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Loss of lung microbiome diversity and immune mechanisms of pulmonary surfactant proteins

Research Project

Project/Area Number 20K08570
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53030:Respiratory medicine-related
Research InstitutionSapporo Medical University

Principal Investigator

Kuronuma Koji  札幌医科大学, 医学部, 准教授 (40563250)

Co-Investigator(Kenkyū-buntansha) 齋藤 充史  札幌医科大学, 医学部, 講師 (00768939)
千葉 弘文  札幌医科大学, 医学部, 教授 (40347175)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2020: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords肺サーファクタント / 自然免疫 / 肺マイクロバイオーム / 肺サーファクタント蛋白質 / 肺内微生物叢 / マイクロバイオーム / マイクロバイオーム解析
Outline of Research at the Start

肺内に豊富に存在する肺サーファクタント蛋白質は、様々な細菌と結合し下気道の自然免疫・感染防御の役割を担っている。高齢化に伴い繰り返す感染や慢性的な肺損傷による肺サーファクタント蛋白質の喪失は肺内微生物叢環境に異常をもたらすと考えられる。 本研究では肺サーファクタント蛋白質遺伝子欠損マウス肺のマイクロバイオーム解析により微生物叢の変化を明らかにし、網羅的な細菌探索から肺サーファクタント蛋白質と結合し免疫作用を及ぼす微生物を特定する。肺サーファクタント蛋白質がin vivoで作用を及ぼしている細菌を明らかにすると共に細菌叢変化を正常化する方法の開発を模索する。

Outline of Final Research Achievements

Microbiome analysis of mice fed a niacin-restricted diet revealed that they were in a state of dysbiosis. When pirfenidone was administered to niacin-deficient mice, pellagra-like symptoms were enhanced, and NNMT was the main contributing factor. Microbiome analysis of stool samples collected from COVID-19 patients revealed that more severely ill patients were in a state of dysbiosis, with a decrease in substances involved in tryptophan metabolism. We found that serum SP-A and SP-D were elevated in COVID-19 patients and associated with the severity of COVID-19 pneumonia.

Academic Significance and Societal Importance of the Research Achievements

マイクロバイオーム解析の手法によりナイアシン欠乏と嘔気嘔吐などの副作用を示す薬剤の関連を明らかにした。その主要因となる物質を特定したため、尿の測定により副作用予測に用いられる可能性がある。また、COVID-19患者のマイクロバイオーム解析でもより重症患者の方が菌の多様性が低下している状態であり、重症化機序の一部を示した。COVID-19肺炎では血清SP-AとSP-Dが重症度を評価するバイオマーカーとなりうる。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (73 results)

All 2023 2022 2021 2020

All Journal Article (33 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 33 results,  Open Access: 29 results) Presentation (40 results) (of which Int'l Joint Research: 7 results,  Invited: 1 results)

  • [Journal Article] Deep learning algorithm to detect fibrosing interstitial lung disease on chest radiographs.2023

    • Author(s)
      Nishikiori H, Kuronuma K, Hirota K, Yama N, Suzuki T, Onodera M, Onodera K, Ikeda K, Mori Y, Asai Y, Takagi Y, Honda S, Ohnishi H, Hatakenaka M, Takahashi H, Chiba H.
    • Journal Title

      Eur Respir J.

      Volume: 61 Issue: 2 Pages: 2102269-2102269

    • DOI

      10.1183/13993003.02269-2021

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of diagnostic performance and factors causing nonspecific reactions in SARS-CoV-2 rapid antigen detection tests.2023

    • Author(s)
      Narumi N, Kondo T, Sato Y, Katayama Y, Nirasawa S, Saeki M, Yakuwa Y, Fujiya Y, Kuronuma K, Takahashi S.
    • Journal Title

      J Infect Chemother.

      Volume: 29 Issue: 2 Pages: 157-162

    • DOI

      10.1016/j.jiac.2022.10.007

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of real-world data and a mouse model indicates that pirfenidone causes pellagra.2023

    • Author(s)
      Kuronuma K, Susai N, Kuroita T, Yamamoto H, Yoshioka T, Kaneko S, Chiba H.
    • Journal Title

      ERJ Open Res.

