Selection of bone marrow ALDH bright cells for treatment of pulmonary fibrosis focusing on changes in bone marrow characteristics

• Project/Area Number: 20K08519
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Hiroshima University
• Principal Investigator: NAKASHIMA Taku 広島大学, 病院(医), 助教 (90643792)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: Aldehyde dehydrogenase / ALDH / 線維化 / 細胞治療 / 骨髄 / 肺線維症 / 酸化ストレス / 性差 / aldehyde dehydrogenase / 骨髄幹細胞 / 間質性肺炎

Outline of Research at the Start

本研究では、様々な疾患に対して動物実験での有効性が確認された骨髄aldehyde dehydrogenase (ALDH)高発現細胞 (ALDHbr)の投与が、ヒト臨床試験で有効性を示さなかった原因を検証することを通じて、肺線維症に対して真に治療効果のある骨髄ALDHbr集団を明らかにすることを目的とする。
「疾患によって骨髄細胞の性質は変化する」という新たな視点に立ち、健常マウスと疾患マウス骨髄ALDHbrの性質および治療効果を確認する研究を計画している。本研究は、ヒト肺線維症を始めとした難病に対する新たな細胞治療への発展が期待できる。

Outline of Final Research Achievements

In this research project, we found the following 3 points.
1) Intravenous administration of bone marrow-derived ALDH-high expressing cells (ALDHbr) improves murine pulmonary fibrosis, 2) female-derived ALDHbr are more resistant to oxidative stress than males and have a higher therapeutic effect, and 3) antioxidant stress is an important mechanism by which bone marrow-derived ALDHbr improves fibrosis.
Since improvement was confirmed by administration during the fibrotic phase, ALDHbr is a promising cell therapy tool for clinical application to human pulmonary fibrosis that has already developed. On the other hand, gender differences in efficacy were evident. The fact that past clinical trials using ALDHbr did not show the expected effect from mouse experiments might be due to differences in efficacy by sex.

Academic Significance and Societal Importance of the Research Achievements

本研究においてLin―/ALDHbr治療により、ブレオマイシンの投与で発生する活性酸素種 (ROS)が抑制され線維化が抑制されるメカニズムを明らかとした。今日までいまだ有効な治療法のない肺線維症は、女性より男性に多く認められる。本研究によって得られた性差は、これらヒト臨床における性差と関連がある可能性がある。また、過去のALDHbrを用いた臨床試験においてマウス実験から期待されたほどの効果が認められなかったのは性差による効果の違いが関与している可能性があり、ドナーおよびレシピエントの性別に注意を払うことで過去に有効性を示すことができなかったALDHbr治療を再度見直す必要がある。

Research Products

• [Journal Article] Serum and bronchoalveolar lavage fluid levels of soluble B7H3 in patients with interstitial lung diseases (2023)
  • Author(s): Nakashima Taku、Omori Keitaro、Namba Masashi、Yamaguchi Kakuhiro、Sakamoto Shinjiro、Horimasu Yasushi、Masuda Takeshi、Miyamoto Shintaro、Iwamoto Hiroshi、Fujitaka Kazunori、Hamada Hironobu、Hattori Noboru
  • Journal Title: Respiratory Medicine Volume: 212 Pages: 107224-107224
  • DOI: 10.1016/j.rmed.2023.107224
  • Peer Reviewed / Open Access
• [Journal Article] Association between Plasminogen Activator Inhibitor-1 and Osimertinib Tolerance in EGFR-Mutated Lung Cancer via Epithelial-Mesenchymal Transition (2023)
  • Author(s): Tokumo Kentaro、Masuda Takeshi、Nakashima Taku、Namba Masashi、Yamaguchi Kakuhiro、Sakamoto Shinjiro、Horimasu Yasushi、Miyamoto Shintaro、Iwamoto Hiroshi、Fujitaka Kazunori、Miyata Yoshihiro、Okada Morihito、Hamada Hironobu、Hattori Noboru
  • Journal Title: Cancers Volume: 15 Issue: 4 Pages: 1092-1092
  • DOI: 10.3390/cancers15041092
  • Peer Reviewed / Open Access
• [Journal Article] Preserved ratio impaired spirometry with or without restrictive spirometric abnormality (2023)
