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Study on the mechanisms of kidney disease progression and their regulation: roles of chronic inflammation and humoral mediators

Research Project

Project/Area Number 20K08611
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53040:Nephrology-related
Research InstitutionKumamoto University

Principal Investigator

MUKOYAMA Masashi  熊本大学, 大学院生命科学研究部(医), 教授 (40270558)

Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords慢性腎臓病 / 慢性炎症 / 糖尿病性腎症 / マクロファージ / ERストレス / MRP8 / ANGPTL2 / オステオクリン / エクソソーム / シングルセル解析 / 急性腎障害 / osteocrin / バイオマーカー / 慢性腎躁病 / 臓器連関
Outline of Research at the Start

これまでCKDの治療を目標として数多くの研究がなされてきたが、いまだ進行を抑止するのに十分な治療法は開発されていない。本研究は、腎障害進展に重要と考えられる腎内慢性炎症に着目し、さらにそれを司る液性因子に焦点をあてながら、それらによる病態解明と新たな治療応用を目指して研究を進めていく。特に、マクロファージに由来する炎症惹起因子MRP8、また腎臓で多くの細胞が産生し多彩な機能を有するANGPTL2は炎症持続の重要な分子基盤となっている可能性が高く、その機序の解明及びこれらを標的とした創薬を目指して研究を行う。さらに、骨由来で腎臓でも産生されるOstnの腎保護作用についても明らかにする。

Outline of Final Research Achievements

Chronic kidney disease (CKD) is a growing health problem worldwide. The mechanisms for CKD progression remain obscure, and therefore we explored key factors, focusing on chronic inflammation and humoral factors.
We found that a macrophage-derived factor MRP8 is critical in disease progression through intra-glomerular crosstalk, activated by mesangium-derived exosomes. Mesangium-derived factors also impair podocyte function in diabetes through inhibition of ER-associated degradation. We found several factors that may aggravate CKD with diabetes by single-cell RNA analysis. A potential proinflammatory factor ANGPTL2, in contrast, may work renoprotective in an ischemia-reperfusion injury (IRI) model. In addition, bone-derived osteocrin can exert renoprotective actions upon IRI by potentiating natriuretic peptide actions locally. Furthermore, high serum levels of MRP8 and ANGPTL2 can be risk factors in hemodialysis patients. These findings may provide potential therapeutic targets for CKD.

Academic Significance and Societal Importance of the Research Achievements

糖尿病性腎症に代表されるmetabolic kidney diseaseにおける局所因子の意義、特にマクロファージ由来炎症惹起因子の増悪因子としての役割を明らかにすることで、これらを標的とした新たな創薬への基盤となる。さらに、急性腎障害慢性化の機序を明らかにすることで腎症進展阻止のための治療戦略となりうる。MRP8やANGPLT2、オステオクリンはその候補分子であり、これらを標的とした治療法はなく、病態での意義の解析から新たな治療戦略の提案へと繋がる可能性がある。一方で、これらの血中濃度は腎症患者の予後予測におけるバイオマーカーとしての意義が示唆され、今後の腎疾患診療に貢献する可能性が高い。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (56 results)

All 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (1 results) Journal Article (27 results) (of which Int'l Joint Research: 9 results,  Peer Reviewed: 27 results,  Open Access: 21 results) Presentation (28 results) (of which Int'l Joint Research: 14 results,  Invited: 8 results)

  • [Int'l Joint Research] UC Irvine(米国)

    • Related Report
      2022 Annual Research Report
  • [Journal Article] Prognostic Nutritional Index as a Predictor of Mortality in 101,616 Patients Undergoing Hemodialysis2023

    • Author(s)
      Miyasato Yoshikazu、Hanna Ramy M.、Morinaga Jun、Mukoyama Masashi、Kalantar-Zadeh Kamyar
    • Journal Title

      Nutrients

      Volume: 15 Issue: 2 Pages: 311-311

    • DOI

      10.3390/nu15020311

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of Conditional KO Mice of CCN2 and Its Function in the Kidney2023

