(Pro)renin receptor and renal fibrosis

• Project/Area Number: 20K08612
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53040:Nephrology-related
• Research Institution: Tohoku University
• Principal Investigator: Hirose Takuo 東北大学, 医学系研究科, 助教 (20599302)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: (プロ)レニン受容体 / 線維化 / 腎臓 / レニン・アンジオテンシン系 / 形質転換 / 尿細管障害 / 周皮細胞 / 腎障害

Outline of Research at the Start

腎臓で線維化が進行すると腎機能が低下し、透析や腎移植などの腎代替療法を迫られる。一度生じた線維化は不可逆的であり、腎臓線維化を引き起こす機序を明らかにし、治療標的を見つけ出すことは危急の課題である。本研究では、（プロ）レニン受容体の腎臓線維化への関与とその作用機序をヒト及び動物実験、培養細胞を用いた解析を行うことにより相補的・網羅的に解明する。これにより、腎臓線維化における（プロ）レニン受容体の病態生理学的役割を解明し、（プロ）レニン受容体による臓器障害という観点に立脚した新しい予防・治療戦略の基盤を構築する。

Outline of Final Research Achievements

The (pro)renin receptor [(P)RR] is identified as a component of the renin-angiotensin system and this has been shown to be involved in many human diseases. To elucidate the pathophysiological role of (P)RR in renal fibrosis, we performed experiments in human, animals, and cultured cells. (P)RR contributes to renal fibrosis by regulating V-ATPase function and the transport of fibrotic proteins such as fibronectin and collagen to the extracellular space.

Academic Significance and Societal Importance of the Research Achievements

本研究のヒト及び動物実験、培養細胞を用いた検討により、腎臓線維化における(P)RRの病態生理学的役割が明らかとなった。腎臓線維化において、(P)RRは維化タンパク質の細胞外への輸送をV-ATPaseを介して制御していた。これまで(P)RRを標的する薬剤は開発されておらず、本研究成果が腎臓線維化に対する新たな予防・治療戦略の基盤となることが期待される。

Research Products

• [Journal Article] Female Reproductive Events and Subclinical Atherosclerosis of the Brain and Carotid Arteriopathy: the Ohasama Study (2023)
  • Author(s): Sato Wakana、Nomura Kyoko、Satoh Michihiro、Hara Azusa、Tsubota-Utsugi Megumi、Murakami Takahisa、Asayama Kei、Tatsumi Yukako、Kobayashi Yuki、Hirose Takuo、Inoue Ryusuke、Totsune Tomoko、Kikuya Masahiro、Hozawa Atsushi、Metoki Hirohito、Imai Yutaka、Watanabe Hiroyuki、Ohkubo Takayoshi
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 30 Issue: 8 Pages: 956-978
  • DOI: 10.5551/jat.63592
  • ISSN: 1340-3478, 1880-3873
  • Year and Date: 2023-08-01
  • Peer Reviewed / Open Access
• [Journal Article] Cross-classification by systolic and diastolic blood pressure levels and chronic kidney disease, proteinuria, or kidney function decline (2023)
  • Author(s): Suenaga Tsukasa、Satoh Michihiro、Murakami Takahisa、Hirose Takuo、Obara Taku、Nakayama Shingo、Hashimoto Hideaki、Toyama Maya、Muroya Tomoko、Kanno Atsuhiro、Mori Takefumi、Ohkubo Takayoshi、Imai Yutaka、Metoki Hirohito
  • Journal Title: Hypertension Research Volume: - Issue: 8 Pages: 1860-1869
  • DOI: 10.1038/s41440-023-01267-1
  • Peer Reviewed
• [Journal Article] The long-term reproducibility of the white-coat effect on blood pressure as a continuous variable from the Ohasama Study (2023)