  • Author(s): Miura Shinichiro、Iwamoto Hiroshi、Omori Keitaro、Yamaguchi Kakuhiro、Sakamoto Shinjiro、Horimasu Yasushi、Masuda Takeshi、Miyamoto Shintaro、Nakashima Taku、Fujitaka Kazunori、Hamada Hironobu、Yokoyama Akihito、Hattori Noboru
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 2988-2988
  • DOI: 10.1038/s41598-023-29922-0
  • Peer Reviewed / Open Access
• [Journal Article] Association of the RAGE/RAGE-ligand axis with interstitial lung disease and its acute exacerbation (2022)
  • Author(s): Yamaguchi Kakuhiro、Iwamoto Hiroshi、Sakamoto Shinjiro、Horimasu Yasushi、Masuda Takeshi、Miyamoto Shintaro、Nakashima Taku、Fujitaka Kazunori、Hamada Hironobu、Hattori Noboru
  • Journal Title: Respiratory Investigation Volume: 60 Issue: 4 Pages: 531-542
  • DOI: 10.1016/j.resinv.2022.04.004
  • Peer Reviewed / Open Access
• [Journal Article] Association Between Patient Preference for Inhaler Medications and Asthma Outcomes (2022)
  • Author(s): Nakanishi Y, Iwamoto H, Miyamoto S, Nakao S, Higaki N, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Matsumoto N, Nakashima T, Onari Y, Fujitaka K, Haruta Y, Hamada H, Hozawa S, Hattori N
  • Journal Title: Journal of Asthma and Allergy Volume: 15 Pages: 1539-1547
  • DOI: 10.2147/jaa.s381509
  • Peer Reviewed / Open Access
• [Journal Article] Characteristic computed tomography features in mesenchymal-epithelial transition exon14 skipping-positive non-small cell lung cancer (2022)
  • Author(s): Watari N, Yamaguchi K, Masuda T, Ito N, Sakamoto S, Horimasu Y, Miyamoto S, Nakashima T, Iwamoto H, Fujitaka K, Hamada H, Hattori N.
  • Journal Title: BMC Pulmonary Medicine Volume: 22 Issue: 1 Pages: 260-260
  • DOI: 10.1186/s12890-022-02037-4
  • Peer Reviewed / Open Access
• [Journal Article] Predictive value of serum high‐mobility group box 1 levels for checkpoint inhibitor pneumonitis (2022)
  • Author(s): Tanahashi Hiroki、Yamaguchi Kakuhiro、Kurose Koji、Nakao Satoshi、Sakamoto Shinjiro、Horimasu Yasushi、Masuda Takeshi、Miyamoto Shintaro、Nakashima Taku、Iwamoto Hiroshi、Fujitaka Kazunori、Hamada Hironobu、Oga Toru、Oka Mikio、Hattori Noboru
  • Journal Title: Respirology Volume: 28 Issue: 4 Pages: 380-388
  • DOI: 10.1111/resp.14425
  • Peer Reviewed
• [Journal Article] Predictive role of circulatory levels of high-mobility group box 1 for radiation pneumonitis in patients with non-small cell lung cancer treated with definitive thoracic radiotherapy (2022)
  • Author(s): Isoyama Shoko、Yamaguchi Kakuhiro、Imano Nobuki、Sakamoto Shinjiro、Horimasu Yasushi、Masuda Takeshi、Miyamoto Shintaro、Nakashima Taku、Iwamoto Hiroshi、Fujitaka Kazunori、Hamada Hironobu、Nagata Yasushi、Hattori Noboru
  • Journal Title: International Journal of Clinical Oncology Volume: 27 Issue: 11 Pages: 1698-1705
  • DOI: 10.1007/s10147-022-02239-0
  • Peer Reviewed
• [Journal Article] Accelerated decline in lung function in adults with a history of remitted childhood asthma. (2022)
  • Author(s): Miura S, Iwamoto H, Omori K, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Fujitaka K, Hamada H, Yokoyama A, Hattori N.