    • Author(s)
      Yokoi Hideki、Toda Naohiro、Mukoyama Masashi
    • Journal Title

      Methods in Molecular Biology

      Volume: 2582 Pages: 391-409

    • DOI

      10.1007/978-1-0716-2744-0_27

    • ISBN
      9781071627433, 9781071627440
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long-term effectiveness of a primary care practice facilitation program for chronic kidney disease management: an extended follow-up of a cluster-randomized FROM-J study2023

    • Author(s)
      Imasawa Toshiyuki、Saito Chie、Kai Hirayasu、Iseki Kunitoshi、Kazama Junichiro James、Shibagaki Yugo、Sugiyama Hitoshi、Nagata Daisuke、Narita Ichiei、Nishino Tomoya、Hasegawa Hajime、Honda Hirokazu、Maruyama Shoichi、Miyazaki Mariko、Mukoyama Masashi、Yamagata Kunihiro、et al.
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: 38 Issue: 1 Pages: 158-166

    • DOI

      10.1093/ndt/gfac041

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The serine protease plasmin plays detrimental roles in epithelial sodium channel activation and podocyte injury in Dahl salt-sensitive rats2022

    • Author(s)
      Deng Qinyuan、Kakizoe Yutaka、Iwata Yasunobu、Nakagawa Terumasa、Miyasato Yoshikazu、Nakagawa Miyuki、Nishiguchi Kayo、Nagayoshi Yu、Adachi Masataka、Narita Yuki、Izumi Yuichiro、Kuwabara Takashige、Tsuda Yuko、Mukoyama Masashi
    • Journal Title

      Hypertension Research

      Volume: 46 Issue: 1 Pages: 50-62

    • DOI

      10.1038/s41440-022-01064-2

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Camostat mesilate, a serine protease inhibitor, exerts aquaretic effects and decreases urinary exosomal AQP2 levels2022

    • Author(s)
      Kakizoe Yutaka、Nakagawa Terumasa、Iwata Yasunobu、Deng Qinyuan、Adachi Masataka、Miyasato Yoshikazu、Nakagawa Miyuki、Nagayoshi Yu、Nishiguchi Kayo、Narita Yuki、Izumi Yuichiro、Kuwabara Takashige、Tomita Kimio、Kitamura Kenichiro、Mukoyama Masashi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 150 Issue: 4 Pages: 204-210

    • DOI

      10.1016/j.jphs.2022.09.003

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] t6A and ms2t6A Modified Nucleosides in Serum and Urine as Strong Candidate Biomarkers of COVID-19 Infection and Severity2022

    • Author(s)
      Nagayoshi Y、Nishiguchi K、Yamamura R、Chujo T、Oshiumi H、Nagata H、Kaneko Hi、Yamamoto K、Nakata H、Sakakida K、Kunisawa A、Adachi M、Kakizoe Y、Mizobe T、Kuratsu Ji、Shimada S、Nakamori Y、Matsuoka M、Mukoyama M、Wei FY、Tomizawa K
    • Journal Title

      Biomolecules

      Volume: 12 Issue: 9 Pages: 1233-1233

    • DOI

      10.3390/biom12091233

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A Novel VCP modulator KUS121 exerts renoprotective effects in ischemia-reperfusion injury with retaining ATP and restoring ERAD-processing capacity.2022

    • Author(s)
      Hata Yusuke、Date Ryosuke、Fujimoto Daisuke、Ikeda Hanako Ohashi、Umemoto Shuro、Kanki Tomoko、Nishiguchi Yoshihiko、Mizumoto Teruhiko、Hayata Manabu、Kakizoe Yutaka、Izumi Yuichiro、Kakizuka Akira、Mukoyama Masashi、Kuwabara Takashige
    • Journal Title

      American Journal of Physiology-Renal Physiology

      Volume: - Issue: 5 Pages: F577-F586

    • DOI

      10.1152/ajprenal.00392.2021

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibition of mitochondrial fission protects podocytes from albumin-induced cell damage in diabetic kidney disease2022

