Immunomodulatory effects of biologics for asthma.

• Project/Area Number: 20K08549
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53030:Respiratory medicine-related
• Research Institution: Juntendo University
• Principal Investigator: Norihiro Harada 順天堂大学, 医学部, 准教授 (10465065)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 気管支喘息 / 生物学的製剤 / 好酸球 / タイプ２炎症 / 免疫調節 / メポリズマブ / ベンラリズマブ / デュピルマブ / 免疫

Outline of Research at the Start

喘息に対する生物学的製剤がもたらす治療効果や副作用に関してのデータはあるものの、生物学的製剤が生体内に及ぼす影響、とくに免疫に及ぼす変化はあきらかではない。本研究においては、生物学的製剤の投与前後の喘息患者の検体を用いて、末梢血単核球・白血球のフローサイトメトリーに加えシングルセルRNAシーケンスと皮脂RNAの解析を行い、各生物学的製剤が人体に及ぼす影響を明らかにし、喘息患者病態の解明、各生物学的製剤に対する新規バイオマーカーや喘息に対する新規治療標的分子による治療を開発する。

Outline of Final Research Achievements

In this study, the immunomodulatory effects of biologics for severe asthma patients in vivo were analyzed with a focus on peripheral blood lymphocyte fractions. The results of one year of treatment with each of mepolizumab, benralizumab, and dupilumab showed different behavior of peripheral blood lymphocytes in each. Each also showed differences in factors predicting the effectiveness of patients. Each formulation has different mechanisms - IL-5 inhibition, induction of apoptosis in eosinophils, and IL-4/IL-13 inhibition, respectively - and these differences may be reflected in their different in vivo effects. Clarification of these differences is expected to elucidate the mechanisms constituting asthma pathology and elucidate the functions of eosinophils and cytokines in the human organism.

Academic Significance and Societal Importance of the Research Achievements

メポリズマブとベンラリズマブは好酸球を標的とした製剤である。前者はタイプ2炎症マーカーが高く、非タイプ2炎症マーカーが低い症例でより有効であった可能性がある。一方、後者は非タイプ2炎症を司るTh17細胞が多い症例でより有効であった可能性が示唆された。Th17のTh2炎症への修飾はTh2炎症を増強し、ステロイド抵抗性を付与する可能性がある。生物学的製剤の適応のある喘息症例はステロイド抵抗性を有していることが多く、この結果は、生物学的製剤のステロイド抵抗性改善効果について解析を進める契機となった。ステロイド抵抗性喘息の克服はすなわち喘息の克服にほかならず、この目標に向けてさらなる研究を実施する。

Research Products

• [Journal Article] Pretreatment Frequency of Circulating Th17 Cells and FeNO Levels Predicted the Real-World Response after 1 Year of Benralizumab Treatment in Patients with Severe Asthma (2023)
  • Author(s): Sandhu Yuuki、Harada Norihiro、Sasano Hitoshi、Harada Sonoko、Ueda Shoko、Takeshige Tomohito、Tanabe Yuki、Ishimori Ayako、Matsuno Kei、Abe Sumiko、Nagaoka Tetsutaro、Ito Jun、Chiba Asako、Akiba Hisaya、Atsuta Ryo、Izuhara Kenji、Miyake Sachiko、Takahashi Kazuhisa
  • Journal Title: Biomolecules Volume: 13 Issue: 3 Pages: 538-538
  • DOI: 10.3390/biom13030538
  • Peer Reviewed / Open Access
• [Journal Article] Effect of Japanese Cedar Pollen Sublingual Immunotherapy on Asthma Patients with Seasonal Allergic Rhinitis Caused by Japanese Cedar Pollen (2022)
  • Author(s): Ueda Shoko、Ito Jun、Harada Norihiro、Harada Sonoko、Sasano Hitoshi、Sandhu Yuuki、Tanabe Yuki、Abe Sumiko、Shiota Satomi、Kodama Yuzo、Nagaoka Tetsutaro、Makino Fumihiko、Chiba Asako、Akiba Hisaya、Atsuta Ryo、Miyake Sachiko、Takahashi Kazuhisa
