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Polyphosphate: A Novel Marker of Phosphorus Metabolism and its Association with Infection in Kidney Disease

Research Project

Project/Area Number 20K08628
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 53040:Nephrology-related
Research InstitutionNiigata University

Principal Investigator

Yamamoto Suguru  新潟大学, 医歯学総合病院, 准教授 (70444156)

Co-Investigator(Kenkyū-buntansha) 成田 一衛  新潟大学, 医歯学系, 教授 (20272817)
後藤 祐児  大阪大学, 大学院工学研究科, 特任研究員 (40153770)
田中 崇裕  新潟大学, 医歯学総合病院, 助教 (70455400)
北村 信隆  新潟大学, 医歯学総合病院, 特任教授 (90224972)
山口 圭一  大阪大学, 大学院工学研究科, 特任准教授(常勤) (90432187)
Project Period (FY) 2020-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2023: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Keywordsポリリン酸 / 慢性腎臓病 / 血液透析 / マクロファージ / 血小板 / インドキシル硫酸 / 感染症 / 敗血症
Outline of Research at the Start

腎臓病患者では感染症死が多く重要な未解決課題であるが、これまで詳細なメカニズムは不明であり根本的な対応策は提案されていない。腎臓病で高頻度に合併する高リン(単リン酸)血症は感染症と関連することが臨床的に知られているが、その機序は不明である。
本研究では、無機リンが直線状に多数結合したポリリン酸 (polyP)に着目し、腎臓病における感染症にポリリン酸がいかに関与するかを明らかにし、それに対する予防法/治療法を考案する。

Outline of Final Research Achievements

We examined the role and effects of polyphosphates as one potential factor in the abnormal phosphorus metabolism of patients with kidney disease. When macrophages were stimulated with both polyphosphates and LPS, the expression of inflammatory cytokines was enhanced depending on the amount and chain length of polyphosphates. We considered that the mechanism behind this enhancement might involve polyphosphates strengthening the reaction between LPS and toll-like receptors, as well as reducing the micelle size of LPS. We established a system for long-term stimulation of macrophages with indoxyl sulfate, and additionally reacted polyphosphates and LPS. Platelet polyphosphates in dialysis patients showed lower levels compared to platelets from individuals with normal kidney function, and correlated with platelet NADH levels.

Academic Significance and Societal Importance of the Research Achievements

腎臓病患者で特徴的なリン代謝異常に関して、ポリリン酸に着目して、細胞への作用、血小板内ポリリン酸量の測定など多面的に調査した。現在の臨床では腎臓病に伴う高リン血症が生命予後、血管石灰化に関連すること、そしてその治療として高リン血症治療薬や透析療法の工夫で対応しているが、リンの生体内の動態については不明な点が多い。本研究からリンの新しい形態としてのポリリン酸の感染症に対する作用と血小板のエネルギーと関連する可能性が示された。

Report

(5 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Research-status Report
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (76 results)

All 2024 2023 2022 2021 2020 Other

All Int'l Joint Research (5 results) Journal Article (30 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 28 results,  Open Access: 18 results) Presentation (28 results) (of which Int'l Joint Research: 8 results,  Invited: 16 results) Book (13 results)

  • [Int'l Joint Research] University of Liege(ベルギー)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Arbor Research Collaborative for Health/University of Michigan(米国)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Amsterdam University Medical Center,(オランダ)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Sapienza University of Rome(イタリア)

    • Related Report
      2023 Annual Research Report
  • [Int'l Joint Research] Aarhus University(デンマーク)

    • Related Report
      2023 Annual Research Report
  • [Journal Article] Systemic Amyloid A Amyloidosis Secondary to Xanthogranulomatous Pyelonephritis2024

    • Author(s)
      Habuka Masato、Nishikiori Mizusa、Oikawa Chihiro、Takahashi Megumi、Sakamaki Yuichi、Ogawa Asa、Miyajima Norio、Tanabe Yasuhiko、Honma Keiichi、Wakaki Kunihiko、Yamamoto Suguru、Narita Ichiei
    • Journal Title