  • Journal Title: European Respiratory Journal Volume: 59 Issue: 1 Pages: 2100305-2100305
  • DOI: 10.1183/13993003.00305-2021
  • Peer Reviewed
• [Journal Article] Human bone marrow-derived mesenchymal stromal cells cultured in serum-free media demonstrate enhanced antifibrotic abilities via prolonged survival and robust regulatory T cell induction in murine bleomycin-induced pulmonary fibrosis (2021)
  • Author(s): Takao Shun、Nakashima Taku、Masuda Takeshi、Namba Masashi、Sakamoto Shinjiro、Yamaguchi Kakuhiro、Horimasu Yasushi、Miyamoto Shintaro、Iwamoto Hiroshi、Fujitaka Kazunori、Hamada Hironobu、Takahashi Shinya、Nakashima Ayumu、Hattori Noboru
  • Journal Title: Stem Cell Research & Therapy Volume: 12 Issue: 1 Pages: 506-506
  • DOI: 10.1186/s13287-021-02574-5
  • Peer Reviewed / Open Access
• [Journal Article] Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity (2021)
  • Author(s): Takahashi Hiroshi、Nakashima Taku、Masuda Takeshi、Namba Masashi、Sakamoto Shinjiro、Yamaguchi Kakuhiro、Horimasu Yasushi、Miyamoto Shintaro、Iwamoto Hiroshi、Fujitaka Kazunori、Hamada Hironobu、Hattori Noboru
  • Journal Title: Stem Cell Research & Therapy Volume: 12 Issue: 1 Pages: 471-471
  • DOI: 10.1186/s13287-021-02549-6
  • Peer Reviewed / Open Access
• [Journal Article] Prediction of radiation pneumonitis after definitive radiotherapy for locally advanced non-small cell lung cancer using multi-region radiomics analysis (2021)
  • Author(s): Kawahara Daisuke、Imano Nobuki、Nishioka Riku、Ogawa Kouta、Kimura Tomoki、Nakashima Taku、Iwamoto Hiroshi、Fujitaka Kazunori、Hattori Noboru、Nagata Yasushi
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 16232-16232
  • DOI: 10.1038/s41598-021-95643-x
  • Peer Reviewed / Open Access
• [Journal Article] Association between glucose intolerance and chemotherapy-induced lung injury in patients with lung cancer and interstitial lung disease (2021)
  • Author(s): Otani Toshihito、Yamaguchi Kakuhiro、Nakao Satoshi、Sakamoto Shinjiro、Horimasu Yasushi、Masuda Takeshi、Miyamoto Shintaro、Nakashima Taku、Iwamoto Hiroshi、Fujitaka Kazunori、Hamada Hironobu、Hattori Noboru
  • Journal Title: Cancer Chemotherapy and Pharmacology Volume: 88 Issue: 5 Pages: 857-865
  • DOI: 10.1007/s00280-021-04341-y
  • Peer Reviewed
• [Journal Article] Quantitative parameters of lymphocyte nuclear morphology in bronchoalveolar lavage fluid as novel biomarkers for sarcoidosis (2021)
  • Author(s): Horimasu Yasushi、Yamaguchi Kakuhiro、Sakamoto Shinjiro、Masuda Takeshi、Miyamoto Shintaro、Nakashima Taku、Iwamoto Hiroshi、Fujitaka Kazunori、Hamada Hironobu、Hattori Noboru
  • Journal Title: Orphanet Journal of Rare Diseases Volume: 16 Issue: 1 Pages: 298-298
  • DOI: 10.1186/s13023-021-01926-x
  • Peer Reviewed / Open Access
• [Journal Article] IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis. (2021)
  • Author(s): Nakanishi Y, Horimasu Y, Yamaguchi K, Sakamoto S, Masuda T, Nakashima T, Miyamoto S, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N.