  • Author(s): Satoh Michihiro、Yoshida Tomoya、Metoki Hirohito、Murakami Takahisa、Tatsumi Yukako、Hirose Takuo、Takabatake Kyosuke、Tsubota-Utsugi Megumi、Hara Azusa、Nomura Kyoko、Asayama Kei、Kikuya Masahiro、Hozawa Atsushi、Imai Yutaka、Ohkubo Takayoshi
  • Journal Title: Scientific Reports Volume: 13 Issue: 1 Pages: 4985-4985
  • DOI: 10.1038/s41598-023-31861-9
  • Peer Reviewed / Open Access
• [Journal Article] Hidden malignancy in large polycystic liver and kidney (2023)
  • Author(s): Ito Hiroki、Hirose Takuo、Mori Takefumi
  • Journal Title: Clinical and Experimental Nephrology Volume: Epub Issue: 5 Pages: 490-492
  • DOI: 10.1007/s10157-023-02326-0
  • Peer Reviewed
• [Journal Article] Association Between Ambulatory Blood Pressure and Risk of Home Hypertension in a Normotensive Population: The Ohasama Study (2022)
  • Author(s): Nakayama Shingo、Satoh Michihiro、Metoki Hirohito、Murakami Takahisa、Tatsumi Yukako、Asayama Kei、Hara Azusa、Hirose Takuo、Tsubota-Utsugi Megumi、Kikuya Masahiro、Mori Takefumi、Hozawa Atsushi、Imai Yutaka、Ohkubo Takayoshi
  • Journal Title: American Journal of Hypertension Volume: 36 Issue: 3 Pages: 151-158
  • DOI: 10.1093/ajh/hpac121
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of sodium-glucose cotransporter 2 suppresses renal stone formation (2022)
  • Author(s): Anan G, Hirose T, Kikuchi D, Takahashi C, Endo A, Ito H, Sato S, Nakayama S, Hashimoto H, Ishiyama K, Kimura T, Takahashi K, Sato M, Mori T.
  • Journal Title: Pharmacol Res Volume: 1 Pages: 106524-106524
  • DOI: 10.1016/j.phrs.2022.106524
  • Peer Reviewed / Open Access
• [Journal Article] (Pro)renin receptor and insulin signalling regulate cell proliferation in MCF-7 breast cancer cells (2022)
  • Author(s): Sato Shigemitsu、Hirose Takuo、Ohba Koji、Watanabe Fumihiko、Watanabe Tomoki、Minato Kazuya、Endo Akari、Ito Hiroki、Mori Takefumi、Takahashi Kazuhiro
  • Journal Title: The Journal of Biochemistry Volume: 172 Issue: 6 Pages: 355-363
  • DOI: 10.1093/jb/mvac072
  • Peer Reviewed / Open Access
• [Journal Article] Inhibition of platelet-derived growth factor pathway suppresses tubulointerstitial injury in renal congestion (2022)
  • Author(s): Matsuki Takuma、Hirose Takuo、Ohsaki Yusuke、Shimada Satoshi、Endo Akari、Ito Hiroki、Takahashi Chika、Yamakoshi Seiko、Oba-Yabana Ikuko、Anan Go、Kato Toshiko、Tajima Ryo、Nakayama Shingo、Kimura Tomoyoshi、Nakamura Hannah、Tani Junichi、Takahashi Kazuhiro、Kure Shigeo、Mori Takefumi
  • Journal Title: Journal of Hypertension Volume: 40 Issue: 10 Pages: 1935-1949
  • DOI: 10.1097/hjh.0000000000003191
  • Peer Reviewed / Open Access
