito-Abe Mayako、Sato Miori、Miyaji Yumiko、Yang Limin、Mitsubuchi Hiroshi、Oda Masako、Sanefuji Masafumi、Ohga Shouichi、Ikegami Akihiko、Mise Nathan、Suga Reiko、Shimono Masayuki、Yamazaki Shin、Nakayama Shoji F.、Ohya Yukihiro
    • Journal Title

      Allergology International

      Volume: 71 Issue: 3 Pages: 335-344

    • DOI

      10.1016/j.alit.2022.01.002

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Lack of catch-up in weight gain may intermediate between pregnancies with hyperemesis gravidarum and reduced fetal growth: the Japan Environment and Children’s Study2022

    • Author(s)
      Morisaki Naho、Nagata Chie、Morokuma Seiichi、et al.
    • Journal Title

      BMC Pregnancy and Childbirth

      Volume: 22 Issue: 1 Pages: 199-199

    • DOI

      10.1186/s12884-022-04542-0

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of maternal hemoglobin levels during pregnancy with sleep and developmental problems in 1‐year‐old infants: A cohort study2022

    • Author(s)
      Nakahara Kazushige、Michikawa Takehiro、Morokuma Seiichi、Hamada Norio、Ogawa Masanobu、Kato Kiyoko、Sanefuji Masafumi、Shibata Eiji、Tsuji Mayumi、Shimono Masayuki、Kawamoto Toshihiro、Ohga Shouichi、Kusuhara Koichi、The Japan Environment and Children's Study Group
    • Journal Title

      Health Science Reports

      Volume: 5 Issue: 2

    • DOI

      10.1002/hsr2.552

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Maternal Chronic Disease and Congenital Anomalies of the Kidney and Urinary Tract in Offspring: A Japanese Cohort Study2022

    • Author(s)
      Nishiyama Kei、Sanefuji Masafumi、Kurokawa Mari、et al.
    • Journal Title

      American Journal of Kidney Diseases

      Volume: 80 Issue: 5 Pages: 619-628

    • DOI

      10.1053/j.ajkd.2022.03.003

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association of physical activity and sleep habits during pregnancy with autistic spectrum disorder in 3-year-old infants2022

    • Author(s)
      Nakahara Kazushige、Michikawa Takehiro、Morokuma Seiichi、et al.
    • Journal Title

      Communications Medicine

      Volume: 2 Issue: 1 Pages: 35-35

    • DOI

      10.1038/s43856-022-00101-y

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Critical vitamin deficiencies in autism spectrum disorder: Reversible and irreversible outcomes2022

    • Author(s)
      P. F. Chong, M. Torio, F. Fujii, Y. Hirata, W. Matsuoka, Y. Sonoda, et al.
    • Journal Title

      Eur J Clin Nutr

      Volume: 76 Issue: 11 Pages: 1618-1621

    • DOI

      10.1038/s41430-022-01170-x

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] The association between early formula and reduced risk of cow’s milk allergy during the first three year of life: a Japanese cohort study2022

    • Author(s)
      Ikari Kota、Tezuka Junichiro、Sanefuji Masafumi、et al.
    • Journal Title

      Allergy, Asthma & Clinical Immunology

      Volume: 18 Issue: 1 Pages: 71-71

    • DOI

      10.1186/s13223-022-00712-z

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The earliest enzyme replacement for infantile‐onset Pompe disease in Japan2022

    • Author(s)
      Tocan Vlad、Mushimoto Yuichi、Kojima‐Ishii Kanako、Matsuda Akane、Toda Naoko、Toyomura Daisuke、Hirata Yuichiro、Sanefuji Masafumi、Sawada Takaaki、Sakai Yasunari、Nakamura Kimitoshi、Ohga Shouichi
    • Journal Title

      Pediatrics International

      Volume: 64 Issue: 1

    • DOI

      10.1111/ped.15286

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] No association between prenatal lead exposure and neurodevelopment during early childhood in the Japan Environment and Children’s Study2022

    • Author(s)
      Inoue Hirosuke、Sanefuji Masafumi、Sonoda Yuri、et al.
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 15305-15305

    • DOI

      10.1038/s41598-022-19509-6

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of sleep quality with temperament among one-month-old infants in The Japan Environment and Children’s Study2022

    • Author(s)
      Kikuchi Kimiyo、Michikawa Takehiro、Morokuma Seiichi、Hamada Norio、Suetsugu Yoshiko、Nakahara Kazushige、Kato Kiyoko、Sanefuji Masafumi、Shibata Eiji、Tsuji Mayumi、Shimono Masayuki、Kawamoto Toshihiro、Ohga Shouichi、Kusuhara Koichi、The Japan Environment and Children’s Study Group
    • Journal Title

