The association of PCSK7 with coronary calcification

• Project/Area Number: 20K08415
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53020:Cardiology-related
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: Kataoka Yu 国立研究開発法人国立循環器病研究センター, 病院, 医長 (70463271)
• Co-Investigator(Kenkyū-buntansha): 古橋 眞人 札幌医科大学, 医学部, 教授 (20563852) ; 小倉 正恒 国立研究開発法人国立循環器病研究センター, 研究所, 室長 (30532486)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2023: ¥260,000 (Direct Cost: ¥200,000、Indirect Cost: ¥60,000); Fiscal Year 2022: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2020: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
• Keywords: PCSK7 / 石灰化 / 冠動脈 / 冠動脈石灰化 / 冠動脈疾患 / coronary calcification

Outline of Research at the Start

動脈硬化の進展過程において形成される冠動脈粥腫内石灰化は、脂質介入薬剤等の薬物治療では修飾困難な粥腫組織であり、冠動脈カテーテルインターベンションやバイパス術の成績にも影響を及ぼす。申請者は、糖・脂質代謝に関与するプロテアーゼ: proprotein convertase suxilisin/kexin type 7 (PCSK7)が、冠動脈石灰化成分形成に関与することを確認しており、本研究は、冠動脈粥腫内石灰化形成・進展におけるPCSK7の関与を解明することを目指す

Outline of Final Research Achievements

The association of OCT-derived calcification with PCSK7 levels was analyzed in 58 patients with CAD. An increase in PCSK7 level was associated with a greater calcification (r=0.56, p=0.04). We investigated whether PCSk7 level could predict future cardiovascular events in 280 patients. There was a trend toward an increased risk of cardiovascular events in association with elevated levels of PCSK7. In 282 healthy subjects, we investigated factors associated with PCSK7. Liver function, obesity and triglyceride were associated with PCSK7 levels.

Academic Significance and Societal Importance of the Research Achievements

PCSK7は石灰化形成や将来の心血管イベント発生に関与する可能性が示唆された。さらなる大多数の症例で検証を要する。

Research Products

• [Journal Article] Circulating PCSK7 Level is Independently Associated with Obesity, Triglycerides Level and Fatty Liver Index in a General Population without Medication (2022)
  • Author(s): Furuhashi Masato、Kataoka Yu、Nishikawa Ryo、Koyama Masayuki、Sakai Akiko、Higashiura Yukimura、Tanaka Marenao、Saitoh Shigeyuki、Shimamoto Kazuaki、Ohnishi Hirofumi
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 29 Issue: 9 Pages: 1275-1284
  • DOI: 10.5551/jat.63159
  • NAID: 130008091658
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2022-09-01
  • Peer Reviewed / Open Access
• [Journal Article] Phenotypic Features of Coronary Atheroma in Diabetic and Nondiabetic Patients With Low-Density Lipoprotein Cholesterol <55 mg/dL. (2022)
  • Author(s): Iwai T, Kataoka Y, Nicholls SJ, Puri R, Murata S, Nishimura K, Murai K, Kitahara S, Sawada K, Matama H, Honda S, Takagi K, Fujino M, Yoneda S, Otsuka F, Nishihira K, Asaumi Y, Miyamoto Y, Yasuda S, Noguchi T.
  • Journal Title: JACC Cardiovasc Imaging. 2022 Jun;15(6):1166-1169. Volume: 15 Issue: 6 Pages: 1166-1169
  • DOI: 10.1016/j.jcmg.2022.02.005
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Cardiac outcomes in patients with acute coronary syndrome attributable to calcified nodule (2021)
  • Author(s): Sugane Hiroki、Kataoka Yu、Otsuka Fumiyuki、Nakaoku Yuriko、Nishimura Kunihiro、Nakano Hiroki、Murai Kota、Honda Satoshi、Hosoda Hayato、Matama Hideo、Doi Takahito、Nakashima Takahiro、Fujino Masashi、Nakao Kazuhiro、Yoneda Shuichi、Tahara Yoshio、Asaumi Yasuhide、Noguchi Teruo、Kawai Kazuya、Yasuda Satoshi
  • Journal Title: Atherosclerosis Volume: 318 Pages: 70-75
  • DOI: 10.1016/j.atherosclerosis.2020.11.005
  • Peer Reviewed / Open Access
• [Presentation] Apolipoprotein CIII and Coronary Atherosclerosis under LDL-C Control with a Statin: (2022)
  • Author(s): 片岡 有
  • Organizer: 日本循環器学会学術集会総会Topics Session
  • Invited