      Internal Medicine

      Volume: 63 Issue: 4 Pages: 593-599

    • DOI

      10.2169/internalmedicine.1806-23

    • ISSN
      0918-2918, 1349-7235
    • Year and Date
      2024-02-15
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Alkaline Phosphatase and Parathyroid Hormone Levels: International Variation and Associations With Clinical Outcomes in the DOPPS2024

    • Author(s)
      Yamamoto Suguru、J?rgensen Hanne Skou、Zhao Junhui、Karaboyas Angelo、Komaba Hirotaka、Vervloet Marc、Mazzaferro Sandro、Cavalier Etienne、Bieber Brian、Robinson Bruce、Evenepoel Pieter、Fukagawa Masafumi
    • Journal Title

      Kidney International Reports

      Volume: 9 Issue: 4 Pages: 863-876

    • DOI

      10.1016/j.ekir.2024.01.002

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Mass spectrometry-based proteomic analysis of proteins adsorbed by hexadecyl-immobilized cellulose bead column for the treatment of dialysis-related amyloidosis2024

    • Author(s)
      Yamamoto Suguru、Yamamoto Keiko、Hirao Yoshitoshi、Yamaguchi Keiichi、Nakajima Kichitaro、Sato Mami、Kawachi Miho、Domon Mio、Goto Kei、Omori Kentaro、Iino Noriaki、Shimada Hisaki、Aoyagi Ryuzi、Ei Isei、Goto Shin、Goto Yuji、Gejyo Fumitake、Yamamoto Tadashi、Narita Ichiei
    • Journal Title

      Amyloid

      Volume: - Issue: 2 Pages: 1-11

    • DOI

      10.1080/13506129.2024.2315148

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Supersaturation, a Critical Factor Underlying Proteostasis of Amyloid Fibril Formation2024

    • Author(s)
      Goto Yuji、Nakajima Kichitaro、Yamamoto Suguru、Yamaguchi Keiichi
    • Journal Title

      Journal of Molecular Biology

      Volume: - Issue: 14 Pages: 168475-168475

    • DOI

      10.1016/j.jmb.2024.168475

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effectiveness of calcimimetics on fractures in dialysis patients with secondary hyperparathyroidism: meta-analysis of randomized trials2024

    • Author(s)
      Wakamatsu Takuya、Yamamoto Suguru、Matsuo Koji、Taniguchi Masatomo、Hamano Takayuki、Fukagawa Masafumi、Kazama Junichiro James
    • Journal Title

      Journal of Bone and Mineral Metabolism

      Volume: in press Issue: 3 Pages: 316-325

    • DOI

      10.1007/s00774-024-01500-y

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Appropriate Anthropometric Indices for Geriatric Nutritional Risk Index in Predicting Mortality in Older Japanese Patients: A Comparison of the Lorentz Formula and Body Mass Index2024

    • Author(s)
      Kitabayashi Kou、Yamamoto Suguru、Narita Ichiei
    • Journal Title

      The Tohoku Journal of Experimental Medicine

      Volume: 262 Issue: 4 Pages: 221-228

    • DOI

      10.1620/tjem.2024.J001

    • ISSN
      0040-8727, 1349-3329
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protein intake and its relationship with frailty in chronic kidney disease2024

    • Author(s)
      Shirai Nobuyuki、Yamamoto Suguru、Osawa Yutaka、Tsubaki Atsuhiro、Morishita Shinichiro、Murayama Toshiko、Narita Ichiei
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 28 Issue: 5 Pages: 447-453

    • DOI

      10.1007/s10157-023-02452-9

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pruritus and protein-bound uremic toxins in patients undergoing hemodialysis: a cross-sectional study2024