    • Author(s)
      Tagaya Makoto、Kume Shinji、Yasuda-Yamahara Mako、Kuwagata Shogo、Yamahara Kosuke、Takeda Naoko、Tanaka Yuki、Chin-Kanasaki Masami、Nakae Yuki、Yokoi Hideki、Mukoyama Masashi、Ishihara Naotada、Nomura Masatoshi、Araki Shin-ichi、Maegawa Hiroshi
    • Journal Title

      Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease

      Volume: 1868 Issue: 5 Pages: 166368-166368

    • DOI

      10.1016/j.bbadis.2022.166368

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Roxadustat on Erythropoietin Production in the Rat Body2022

    • Author(s)
      Yasuoka Yukiko,Izumi Yuichiro,Fukuyama Takashi,Omiya Haruki,Pham Truyen D.,Inoue Hideki,Oshima Tomomi,Yamazaki Taiga,Uematsu Takayuki,Kobayashi Noritada,Shimada Yoshitaka,Nagaba Yasushi,Yamashita Tetsuro,Mukoyama Masashi,Sato Yuichi,Wall Susan M.,Sands Jeff M.,Takahashi Noriko,Kawahara Katsumasa,Nonoguchi Hiroshi
    • Journal Title

      Molecules

      Volume: 27 Issue: 3 Pages: 1119-1119

    • DOI

      10.3390/molecules27031119

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Regulation of Rhcg, an ammonia transporter, by aldosterone in the kidney.2021

    • Author(s)
      Eguchi K, Izumi Y, Yasuoka Y, Nakagawa T, Ono M, Maruyama K, Matsuo N, Hiramatsu A, Inoue H, Nakayama Y, Nonoguchi H, Lee HW, Weiner ID, Kakizoe Y, Kuwabara T, Mukoyama M.
    • Journal Title

      J Endocrinol.

      Volume: in press Issue: 2 Pages: 95-112

    • DOI

      10.1530/joe-20-0267

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Multicentre Study on the Efficacy of Brachial Artery Transposition Among Haemodialysis Patients2021

    • Author(s)
      Murakami Masaaki、Mori Kiyoshi、Hamanoue Satoshi、Suemitsu Kotaro、Kajiwara Kengo、Miyamoto Masahito、Inoue Hideki、Sueki Shina、Nihei Hiroshi、Mukoyama Masashi
    • Journal Title

      European Journal of Vascular and Endovascular Surgery

      Volume: 61 Issue: 6 Pages: 998-1006

    • DOI

      10.1016/j.ejvs.2021.01.038

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dysregulation of PI3K and Hippo signaling pathways synergistically induces chronic pancreatitis via CTGF upregulation2021

    • Author(s)
      Tamura Takeshi、Kodama Takahiro、Sato Katsuhiko、Murai Kazuhiro、Yoshioka Teppei、Shigekawa Minoru、Yamada Ryoko、Hikita Hayato、Sakamori Ryotaro、Akita Hirofumi、Eguchi Hidetoshi、Johnson Randy L.、Yokoi Hideki、Mukoyama Masashi、Tatsumi Tomohide、Takehara Tetsuo
    • Journal Title

      Journal of Clinical Investigation

      Volume: 131 Issue: 13

    • DOI

      10.1172/jci143414

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats2021

    • Author(s)
      Mizumoto Teruhiko、Kakizoe Yutaka、Nakagawa Terumasa、Iwata Yasunobu、Miyasato Yoshikazu、Uchimura Kohei、Adachi Masataka、Deng Qinyuan、Hayata Manabu、Morinaga Jun、Miyoshi Taku、Izumi Yuichiro、Kuwabara Takashige、Sakai Yoshiki、Tomita Kimio、Kitamura Kenichiro、Mukoyama Masashi
    • Journal Title