  • Journal Title: PLoS One Volume: 16 Issue: 6 Pages: e0252594-e0252594
  • DOI: 10.1371/journal.pone.0252594
  • Peer Reviewed / Open Access
• [Journal Article] Predictive role of circulatory HMGB1 in postoperative acute exacerbation of interstitial lung disease in lung cancer patients (2021)
  • Author(s): Yamaguchi Kakuhiro、Nakao Satoshi、Iwamoto Hiroshi、Kagimoto Atsushi、Handa Yoshinori、Sakamoto Shinjiro、Horimasu Yasushi、Masuda Takeshi、Mimae Takahiro、Miyamoto Shintaro、Nakashima Taku、Tsutani Yasuhiro、Fujitaka Kazunori、Miyata Yoshihiro、Hamada Hironobu、Okada Morihito、Hattori Noboru
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 10105-10105
  • DOI: 10.1038/s41598-021-89663-w
  • Peer Reviewed / Open Access
• [Journal Article] Prognostic Significance of EGFR Gene Mutation in Patients With EGFR Mutated Non-small Cell Lung Cancer Who Received Best Supportive Care Alone (2021)
  • Author(s): MASUDA TAKESHI、WAKABAYASHI YU、NAKASHIMA TAKU、NISHIMURA YOSHIFUMI、SHIMOJI KIYOFUMI、YAMAGUCHI KAKUHIRO、SAKAMOTO SHINJIRO、HORIMASU YASUSHI、MIYAMOTO SHINTARO、SENOO TADASHI、IWAMOTO HIROSHI、OHSHIMO SHINICHIRO、FUJITAKA KAZUNORI、HAMADA HIRONOBU、HATTORI NOBORU
  • Journal Title: Anticancer Research Volume: 41 Issue: 5 Pages: 2661-2667
  • DOI: 10.21873/anticanres.15047
  • Peer Reviewed
• [Journal Article] Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma. (2021)
  • Author(s): Higaki N, Iwamoto H, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Ohshimo S, Fujitaka K, Hamada H, Hattori N.
  • Journal Title: Clin Respir J. Volume: 15 Issue: 1 Pages: 48-55
  • DOI: 10.1111/crj.13268
  • Peer Reviewed
• [Journal Article] A machine-learning based approach to quantify fine crackles in the diagnosis of interstitial pneumonia: A proof-of-concept study. (2021)
  • Author(s): Horimasu Y, Ohshimo S, Yamaguchi K, Sakamoto S, Masuda T, Nakashima T, Miyamoto S, Iwamoto H, Fujitaka K, Hamada H, Sadamori T, Shime N, Hattori N.
  • Journal Title: Medicine (Baltimore). Volume: 100 Issue: 7 Pages: e24738-e24738
  • DOI: 10.1097/md.0000000000024738
  • Peer Reviewed / Open Access
• [Journal Article] Analysis of microRNA Expression in Liquid-Based Cytology Samples May Be Useful for Primary Lung Cancer Diagnosis. (2021)
  • Author(s): Araki Y, Arihiro K, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Iwamoto H, Fujitaka K, Hamada H, Hattori N.
  • Journal Title: Am J Clin Pathol. Volume: N/A Issue: 4 Pages: 644-652
  • DOI: 10.1093/ajcp/aqaa278
  • Peer Reviewed
• [Journal Article] Clinical significance of BIM deletion polymorphism in chemoradiotherapy for non-small cell lung cancer. (2021)
  • Author(s): Wakabayashi Y, Masuda T, Fujitaka K, Nakashima T, Okumoto J, Shimoji K, Nishimura Y, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Iwamoto H, Ohshimo S, Hamada H, Hattori N.
  • Journal Title: Cancer Sci. Volume: 112 Issue: 1 Pages: 369-379
  • DOI: 10.1111/cas.14711
  • Peer Reviewed / Open Access
• [Journal Article] Autoantibody Positivity Is a Risk Factor for Chemotherapy-induced Exacerbation of Interstitial Pneumonia in Lung Cancer. (2021)
  • Author(s): Ito N, Masuda T, Nakashima T, Nakao S, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Iwamoto H, Fujitaka K, Hamada H, Hattori N.
  • Journal Title: Anticancer Res. Volume: 41 Issue: 3 Pages: 1497-1506
  • DOI: 10.21873/anticanres.14908
  • Peer Reviewed
• [Journal Article] Coexisting TIF1γ-positive Primary Pulmonary Lymphoepithelioma-like Carcinoma and Anti-TIF1γ Antibody-positive Dermatomyositis (2020)
  • Author(s): Nakanishi Y, Yamaguchi K, Yoshida Y, Sakamoto S, Horimasu Y, Masuda T, Nakashima T, Miyamoto S, Iwamoto H, Hirata S, Fujitaka K, Hamada H, Sugiyama E, Hattori N.