      Volume: 8 Issue: 4 Pages: 00245-2022

    • DOI

      10.1183/23120541.00245-2022

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a new HISCL automated CXCL9 immunoassay.2023

    • Author(s)
      Hasegawa T, Yoshida M, Watanabe S, Kondo T, Asada H, Nakagawa A, Tomii K, Kameda M, Otsuka M, Kuronuma K, Chiba H, Katayanagi S, Miyazaki Y, Mori A.
    • Journal Title

      Sci Rep.

      Volume: 13 Issue: 1 Pages: 5342-5342

    • DOI

      10.1038/s41598-023-32513-8

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Factors affecting the sensitivity of quantitative severe acute respiratory syndrome coronavirus 2 antigen test.2023

    • Author(s)
      Sato Y, Murai R, Kobayashi R, Togashi A, Fujiya Y, Kuronuma K, Takahashi S.
    • Journal Title

      J Infect Chemother.

      Volume: 29 Issue: 8 Pages: 754-758

    • DOI

      10.1016/j.jiac.2023.04.005

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pseudo-outbreak of Mycobacterium lentiflavum at a general hospital in Japan2023

    • Author(s)
      Nagano Yutaro、Kuronuma Koji、Kitamura Yasuo、Nagano Kanami、Yabe Hayato、Kudo Sayaka、Sato Toyotaka、Nirasawa Shinya、Nakae Mami、Horiuchi Motohiro、Yokota Shin-ichi、Fujiya Yoshihiro、Saito Atsushi、Takahashi Satoshi、Chiba Hirofumi
    • Journal Title

      Infection Control & Hospital Epidemiology

      Volume: 44 Issue: 11 Pages: 1809-1815

    • DOI

      10.1017/ice.2023.68

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Soluble Lectin Families as Novel Biomarkers for COVID-19 Pneumonia.2023

    • Author(s)
      Takenaka H, Saito A, Kuronuma K, Moniwa K, Nishikiori H, Takahashi S, Chiba H.
    • Journal Title

      In Vivo.

      Volume: 37 Issue: 4 Pages: 1721-1728

    • DOI

      10.21873/invivo.13259

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protective effect of <i>Bifidobacterium longum</i> BB536 against nausea caused by pirfenidone in a mouse model of pellagra2023

    • Author(s)
      Kuronuma K, Susai N, Kuroita T, Yoshioka T, Saito A, Chiba H.
    • Journal Title

      Bioscience of Microbiota, Food and Health

      Volume: 42 Issue: 3 Pages: 195-202

    • DOI

      10.12938/bmfh.2022-042

    • ISSN
      2186-3342
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum Testosterone Is Associated With the Severity of COVID-19.2023

    • Author(s)
      Suzuki E, Kuronuma K, Murai R, Fujiya Y, Saito A, Chiba H, Takahashi S.
    • Journal Title

      In Vivo.

      Volume: 37 Issue: 5 Pages: 2314-2319

    • DOI

      10.21873/invivo.13334

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Invasive Haemophilus influenzae disease among adults in Japan during 2014–20182023

    • Author(s)
      Hachisu Y, Tamura K, Murakami K, Fujita J, Watanabe H, Tanabe Y, Kuronuma K, Kubota T, Oshima K, Maruyama T, Kasahara K, Nishi J, Abe S, Nakamura M, Kubota M, Hirai S, Ishioka T, Ikenoue C, Fukusumi M, Sunagawa T, Suzuki M, Akeda Y, Oishi K; Adult IHD Study Group.
    • Journal Title

      Infection.

      Volume: 51 Issue: 2 Pages: 355

    • DOI

      10.1007/s15010-022-01885-w

    • URL

      https://pure.teikyo.jp/en/publications/df147b77-ce87-4379-a9ce-dcf23022f797

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Delayed dexamethasone treatment at initiation of oxygen supplementation for coronavirus disease 2019 is associated with the exacerbation of clinical condition2022

    • Author(s)
      Ibe Y, Ishigo T, Fujii S, Fujiya Y, Kuronuma K, Tsugawa T, Takahashi S, Fukudo M
    • Journal Title

      J Infect Chemother

      Volume: 28 Issue: 7 Pages: 875-883

    • DOI

      10.1016/j.jiac.2022.03.007

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Does the timing of saliva collection affect the diagnosis of SARS-CoV-2 infection?2022

    • Author(s)
      Katayama Y, Murai R, Moriai M, Nirasawa S, Saeki M, Yakuwa Y, Sato Y, Asanuma K, Fujiya Y, Kuronuma K, Takahashi S.
    • Journal Title

      J Infect Chemother.

