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new therapy for neonatal hypoxic ischemic encephalopathy by the crosstalk between inflammatory cells and glial cells

Research Project

Project/Area Number 20K08211
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 52050:Embryonic medicine and pediatrics-related
Research InstitutionNagoya City University

Principal Investigator

Aoyama Mineyoshi  名古屋市立大学, 医薬学総合研究院(薬学), 教授 (70363918)

Co-Investigator(Kenkyū-buntansha) 垣田 博樹  愛知医科大学, 医学部, 准教授 (40528949)
山田 恭聖  愛知医科大学, 医学部, 教授 (60405165)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2023: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2021: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Keywords新生児低酸素性虚血性脳症 / 低体温療法 / 脳内炎症 / グリア / 微小環境 / ミクログリア / エリスロポエチン / 炎症性細胞
Outline of Research at the Start

著しい周産期医療の進歩の一方で、中枢神経の後遺症に苦しむ患児が存在する。低体温療法の普及により、多くの新生児低酸素性虚血性脳症(HIE)患者の予後を改善している。しかし、効果が不十分な症例や他の合併症によって適応を断念する例が存在する。本研究では、新生児のHIEに対して効果が期待されてきた低体温療法の作用メカニズムの解明と至適化に向けた研究を計画する。とくに、グリアによる脳内炎症の制御という観点から治療メカニズムの解明および補完できる新規治療ミックスを提案することを目指す。新生児医療におけるより効果的な低体温療法を提案し、新生児期中枢神経疾患の後遺症の予防法開発を目標とする。

Outline of Final Research Achievements

The development of the perinatal medicine can make the survival rate of newborn better. However, there are still severe issues about neurological sequelae in newborn after the intensive therapy. Hypothermic therapy has the neuroprotective effect on neonatal hypoxic ischemic encephalopathy (HIE). The therapeutic mechanism has not been clarified. In this study, we would show the mechanism of HIE and more effective therapy based on hypothermic therapy. In the cellular analysis, microglia and astrocyte had toxic activation under hypoxic ischemic conditions. However, hypothermic culture suppressed microglial toxic activation and astrocyte toxic activation. In the animal model analysis, hypothermic condition suppressed brain damage by the toxic activation of glial cells. These results may suggest a novel therapeutic approach to complement hypothermia therapy.

Academic Significance and Societal Importance of the Research Achievements

本研究の成果は、いまだ謎の多い脳保護治療である低体温療法の作用メカニズムの解明につながる成果であり、医療現場で効果が不十分な症例や他の合併症によって低体温療法を断念する症例に対する、新たな治療提案につながる。周産期医療の進歩の中で中枢神経の後遺症に苦しむ患児を救う提案である。子育て世代の誰もが直面するかもしれない出産におけるリスクの克服は少子化社会において社会的波及効果が期待できる。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (57 results)

All 2024 2023 2022 2021 2020

All Journal Article (31 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 31 results,  Open Access: 23 results) Presentation (26 results)

  • [Journal Article] Thrombopoietin exerts a neuroprotective effect by inhibiting the suppression of neuronal proliferation and axonal outgrowth in intrauterine growth restriction rats2024

    • Author(s)
      Takeshita Satoru、Kakita Hiroki、Nakamura Nami、Mori Mari、Toriuchi Kohki、Aoki Hiromasa、Inoue Yasumichi、Hayashi Hidetoshi、Yamada Yasumasa、Aoyama Mineyoshi
    • Journal Title

      Experimental Neurology

      Volume: 377 Pages: 114781-114781

    • DOI

      10.1016/j.expneurol.2024.114781

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ID3 is a novel target gene of p53 and modulates lung cancer cell metastasis2024

    • Author(s)
      Nagasaka Mai、Miyajima Chiharu、Inoue Yasumichi、Hashiguchi Sakura、Suzuki Yuya、Morishita Daisuke、Aoki Hiromasa、Toriuchi Kohki、Katayama Ryohei、Aoyama Mineyoshi、Hayashi Hidetoshi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 708 Pages: 149789-149789

    • DOI

      10.1016/j.bbrc.2024.149789

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SET8 is a novel negative regulator of TGF-β signaling in a methylation-independent manner2023