• [Journal Article] Actual impact of angiotensin II receptor blocker or calcium channel blocker monotherapy on renal function in real-world patients (2022)
  • Author(s): Satoh Michihiro、Hirose Takuo、Satoh Hironori、Nakayama Shingo、Obara Taku、Murakami Takahisa、Muroya Tomoko、Asayama Kei、Kikuya Masahiro、Mori Takefumi、Imai Yutaka、Ohkubo Takayoshi、Metoki Hirohito
  • Journal Title: Journal of Hypertension Volume: 40 Issue: 8 Pages: 1564-1576
  • DOI: 10.1097/hjh.0000000000003186
  • Peer Reviewed
• [Journal Article] Association of home and office systolic and diastolic hypertension with glucose metabolism in a general population: the Ohasama study (2022)
  • Author(s): Tatsumi Yukako、Satoh Michihiro、Asayama Kei、Murakami Takahisa、Hirose Takuo、Hara Azusa、Tsubota-Utsugi Megumi、Inoue Ryusuke、Kikuya Masahiro、Nomura Kyoko、Metoki Hirohito、Hozawa Atsushi、Katagiri Hideki、Imai Yutaka、Ohkubo Takayoshi
  • Journal Title: Journal of Hypertension Volume: 40 Issue: 7 Pages: 1336-1343
  • DOI: 10.1097/hjh.0000000000003145
  • Peer Reviewed
• [Journal Article] The sexual dimorphism of kidney growth in mice and humans (2022)
  • Author(s): Laouari Denise、Vergnaud Paul、Hirose Takuo、Zaidan Mohamad、Rabant Marion、Nguyen Cl?ment、Burtin Martine、Legendre Christophe、Codogno Patrice、Friedlander Gerard、Anglicheau Dany、Terzi Fabiola
  • Journal Title: Kidney International Volume: 102 Issue: 1 Pages: 78-95
  • DOI: 10.1016/j.kint.2022.02.027
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Association between urinary sodium-to-potassium ratio and home blood pressure and ambulatory blood pressure: the Ohasama study (2022)
  • Author(s): Muroya Tomoko、Satoh Michihiro、Murakami Takahisa、Nakayama Shingo、Asayama Kei、Hirose Takuo、Tatsumi Yukako、Inoue Ryusuke、Tsubota-Utsugi Megumi、Hara Azusa、Kogure Mana、Nakaya Naoki、Nomura Kyoko、Kikuya Masahiro、Metoki Hirohito、Imai Yutaka、Hozawa Atsushi、Ohkubo Takayoshi
  • Journal Title: Journal of Hypertension Volume: 40 Issue: 5 Pages: 862-869
  • DOI: 10.1097/hjh.0000000000003087
  • Peer Reviewed / Open Access
• [Journal Article] Creation of X-linked Alport syndrome rat model with Col4a5 deficiency (2021)
  • Author(s): Namba Masumi、Kobayashi Tomoe、Kohno Mayumi、Koyano Takayuki、Hirose Takuo、Fukushima Masaki、Matsuyama Makoto
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 20836-20836
  • DOI: 10.1038/s41598-021-00354-y
  • Peer Reviewed / Open Access
• [Journal Article] Elevated (Pro)renin Receptor Expression by Anti-Cancer Drugs, Carboplatin and Paclitaxel, in Cultured Cancer Cells: Possible Involvement of Apoptosis and Autophagy (2021)
  • Author(s): Kashio-Yokota Yurina、Sato Shigemitsu、Hirose Takuo、Watanabe Tomoki、Endo Akari、Watanabe Fumihiko、Endo Moe、Ohba Koji、Mori Takefumi、Takahashi Kazuhiro