      Volume: 28 Issue: 7 Pages: 1033-1036

    • DOI

      10.1016/j.jiac.2022.03.009

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of niacin supplementation on nausea-like behaviour in an isoniazid-induced mouse model of pellagra.2022

    • Author(s)
      Natsumi S, Kuroita T, Ishikawa T, Kuronuma K, Yoshioka T.
    • Journal Title

      Br J Nutr.

      Volume: 127 Issue: 7 Pages: 961-971

    • DOI

      10.1017/s0007114521001835

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparative study of rapid antigen testing and two nucleic acid amplification tests for influenza virus detection.2022

    • Author(s)
      Sato Y, Nirasawa S, Saeki M, Yakuwa Y, Ono M, Kobayashi R, Nakafuri H, Murai R, Fujiya Y, Kuronuma K, Takahashi S.
    • Journal Title

      J Infect Chemother.

      Volume: 28 Issue: 7 Pages: 1033-1036

    • DOI

      10.1016/j.jiac.2022.04.009

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of the gut microbiome to validate a mouse model of pellagra2022

    • Author(s)
      Susai N, Kuroita T, Kuronuma K, Yoshioka T.
    • Journal Title

      Bioscience of Microbiota, Food and Health

      Volume: 41 Issue: 2 Pages: 73-82

    • DOI

      10.12938/bmfh.2021-059

    • NAID

      130008143948

    • ISSN
      2186-3342
    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dynamic changes in clinical characteristics and serotype distribution of invasive pneumococcal disease among adults in Japan after introduction of the pediatric 13-valent pneumococcal conjugate vaccine in 2013-2019.2022

    • Author(s)
      Tamura K, Chang B, Shimbashi R, Watanabe H, Tanabe Y, Kuronuma K, Oshima K, Maruyama T, Fujita J, Abe S, Kasahara K, Nishi J, Kubota T, Kinjo Y, Fujikura H, Fukusumi M, Shimada T, Sunagawa T, Suzuki M, Yamamoto Y, Oishi K.
    • Journal Title

      Vaccine

      Volume: 40 Issue: 24 Pages: 3338-3344

    • DOI

      10.1016/j.vaccine.2022.04.062

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of transient receptor potential vanilloid 4 in therapeutic antifibrotic effects of pirfenidone.2022

    • Author(s)
      Kuronuma K, Otsuka M, Wakabayashi M, Yoshioka T, Kobayashi T, Kameda M, Morioka Y, Chiba H, Takahashi H.
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol.

      Volume: 323 Issue: 2 Pages: L193-L205

    • DOI

      10.1152/ajplung.00565.2020

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Viral load may impact the diagnostic performance of nasal swabs in nucleic acid amplification test and quantitative antigen test for SARS-CoV-2 detection.2022

    • Author(s)
      Fujiya Y, Sato Y, Katayama Y, Nirasawa S, Moriai M, Saeki M, Yakuwa Y, Kitayama I, Asanuma K, Kuronuma K, Takahashi S.
    • Journal Title

      J Infect Chemother.

      Volume: 20 Issue: 11 Pages: 1590-1593

    • DOI

      10.1016/j.jiac.2022.07.023

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Impaired tryptophan metabolism in the gastrointestinal tract of patients with critical coronavirus disease 2019.2022

    • Author(s)
      Yokoyama Y, Ichiki T, Yamakawa T, Tsuji Y, Kuronuma K, Takahashi S, Narimatsu E, Nakase H.
    • Journal Title

      Front Med (Lausanne).

      Volume: 9 Pages: 941422-941422

    • DOI

      10.3389/fmed.2022.941422

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genotypes and transmission routes of noroviruses causing sporadic acute gastroenteritis among adults and children, Japan, 2015-2019.2022

    • Author(s)
      Honjo S, Kuronuma K, Fujiya Y, Nakae M, Ukae S, Nihira H, Yamamoto M, Akane Y, Kondo K, Takahashi S, Kimura H, Tsutsumi H, Kawasaki Y, Tsugawa T.
    • Journal Title

      Infect Genet Evol.