    • Author(s)
      Nagasaka Mai、Inoue Yasumichi、Nagao Yuji、Miyajima Chiharu、Morishita Daisuke、Aoki Hiromasa、Aoyama Mineyoshi、Imamura Takeshi、Hayashi Hidetoshi
    • Journal Title

      Scientific Reports

      Volume: 13 Issue: 1 Pages: 22877-22877

    • DOI

      10.1038/s41598-023-49961-x

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypothermia Attenuates Neurotoxic Microglial Activation via TRPV42023

    • Author(s)
      Fukuda Naoya、Toriuchi Kohki、Mimoto Rina、Aoki Hiromasa、Kakita Hiroki、Suzuki Yoshiaki、Takeshita Satoru、Tamura Tetsuya、Yamamura Hisao、Inoue Yasumichi、Hayashi Hidetoshi、Yamada Yasumasa、Aoyama Mineyoshi
    • Journal Title

      Neurochemical Research

      Volume: 49 Issue: 3 Pages: 800-813

    • DOI

      10.1007/s11064-023-04075-8

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Involvement of cardiac glycosides targeting Na/K-ATPase in their inhibitory effects on c-Myc expression <i>via</i> its transcription, translation and proteasomal degradation2023

    • Author(s)
      Tokugawa Muneshige、Inoue Yasumichi、Aoki Hiromasa、Miyajima Chiharu、Ishiuchi Kan'ichiro、Tsurumi Kento、Kujirai Chisane、Morishita Daisuke、Matsuno Michiyo、Mizukami Hajime、Ri Masaki、Iida Shinsuke、Makino Toshiaki、Aoyama Mineyoshi、Hayashi Hidetoshi
    • Journal Title

      The Journal of Biochemistry

      Volume: 175 Issue: 3 Pages: 253-263

    • DOI

      10.1093/jb/mvad085

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] AMPK activators suppress cholesterol accumulation in macrophages via suppression of the mTOR pathway2023

    • Author(s)
      Owaki Reina、Aoki Hiromasa、Toriuchi Kohki、Inoue Yasumichi、Hayashi Hidetoshi、Takeshita Satoru、Kakita Hiroki、Yamada Yasumasa、Aoyama Mineyoshi
    • Journal Title

      Experimental Cell Research

      Volume: 432 Issue: 1 Pages: 113784-113784

    • DOI

      10.1016/j.yexcr.2023.113784

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of tolvaptan in an infant with syndrome of inappropriate antidiuretic hormone secretion associated with holoprosencephaly: A case report2023

    • Author(s)
      Mori Mari、Takeshita Satoru、Nakamura Nami、Mizuno Yuki、Tomita Akiko、Aoyama Mineyoshi、Kakita Hiroki、Yamada Yasumasa
    • Journal Title

      World Journal of Clinical Cases

      Volume: 11 Issue: 26 Pages: 6262-6267

    • DOI

      10.12998/wjcc.v11.i26.6262

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Reovirus combined with a STING agonist enhances anti-tumor immunity in a mouse model of colorectal cancer2023

    • Author(s)
      Sugimura Naomi、Kubota Eiji、Mori Yoshinori、Aoyama Mineyoshi、Tanaka Mamoru、Shimura Takaya、Tanida Satoshi、Johnston Randal N.、Kataoka Hiromi
    • Journal Title

      Cancer Immunology, Immunotherapy

      Volume: 72 Issue: 11 Pages: 3593-3608

    • DOI

      10.1007/s00262-023-03509-0

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Successful Noninvasive Respiratory Management of an Infant with Bilateral Choanal Atresia and a Supernumerary Nostril Located on the Columella by a Mouthpiece: A Case Report2023

    • Author(s)
      Nakamura Nami、Kakita Hiroki、Takagi Mizuki、Asai Shimpei、Asai Takafumi、Mori Mari、Takeshita Satoru、Ueda Hiroko、Aoyama Mineyoshi、Kishimoto Mayuko、Ito Kunihiro、Yamada Yasumasa
    • Journal Title