      Journal of Pharmacological Sciences

      Volume: 146 Issue: 4 Pages: 192-199

    • DOI

      10.1016/j.jphs.2021.04.003

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of Angiotensin II on Erythropoietin Production in the Kidney and Liver2021

    • Author(s)
      Yasuoka Yukiko、Izumi Yuichiro、Fukuyama Takashi、Inoue Hideki、Oshima Tomomi、Yamazaki Taiga、Uematsu Takayuki、Kobayashi Noritada、Shimada Yoshitaka、Nagaba Yasushi、Mukoyama Masashi、Sato Yuichi、Sands Jeff M、Kawahara Katsumasa、Nonoguchi Hiroshi
    • Journal Title

      Molecules

      Volume: 26 Issue: 17 Pages: 5399-5399

    • DOI

      10.3390/molecules26175399

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Salt-Sensitive Hypertension of the Renal Tubular Cell-Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice2021

    • Author(s)
      Hiramatsu Akiko、Izumi Yuichiro、Eguchi Koji、Matsuo Naomi、Deng Qinyuan、Inoue Hideki、Nakayama Yushi、Nonoguchi Hiroshi、Aramburu Jose、Lopez-Rodriguez Cristina、Kakizoe Yutaka、Adachi Masataka、Kuwabara Takashige、Kim-Mitsuyama Shokei、Mukoyama Masashi
    • Journal Title

      Hypertension

      Volume: 78 Issue: 5 Pages: 1335-1346

    • DOI

      10.1161/hypertensionaha.121.17435

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Osteocrin ameliorates adriamycin nephropathy via p38 mitogen-activated protein kinase inhibition2021

    • Author(s)
      Handa Takaya、Mori Keita P.、Ishii Akira、Ohno Shoko、Kanai Yugo、Watanabe-Takano Haruko、Yasoda Akihiro、Kuwabara Takashige、Takahashi Nobuyuki、Mochizuki Naoki、Mukoyama Masashi、Yanagita Motoko、Yokoi Hideki
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 21835-21835

    • DOI

      10.1038/s41598-021-01095-8

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Vaccine targeting ANGPTL3 ameliorates dyslipidemia and associated diseases in mouse models of obese dyslipidemia and familial hypercholesterolemia2021

    • Author(s)
      Fukami Hirotaka、Morinaga Jun、Nakagami Hironori、Hayashi Hiroki、Okadome Yusuke、Matsunaga Eiji、Kadomatsu Tsuyoshi、Horiguchi Haruki、Sato Michio、Sugizaki Taichi、Kuwabara Takashige、Miyata Keishi、Mukoyama Masashi、Morishita Ryuichi、Oike Yuichi
    • Journal Title

      Cell Reports Medicine

      Volume: 2 Issue: 11 Pages: 100446-100446

    • DOI

      10.1016/j.xcrm.2021.100446

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia-reperfusion injury in mice2021

    • Author(s)
      Nishiguchi Yoshihiko、Hata Yusuke、Date Ryosuke、Fujimoto Daisuke、Umemoto Shuro、Kanki Tomoko、Yokoi Hideki、Mori Keita P、Handa Takaya、Watanabe-Takano Haruko、Kanai Yugo、Yasoda Akihiro、Izumi Yuichiro、Kakizoe Yutaka、Mochizuki Naoki、Mukoyama Masashi、Kuwabara Takashige
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: 37 Issue: 3 Pages: 444-453

    • DOI

      10.1093/ndt/gfab286

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] MAGI-2 orchestrates the localization of backbone proteins in the slit diaphragm of podocytes2021

    • Author(s)
      Yamada Hiroyuki, Mukoyama Masashi, Asanuma Katsuhiko, et al.
    • Journal Title

      Kidney International

      Volume: 99 Issue: 2 Pages: 382-395

    • DOI

      10.1016/j.kint.2020.09.027

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating angiopoietin-like protein 2 levels and arterial stiffness in patients receiving maintenance hemodialysis: A cross-sectional study.2020

    • Author(s)
      Fukami H, Morinaga J, Okadome Y, Nishiguchi Y, Iwata Y, Kanki T, Nakagawa T, Izumi Y, Kakizoe Y, Kuwabara T, Horiguchi H, Sato M, Kadomatsu T, Miyata K, Tajiri T, Oike Y, Mukoyama M.
    • Journal Title

      Atherosclerosis.