      Volume: 104 Pages: 105348-105348

    • DOI

      10.1016/j.meegid.2022.105348

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Study of post-opening stability of active ingredients in hand sanitizers.2022

    • Author(s)
      Kobayashi R, Murai R, Sato Y, Nakae M, Nirasawa S, Asanuma K, Kuronuma K, Takahashi S.
    • Journal Title

      J Infect Chemother.

      Volume: 28 Issue: 12 Pages: 1605-1609

    • DOI

      10.1016/j.jiac.2022.08.012

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pneumocystis jirovecii Pneumonia Associated with COVID-19 in Patients with Interstitial Pneumonia.2022

    • Author(s)
      Takahashi T, Saito A, Kuronuma K, Nishikiori H, Chiba H.
    • Journal Title

      Medicina (Kaunas).

      Volume: 58 Issue: 9 Pages: 1151-1151

    • DOI

      10.3390/medicina58091151

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] N-glycosylation regulates MET processing and signaling2022

    • Author(s)
      Atsushi Saitou, Yoshihiro Hasegawa, Naoki Fujitani, Shigeru Ariki, Yasuaki Uehara, Ukichiro Hashimoto, Atsushi Saito, Koji Kuronuma, Kunio Matsumoto, Hirofumi Chiba, Motoko Takahashi
    • Journal Title

      Cancer Science

      Volume: ー Issue: 4 Pages: 1292-1304

    • DOI

      10.1111/cas.15278

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pneumococcal meningitis in adults in 2014-2018 after introduction of pediatric 13-valent pneumococcal conjugate vaccine in Japan.2022

    • Author(s)
      Chang B, Tamura K, Fujikura H, Watanabe H, Tanabe Y, Kuronuma K, Fujita J, Oshima K, Maruyama T, Abe S, Kasahara K, Nishi J, Kubota T, Kinjo Y, Serizawa Y, Shimbashi R, Fukusumi M, Shimada T, Sunagawa T, Suzuki M, Oishi K; Adult IPD Study Group.
    • Journal Title

      Sci Rep.

      Volume: 12 Issue: 1 Pages: 3066-3066

    • DOI

      10.1038/s41598-022-06950-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Self-reported Smell and Taste Disorders in Patients With COVID-19: A Japanese Single-center Study.2022

    • Author(s)
      Yamamoto K, Fujiya Y, Kuronuma K, Ogasawara N, Ohkuni T, Yokota SI, Takahashi S, Takano K.
    • Journal Title

      In Vivo

      Volume: 36 Issue: 2 Pages: 918-924

    • DOI

      10.21873/invivo.12781

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Early favipiravir treatment was associated with early defervescence in non-severe COVID-19 patients2021

    • Author(s)
      Fujii Satoshi、Ibe Yuta、Ishigo Tomoyuki、Inamura Hirotoshi、Kunimoto Yusuke、Fujiya Yoshihiro、Kuronuma Koji、Nakata Hiromasa、Fukudo Masahide、Takahashi Satoshi
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: 27 Issue: 7 Pages: 1051-1057

    • DOI

      10.1016/j.jiac.2021.04.013

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Characteristics of COVID-19 patients admitted into two hospitals in sapporo, Japan: Analyses and insights from two outbreak waves2021

    • Author(s)
      Hattori Takeshi、Saito Atsushi、Chiba Hirofumi、Kuronuma Koji、Amishima Masaru、Morinaga Daisuke、Shichinohe Yasuo、Nasuhara Yasuyuki、Konno Satoshi
    • Journal Title

      Respiratory Investigation

      Volume: 59 Issue: 2 Pages: 180-186

    • DOI

      10.1016/j.resinv.2020.11.008

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Invasive pneumococcal disease affected the fatal outcome in a COVID-19 patient2021

    • Author(s)
      Kuronuma Koji、Bunya Naofumi、Chang Bin、Fujiya Yoshihiro、Oishi Kazunori、Narimatsu Eichi、Takahashi Satoshi、Chiba Hirofumi
    • Journal Title