      American Journal of Case Reports

      Volume: 24

    • DOI

      10.12659/ajcr.939642

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The DNMT3B Inhibitor Nanaomycin A as a Neuroblastoma TherapeuticAgent2023

    • Author(s)
      Izumi Kazuya、Aoki Hiromasa、Kakita Hiroki、Takeshita Satoru、Ueda Hiroko、Inoue Yasumichi、Hayashi Hidetoshi、Yamada Yasumasa、Aoyama Mineyoshi
    • Journal Title

      Current Cancer Drug Targets

      Volume: 23 Issue: 11 Pages: 837-842

    • DOI

      10.2174/1568009623666230522113645

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Monocyte-Derived miRNA-1914-5p Attenuates IL-1β?Induced Monocyte Adhesion and Transmigration2023

    • Author(s)
      Toriuchi Kohki、Kihara Toshie、Aoki Hiromasa、Kakita Hiroki、Takeshita Satoru、Ueda Hiroko、Inoue Yasumichi、Hayashi Hidetoshi、Shimono Yohei、Yamada Yasumasa、Aoyama Mineyoshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 3 Pages: 2829-2829

    • DOI

      10.3390/ijms24032829

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Combination of ATM and Chk1 Inhibitors Induces Synthetic Lethality in Colorectal Cancer Cells2023

    • Author(s)
      Tozaki Yuri、Aoki Hiromasa、Kato Rina、Toriuchi Kohki、Arame Saki、Inoue Yasumichi、Hayashi Hidetoshi、Kubota Eiji、Kataoka Hiromi、Aoyama Mineyoshi
    • Journal Title

      Cancers

      Volume: 15 Issue: 3 Pages: 735-735

    • DOI

      10.3390/cancers15030735

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypoxia increases cellular levels of phosphatidic acid and lysophospholipids in undifferentiated Caco‐2 cells2023

    • Author(s)
      Shimizu Yoshibumi、Tamiya‐Koizumi Keiko、Tsutsumi Toshihiko、Kyogashima Mamoru、Kannagi Reiji、Iwaki Soichiro、Aoyama Mineyoshi、Tokumura Akira
    • Journal Title

      Lipids

      Volume: 58 Issue: 2 Pages: 93-103

    • DOI

      10.1002/lipd.12366

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-1β promotes osteoclastogenesis by increasing the expression of IGF2 and chemokines in non-osteoclastic cells2023

    • Author(s)
      Otsuka Yuto、Kondo Takao、Aoki Hiromasa、Goto Yoh、Kawaguchi Yohei、Waguri-Nagaya Yuko、Miyazawa Ken、Goto Shigemi、Aoyama Mineyoshi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 151 Issue: 1 Pages: 1-8

    • DOI

      10.1016/j.jphs.2022.10.007

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Thrombocytopenia and insufficient thrombopoietin production in human small-for-gestational-age infants2022

    • Author(s)
      Takeshita Satoru、Kakita Hiroki、Asai Shimpei、Asai Takafumi、Mori Mari、Ueda Hiroko、Aoki Hiromasa、Aoyama Mineyoshi、Yamada Yasumasa
    • Journal Title

      Pediatric Research

      Volume: 93 Issue: 3 Pages: 619-624

    • DOI

      10.1038/s41390-022-02107-7

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Generation of Brain Microvascular Endothelial-like Cells from Human iPS Cell-Derived Endothelial Progenitor Cells Using TGF-β Receptor Inhibitor, Laminin 511 Fragment, and Neuronal Cell Culture Supplements2022

    • Author(s)
      Aoki Hiromasa、Yamashita Misaki、Hashita Tadahiro、Iwao Takahiro、Aoyama Mineyoshi、Matsunaga Tamihide
    • Journal Title

      Pharmaceutics

      Volume: 14 Issue: 12 Pages: 2697-2697

    • DOI

      10.3390/pharmaceutics14122697

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insights into Regulators of p53 Acetylation2022

    • Author(s)
      Nagasaka Mai、Miyajima Chiharu、Aoki Hiromasa、Aoyama Mineyoshi、Morishita Daisuke、Inoue Yasumichi、Hayashi Hidetoshi
    • Journal Title