  • Journal Title: Biomolecules Volume: 12 Issue: 4 Pages: 518-518
  • DOI: 10.3390/biom12040518
  • Peer Reviewed / Open Access
• [Journal Article] Chitin induces steroid-resistant airway inflammation and airway hyperresponsiveness in mice (2021)
  • Author(s): Takeshige Tomohito、Harada Norihiro、Harada Sonoko、Ishimori Ayako、Katsura Yoko、Sasano Hitoshi、Sandhu Yuuki、Matsuno Kei、Makino Fumihiko、Ito Jun、Atsuta Ryo、Akiba Hisaya、Takahashi Kazuhisa
  • Journal Title: Allergology International Volume: 70 Issue: 3 Pages: 343-350
  • DOI: 10.1016/j.alit.2020.12.004
  • NAID: 130008064045
  • Peer Reviewed / Open Access
• [Journal Article] A case of hand urticaria, lip angioedema, and oropharyngeal pruritus induced by Japanese radish through IgE-mediated immediate allergic reaction (2021)
  • Author(s): Abe Sumiko、Ito Jun、Harada Sonoko、Sasano Hitoshi、Ueda Shoko、Sandhu Yuuki、Takeshige Tomohito、Katsura Yoko、Harada Norihiro、Takahashi Kazuhisa
  • Journal Title: Allergy, Asthma & Clinical Immunology Volume: 17 Issue: 1 Pages: 36-36
  • DOI: 10.1186/s13223-021-00538-1
  • Peer Reviewed / Open Access
• [Journal Article] Disseminated nontuberculous mycobacteriosis and fungemia after second delivery in a patient with MonoMAC syndrome/GATA2 mutation: a case report (2021)
  • Author(s): Haraguchi Mizuki、Harada Norihiro、Watanabe Junko、Yoshikawa Hitomi、Shirai Yukina、Komura Moegi、Koyama Mika、Ito Jun、Tsukune Yutaka、Horimoto Yoshiya、Hayashi Takuo、Nagaoka Tetsutaro、Uekusa Toshimasa、Takahashi Kazuhisa
  • Journal Title: BMC Infectious Diseases Volume: 21 Issue: 1 Pages: 502-502
  • DOI: 10.1186/s12879-021-06203-7
  • Peer Reviewed / Open Access
• [Journal Article] Clinical effects and immune modulation of biologics in asthma (2021)
  • Author(s): Harada Norihiro、Ito Jun、Takahashi Kazuhisa
  • Journal Title: Respiratory Investigation Volume: 59 Issue: 4 Pages: 389-396
  • DOI: 10.1016/j.resinv.2021.03.003
  • Peer Reviewed / Open Access
• [Journal Article] Anaphylaxis to three humanized antibodies for severe asthma: a case study (2020)
  • Author(s): Jingo Koichi、Harada Norihiro、Nishioki Toshihiko、Torasawa Masahiro、Yamada Tomoko、Asao Tetsuhiko、Takagi Haruhi、Takeshige Tomohito、Ito Jun、Takahashi Kazuhisa
  • Journal Title: Allergy, Asthma & Clinical Immunology Volume: 16 Issue: 1 Pages: 46-46
  • DOI: 10.1186/s13223-020-00446-w
  • Peer Reviewed
• [Journal Article] Mobile Health App for Japanese Adult Patients With Asthma: Clinical Observational Study (2020)
  • Author(s): Harada Norihiro、Harada Sonoko、Ito Jun、Atsuta Ryo、Hori Satoshi、Takahashi Kazuhisa
  • Journal Title: Journal of Medical Internet Research Volume: 22 Issue: 8 Pages: e19006-e19006
  • DOI: 10.2196/19006
  • Peer Reviewed
• [Journal Article] Pulmonary infection due to fluoroquinolone-resistant Mycolicibacterium fortuitum: a case report. (2020)
  • Author(s): Kurokawa K, Harada N, Sasano H, Takagi H, Takei S, Nakamura A, Kamada K, Yoshida A, Kikuchi K, Takahashi K.