      Journal of Infection and Chemotherapy

      Volume: - Issue: 7 Pages: 1108-1111

    • DOI

      10.1016/j.jiac.2021.04.004

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Distribution and Variation of Serotypes and Pneumococcal Surface Protein A Clades of Streptococcus pneumoniae Strains Isolated From Adult Patients With Invasive Pneumococcal Disease in Japan2021

    • Author(s)
      Chang Bin、Kinjo Yuki、Morita Masatomo、Tamura Kosuke、Watanabe Hiroshi、Tanabe Yoshinari、Kuronuma Koji、Fujita Jiro、Oshima Kengo、Maruyama Takaya、Abe Shuichi、Kasahara Kei、Nishi Junichiro、Kubota Tetsuya、Ohnishi Makoto、Suga Shigeru、Oishi Kazunori
    • Journal Title

      Frontiers in Cellular and Infection Microbiology

      Volume: 11 Pages: 617573-617573

    • DOI

      10.3389/fcimb.2021.617573

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] A modified GAP model for East-Asian populations with idiopathic pulmonary fibrosis2020

    • Author(s)
      Nishikiori Hirotaka、Chiba Hirofumi、Lee Sang Hoon、Kondoh Shun、Kamo Ken-ichi、Nakamura Koshi、Ikeda Kimiyuki、Kuronuma Koji、Chung Man Pyo、Kondoh Yasuhiro、Homma Sakae、Inase Naohiko、Park Moo Suk、Takahashi Hiroki
    • Journal Title

      Respiratory Investigation

      Volume: 58 Issue: 5 Pages: 395-402

    • DOI

      10.1016/j.resinv.2020.04.001

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effectiveness of 23-valent pneumococcal polysaccharide vaccine against invasive pneumococcal disease in adults, Japan, 2013-20172020

    • Author(s)
      Shimbashi R, Suzuki M, Chang B, Watanabe H, Tanabe Y, Kuronuma K, Oshima K, Maruyama T, Takeda H, Kasahara K, Fujita J, Nishi J, Kubota T, Tanaka-Taya K, Matsui T, Sunagawa T, Oishi K
    • Journal Title

      Emerg Infect Dis

      Volume: 26(10) Issue: 10 Pages: 2378-2386

    • DOI

      10.3201/eid2610.191531

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CXCL9, CXCL10, and CXCL11; biomarkers of pulmonary inflammation associated with autoimmunity in patients with collagen vascular diseases?associated interstitial lung disease and interstitial pneumonia with autoimmune features2020

    • Author(s)
      Kameda Masami、Otsuka Mitsuo、Chiba Hirofumi、Kuronuma Koji、Hasegawa Takehiro、Takahashi Hiroki、Takahashi Hiroki
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 11 Pages: e0241719-e0241719

    • DOI

      10.1371/journal.pone.0241719

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Acute eosinophilic pneumonia accompanied with COVID ‐19: a case report2020

    • Author(s)
      Murao Koutaro、Saito Atsushi、Kuronuma Koji、Fujiya Yoshihiro、Takahashi Satoshi、Chiba Hirofumi
    • Journal Title

      Respirology Case Reports

      Volume: 8 Issue: 9

    • DOI

      10.1002/rcr2.683

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] Effect of pirfenidone on the development of pellagra-related nausea in mice.2023

    • Author(s)
      Kuronuma K, Susai N, Kuroita T, and Yoshioka T.
    • Organizer
      33th European Respiratory Society Annual Congress
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] COVID-19流行前後の成人侵襲性肺炎球菌感染症の罹患率と臨床像の比較.2023

    • Author(s)
      田村 恒介、常 彬、新橋 玲子、渡邊 浩、田邊 嘉也、黒沼 幸治、大島 謙吾、丸山 貴也、仲松 正司、阿部 修一、笠原 敬、西 順一郎、横山 彰仁、金城 雄樹、有馬 雄三、大石 和徳、明田 幸宏.
    • Organizer
      第97回日本感染症学会総会・学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] SARS-CoV-2 ワクチン接種後の長期的抗体価推移と次期接種のタイミングの検討.2023