    • Author(s)
      Yamamoto Suguru、Tanaka Takahiro、Omori Kentaro、Ei Isei、Kikuchi Kaori、Konagai Ayano、Goto Shin、Kitamura Nobutaka、Narita Ichiei
    • Journal Title

      Clinical Kidney Journal

      Volume: 17 Issue: 1 Pages: 7-7

    • DOI

      10.1093/ckj/sfae007

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Removal of α<sub>1</sub>-Microglobulin Using Post-Dilution Online Hemodiafiltration with Polymethylmethacrylate Membrane: An Open-Label, Single-Arm Study2023

    • Author(s)
      Yoshida Shiori、Yamamoto Suguru、Miyauchi Daisuke、Terashima Ryohei、Hashimoto Atsushi、Miyazawa Haruna、Tanaka Takahiro、Ishizawa Masahiro、Tanaka Mototsugu、Tomita Yoshihiko、Aoike Ikuo、Goto Shin、Narita Ichiei
    • Journal Title

      Blood Purification

      Volume: 53 Issue: 2 Pages: 123-129

    • DOI

      10.1159/000534459

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low muscle strength and physical function contribute to falls in hemodialysis patients, but not muscle mass2023

    • Author(s)
      Shirai Nobuyuki、Yamamoto Suguru、Osawa Yutaka、Tsubaki Atsuhiro、Morishita Shinichiro、Sugahara Tsubasa、Narita Ichiei
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 28 Issue: 1 Pages: 67-74

    • DOI

      10.1007/s10157-023-02403-4

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Active Vitamin D Use and Fractures in Hemodialysis Patients: Results from the International DOPPS2023

    • Author(s)
      Komaba Hirotaka、Zhao Junhui、Karaboyas Angelo、Yamamoto Suguru、Dasgupta Indranil、Hassan Mohamed、Zuo Li、Christensson Anders、Combe Christian、Robinson Bruce M.、Fukagawa Masafumi
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 38 Issue: 11 Pages: 1577-1585

    • DOI

      10.1002/jbmr.4913

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Sodium magnetic resonance imaging shows impairment of the counter-current multiplication system in diabetic mice kidney2023

    • Author(s)
      Nakagawa Yusuke、Kaseda Ryohei、Suzuki Yuya、Watanabe Hirofumi、Otsuka Tadashi、Yamamoto Suguru、Kaneko Yoshikatsu、Goto Shin、Terada Yasuhiko、Haishi Tomoyuki、Sasaki Susumu、Narita Ichiei
    • Journal Title

      Kidney360

      Volume: Publish Ahead of Print Pages: 0-0

    • DOI

      10.34067/kid.0000000000000072

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Assessing fluid volume and determining outcomes of acute heart failure using plasma human atrial natriuretic peptide2023

    • Author(s)
      Suzuki Yuya、Otsuka Tadashi、Yoshioka Yuki、Iida Tomomichi、Maruyama Shingo、Watanabe Hirofumi、Kaseda Ryohei、Yamamoto Suguru、Kaneko Yoshikatsu、Goto Shin、Aoyagi Ryuji、Narita Ichiei
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: Online ahead of print Issue: 6 Pages: 0-0

    • DOI

      10.1007/s10157-023-02333-1

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dynamic and static balance functions in hemodialysis patients and non‐dialysis dependent <scp>CKD</scp> patients2022

    • Author(s)
      Shirai Nobuyuki、Yamamoto Suguru、Osawa Yutaka、Tsubaki Atsuhiro、Morishita Shinichiro、Narita Ichiei
    • Journal Title

      Therapeutic Apheresis and Dialysis

      Volume: 27 Issue: 3 Pages: 412-418

    • DOI

      10.1111/1744-9987.13931

    • Related Report
      2023 Annual Research Report 2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Macromolecular crowding and supersaturation protect hemodialysis patients from the onset of dialysis-related amyloidosis2022