      Volume: 315 Pages: 18-23

    • DOI

      10.1016/j.atherosclerosis.2020.10.890

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Efficacy of continuous erythropoietin receptor activator for end-stage renal disease patients with renal anemia before and after peritoneal dialysis initiation2020

    • Author(s)
      Fujimoto Daisuke, Adachi Masataka, Mukoyama Masashi, et al.
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 25 Issue: 2 Pages: 191-199

    • DOI

      10.1007/s10157-020-01973-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Differentiation of endogenous erythropoietin and exogenous ESAs by Western blotting.2020

    • Author(s)
      Yasuoka Y, Fukuyama T, Izumi Y, Yamashita T, Nakayama Y, Inoue H, Yanagita K, Oshima T, Yamazaki T, Uematsu T, Kobayashi N, Shimada Y, Nagaba Y, Mukoyama M, Sato Y, Sands JM, Kawahara K, Nonoguchi H.
    • Journal Title

      Heliyon.

      Volume: 6 Issue: 11 Pages: e05389-e05389

    • DOI

      10.1016/j.heliyon.2020.e05389

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Suppressed ER-associated degradation by intraglomerular cross talk between mesangial cells and podocytes causes podocyte injury in diabetic kidney disease.2020

    • Author(s)
      Fujimoto D, Kuwabara T, Hata Y, Umemoto S, Kanki T, Nishiguchi Y, Mizumoto T, Hayata M, Kakizoe Y, Izumi Y, Takahashi S, Mukoyama M.
    • Journal Title

      FASEB J

      Volume: 34 Issue: 11 Pages: 854-860

    • DOI

      10.1096/fj.202000078rr

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Erythropoietin production by the kidney and the liver in response to severe hypoxia evaluated by Western blotting with deglycosylation2020

    • Author(s)
      Yukiko Yasuoka, Takashi Fukuyama, Yuichiro Izumi, Yushi Nakayama, Hideki Inoue, Kengo Yanagita, Tomomi Oshima, Taiga Yamazaki, Takayuki Uematsu 2, Noritada Kobayashi 2, Yoshitaka Shimada 5, Yasushi Nagaba, Masashi Mukoyama, Tetsuro Yamashita, Yuichi Sato, Jeff M Sands, Katsumasa Kawahara, Hiroshi Nonoguchi
    • Journal Title

      Physiol Rep.

      Volume: 12 Issue: 12

    • DOI

      10.14814/phy2.14485

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The predictive role of serum calprotectin on mortality in hemodialysis patients with high phosphoremia2020

    • Author(s)
      Kanki Tomoko、Kuwabara Takashige、Morinaga Jun、Fukami Hirotaka、Umemoto Shuro、Fujimoto Daisuke、Mizumoto Teruhiko、Hayata Manabu、Kakizoe Yutaka、Izumi Yuichiro、Tajiri Saeko、Tajiri Tetsuya、Kitamura Kenichiro、Mukoyama Masashi
    • Journal Title

      BMC Nephrology

      Volume: 21 Issue: 1 Pages: 158-158

    • DOI

      10.1186/s12882-020-01812-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pivotal role of podocyte autophagy against glomerular endothelial dysfunction in diabetes.2020

    • Author(s)
      Yoshibayashi M, Kume S, Yasuda-Yamahara M, Yamahara K, Takeda N, Osawa N, Chin-Kanasaki M, Nakae Y, Yokoi H, Mukoyama M, Asanuma K, Maegawa H, Araki SI.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 525 Issue: 2 Pages: 319-325