    • Author(s)
      藤谷 好弘、中江 舞美、小林 亮、村井 良精、中村 広士、富樫 篤生、齋藤 充史、黒沼 幸治、高橋 聡.
    • Organizer
      第97回日本感染症学会総会・学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 間質性肺疾患を有する難治性咳嗽に対してのP2X3受容体拮抗薬の有効性の検討.2023

    • Author(s)
      髙橋 知之、齋藤 充史、萬谷 峻史、池田 貴美之、黒沼 幸治、千葉 弘文.
    • Organizer
      第63回日本呼吸器学会学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 特発性肺線維症患者におけるモストグラフで測定した呼吸リアクタンスと生命予後との関連の検討.2023

    • Author(s)
      石川 立、森 勇樹、錦織 博貴、黒沼 幸治、千葉 弘文.
    • Organizer
      第63回日本呼吸器学会学術講演会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 気管支鏡検査に関連したMycobacterium lentiflavumの偽アウトブレイク.2023

    • Author(s)
      黒沼幸治、長野佑太郎、千葉弘文.
    • Organizer
      第97回日本呼吸器内視鏡学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 小児感染症専門医が成人の感染症内科で働く意義:感染症内科開設から1年を振り返る.2023

    • Author(s)
      富樫 篤生、下川 萌、平川 賢史、長岡 由修、石郷 友之、伊部 裕太、中江 舞美、藤谷 好弘、齋藤 充史、黒沼 幸治、高橋 聡、津川 毅.
    • Organizer
      第74回北日本小児科学会
    • Related Report
      2023 Annual Research Report
  • [Presentation] COVID-19の濃厚接触者が陽性となる要因の検討2023

    • Author(s)
      中江 舞美、藤谷 好弘、富樫 篤生、中村 広士、齋藤 充史、黒沼 幸治、高橋 聡.
    • Organizer
      第38回日本環境感染学会総会・学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] ゲノム解析は同時期に複数病棟で発生したCOVID-19クラスター事例の全体像の把握に有用である.2023

    • Author(s)
      藤谷 好弘、中江 舞美、富樫 篤生、中村 広士、齋藤 充史、黒沼 幸治、高橋 聡.
    • Organizer
      第38回日本環境感染学会総会・学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 当院改修時におけるアスペルギルス対策の評価.2023

    • Author(s)
      黒沼幸治、中江舞美、韮澤慎也、富樫篤生、藤谷好弘、齋藤充史、高橋聡.
    • Organizer
      第93回日本感染症学会西日本地方会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] 当院改修中アスペルギルス対策として行った環境エアサンプリングと患者血清アスペルギルス抗原検査の評価.2023

    • Author(s)
      黒沼幸治、富樫篤生、高橋聡.
    • Organizer
      第70回日本臨床検査医学会学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] Latest Evidences of Pirfenidone in IPF Treatment.2022

    • Author(s)
      Koji Kuronuma
    • Organizer
      Taiwan Society of Pulmonary and Critical Care Medicine
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research / Invited
  • [Presentation] Covid-19肺炎における肺サーファクタントの臨床的意義2022

    • Author(s)
      黒沼幸治
    • Organizer
      日本肺サーファクタント・界面医学会 第57回学術研究会
    • Related Report
      2022 Research-status Report
  • [Presentation] COVID-19肺炎重症度予測マーカーとしてのIL-6, INF-l3, NGALの検討2022

    • Author(s)
      齋藤充史、安田健人、黒沼幸治、中江舞美、藤谷好弘、高橋聡、千葉弘文
    • Organizer
      第62回日本呼吸器学会学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] マウスモデルにおけるペラグラ関連悪心に関するピルフェニドンの作用2022

    • Author(s)
      小林智史、黒沼幸治、須佐井菜摘、黒板智博、吉岡健、千葉弘文
    • Organizer
      第62回日本呼吸器学会学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] リアルワールドデータ解析によるピルフェニドン誘発ペラグラ様光線過敏症の因子探索2022

    • Author(s)
      黒沼幸治、小林智史、黒板智博、山本浩貴、須佐井菜摘、吉岡健、金子周司、千葉弘文
    • Organizer
      第62回日本呼吸器学会学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] Mycobacterium lentiflavumによるpseudo-outbreakの事例2022

    • Author(s)
      黒沼幸治、長野佑太郎、千葉弘文
    • Organizer
      第37回日本環境感染学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] SARS-CoV-2変異株スクリーニングに関する報告2022