    • Author(s)
      Nakajima Kichitaro、Yamaguchi Keiichi、Noji Masahiro、Aguirre Cesar、Ikenaka Kensuke、Mochizuki Hideki、Zhou Lianjie、Ogi Hirotsugu、Ito Toru、Narita Ichiei、Gejyo Fumitake、Naiki Hironobu、Yamamoto Suguru、Goto Yuji
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 5689-5689

    • DOI

      10.1038/s41467-022-33247-3

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of the nutritional risk index for Japanese hemodialysis with mortality and dietary nutritional intake in patients undergoing hemodialysis during long-term hospitalization2022

    • Author(s)
      Kitabayashi Kou、Yamamoto Suguru、Narita Ichiei
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 26 Issue: 12 Pages: 1200-1207

    • DOI

      10.1007/s10157-022-02259-0

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dysfunction in dynamic, but not static balance is associated with risk of accidental falls in hemodialysis patients: a prospective cohort study2022

    • Author(s)
      Shirai Nobuyuki、Yamamoto Suguru、Osawa Yutaka、Tsubaki Atsuhiro、Morishita Shinichiro、Narita Ichiei
    • Journal Title

      BMC Nephrology

      Volume: 23 Issue: 1 Pages: 237-237

    • DOI

      10.1186/s12882-022-02877-6

    • Related Report
      2022 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Magnesium intake by enteral formulation affects serum magnesium concentration in patients undergoing hemodialysis2022

    • Author(s)
      Kitabayashi Kou、Yamamoto Suguru、Narita Ichiei
    • Journal Title

      Therapeutic Apheresis and Dialysis

      Volume: 26 Issue: 4 Pages: 749-755

    • DOI

      10.1111/1744-9987.13760

    • Related Report
      2022 Research-status Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] CKD・透析患者の骨折とその対策2022

    • Author(s)
      山本卓
    • Journal Title

      日本透析医会誌

      Volume: 37 Pages: 25-28

    • Related Report
      2022 Research-status Report
  • [Journal Article] プロテオーム解析2022

    • Author(s)
      羽深将人、山本卓、内木宏延、山本格、成田一衛
    • Journal Title

      日本腎臓学会誌

      Volume: 64 Pages: 863-867

    • Related Report
      2022 Research-status Report
    • Peer Reviewed
  • [Journal Article] Comparison of muscle strength between hemodialysis patients and non-dialysis patients with chronic kidney disease2021

    • Author(s)
      Shirai Nobuyuki、Yamamoto Suguru、Osawa Yutaka、Tsubaki Atsuhiro、Morishita Shinichiro、Igarashi Kanami、Narita Ichiei
    • Journal Title

      Journal of Physical Therapy Science

      Volume: 33 Issue: 10 Pages: 742-747

    • DOI

      10.1589/jpts.33.742

    • NAID

      130008103580

    • ISSN
      0915-5287, 2187-5626
    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro2021

    • Author(s)
      Yamamoto Suguru、Sasahara Kenichi、Domon Mio、Yamaguchi Keiichi、Ito Toru、Goto Shin、Goto Yuji、Narita Ichiei
    • Journal Title

      Toxins

      Volume: 13 Issue: 2 Pages: 116-116

    • DOI

      10.3390/toxins13020116

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fear of falling and physical activity in hemodialysis patients: a pilot study2021

    • Author(s)
      Shirai Nobuyuki、Yamamoto Suguru、Osawa Yutaka、Tsubaki Atsuhiro、Morishita Shinichiro、Nitami Sumiyo、Narita Ichiei
    • Journal Title

      Renal Replacement Therapy

      Volume: 7 Issue: 1

    • DOI

      10.1186/s41100-021-00383-3

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Locomotive syndrome in hemodialysis patients and its association with quality of life?a cross-sectional study2021

    • Author(s)
      Kitabayashi Kou、Yamamoto Suguru、Katano Yumi、Giustini Kayoko、Ei Isei、Ishii Yuji、Narita Ichiei
    • Journal Title