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 255 Issue: 2 Pages: 91-104
  • DOI: 10.1620/tjem.255.91
  • NAID: 130008104155
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] Detailed association between serum uric acid levels and the incidence of chronic kidney disease stratified by sex in middle-aged adults (2021)
  • Author(s): Nakayama Shingo、Satoh Michihiro、Tatsumi Yukako、Murakami Takahisa、Muroya Tomoko、Hirose Takuo、Ohkubo Takayoshi、Mori Takefumi、Hozawa Atsushi、Metoki Hirohito
  • Journal Title: Atherosclerosis Volume: 330 Pages: 107-113
  • DOI: 10.1016/j.atherosclerosis.2021.06.908
  • Peer Reviewed
• [Journal Article] Lifetime risk of stroke stratified by chronic kidney disease and hypertension in the general Asian population: the Ohasama study (2021)
  • Author(s): Nakayama Shingo、Satoh Michihiro、Metoki Hirohito、Murakami Takahisa、Asayama Kei、Hara Azusa、Hirose Takuo、Kanno Atsuhiro、Inoue Ryusuke、Tsubota-Utsugi Megumi、Kikuya Masahiro、Mori Takefumi、Hozawa Atsushi、Imai Yutaka、Ohkubo Takayoshi
  • Journal Title: Hypertension Research Volume: 44 Issue: 7 Pages: 866-873
  • DOI: 10.1038/s41440-021-00635-z
  • Peer Reviewed
• [Journal Article] Metformin slows liver cyst formation and fibrosis in experimental model of polycystic liver disease (2021)
  • Author(s): Sato Yoichi、Qiu Jiahe、Hirose Takuo、Miura Takahiro、Sato Yasunori、Kohzuki Masahiro、Ito Osamu
  • Journal Title: American Journal of Physiology-Gastrointestinal and Liver Physiology Volume: 320 Issue: 4 Pages: G464-G473
  • DOI: 10.1152/ajpgi.00120.2020
  • Peer Reviewed / Open Access
• [Journal Article] (Pro)renin receptor/ATP6AP2 is required for autophagy and regulates proliferation in lung adenocarcinoma cells (2020)
  • Author(s): Ohba K, Endo E, Sato S, Kashio-Yokota Y, Hirose T, Takahashi K
  • Journal Title: Genes Cells Volume: 25 Issue: 12 Pages: 782-795
  • DOI: 10.1111/gtc.12812
  • Peer Reviewed
• [Journal Article] Blood pressure and chronic kidney disease stratified by gender and the use of antihypertensive drugs (2020)
  • Author(s): Satoh M, Hirose T, Nakayama S, Murakami T, Takabatake K, Asayama K, Imai Y, Ohkubo T, Mori T, Metoki H
  • Journal Title: J Am Heart Assoc Volume: 9 Issue: 16
  • DOI: 10.1161/jaha.119.015592
  • Peer Reviewed / Open Access
• [Journal Article] High Salt Intake-Increased (Pro)renin Receptor Expression Is Exaggerated in the Kidney of Dahl Salt-Sensitive Rats (2020)
  • Author(s): Yamakoshi Seiko、Ito Osamu、Rong Rong、Ohsaki Yusuke、Nakamura Takahiro、Hirose Takuo、Takahashi Kazuhiro、Mori Takefumi、Totsune Kazuhito、Kohzuki Masahiro
  • Journal Title: Hypertension Volume: 75 Issue: 6 Pages: 1447-1454
  • DOI: 10.1161/hypertensionaha.119.13905