    • Author(s)
      北山育実、村井良精、小林 亮、中江舞美、藤谷好弘、黒沼幸治、髙橋 聡
    • Organizer
      第37回日本環境感染学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 市立釧路総合病院におけるMycobacterium lentiflavumによるpseudo-outbreakの事例に関する遺伝子学的解析を用いた後方視的研究2022

    • Author(s)
      長野佑太郎、黒沼幸治
    • Organizer
      第97回日本結核・非結核性抗酸菌症学会学術講演会
    • Related Report
      2022 Research-status Report
  • [Presentation] 男性COVID-19患者の血清テストステロン値は重症度と関連する2022

    • Author(s)
      黒沼幸治、鈴木瑛真、村井良精、中江舞美、藤谷好弘、齋藤充史、高橋聡
    • Organizer
      第71回日本感染症学会東日本地方会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 当院における10年間のvanC保有腸球菌菌血症の特徴から見る治療において重要なこと2022

    • Author(s)
      藤谷好弘、佐藤勇樹、韮澤慎也、富樫篤生、斎藤充史、黒沼幸治、高橋 聡
    • Organizer
      第71回日本感染症学会東日本地方会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] COVID-19における血清レクチン値の臨床バイオマーカーとしての有用性についての検討2022

    • Author(s)
      斎藤充史、黒沼幸治、富樫篤生、藤谷好弘、高橋 聡
    • Organizer
      第71回日本感染症学会東日本地方会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] 集中治療を要する症例における1点または2点採血によるバンコマイシンのAUC達成率の比較2022

    • Author(s)
      伊部裕太,石郷友之,藤谷好弘,黒沼幸治,藤居賢,髙橋聡
    • Organizer
      第69回日本化学療法学会東日本支部総会
    • Related Report
      2022 Research-status Report
  • [Presentation] 集中治療を要する症例における過大腎クリアランスはバンコマイシンの早期AUC乖離に関連する2022

    • Author(s)
      石郷友之,伊部裕太,相神智宏,藤谷好弘,数馬聡,黒沼幸治,藤居賢,髙橋聡
    • Organizer
      第69回日本化学療法学会東日本支部総会
    • Related Report
      2022 Research-status Report
  • [Presentation] COVID-19における血清テストステロン値と重症化因子の検討2022

    • Author(s)
      黒沼幸治、鈴木瑛真、村井良精、米澤仁、遠藤明美、藤谷好弘、高橋聡
    • Organizer
      第69回日本臨床検査医学会学術集会
    • Related Report
      2022 Research-status Report
  • [Presentation] Covid-19肺炎における肺サーファクタントの臨床的意義.2022

    • Author(s)
      黒沼幸治.
    • Organizer
      日本肺サーファクタント・界面医学会 第57回学術研究会
    • Related Report
      2021 Research-status Report
  • [Presentation] 年齢と血清型による侵襲性肺炎球菌感染症(IPD)の臨床的特徴.2021

    • Author(s)
      田村 恒介、仲松正司、藤田次郎、西 順一郎、渡邉 浩、笠原 敬、丸山 貴也、窪田哲也、石田正之、田邊嘉也、大島謙吾、阿部修一、武田博明、黒沼幸治、金城雄樹、常 彬、砂川富正、鈴木基、山本善裕、大石 和徳.
    • Organizer
      第95回日本感染症学会学術講演会2021年5月7-9日、横浜
    • Related Report
      2021 Research-status Report
  • [Presentation] 新型コロナウイルス感染症に対するデキサメタゾン投与による臨床転帰の検討.2021

    • Author(s)
      伊部 裕太,石郷 友之,北川 学, 木明 智子, 藤谷 好弘,黒沼 幸治, 藤居 賢, 髙橋 聡, 福土 将秀.
    • Organizer
      第31回日本医療薬学会年会 2021年10月9日-10日 熊本
    • Related Report
      2021 Research-status Report
  • [Presentation] COVID-19ワクチン接種後感染者1事例の抗体獲得推移.2021