      Renal Replacement Therapy

      Volume: 7 Issue: 1

    • DOI

      10.1186/s41100-021-00352-w

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Secondary hyperparathyroidism, weight loss, and longer term mortality in haemodialysis patients: results from the DOPPS2021

    • Author(s)
      Komaba Hirotaka、Zhao Junhui、Yamamoto Suguru、Nomura Takanobu、Fuller Douglas S.、McCullough Keith P.、Evenepoel Pieter、Christensson Anders、Zhao Xinju、Alrukhaimi Mona、Al‐Ali Fadwa、Young Eric W.、Robinson Bruce M.、Fukagawa Masafumi
    • Journal Title

      Journal of Cachexia, Sarcopenia and Muscle

      Volume: 12 Issue: 4 Pages: 855-865

    • DOI

      10.1002/jcsm.12722

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Aberrant mucosal immunoreaction to tonsillar microbiota in immunoglobulin A nephropathy2021

    • Author(s)
      Hiroki Yamaguchi, Shin Goto, Nao Takahashi, Masafumi Tsuchida, Hirofumi Watanabe, Suguru Yamamoto, Yoshikatsu Kaneko, Koichi Higashi, Hiroshi Mori, Yukio Nakamura, Arata Horii, Ken Kurokawa, Ichiei Narita
    • Journal Title

      Nephrol Dial Transplant.

      Volume: 36 Issue: 1 Pages: 75-86

    • DOI

      10.1093/ndt/gfaa223

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inorganic polyphosphate potentiates lipopolysaccharide-induced macrophage inflammatory response2020

    • Author(s)
      Ito Toru、Yamamoto Suguru、Yamaguchi Keiichi、Sato Mami、Kaneko Yoshikatsu、Goto Shin、Goto Yuji、Narita Ichiei
    • Journal Title

      Journal of Biological Chemistry

      Volume: 295 Issue: 12 Pages: 4014-4023

    • DOI

      10.1074/jbc.ra119.011763

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of sucroferric oxyhydroxide on gastrointestinal microbiome and uremic toxins in patients with chronic kidney disease undergoing hemodialysis2020

    • Author(s)
      Iguchi Akira、Yamamoto Suguru、Oda Akira、Tanaka Kenichi、Kazama Junichiro James、Saeki Takako、Yamazaki Hajime、Ishioka Ken、Suzutani Tatsuo、Narita Ichiei
    • Journal Title

      Clinical and Experimental Nephrology

      Volume: 24 Issue: 8 Pages: 725-733

    • DOI

      10.1007/s10157-020-01892-x

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Type I Angiotensin II Receptor Blockade Reduces Uremia‐Induced Deterioration of Bone Material Properties2020

    • Author(s)
      Wakamatsu Takuya、Iwasaki Yoshiko、Yamamoto Suguru、Matsuo Koji、Goto Shin、Narita Ichiei、Kazama Junichiro J、Tanaka Kennichi、Ito Akemi、Ozasa Ryosuke、Nakano Takayoshi、Miyakoshi Chisato、Onishi Yoshihiro、Fukuma Shingo、Fukuhara Shunichi、Yamato Hideyuki、Fukagawa Masafumi、Akizawa Tadao
    • Journal Title

      Journal of Bone and Mineral Research

      Volume: 36 Issue: 1 Pages: 67-79

    • DOI

      10.1002/jbmr.4159

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum total indoxyl sulfate and clinical outcomes in hemodialysis patients: results from the Japan Dialysis Outcomes and Practice Patterns Study2020

    • Author(s)
      Yamamoto Suguru、Fuller Douglas S、Komaba Hirotaka、Nomura Takanobu、Massy Ziad A、Bieber Brian、Robinson Bruce、Pisoni Ronald、Fukagawa Masafumi
    • Journal Title