      Cells

      Volume: 11 Issue: 23 Pages: 3825-3825

    • DOI

      10.3390/cells11233825

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hyperglycemia and Lactic Acidosis Associated with Linezolid Therapy in an Extremely Premature Infant2022

    • Author(s)
      Asai Takafumi、Kakita Hiroki、Nakamura Nami、Asai Shimpei、Mori Mari、Takeshita Satoru、Ueda Hiroko、Mizuno Yuki、Tomita Akiko、Aoyama Mineyoshi、Yamada Yasumasa
    • Journal Title

      Neonatology

      Volume: 119 Issue: 6 Pages: 781-784

    • DOI

      10.1159/000526702

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Cellular concentrations of plasmalogen species containing a polyunsaturated fatty acid significantly increase under hypoxia in human colorectal cancer, Caco2 cells2022

    • Author(s)
      Tamiya-Koizumi Keiko、Otoki Yurika、Nakagawa Kiyotaka、Kannagi Reiji、Mizutani Naoki、Suzuki Motoshi、Kyogashima Mamoru、Iwaki Soichiro、Aoyama Mineyoshi、Murate Takashi、Kitatani Kazuyuki、Kuga Takahisa、Mizutani Yasuyoshi、Tokumura Akira
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 611 Pages: 1-7

    • DOI

      10.1016/j.bbrc.2022.04.061

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insulin-like growth factor 2 promotes osteoclastogenesis increasing inflammatory cytokine levels under hypoxia2022

    • Author(s)
      Kondo Takao、Aoki Hiromasa、Otsuka Yuto、Kawaguchi Yohei、Waguri-Nagaya Yuko、Aoyama Mineyoshi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 149 Issue: 3 Pages: 93-99

    • DOI

      10.1016/j.jphs.2022.03.007

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Photodynamic therapy using mannose-conjugated chlorin e6 increases cell surface calreticulin in cancer cells and promotes macrophage phagocytosis2022

    • Author(s)
      Kimura Yuka、Aoki Hiromasa、Soyama Tatsuki、Sakuragi Akira、Otsuka Yuto、Nomoto Akihiro、Yano Shigenobu、Nishie Hirotada、Kataoka Hiromi、Aoyama Mineyoshi
    • Journal Title

      Medical Oncology

      Volume: 39 Issue: 6 Pages: 82-82

    • DOI

      10.1007/s12032-022-01674-3

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The Janus kinase inhibitor (baricitinib) suppresses the rheumatoid arthritis active marker gliostatin/thymidine phosphorylase in human fibroblast-like synoviocytes2022

    • Author(s)
      Joyo Yuji、Kawaguchi Yohei、Yonezu Hiroki、Senda Hiroya、Yasuma Sanshiro、Shiraga Hiroo、Nozaki Masahiro、Aoyama Mineyoshi、Asai Kiyofumi、Murakami Hideki、Waguri-Nagaya Yuko
    • Journal Title

      Immunologic Research

      Volume: 70 Issue: 2 Pages: 208-215

    • DOI

      10.1007/s12026-022-09261-4

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Inducible Nitric Oxide Synthase Pathway Promotes Osteoclastogenesis under Hypoxic Culture Conditions2021

    • Author(s)
      Kondo Takao、Otsuka Yuto、Aoki Hiromasa、Goto Yoh、Kawaguchi Yohei、Waguri-Nagaya Yuko、Miyazawa Ken、Goto Shigemi、Aoyama Mineyoshi
    • Journal Title

      The American Journal of Pathology

      Volume: 191 Issue: 12 Pages: 2072-2079

    • DOI

      10.1016/j.ajpath.2021.08.014

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Interleukin-1β enhances cell adhesion in human endothelial cells via microRNA-1914?5p suppression2021

    • Author(s)
      Kihara Toshie、Toriuchi Kohki、Aoki Hiromasa、Kakita Hiroki、Yamada Yasumasa、Aoyama Mineyoshi
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 27 Pages: 101046-101046

    • DOI

      10.1016/j.bbrep.2021.101046

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Three-dimensional spheroid culture induces apical-basal polarity and the original characteristics of immortalized human renal proximal tubule epithelial cells2021