  • Journal Title: BMC Infect Dis Volume: 20 Issue: 1 Pages: 866-866
  • DOI: 10.1186/s12879-020-05596-1
  • Peer Reviewed / Open Access
• [Presentation] Circulating CD69-positive MAIT cells, neutrophils, and serum periostin as a novel predictive biomarker for mepolizumab therapy (2022)
  • Author(s): 笹野仁史、原田紀宏、原田園子、竹重智仁、三道ユウキ、田辺悠記、石森絢子、松野圭、長岡鉄太郎、伊藤潤 、熱田了、出原賢治、高橋和久
  • Organizer: 第31回国際喘息学会日本・北アジア部会
  • Int'l Joint Research
• [Presentation] Novel biomarkers of clinical remission with anti-IL-5 receptor antibody therapy in patients with severe asthma (2022)
  • Author(s): 三道ユウキ、原田紀宏、笹野仁史、田辺悠記、原田園子、佐藤良彦、西牧孝泰、安部寿美子、上田翔子、竹重智仁、長岡鉄太郎、伊藤潤、熱田了、高橋和久
  • Organizer: 第31回国際喘息学会日本・北アジア部会
  • Int'l Joint Research
• [Presentation] Effectiveness of dupilumab treatment in patients with severe asthma (2022)
  • Author(s): 安部寿美子、原田紀宏、三道ユウキ、笹野仁史、田辺悠記、原田園子、佐藤良彦、西牧孝泰、加藤由香里、上田翔子、竹重智仁、伊藤潤、熱田了、高橋和久
  • Organizer: 第31回国際喘息学会日本・北アジア部会
  • Int'l Joint Research
• [Presentation] Long term clinical effectiveness for more than three years of omalizumab therapy in patients with severe asthma (2022)
  • Author(s): 上田翔子、原田紀宏、原田園子、後藤愛、笹野仁史、三道ユウキ、田辺悠記、安部寿美子、竹重智仁、松野圭、長岡鉄太郎、伊藤潤、熱田了、高橋和久
  • Organizer: 第31回国際喘息学会日本・北アジア部会
  • Int'l Joint Research
• [Presentation] The impact of one-year treatment with dupilumab in patients with severe asthma (2022)
  • Author(s): Sumiko Abe, Norihiro Harada, Yuuki Sandhu, Hitoshi Sasano, Yuuki Tanabe, Sonoko Harada, Ai Goto, Takayasu Watanabe, Yoshihiko Sato, Takayasu Nishimaki, Yukari Kato, Shoko Ueda, Tomohito Takeshige, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi
  • Organizer: The 26th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] Mucosal Associated Invariant T Cells May Have Any Protective Role against Type 2 Airway Inflammation in OVA-Induced Murine Asthma Model (2022)
  • Author(s): Hitoshi Sasano, Norihiro Harada, Yuuki Sandhu, Yuki Tanabe, Sonoko Harada, Takayasu Watanabe, Yoshihiko Sato, Takayasu Nishimaki, Sumiko Abe, Shoko Ueda, Ai Goto, Tomohito Takeshige, Kei Matsuno, Jun Ito, Tetsutaro Nagaoka, Ryo Atsuta, Asako Chiba, Hisaya Akiba, Sachiko Miyake, Kazuhisa Takahashi
  • Organizer: American Thoracic Society International Conference 2022
  • Int'l Joint Research
• [Presentation] Role of MAP3K19 in allergic airway inflammation of asthma, (2022)
  • Author(s): Yuuki Sandhu, Norihiro Harada, Sonoko. Harada, Hitoshi. Sasano, Tomohito Takeshige, Kei Matsuno, Ayako Ishimori, Yoko Katsura, Jun Ito, Hisaya Akiba, Kazuhisa Takahashi
  • Organizer: American Thoracic Society International Conference 2022