  • Peer Reviewed
• [Presentation] The long-term reproducibility of the white-coat effect on blood pressure as a continuous variable: the Ohasama Study (2023)
  • Author(s): Satoh M, Yoshida T, Metoki H, Murakami T, Tatsumi Y, Hirose T, Takabatake K, Tsubota-Utsugi M, Hara A, Nomura K, Asayama K, Kikuya M, Hozawa A, Imai Y, Ohkubo T
  • Organizer: 32nd European Meeting on Hypertension and Cardiovascular Protection
  • Int'l Joint Research
• [Presentation] バゾプレシン2型受容体ノックアウトラットにおける腎性尿崩症の解析 (2023)
  • Author(s): 廣瀬卓男、鎌田綾佳、伊藤大樹、佐藤重光、髙橋知香、石川里紗、遠藤明里、加藤季子、矢花郁子、中村はな、高橋和広、森建文
  • Organizer: 第96回日本内分泌学会学術総会
• [Presentation] バゾプレシン2型受容体ノックアウトラットの作出と表現型の解析 (2023)
  • Author(s): 廣瀬卓男、鎌田綾佳、伊藤大樹、佐藤重光、髙橋知香、石川里紗、遠藤明里、加藤季子、矢花郁子、中村はな、高橋和広、森建文
  • Organizer: 第32回バソプレシン・オキシトシン研究会
• [Presentation] Pericyte detachment and interstitial fibrosis in Dahl salt-sensitive hypertensive (DahlS) rats (2022)
  • Author(s): Ito H, Hirose T, Sato S, Takahashi K, Mori T
  • Organizer: Kidney week 2022
  • Int'l Joint Research
• [Presentation] The relation between pericyte detachment and interstitial fibrosis in Dahl salt-sensitive hypertensive (DahlS) rats (2022)
  • Author(s): Ito H, Hirose T, Sato S, Endo A, Oba-Yabana I, Takahashi K, Mori T
  • Organizer: The 29th Scientific Meeting of the International Society of Hypertension
  • Int'l Joint Research
• [Presentation] Sodium-glucose cotransporter (SGLT) inhibitor suppresses renal stone formation - a novel therapeutic approach for nephrolithiasis (2022)
  • Author(s): Anan G, Hirose T, Kikuchi D, Takahashi C, Yamakoshi S, Sato M, Mori T
  • Organizer: American Urological Association
  • Int'l Joint Research
• [Presentation] ラット腎うっ血モデルの腎間質線維化に対するSGLT2阻害薬の効果 (2022)
  • Author(s): 遠藤明里、廣瀬卓男、伊藤大樹、佐藤重光、矢花郁子、中山晋吾、加藤季子、中村はな、高橋和広、森建文
  • Organizer: 第26回日本心血管内分泌代謝学会学術総会
• [Presentation] 尿ナトリウム/カリウム比と脳性ナトリウム利尿ペプチド：大迫研究 (2022)
  • Author(s): 室谷智子、佐藤倫広、村上任尚、中山晋吾、廣瀬卓男、橋本英明、遠山真弥、高畠恭介、辰巳友佳子、井上隆輔、坪田(宇津木)恵、小暮真奈、中谷直樹、浅山敬、野村恭子、菊谷昌浩、目時弘仁、今井潤、寳澤篤、大久保孝義
  • Organizer: 第71回東北公衆衛生学会
• [Presentation] Col4a5欠損アルポート症候群モデルラットの糸球体超微形態の観察 (2022)
  • Author(s): 廣瀬卓男、伊藤大樹、難波真澄、佐藤重光、遠藤明里、鎌田綾佳、中山晋吾、矢花郁子、橋本英明、石山勝也、木村朋由、高橋和広、松山誠、森建文
  • Organizer: 第32回東北腎フォーラム
• [Presentation] ラット腎うっ血モデルにおけるアンジオテンシン受容体・ネプリライシン阻害薬の効果 (2022)
  • Author(s): 廣瀬卓男、伊藤大樹、佐藤重光、遠藤明里、加藤季子、髙橋知香、矢花郁子、中村はな、高橋和広、森建文
  • Organizer: 第40回内分泌代謝学サマーセミナー
• [Presentation] SGLT2阻害は抗炎症作用により腎臓結石形成を抑制する (2022)
  • Author(s): 阿南剛、廣瀬卓男、遠藤明里、松本啓而、伊藤大樹、中山晋吾、橋本英明、石山勝也、矢花郁子、木村朋由、佐藤信、森建文
  • Organizer: 第65回日本腎臓学会学術総会
• [Presentation] Dahl食塩感受性高血圧ラットにおける尿細管間質線維化と直血管ペリサイト剥離 (2022)
  • Author(s): 伊藤大樹、廣瀬卓男、山越聖子、遠藤明里、松本啓而、鎌田綾佳、中山晋吾、橋本英明、阿南剛、石山勝也、矢花郁子、木村朋由、中村はな、谷淳一、高橋和広、森建文
  • Organizer: 第65回日本腎臓学会学術総会