    • Author(s)
      中江 舞美, 藤谷 好弘, 藤居 賢, 黒沼 幸治, 高橋 聡
    • Organizer
      第36回日本環境感染学会学術集会2021年9月19-20日、名古屋
    • Related Report
      2021 Research-status Report
  • [Presentation] 新型コロナウイルス感染症専用病棟の職員の感染リスクにかかる後向きコホート研究.2021

    • Author(s)
      藤谷 好弘, 中江 舞美, 中村 広士, 黒沼 幸治, 高橋 聡.
    • Organizer
      第36回日本環境感染学会学術集会2021年9月19-20日、名古屋
    • Related Report
      2021 Research-status Report
  • [Presentation] 未分化大細胞リンパ腫の加療中に発症したCOVID-19関連肺炎.2021

    • Author(s)
      小野 賢人, 堀口 拓人, 下山 紗央莉, 藤田 千紗, 後藤 亜香利, 池田 博, 井山 諭, 藤谷 好弘, 高橋 聡, 黒沼 幸治, 小船 雅義.
    • Organizer
      第83回日本血液学会学術集会2021年9月23-25日、Web
    • Related Report
      2021 Research-status Report
  • [Presentation] COVID-19肺炎重症度予測マーカーとしての血清SP-A,D値の検討.2021

    • Author(s)
      齋藤 充史, 黒沼 幸治, 小玉 賢太郎, 茂庭 慶悟, 高橋 聡, 高橋 弘毅, 千葉 弘文.
    • Organizer
      第61回日本呼吸器学会学術講演会2021年4月23-25日、東京
    • Related Report
      2021 Research-status Report
  • [Presentation] ピルフェニドンの抗線維化作用におけるTRPV4の役割.2021

    • Author(s)
      黒沼 幸治, 大塚 満雄, 若林 雅人, 吉岡 健, 小林 智史, 亀田 優美, 森岡 靖英, 千葉 弘文, 高橋 弘毅.
    • Organizer
      第61回日本呼吸器学会学術講演会2021年4月23-25日、東京
    • Related Report
      2021 Research-status Report
  • [Presentation] 鼻腔ぬぐい液および抗原定量検査の臨床的有効性に関する検討.2021

    • Author(s)
      藤谷 好弘, 黒沼 幸治, 高橋 聡.
    • Organizer
      第95回日本感染症学会学術講演会2021年5月7-9日、横浜
    • Related Report
      2021 Research-status Report
  • [Presentation] 新型コロナウイルス感染症におけるファビピラビル投与の評価.2021

    • Author(s)
      伊部 裕太, 藤居 賢, 石郷 友之, 國本 雄介, 藤谷 好弘, 黒沼 幸治, 高橋 聡.
    • Organizer
      第69回日本化学療法学会総会2021年5月7-9日、横浜
    • Related Report
      2021 Research-status Report
  • [Presentation] Effect of niacin in a pellagra-related nausea mouse model established using isoniazid.2021

    • Author(s)
      Susai N, Kuroita T, Yoshioka T, and Kuronuma K.
    • Organizer
      31th European Respiratory Society Annual Congress 2021 Sep 6-8:Web
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Effect of pirfenidone on the development of pellagra-related nausea in mice.2021

    • Author(s)
      Kuronuma K, Susai N, Kuroita T, and Yoshioka T.
    • Organizer
      31th European Respiratory Society Annual Congress 2021 Sep 6-8:Web
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Real world data analysis indicates that pirfenidone causes pellagra-like photosensitivity in vivo.2021

    • Author(s)
      Kuroita T, Yamamoto H, Susai N, Yoshioka T, Kuronuma K, and Kaneko S.
    • Organizer
      31th European Respiratory Society Annual Congress 2021 Sep 6-8:Web
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] The phosphate binder attenuates microlith formation and cox-2 induction in pulmonary alveolar microlithiasis.2021

    • Author(s)
      Saito A, Takamiya R, Fujitani N, Ariki S, Kuronuma K, Chiba H.
    • Organizer
      25th Congress of the APSR in Kyoto. 2021 Nov 19-20.
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Epidemiology of adult pneumococcal infections in Japan.2021

    • Author(s)
      Kuronuma K.
    • Organizer
      The 3rd Asian Pneumococcal Symposium in Nagano. 2021 Dec 2-3.
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research

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Published: 2020-04-28   Modified: 2025-01-30  

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