  • Journal Title: Internal Medicine Volume: 59 Issue: 20 Pages: 2553-2558
  • DOI: 10.2169/internalmedicine.4702-20
  • NAID: 130007926291
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2020-10-15
  • Peer Reviewed / Open Access
• [Journal Article] Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis. (2020)
  • Author(s): Yamaguchi K, Iwamoto H, Mazur W, Miura S, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Ohshimo S, Fujitaka K, Hamada H, Hattori N.
  • Journal Title: Respir Res. Volume: 21 Issue: 1 Pages: 145-145
  • DOI: 10.1186/s12931-020-01410-3
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Extent of pulmonary fibrosis on high-resolution computed tomography is a prognostic factor in patients with pleuroparenchymal fibroelastosis. (2020)
  • Author(s): Namba M, Masuda T, Takao S, Terada H, Yamaguchi K, Sakamoto S, Horimasu Y, Miyamoto S, Nakashima T, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Awai K, Hattori N.
  • Journal Title: Respir Investig. Volume: 58 Issue: 6 Pages: 465-472
  • DOI: 10.1016/j.resinv.2020.05.009
  • Peer Reviewed
• [Journal Article] Serum high-mobility group box 1 as a predictive marker for cytotoxic chemotherapy-induced lung injury in patients with lung cancer and interstitial lung disease. (2020)
  • Author(s): Nakao S, Yamaguchi K, Iwamoto H, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Ohshimo S, Fujitaka K, Hamada H, Hattori N.
  • Journal Title: Respir Med. Volume: 172 Pages: 106131-106131
  • DOI: 10.1016/j.rmed.2020.106131
  • Peer Reviewed
• [Journal Article] Association of Preexisting Interstitial Lung Abnormalities With Immune Checkpoint Inhibitor-Induced Interstitial Lung Disease Among Patients With Nonlung Cancers. (2020)
  • Author(s): Shimoji K, Masuda T, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Miyamoto S, Iwamoto H, Fujitaka K, Hamada H, Takeno S, Hide M, Teishima J, Ohdan H, Hattori N.
  • Journal Title: JAMA Netw Open. Volume: 3 Issue: 11 Pages: e2022906-e2022906
  • DOI: 10.1001/jamanetworkopen.2020.22906
  • Peer Reviewed / Open Access
• [Presentation] 無血清培養はブレオマイシン肺線維症に対する間葉系幹細胞の治療効果を増強する (2022)
  • Author(s): 高尾 俊、中島 拓、益田 武、難波 将史、坂本 信二郎、山口 覚博、堀益 靖、宮本 真太郎、岩本 博志、藤高 一慶、濱田 泰伸、高橋 信也、中島 歩、服部 登
  • Organizer: 第62回日本呼吸器学会総会
• [Presentation] Mesenchymal stem cells cultured in serum-free medium suppress murine bleomycin-induced pulmonary fibrosis by enhancing regulatory T cell induction (2021)
  • Author(s): Takao S，Nakashima T，Masuda T，Namba M，Sakamoto S，Yamaguchi K，Horimasu Y，Miyamoto S，Iwamoto H， Fujitaka K，Hamada H，Nakashima A，Hattori N
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] Autoantibody positivity is a risk factor for chemotherapy-induced exacerbation of interstitial pneumonia in lung cancer (2021)
  • Author(s): Ito N，Masuda T，Yamaguchi K，Sakamoto S，Horimasu Y，Miyamoto S，Nakashima T，Iwamoto H，Fujitaka K， Hamada H，Hattori N
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity (2021)
  • Author(s): Takahashi H，Nakashima T，Masuda T，Namba M， Sakamoto S，Yamaguchi K，Horimasu Y，Miyamoto S， Iwamoto H，Fujitaka K，Hamada H，Hattori N