    • Author(s)
      Mizuguchi Ken、Aoki Hiromasa、Aoyama Mineyoshi、Kawaguchi Yohei、Waguri-Nagaya Yuko、Ohte Nobuyuki、Asai Kiyofumi
    • Journal Title

      Experimental Cell Research

      Volume: 404 Issue: 1 Pages: 112630-112630

    • DOI

      10.1016/j.yexcr.2021.112630

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Insufficient thrombopoietin due to hepatic dysmature results in thrombocytopenia in small‐for‐gestational‐age rats2021

    • Author(s)
      Takeshita Satoru、Kakita Hiroki、Toriuchi Kohki、Aoki Hiromasa、Ueda Hiroko、Wakatsuki Akihiko、Yamada Yasumasa、Aoyama Mineyoshi
    • Journal Title

      British Journal of Haematology

      Volume: 192 Issue: 4

    • DOI

      10.1111/bjh.17294

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Photodynamic therapy exploiting the anti-tumor activity of mannose-conjugated chlorin e6 reduced M2-like tumor-associated macrophages2021

    • Author(s)
      Soyama Tatsuki、Sakuragi Akira、Oishi Daisuke、Kimura Yuka、Aoki Hiromasa、Nomoto Akihiro、Yano Shigenobu、Nishie Hirotada、Kataoka Hiromi、Aoyama Mineyoshi
    • Journal Title

      Translational Oncology

      Volume: 14 Issue: 2 Pages: 101005-101005

    • DOI

      10.1016/j.tranon.2020.101005

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hypothermia Attenuates Neuronal Damage via Inhibition of Microglial Activation, Including Suppression of Microglial Cytokine Production and Phagocytosis2021

    • Author(s)
      Kimura Tomoka、Toriuchi Kohki、Kakita Hiroki、Tamura Tetsuya、Takeshita Satoru、Yamada Yasumasa、Aoyama Mineyoshi
    • Journal Title

      Cellular and Molecular Neurobiology

      Volume: 41 Issue: 3 Pages: 459-468

    • DOI

      10.1007/s10571-020-00860-z

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Secreted Glycoprotein Reelin Suppresses the Proliferation and Regulates the Distribution of Oligodendrocyte Progenitor Cells in the Embryonic Neocortex2020

    • Author(s)
      Himari Ogino,1 Tsuzumi Nakajima,1 Yuki Hirota,2 Kohki Toriuchi,3 Mineyoshi Aoyama,3 Kazunori Nakajima,2 and Mitsuharu Hattoricorresponding author1
    • Journal Title

      J Neurosci.

      Volume: 40 Issue: 40 Pages: 7625-7636

    • DOI

      10.1523/jneurosci.0125-20.2020

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] IL-6 promotes cell adhesion in human endothelial cells via microRNA-126?3p suppression2020

    • Author(s)
      Ohta Momoka、Kihara Toshie、Toriuchi Kohki、Aoki Hiromasa、Iwaki Soichiro、Kakita Hiroki、Yamada Yasumasa、Aoyama Mineyoshi
    • Journal Title

      Experimental Cell Research

      Volume: 393 Issue: 2 Pages: 112094-112094

    • DOI

      10.1016/j.yexcr.2020.112094

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolonged astrocyte-derived erythropoietin expression attenuates neuronal damage under hypothermic conditions2020

    • Author(s)
      Kohki Toriuchi,1 Hiroki Kakita,1,2 Tetsuya Tamura,3 Satoru Takeshita,1,2 Yasumasa Yamada,2 and Mineyoshi Aoyamacorresponding author1
    • Journal Title

      J Neuroinflammation.