  • Int'l Joint Research
• [Presentation] Novel predictive biomarkers for mepolizumab treatment in patients with severe asthma (2021)
  • Author(s): Hitoshi Sasano, Norihiro Harada, Yuuki Sandhu, Yuki Tanabe, Sonoko Harada, Takayasu Watanabe, Yoshihiko Sato, Takayasu Nishimaki, Sumiko Abe, Shoko Ueda, Tomohito Takeshige, Kei Matsuno, Jun Ito, Tetsutaro Nagaoka, Ryo Atsuta, Asako Chiba, Hisaya Akiba, Kenji Izuhara, Sachiko Miyake, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] Soluble TIM-4 levels in serum are associated with severe asthma phenotype (2021)
  • Author(s): Yuki Tanabe, Hisaya Akiba, Norihiro Harada, Kei Matsuno, Jun Ito, Sachiko Miyake, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] A Study of lymphocyte fraction in bronchoalveolar lavage fluid in interstitial lung disease (2021)
  • Author(s): Sonoko Harada, Norihiro Harada, Tomohito Takeshige, Hitoshi Sasano, Yuuki Sandhu, Yuki Tanabe, Kei Matsuno, Shun Shinomiya, Motoyasu Kato, Jun Ito, Kazuyuki Nakagome, Makoto Nagata, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] Analysis of lymphocyte fractions in bronchoalveolar lavage fluid in chronic eosinophilic pneumonia (2021)
  • Author(s): Sonoko Harada, Norihiro Harada, Tomohito Takeshige, Hitoshi Sasano, Yuuki Sandhu, Yuki Tanabe, Kei Matsuno, Shun Shinomiya, Motoyasu Kato, Jun Ito, Kazuyuki Nakagome, Makoto Nagata, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] Japanese cedar pollen sublingual immunotherapy for asthma patients with Japanese cedar pollinosis provided stability of symptoms of asthma in the off-season (2021)
  • Author(s): Shoko Ueda, Jun Ito, Yuuki Sandhu, Takayasu Watanabe, Yoshihiko Sato, Takayasu Nishimaki, Yukari Kato, Sumiko Abe, Hitoshi Sasano, Yuki Tanabe, Tomohito Takeshig1, Sonoko Harada, Ryo Atsuta, Norihiro Harada, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] Steroid-resistant airway inflammation in mice induced by chitin (2021)
  • Author(s): Tomohito Takeshige, Norihiro Harada, Sonoko Harada, Ayako Ishimori, Yoko Katsura, Hitoshi Sasano, Yuuki Sandhu, Kei Matsuno, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] Effects of one-year of dupilumab treatment in patients with severe asthma (2021)
  • Author(s): Sumiko Abe, Norihiro Harada, Yuuki Sandhu, Hitoshi Sasano, Yuuki Tanabe, Sonoko Harada, Ai Goto, Takayasu Watanabe, Yoshihiko Sato, Takayasu Nishimaki, Yukari Kato, Shoko Ueda, Tomohito Takeshige, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] The usefulness of CT images in evaluating the effects of bronchial thermoplasty in patients with severe asthma (2021)