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] The role of circulatory high-mobility group box 1 for predicting checkpoint inhibitor pneumonitis caused by anti-PD-1/PD-L1 antibody monotherapy (2021)
  • Author(s): Yamaguchi K，Tanahashi H，Kurose K，Nakao S， Sakamoto S，Horimasu Y，Masuda T，Miyamoto S， Nakashima T，Iwamoto H， Fujitaka K，Hamada H，Oga T，Oka M，Hattori N
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] Clinical characteristics of Preserved Ratio Impaired Spirometry in Japan (2021)
  • Author(s): Miura S，Iwamoto H，Omori K，Yamaguchi K，Sakamoto S，Horimasu Y，Masuda T，Miyamoto S，Nakashima T， Fujitaka K，Hamada H，Yokoyama A，Hattori N
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] The associations between patients’ preference for inhaled medications and asthma control (2021)
  • Author(s): Nakanishi Y，Iwamoto H，Miyamoto S，Nakao S，Higaki N，Yamaguchi K，Sakamoto S，Horimasu Y，Masuda T，Matsumoto N，Nakashima T，Onari Y，Fujitaka K，Haruta Y，Hamada H，Hozawa S，Hattori N
  • Organizer: The 25th Congress of the Asian Pacific Society of Respirology
  • Int'l Joint Research
• [Presentation] サルコイドーシスの診断における小型円形リンパ球分画の有用性 (2021)
  • Author(s): 堀益靖，山口覚博，坂本信二郎，益田武，宮本真太郎， 中島拓，岩本博志，藤高一慶，濱田泰伸，服部登
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 特発性肺線維症におけるIL-18 binding proitenの有用性に関する検討 (2021)
  • Author(s): 中西雄，堀益靖，山口覚博，坂本信二郎，益田武，中島拓，宮本真太郎 岩本博志，大下慎一郎，藤高一慶，濱田泰伸，服部登
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 自己抗体陽性の間質性肺炎合併肺癌患者における化学療法による急性増悪の特徴の検討 (2021)
  • Author(s): 伊藤徳明，益田武，山口覚博，坂本信二郎，堀益靖， 宮本真太郎，中島拓，岩本博志，藤高一慶，濱田泰伸， 服部登
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] マウス肺aldehyde dehydrogenase高発現細胞の抗線維化作用 (2021)
  • Author(s): 高橋広，中島拓，益田武，難波将史，坂本信二郎， 山口覚博，堀益靖，宮本真太郎，岩本博志，藤高一慶， 濱田 泰伸，服部登
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] Preserved Ratio Impaired Spirometryの臨床的特徴の検討 (2021)
  • Author(s): 三浦慎一朗，岩本博志，大森慶太郎，山口覚博， 坂本信二郎，堀益靖，益田武，宮本真太郎，中島拓， 藤高一慶，濱田泰伸，横山彰仁，服部登
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 間質性肺炎合併肺癌における肺切除後の間質性肺炎急性増悪発症予測因子としての血中sRAGEの有用性 (2021)
  • Author(s): 中尾聡志，山口覚博，鍵本篤志，半田良憲，坂本信二郎，堀益靖，益田武，見前隆洋，宮本真太郎，中島拓， 津谷康大，岩本博志，藤高一慶，宮田義浩，濱田泰伸， 岡田守人，服部登
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 肺線維症マウスにおける骨髄性質の変化 (2020)
  • Author(s): 中島 拓
  • Organizer: 第60回日本呼吸器学会学術講演会
  • Invited
• [Presentation] EGFR gene mutation is not a significant risk factor in patients with EGFR mutated non-small cell lung cancer who receive best supportive care alone (2020)
  • Author(s): Masuda T, Wakabayashi Y, Shimoji K, Yamaguchi K, Sakamoto S, Nishimura Y, Horimasu Y, Nakashima T, Miyamoto S, Senoo T, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N.
  • Organizer: 2020 ASCO Annual Meeting
  • Int'l Joint Research
• [Presentation] Clinical significance of BIM deletion polymorphism on chemoradiotherapy in patients with non-small cell lung cancer (2020)
  • Author(s): Wakabayashi Y, Masuda T, Nakashima T, Fujitaka K, Yamaguchi K, Sakamoto S, Nishimura Y, Horimasu Y, Miyamoto S, Senoo T, IwamotoH, Ohshimo S, Hamada H, Hattori N.