      Volume: 17 Issue: 1 Pages: 141-141

    • DOI

      10.1186/s12974-020-01831-3

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Hypoxic condition enhanced osteoclast differentiation via inducible nitric oxide synthase pathways.2023

    • Author(s)
      青山峰芳、近藤崇雄、大塚勇斗、青木啓将、鳥内皐暉、後藤洋、宮澤健、後藤滋己
    • Organizer
      第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Potential therapeutic agent nanaomycin A as a DNMT3B inhibitor in neuroblastoma.2023

    • Author(s)
      泉和弥、青木啓将、垣田博樹、竹下覚、上田博子、井上靖道、林秀敏、山田恭聖、青山峰芳
    • Organizer
      第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] miR-1914-5p regulates vascular endothelial cell-monocyte adhesion in the inflammatory environment of atherosclerosis2023

    • Author(s)
      鳥内皐暉、木原星衣、青木啓将、竹下覚、垣田博樹、山田恭聖、青山峰芳
    • Organizer
      第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Anti-tumor effect of mannose-conjugated chlorin e6 photodynamic therapy targeting M2-like tumor-associated macrophages2023

    • Author(s)
      青木 啓将、鳥内 皐暉、野元 昭宏、矢野 重信、西江 裕忠、片岡 洋望、青山峰芳
    • Organizer
      第97回日本薬理学会年会・第44回日本臨床薬理学会学術総会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Neuroprotective mechanisms of hypothermia by maintaining astrocytic erythropoietin production2023

    • Author(s)
      鳥内皐暉、垣田博樹、青木啓将、田村哲也、竹下覚、山田恭聖、青山峰芳
    • Organizer
      Neuroscience 2023
    • Related Report
      2023 Annual Research Report
  • [Presentation] 低温刺激はTRPV4を介してミクログリアの神経傷害的な活性化を抑制する2023

    • Author(s)
      三本里奈、鳥内皐暉、福田直哉、垣田博樹、青木啓将、田村哲也、竹下覚、山田恭聖、青山峰芳
    • Organizer
      日本薬学会東海支部総会・大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Hypothermia attenuates neurotoxic microglial activation via TRPV4 channel2023

    • Author(s)
      鳥内皐暉、福田直哉、垣田博樹、青木啓将、田村哲也、竹下覚、山田恭聖、青山峰芳
    • Organizer
      第66回日本神経化学会大会
    • Related Report
      2023 Annual Research Report
  • [Presentation] TRPV4-AMPK-NF-κB経路抑制を介する低温刺激によってミクログリアの過剰な炎症反応は鎮静化する2023

    • Author(s)
      三本里奈、鳥内皐暉、福田直哉、垣田博樹、青木啓将、田村哲也、竹下覚、山田恭聖、青山峰芳
    • Organizer
      日本薬理学会近畿部会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Hypothermic culture enhances secretion of astrocyte-derived neuroprotective erythropoietin.2022

    • Author(s)
      鳥内皐暉, 垣田博樹, 青木啓将, 田村哲也, 竹下覚, 山田恭聖, 青山峰芳
    • Organizer
      先端モデル動物支援プラットフォーム 若手支援技術講習会
    • Related Report
      2022 Research-status Report
  • [Presentation] IL-1βは非破骨細胞のケモカインとIGF2の発現を上昇させることで破骨細胞の分化を促進する2022

    • Author(s)
      大塚勇斗、青山峰芳
    • Organizer
      第40回日本骨代謝学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 非破骨細胞でのケモカインとIGF2の発現上昇を介して、IL-1βは破骨細胞の形成を促進する2022

    • Author(s)
      大塚勇斗、後藤洋、青木啓将、永谷裕子、宮澤健、後藤滋巳、青山峰芳
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Research-status Report
  • [Presentation] IL-1β enhances osteoclastgenesis by upregulating the expressions of IGF2 and chemokines in non-osteoclastic cells2022

    • Author(s)
      大塚勇斗、後藤洋、青木啓将、永谷裕子、宮澤健、後藤滋巳、青山峰芳
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Research-status Report
  • [Presentation] Neuroprotective effect of hypothermia by maintaining erythropoietin expression in astrocytes2021

    • Author(s)
      鳥内皐暉、垣田博樹、青木啓将、田村哲也、竹下覚、山田恭聖、青山峰芳
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Research-status Report
  • [Presentation] 低温培養によるアストロサイトのエリスロポエチン分泌亢進を介した神経保護効果2021