• [Presentation] 腎うっ血に伴う腎間質線維化に対するマイオカイン・アイリシンの保護効果 (2022)
  • Author(s): 廣瀬卓男、伊藤大樹、遠藤明里、加藤季子、石川里紗、佐藤峻行、髙橋知香、山越聖子、佐藤重光、松本啓而、橋本英明、石山勝也、矢花郁子、木村朋由、中村はな、谷淳一、高橋和広、森建文
  • Organizer: 第95回日本内分泌学会学術総会
• [Presentation] Inhibition of Sodium-Glucose Cotransporters Ameliorates Renal Cortical Interstitial Fibrosis after Renal Venous Congestion (2022)
  • Author(s): Takefumi Mori, Akari Endo, Takuo Hirose, Hiroki Ito, Chika Takahashi, Seiko Yamakoshi, Ikuko Oba-Yabana, Kazuhiro Takahashi
  • Organizer: 第86回日本循環器学会学術集会
• [Presentation] ラット腎うっ血モデルにおけるマイオカイン誘導による腎保護効果の検討 (2022)
  • Author(s): 廣瀬卓男、伊藤大樹、遠藤明里、髙橋知香、山越聖子、矢花郁子、佐藤重光、木村朋由、高橋和広、森建文
  • Organizer: 第12回日本腎臓リハビリテーション学会
• [Presentation] SGLT2阻害薬は腎結石形成を抑制する-新規尿路結石治療薬の候補- (2021)
  • Author(s): 阿南剛、廣瀬卓男、菊池大輔、高橋知香、山越聖子、遠藤明里、佐藤信、 森建文
  • Organizer: 第109回日本泌尿器科学会総会
• [Presentation] 腎うっ血に伴う腎間質線維化に対するSGLT2阻害薬の効果 (2021)
  • Author(s): 遠藤明里、廣瀬卓男、伊藤大樹、髙橋知香、山越聖子、矢花郁子、阿南剛、中山晋吾、田島亮、加藤季子、橋本英明、石山勝也、木村朋由、高橋和広、森建文
  • Organizer: 第43回日本高血圧学会総会
• [Presentation] Effect of insulin on cell proliferation and the involvement of (pro) renin receptor in breast cancer cells (2021)
  • Author(s): 佐藤重光、廣瀬卓男、渡部智記、湊和也、大場浩史、森建文、高橋和広
  • Organizer: 第80回日本癌学会学術総会
• [Presentation] (プロ)レニン受容体の腎うっ血モデルラットにおける発現 (2021)
  • Author(s): 廣瀬卓男、遠藤明里、伊藤大、髙橋知香、佐藤重光、渡邉智記、湊和也、山越聖子、矢花郁子、森建文、高橋和広
  • Organizer: 第39回内分泌代謝学サマーセミナー
• [Presentation] ラット腎うっ血モデルにおけるトホグリフロジンの効果 (2021)
  • Author(s): 廣瀬卓男、遠藤明里、髙橋知香、矢花郁子、佐藤重光、渡邉智記、阿南剛、星野賢人、三宅由桂、福永継実、中山晋吾、田島亮、加藤季子、関敬之、中村はな、谷淳一、高橋和広、森建文
  • Organizer: 第64回日本腎臓学会学術総会
• [Presentation] Renoprotective effect of SGLT1/2 inhibitor in rat renal congestion model (2020)
  • Author(s): Hirose T, Matsuki T, Takahashi C, Yamakoshi S, Oba-Yabana I, Endo A, Anan G, Kato T, Tajima R, Seki T, Nakayama S, Nakamura H, Tani J, Mori T
  • Organizer: Counsil on Hypretension Scientific Sessions
  • Int'l Joint Research
• [Presentation] 中枢神経における(プロ)レニン受容体の機能解析 (2020)
  • Author(s): 廣瀬卓男, Alfredo Cabrera-Socorro, 高橋知香, 森建文, 高橋和広, Genevieve Nguyen, Matthias Groszer
  • Organizer: 日仏生物学会 第193回例会
  • Invited
• [Presentation] 腎うっ血における腎障害と血小板由来成長因子受容体との関連 (2020)
  • Author(s): 松木琢磨, 廣瀬卓男, 島田佐登志, 高橋知香, 森建文
  • Organizer: 第63回日本腎臓学会学術総会
• [Presentation] Dahl食塩感受性高血圧ラットにおける高食塩食摂取による（プロ）レニン受容体腎内発現と腎間質線維化 (2020)
  • Author(s): 山越聖子, 伊藤修, 大崎雄介, 中村貴裕, 廣瀬卓男, 高橋和広, 森建文, 戸恒和人, 戎栄, 上月正博
  • Organizer: 第63回日本腎臓学会学術総会
• [Presentation] ラット腎うっ血モデルにおける腎障害に対するSGLT阻害の効果 (2020)
  • Author(s): 廣瀬卓男, 松木琢磨, 高橋知香, 矢花郁子, 遠藤明里, 阿南剛, 田島亮, 三宅由桂, 加藤季子, 遠山真弥, 中山晋吾, 関敬之, 中村はな, 衣笠哲史, 谷淳一, 森建文
  • Organizer: 第63回日本腎臓学会学術総会
• [Remarks] 内分泌応用医科学分野HP
  • URL: https://www.med.tohoku.ac.jp/laboratory/view/93
• [Remarks] Research map
  • URL: https://researchmap.jp/hirose_t