  • Author(s): Sumiko Abe, Mina Yasuda, Kazunori Tobino, Sonoko Harada, Hitoshi Sasano, Yuuki Sandhu, Tomohito Takeshige, Kei Matsuno, Tetsuhiko Asao, Takuto Sueyasu, Saori Nishizawa, Kohei Yoshimine, Yuki Ko, Yuki Yoshimatsu, Kosuke Tsuruno, Hiromi Ide, Haruhi Takagi, Tetsutaro Nagaoka, Norihiro Harada, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] A study of severe asthma patients who continued omalizumab treatment for more than 3 years (2021)
  • Author(s): Ai Goto, Norihiro Harada, Yuuki Sandhu, Hitoshi Sasano, Yuki Tanabe, Sonoko Harada, Takayasu Watanabe, Yoshihiko Sato, Takayasu Nishimaki, Yukari Kato, Sumiko Abe, Shoko Ueda, Tomohito Takeshige, Kei Matsuno, Jun Ito, Tetsutaro Nagaoka, Ryo Atsuta, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] One-year treatment with benralizumab in patients with severe asthma (2021)
  • Author(s): Yuuki Sandhu, Norihiro Harada, Hitoshi Sasano, Sumiko Abe, Sonoko Harada, Takayasu Watanabe, Yoshihiko Sato, Takayasu Nishimaki, Yukari Kato, Shoko Ueda, Yuki Tanabe, Tomohito Takeshige, Tetsutaro Nagaoka, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] A study of severe asthma patients who continued mepolizumab treatment for more than 3 years (2021)
  • Author(s): Takayasu Nishimaki, Norihiro Harada, Ai Goto, Yuuki Sandhu, Hitoshi Sasano, Yuki Tanabe, Sonoko Harada, Takayasu Watanabe, Yoshihiko Sato, Yukari Kato, Sumiko Abe, Shoko Ueda, Tomohito Takeshige, Kei Matsuno, Jun Ito, Nagaoka Tetsutaro, Atsuta Ryo, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] The prevalence of Obstructive Sleep Apnea in Japanese patients with asthma (2021)
  • Author(s): Mina Yasuda, Kazunori Tobino, Norihiro Harada, Ryunosuke Ooi, Takuto Sueyasu, Saori Nishizawa, Kohei Yoshimine, Yuki Ko, Yuki Yoshimatsu, Kosuke Tsuruno, Hiromi Ide, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] A novel mechanism for TWEAK induces the production of TSLP, RANTES, and TARC in BEAS-2B human bronchial epithelial cells during epithelial-mesenchymal transition (2021)
  • Author(s): Kei Matsuno, Norihiro Harada, Tomohito Takeshige, Sonoko Harada, Ayako Ishimori, Yukinari Itoigawa, Yoko Katsura, Yuzo Kodama, Fumihiko Makino, Jun Ito, Ryo Atsuta, Hisaya Akiba, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] Role of MAP3K19 in allergic airway inflammation of asthma (2021)