    • Author(s)
      鳥内皐暉、垣田博樹、青木啓将、田村哲也、竹下覚、山田恭聖、青山峰芳
    • Organizer
      医療薬学フォーラム2021
    • Related Report
      2021 Research-status Report
  • [Presentation] 低酸素刺激は一酸化窒素合成経路の活性化を介して破骨細胞分化を促進した2021

    • Author(s)
      近藤崇雄,大塚勇斗,益川成美,青木啓将,後藤洋,宮澤健,後藤滋己,青山峰芳
    • Organizer
      第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会 合同大会
    • Related Report
      2020 Research-status Report
  • [Presentation] CXCR4+CD45-細胞は低酸素条件において破骨細胞の形成を支える2021

    • Author(s)
      大塚勇斗,後藤洋,関谷健夫,青木啓将,永谷祐子,宮澤健,後藤滋己,青山峰芳
    • Organizer
      第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会 合同大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 低温培養はLPSによるミクログリアの神経傷害的な活性化を抑制する2021

    • Author(s)
      福田直哉、木村友香、鳥内皐暉、青木啓将、垣田博樹、田村哲也、竹下覚、山田恭聖、青山峰芳
    • Organizer
      第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会 合同大会
    • Related Report
      2020 Research-status Report
  • [Presentation] 低温培養はアストロサイトにおけるエリスロポエチン発現を持続させニューロンのアポトーシスを抑制する2021

    • Author(s)
      鳥内皐暉、垣田博樹、青木啓将、田村哲也、竹下覚、山田恭聖、青山峰芳
    • Organizer
      第126回日本解剖学会総会・全国学術集会 / 第98回日本生理学会大会 合同大会
    • Related Report
      2020 Research-status Report
  • [Presentation] miR-1914-5pは血管内皮細胞の単球接着性を変化させ動脈硬化の病変形成に関与する2020

    • Author(s)
      木原星衣、鳥内皐暉、青木啓将、垣田博樹、山田恭聖、青山峰芳
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 腫瘍関連マクロファージ(TAM)を標的とした光線力学療法(PDT)によるがんの治療2020

    • Author(s)
      木村優花、曽山樹、櫻木章、大石大祐、青木啓将、西江裕忠、野元昭宏、矢野重信、片岡洋望、青山峰芳
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 細胞周期チェックポイント阻害剤併用による抗腫瘍効果2020

    • Author(s)
      戸崎友梨、青木啓将、久保田英嗣、垣田博樹、山田恭聖、片岡洋望、青山峰芳
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 低温培養はミクログリアの神経傷害的な活性化を抑制し神経保護効果をもたらす2020

    • Author(s)
      鳥内皐暉、木村友香、垣田博樹、青木啓将、田村哲也、竹下覚、山田恭聖、青山峰芳
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 炎症性サイトカインが破骨細胞分化微小環境に与える影響2020

    • Author(s)
      益川成美、大塚勇斗、近藤崇雄、青木啓将、後藤洋、関谷健夫、宮澤健、後藤滋巳、青山峰芳
    • Organizer
      日本病院薬剤師会東海ブロック・日本薬学会東海支部 合同学術大会2020
    • Related Report
      2020 Research-status Report
  • [Presentation] 低温培養はミクログリアの過剰な炎症反応を鎮静し神経保護効果をもたらす2020

    • Author(s)
      鳥内皐暉、木村友香、垣田博樹、青木啓将、田村哲也、竹下覚、山田恭聖、青山峰芳
    • Organizer
      第138回 日本薬理学会近畿部会
    • Related Report
      2020 Research-status Report
  • [Presentation] 低温培養はミクログリアの活性化を制御し神経細胞死を抑制する2020

    • Author(s)
      鳥内皐暉、木村友香、垣田博樹、青木啓将、田村哲也、竹下覚、山田恭聖、青山峰芳
    • Organizer
      第67回中部日本生理学会
    • Related Report
      2020 Research-status Report
  • [Presentation] Hillの式を利用した破骨細胞分化の数理モデリングおよび破骨細胞分化メカニズムの解析2020

    • Author(s)
      泉 和弥、安冨 栄人、竹入 雅敏、野間 成人、肥田 重明、青山 峰芳、朝霧 成挙
    • Organizer
      第137回日本薬理学会近畿部会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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