  • Organizer: 2020 ASCO Annual Meeting
  • Int'l Joint Research
• [Presentation] Pre-existing interstitial lung abnormalities are risk factors for immune checkpoint inhibitor-induced interstitial lung disease in non-NSCLC cancers. (2020)
  • Author(s): Shimoji K, Masuda T, Nakanishi Y, Yamaguchi K, Sakamoto S, Horimasu Y, Nakashima T, Miyamoto S, Iwamoto H, Fujitaka K, Hamada H, Hattori N.
  • Organizer: 2020 ASCO Annual Meeting
  • Int'l Joint Research
• [Presentation] Increased fraction of small round lymphocyte in BALF is a diagnostic indicator for sarcoidosis (2020)
  • Author(s): Horimasu Y, Yamaguchi K, Sakamoto S, Masuda T, Miyamoto S, Nakashima T, Iwamoto H, Fujitaka K, Hamada H, Hattori N.
  • Organizer: 30th International Congress of the European Respiratory Society
  • Int'l Joint Research
• [Presentation] Reduced endogenous secretory RAGE in blood and bronchoalveolar lavage fluid is associated with poor prognosis in idiopathic pulmonary fibrosis (2020)
  • Author(s): Yamaguchi K, Iwamoto H, Mazur W*, Miura S, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Ohshimo S, Fujitaka K, Hamada H, Hattori N.
  • Organizer: 30th International Congress of the European Respiratory Society
  • Int'l Joint Research
• [Presentation] IL-18 binding protein can be a prognostic biomarker for idiopathic pulmonary fibrosis (2020)
  • Author(s): Nakanishi Y, Horimasu Y, Yamaguchi K, Sakamoto S, Masuda T, Nakashima T, Miyamoto S, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N.
  • Organizer: 30th International Congress of the European Respiratory Society
  • Int'l Joint Research
• [Presentation] Pivotal role of the HMGB1/sRAGE axis in drug-induced lung injury in advanced lung cancer with pre-existing interstitial lung disease (2020)
  • Author(s): Nakao S, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Iwamoto H, Ohshimo S, Fujitaka K, Hamada H, Hattori N.
  • Organizer: 30th International Congress of the European Respiratory Society
  • Int'l Joint Research
• [Presentation] Correlations of forced oscillometric bronchodilator response with airway inflammation and disease duration in asthma (2020)
  • Author(s): Higaki N, Iwamoto H, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Fujitaka K, Hamada H, Hattori N.
  • Organizer: JSA/WAO Joint Congress 2020
  • Int'l Joint Research
• [Presentation] Real-world study of prescription pattern of inhaled corticosteroids in adult asthma (2020)
  • Author(s): Nakanishi Y, Iwamoto H, Nakao S, Higaki N, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Matsumoto N, Nakashima T, Miyamoto S, Onari Y, Fujitaka K, Haruta Y, Hamada H, Hozawa S, Hattori N.
  • Organizer: JSA/WAO Joint Congress 2020
  • Int'l Joint Research
• [Presentation] Decline of lung function in adults with a history of childhood asthma (2020)
  • Author(s): Miura S, Iwamoto H, Omori K, Yamaguchi K, Sakamoto S, Horimasu Y, Masuda T, Miyamoto S, Nakashima T, Fujitaka K, Hamada H, Yokoyama A*, Hattori N.
  • Organizer: JSA/WAO Joint Congress 2020
  • Int'l Joint Research
• [Book] 特発性間質性肺炎 診断と治療の手引き2022（改訂第4版） (2022)
  • Author(s): 日本呼吸器学会 びまん性肺疾患診断・治療ガイドライン作成委員会
  • Total Pages: 212
  • Publisher: 南江堂
• [Book] Acute Respiratory Distress Syndrome (2022)
  • Author(s): Taku Nakashima, Noboru Hattori
  • Total Pages: 183
  • Publisher: Springer Nature Singapore Pte Ltd.
• [Book] 特発性間質性肺炎 診断と治療の手引き2022（改訂第4版） (2022)
  • Author(s): 日本呼吸器学会 びまん性肺疾患診断・治療ガイドライン作成委員会
  • Total Pages: 212
  • Publisher: 南江堂
  • ISBN: 9784524228287
• [Book] 呼吸器疾患最新の治療 2021-2022 (2021)
  • Author(s): 中島 拓，服部 登
  • Total Pages: 3
  • Publisher: 南江堂