      PLOS ONE

      Volume: 17 Issue: 9 Pages: e0274610-e0274610

    • DOI

      10.1371/journal.pone.0274610

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Favorable outcomes of interferon-α and ribavirin treatment for a male with subacute sclerosing panencephalitis2021

    • Author(s)
      Sonoda Yuri、Sonoda Motoshi、Yonemoto Kousuke、Sanefuji Masafumi、Taira Ryoji、Motomura Yoshitomo、Ishimura Masataka、Torisu Hiroyuki、Kira Ryutaro、Kusuhara Koichi、Sakai Yasunari、Ohga Shouichi
    • Journal Title

      Journal of Neuroimmunology

      Volume: 358 Pages: 577656-577656

    • DOI

      10.1016/j.jneuroim.2021.577656

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Predictive values of early head computed tomography for survival outcome after cardiac arrest in childhood: a pilot study2021

    • Author(s)
      Tetsuhara Kenichi、Kaku Noriyuki、Watanabe Yuka、Kumamoto Masaya、Ichimiya Yuko、Mizuguchi Soichi、Higashi Kanako、Matsuoka Wakato、Motomura Yoshitomo、Sanefuji Masafumi、Hiwatashi Akio、Sakai Yasunari、Ohga Shouichi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 12090-12090

    • DOI

      10.1038/s41598-021-91628-y

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vitamin A deficiency?associated corneal perforation in a boy with autism spectrum disorder: A case report and literature review2021

    • Author(s)
      Adachi Shunichi、Torio Michiko、Okuzono Sayaka、Motomura Yoshitomo、Ichimiya Yuko、Sonoda Yuri、Nagata Jyunya、Okamoto Misato、Notomi Shoji、Sanefuji Masafumi、Sakai Yasunari、Ohga Shouichi
    • Journal Title

      Nutrition

      Volume: 90 Pages: 111275-111275

    • DOI

      10.1016/j.nut.2021.111275

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Age-related morphological differences in the spike-and-wave complexes of absence epilepsy2021

    • Author(s)
      Sonoda Yuri、Sanefuji Masafumi、Ichimiya Yuko、Torio Michiko、Watanabe Eriko、Sakata Ayumi、Ishizaki Yoshito、Sakai Yasunari、Ohga Shouichi
    • Journal Title

      Epilepsy Research

      Volume: 174 Pages: 106647-106647

    • DOI

      10.1016/j.eplepsyres.2021.106647

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] GNAO1 organizes the cytoskeletal remodeling and firing of developing neurons.2020

    • Author(s)
      Akamine S, Okuzono S, Yamamoto H, Setoyama D, Sagata N, Ohgidani M, Kato TA, Ishitani T, Kato H, Masuda K, Matsushita Y, Ono H, Ishizaki Y, Sanefuji M, Saitsu H, Matsumoto N, Kang D, Kanba S, Nakabeppu Y, Sakai Y, Ohga S.
    • Journal Title

      FASEB J

      Volume: 34 Issue: 12 Pages: 16601-16621

    • DOI

      10.1096/fj.202001113r

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 自己免疫的機序による自律神経障害を呈した小児例の臨床的多様性2023

    • Author(s)
      實藤雅文、前田寿幸、一ノ瀬文男、中村拓自、松尾宗明
    • Organizer
      第126回日本小児科学会学術総会
    • Related Report
      2023 Research-status Report
  • [Presentation] 自己免疫性自律神経障害の小児における心電図心拍変動の有用性2023

    • Author(s)
      實藤雅文、前田寿幸、一ノ瀬文男、中村拓自、松尾宗明
    • Organizer
      第65回日本小児神経学会学術総会
    • Related Report
      2023 Research-status Report
  • [Presentation] 母親の慢性疾患と児の先天性腎尿路異常:子どもの健康と環境に関する調査(エコチル調査)2023

    • Author(s)
      實藤雅文、西山 慶、黒川麻里、岩屋友香、濱田律雄、園田有里、小川昌宣、下野昌幸、菅 礼子7、楠原浩一、大賀 正一、子どもの健康と環境に関する全国調査研究グループ
    • Organizer
      第33回日本疫学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 脱力発作を示す小児てんかん~臨床像と脳波~2020

    • Author(s)
      實藤雅文、園田有里、鳥尾倫子、一宮優子、米元耕輔、平良遼志、酒井康成、大賀正一
    • Organizer
      第62回日本小児神経学会学術集会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-12-25  

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