  • Author(s): Yuuki Sandhu, Norihiro Harada, Sonoko Harada, Hitosh. Sasano, Tomohito Takeshige, Kei Matsuno, Ayako Ishimori, Yoko Katsura, Jun Ito, Hisaya Akiba, Kazuhisa Takahashi
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research
• [Presentation] Predictive and Response Biomarkers for Biologics in Asthma (2021)
  • Author(s): Norihiro Harada
  • Organizer: The 25th congress of the Asian Paciffic Society of Respirology
  • Int'l Joint Research / Invited
• [Presentation] Clinical and immunological effect of mepolizumab treatment in patients with severe asthma (2021)
  • Author(s): Hitoshi Sasano, Norihiro Harada, Yuuki Sandhu, Yuki Tanabe, Sonoko Harada, Takayasu Watanabe, Yoshihiko Sato, Takayasu Nishimaki, Yukari Oyama, Sumiko Abe, Shoko Ueda, Tomohito Takeshige, Kei Matsuno, Jun Ito, Kazuhisa Takahashi
  • Organizer: American Thoracic Society International Conference 2021
  • Int'l Joint Research
• [Presentation] 重症気管支喘息におけるメポリズマブ治療の効果予測に関する新規バイオマーカー (2021)
  • Author(s): 笹野仁史、原田紀宏、三道ユウキ、田辺悠記、原田園子、渡邉敬康、佐藤良彦、西牧孝泰、安部寿美子、上田翔子、竹重智仁、松野圭、伊藤潤、長岡鉄太郎、熱田了、千葉麻子、秋葉久弥、出原賢治、三宅幸子、高橋和久
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 重症気管支喘息患者に対するデュピルマブ治療１年間の検討 (2021)
  • Author(s): 安部寿美子、原田紀宏、三道ユウキ、笹野仁史、田辺悠記、原田園子、後藤愛、渡邉敬康、佐藤良彦、西牧孝泰、加藤由香里、上田翔子、竹重智仁、伊藤潤、熱田了、高橋和久
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 3年以上メポリズマブを使用した重症気管支喘息症例の検討 (2021)
  • Author(s): 後藤愛、原田紀宏、三道ユウキ、笹野仁史、田辺悠記、原田園子、渡邉敬康、佐藤良彦、西牧孝泰、加藤由香里、安部寿美子、上田翔子、竹重智仁、松野圭、伊藤潤、長岡鉄太郎、熱田了、高橋和久
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 3年以上オマリズマブを使用した重症気管支喘息症例の検討 (2021)
  • Author(s): 後藤愛、原田紀宏、三道ユウキ、笹野仁史、田辺悠記、原田園子、渡邉敬康、佐藤良彦、西牧孝泰、加藤由香里、安部寿美子、上田翔子、竹重智仁、松野圭、伊藤潤、長岡鉄太郎、熱田了、高橋和久
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 重症気管支喘息に対するベンラリズマブ投与1年の検討 (2021)
  • Author(s): 三道ユウキ、原田紀宏、笹野仁史、安部寿美子、原田園子、渡邉敬康、佐藤良彦、西牧孝泰、加藤由香里、上田翔子、田辺悠記、竹重智仁、長岡鉄太郎、伊藤潤、熱田了、高橋和久
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 重症気管支喘息患者に対するデュピルマブの効果に関する検討 (2021)
  • Author(s): 安部寿美子、原田紀宏、三道ユウキ、笹野仁史、田辺悠記、原田園子、渡邉敬康、佐藤良彦、西牧孝泰、大山由香里、上田翔子、竹重智仁、伊藤潤、熱田了、高橋和久
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 重症気管支喘息患者に対するメポリズマブの効果に関する検討 (2021)
  • Author(s): 笹野仁史、原田紀宏、三道ユウキ、田辺悠記、原田園子、渡邉敬康、佐藤良彦、西牧孝泰、大山由香里、安部寿美子、上田翔子、竹重智仁、松野圭、長岡鉄太郎、伊藤潤、熱田了、高橋和久
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] Clinical and immunological effect of mepolizumab treatment in patients with severe asthma (2020)
  • Author(s): Hitoshi Sasano, Norihiro Harada , Yuuki Sandhu, Yuki Tanabe, Sonoko Harada, Takayasu Watanabe, Yoshihiko Sato, Takayasu Nishimaki, Yukari Oyama, Sumiko Abe, Shoko Ueda, Tomohito Takeshige, Kei Matsuno, Jun Ito, Kazuhisa Takahashi