    • DOI

      10.1016/j.bbrc.2020.02.088

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circulating angiopoietin-like protein 2 levels and mortality risk in patients receiving maintenance hemodialysis: a prospective cohort study2019

    • Author(s)
      Morinaga J, Kakuma T, Fukami H, Hayata M, Uchimura K, Mizumoto T, Kakizoe Y, Miyoshi T, Shiraishi N, Adachi M, Izumi Y, Kuwabara T, Okadome Y, Sato M, Horiguchi H, Sugizaki T, Kadomatsu T, Miyata K, Tajiri S, Tajiri T, Tomita K, Kitamura K, Oike Y, Mukoyama M.
    • Journal Title

      Nephrology Dialysis Transplantation

      Volume: 印刷中 Issue: 5 Pages: 854-860

    • DOI

      10.1093/ndt/gfz236

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] Natriuretic Peptides and Humoral Factors in Cardiorenal Syndrome and Resistant Hypertension2022

    • Author(s)
      Mukoyama Masashi
    • Organizer
      International Society of Hypertension (ISH2022 Kyoto)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exosome-mediated intercellular crosstalk between mesangial cells and macrophages participates in the progression of diabetic kidney disease2022

    • Author(s)
      Fujimoto Daisuke, Kuwabara Takashige, Mukoyama Masashi, et al.
    • Organizer
      International Society of Hypertension (ISH2022 Kyoto)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of renal tubular NFAT5 in the regulation of blood pressure and body fluid volume2022

    • Author(s)
      Izumi Yuichiro, Hiramatsu Akiko, Mukoyama Masashi, et al.
    • Organizer
      International Society of Hypertension (ISH2022 Kyoto)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Novel molecular mechanisms of cardio-renal interaction mediated by increased serum modified nucleosides associated with renal failure2022

    • Author(s)
      Nagayoshi Yu, Yamamura Ryosuke, Mukoyama Masashi, et al.
    • Organizer
      International Society of Hypertension (ISH2022 Kyoto)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of a therapeutic vaccine for dyslipidemia and related diseases targeting angiopoietin-like protein 3 (ANGPTL3)2022

    • Author(s)
      Fukami Hirotaka, Morinaga Jun, Mukoyama Masashi, et al.
    • Organizer
      International Society of Hypertension (ISH2022 Kyoto)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Plasmin inhibition alleviates hypertension and podocyte injury in Dahl salt-sensitive rats2022

    • Author(s)
      Deng Qinyuan, Kakizoe Yutaka, Mukoyama Masashi, et al.
    • Organizer
      International Society of Hypertension (ISH2022 Kyoto)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Serine protease inhibition exerts aquaretic effects and decreases urinary exosomal AQP2 levels2022

    • Author(s)
      Kakizoe Yutaka, Iwata Yasunobu, Mukoyama Masashi, et al.
    • Organizer
      International Society of Hypertension (ISH2022 Kyoto)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] CVEM, natriuretic peptides, and metabolic kidney disease2022

    • Author(s)
      Mukoyama Masashi
    • Organizer
      International Meeting of Cardiovascular Endocrinology and Metabolism (CVEM2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Exploration of novel exosome-targeted strategy for diabetic kidney disease by drug library screening to inhibit intraglomerular crosstalk2022

    • Author(s)
      Fujimoto Daisuke, Kuwabara Takashige, Mukoyama Masashi, et al.
    • Organizer
      International Meeting of Cardiovascular Endocrinology and Metabolism (CVEM2022)
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of exosome-mediated intraglomerular crosstalk between mesangial cells and macrophages in the progression of diabetic kidney disease2022

    • Author(s)
      Fujimoto Daisuke, Kuwabara Takashige, Mukoyama Masashi, et al.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] KUS121, an ATP-retaining VCP modulator, exerts renoprotective effects in ischemia-reperfusion injury with enhancing ER-associated degradation2022

    • Author(s)
      Date Ryosuke, Kuwabara Takashige, Mukoyama Masashi, et al.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ARNI による高血圧/CKD 診療の新展開2022

    • Author(s)
      桒原孝成、向山政志
    • Organizer
      第65回日本腎臓学会学術総会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 内分泌因子からみた腎恒常性維持機構とその破綻:臓器連関の意義2022

    • Author(s)
      向山政志
    • Organizer
      第52回日本腎臓学会西部学術大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] A novel ATP-retaining compound, KUS121, enhances ER-associated degradation and exerts renoprotective effects against acute kidney injury2022

    • Author(s)
      Hata Yusuke, Kuwabara Takashige, Mukoyama Masashi, et al.
    • Organizer
      World Congress of Nephrology 2022
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Suppression of ER-associated degradation by intraglomerular cross-communication between mesangial cells and podocytes causes podocyte injury in diabetic kidney disease2022

    • Author(s)
      Fujimoto Daisuke, Kuwabara Takashige, Mukoyama Masashi, et al.
    • Organizer
      World Congress of Nephrology 2022
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] Regulation of sodium excretion and blood pressure by the nuclear factor of activated T cells 5 (NFAT5) in renal tubular cells2021

    • Author(s)
      Hiramatsu Akiko, Izumi Yuichiro, Mukoyama Masashi, et al.
    • Organizer
      Annual Meeting of the American Society of Nephrology
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] ナトリウム利尿ペプチド系からみた高血圧病態と臓器連関2021

    • Author(s)
      向山政志
    • Organizer
      第94回日本内分泌学会学術総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 腎尿細管細胞内NFAT5の塩分感受性高血圧への関与の検討2021

    • Author(s)
      平松晶子、泉裕一郎、向山政志、他
    • Organizer
      第94回日本内分泌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 糖尿病においてメサンギウム細胞との連関がポドサイトの小胞体関連分解経路の阻害を介して腎症を進展させる2021

    • Author(s)
      藤本大介、桒原孝成、向山政志、他
    • Organizer
      第64回日本腎臓学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 新規VCP modulatorであるKUS121はATPを保持し腎虚血再灌流傷害を軽減する2021

    • Author(s)
      秦 雄介、桒原孝成、向山政志、他
    • Organizer
      第64回日本腎臓学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 尿細管細胞内NFAT5による腎間質線維化抑制の機序の検討2021

    • Author(s)
      小野 真、泉裕一郎、向山政志、他
    • Organizer
      第64回日本腎臓学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 尿中酸排泄に対するユビキチン-プロテアソーム系の意義の検討2021

    • Author(s)
      丸山功祐、泉裕一郎、向山政志、他
    • Organizer
      第64回日本腎臓学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] アンジオポエチン様因子3(ANGPTL3)を標的とした新規脂質異常症治療ワクチンの開発2021

    • Author(s)
      深水大天、森永 潤、向山政志、他
    • Organizer
      第25回日本心血管内分泌代謝学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 循環調節ホルモンによる腎臓恒常性維持・破綻と臓器連関に関する研究2021

    • Author(s)
      向山政志
    • Organizer
      第24回日本心血管内分泌代謝学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 腎生理から考えるカリウム代謝異常の臨床的意義2020

    • Author(s)
      泉裕一郎, 向山政志
    • Organizer
      第63回日本腎臓学会学術総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] MRP8欠損はMφ Mincle発現制御を介して腎炎進展を抑制する2020

    • Author(s)
      秦 雄介, 向山政志, 他
    • Organizer
      第63回日本腎臓学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 腎障害進展における骨由来分泌因子Osteocrinの腎保護効果2020

    • Author(s)
      西口佳彦, 向山政志, 他
    • Organizer
      第63回日本腎臓学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 神経体液性因子から考えるナトリウム利尿ペプチドと心腎連関2020

    • Author(s)
      向山政志
    • Organizer
      日本糖尿病学会 第54回糖尿病学の進歩
    • Related Report
      2020 Research-status Report
    • Invited

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Published: 2020-04-28   Modified: 2024-01-30  

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