  • Organizer: American Thoracic Society International Conference 2021. Virtual Conference,
  • Int'l Joint Research
• [Presentation] 重症気管支喘息患者に対するデュピルマブの効果に関する検討 (2020)
  • Author(s): 安部寿美子、原田紀宏、三道ユウキ、笹野仁史、田辺悠記、原田園子、渡邉敬康、佐藤良彦、西牧孝泰、大山由香里、上田翔子、竹重智仁、伊藤潤、熱田了、高橋和久
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 重症気管支喘息に対するベンラリズマブ投与1年の検討 (2020)
  • Author(s): 三道ユウキ、原田紀宏、笹野仁史、田辺悠記、原田園子、渡邉敬康、佐藤良彦、西牧孝泰、大山由香里、安部寿美子、上田翔子、竹重智仁、長岡鉄太郎、伊藤潤、熱田了、高橋和久
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 重症気管支喘息患者に対するメポリズマブの効果に関する検討 (2020)
  • Author(s): 笹野仁史、原田紀宏、三道ユウキ、田辺悠記、原田園子、渡邉敬康、佐藤良彦、西牧孝泰、大山由香里、安部寿美子、上田翔子、竹重智仁、松野圭、長岡鉄太郎、伊藤潤、熱田了、高橋和久
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 当院における重症喘息に対するベンラリズマブ投与1年の検討 (2020)
  • Author(s): 三道ユウキ、原田紀宏、笹野仁史、田辺悠記、原田園子、安部寿美子、上田翔子、竹重智仁、伊藤潤、高橋和久
  • Organizer: 第4回日本アレルギー学会関東地方会
• [Presentation] 当院における重症喘息に対するメポリズマブ投与1年の検討 (2020)
  • Author(s): 笹野仁史、原田紀宏、三道ユウキ、田辺悠記、原田園子、佐藤良彦、渡邉敬康、西牧孝泰、大山由香里、安部寿美子、上田翔子、竹重智仁、松野圭、伊藤潤、熱田了、高橋和久
  • Organizer: 第51回日本職業・環境アレルギー学会総会・学術大会
• [Presentation] 重症気管支喘息患者に対するデュピルマブの臨床効果 (2020)
  • Author(s): 三道ユウキ、原田紀宏、笹野仁史、田辺悠記、原田園子、渡邉敬康、佐藤良彦、西牧孝泰、大山由香里、安部寿美子、上田翔子、竹重智仁、伊藤潤、熱田了、高橋和久
  • Organizer: アレルギー・好酸球研究会2020
• [Presentation] 重症喘息に対するメポリズマブ投与1年の検討 (2020)
  • Author(s): 笹野仁史、原田紀宏、三道ユウキ、田辺悠記、原田園子、渡邉敬康、西牧孝泰、大山由香里、安部寿美子、上田翔子、竹重智仁、松野圭、牧野文彦、伊藤潤、熱田了、高橋和久
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 当院における重症喘息に対するベンラリズマブの使用経験 (2020)
  • Author(s): 笹野仁史、原田紀宏、三道ユウキ、田辺悠記、原田園子、渡邉敬康、西牧孝泰、大山由香里、安部寿美子、上田翔子、竹重智仁、松野圭、牧野文彦、伊藤潤、熱田了、高橋和久
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 気管支喘息患者における血中可溶性TIM－4濃度 (2020)
  • Author(s): 田辺悠記、原田紀宏、原田園子、笹野仁史、三道ユウキ、松野圭、竹重智仁、牧野文彦、伊藤潤、熱田了、三宅幸子、高橋和久、秋葉久弥
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 当院における気管支喘息に対するデュピルマブの使用経験 (2020)
  • Author(s): 三道ユウキ、原田紀宏、笹野仁史、田辺悠記、原田園子、渡邉敬康、西牧孝泰、大山由香里、安部寿美子、上田翔子、竹重智仁、松野圭、牧野文彦、伊藤潤、熱田了、高橋和久
  • Organizer: 第60回日本呼吸器学会学術講演会
• [Presentation] 重症気管支喘息患者に対するデュピルマブの臨床効果 (2020)
  • Author(s): 三道ユウキ、原田紀宏、笹野仁史、田辺悠記、原田園子、佐藤良彦、渡邉敬康、西牧孝泰、大山由香里、安部寿美子、上田翔子、竹重智仁、伊藤潤、熱田了、高橋和久
  • Organizer: 第1回日本喘息学会総会学術大会
• [Presentation] One Year Treatment With Benralizumab In Patients With Severe Asthma (2020)
  • Author(s): Yuuki Sandhu, Norihiro Harada , Yuki Tanabe, Hitoshi Sasano, Sonoko Harada, Takayasu Watanabe, Takayasu Nishimaki, Yukari Oyama, Sumiko Abe, Shoko Ueda, Tomohito Takeshige, Kei Matsuno, Fumihiko Makino, Jun Ito, Ryo Atsuta, Kazuhisa Takahashi
  • Organizer: American Thoracic Society International Conference 2020. Virtual Conference
  • Int'l Joint Research