      Clinical Kidney Journal

      Volume: 14 Issue: 4 Pages: 1236-1243

    • DOI

      10.1093/ckj/sfaa121

    • Related Report
      2020 Research-status Report
  • [Presentation] CKDステージ別における腎臓リハビリテーションの実際. CKDステージG5の腎臓リハビリテーション保存期から透析期2024

    • Author(s)
      山本卓、白井信行、成田一衛
    • Organizer
      第14回日本腎臓リハビリテーション学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] リハビリを安全かつ効果的に行うための慢性腎臓病の合併症管理. CKD-MBD2024

    • Author(s)
      山本卓、成田一衛
    • Organizer
      第14回日本腎臓リハビリテーション学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Frailty in dialysis patients surviving more than 40 years is common and severe: a nationwide study.2023

    • Author(s)
      Yamamoto S, Niihata K, Toida T, Abe M, Hanafusa N, Kurira N
    • Organizer
      Kidney Week 2023
    • Related Report
      2023 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 透析アミロイドーシス発症に、患者血清アルブミン濃度が関与しているという臨床的・蛋白質科学的研究2023

    • Author(s)
      山本卓
    • Organizer
      第10回日本アミロイドーシス学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 腎代替療法における腹膜透析の役割2023

    • Author(s)
      山本卓
    • Organizer
      第5回日本在宅医療連合学会大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 災害時の透析医療2023

    • Author(s)
      山本卓
    • Organizer
      第5回日本在宅医療連合学会大会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] DOPPSからわかる透析患者の栄養指標とアウトカム2023

    • Author(s)
      山本卓
    • Organizer
      第68回 日本透析医学会学術集会・総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 透析患者における骨粗鬆症診断のPros & Cons ―骨生検は不要という立場から―2023

    • Author(s)
      山本卓
    • Organizer
      第68回 日本透析医学会学術集会・総会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] 骨折と骨塩量のメタ解析2023

    • Author(s)
      山本卓
    • Organizer
      第7回 日本CKD-MBD学会
    • Related Report
      2023 Annual Research Report
    • Invited
  • [Presentation] Mass spectrometry-based proteomic analysis of adsorbed molecules associated with dialysis-related amyloidosis in hexadecyl-immobilized cellulose beads2022

    • Author(s)
      Yamamoto S, Yamamoto K, Hirao Y, Yamamoto T, Yamaguchi K, Nakajima K, Goto Y, Goto S, Gejyo F, Narita I
    • Organizer
      XVIII. International Symposium on Amyloidosis
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Skeletal responsiveness to parathyroid hormone in hemodialysis patients: International variation, association with factors and risk of fractures in the DOPPS2022

    • Author(s)
      Yamamoto S, Zhao J, Karaboyas A, Komaba H, Jonsen HS, Vervloet M, Mazzaferro S, Cavalier E, Bieber B, Robinson B, Evenepoel P, Fukagawa M
    • Organizer
      Kidney Week 2022
    • Related Report
      2022 Research-status Report
    • Int'l Joint Research
  • [Presentation] Medical director practice of advising increased dietary protein intake in hemodialysis patients with hyperphosphatemia: Associations with mortality in the Dialysis Outcomes and Practice Patterns Study (DOPPS) 高リン血症でもタンパク質摂取の増加を勧める医師の姿勢と 血液透析患者の栄養指標・死亡との関連2022

    • Author(s)
      山本卓
    • Organizer
      第67回日本透析医学会学術集会・総会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 透析アミロイド症の診断と治療 長期透析患者に重要な透析アミロイド症の病態2022

    • Author(s)
      山本卓
    • Organizer
      第67回日本透析医学会学術集会・総会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] ワークショップ14 CKD・ESRD患者における骨粗鬆症治療の課題 CKD患者における骨密度、骨代謝マーカーの有用性と限界2022

    • Author(s)
      山本卓
    • Organizer
      第65回日本腎臓学会学術総会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] 新しいCKD-MBDガイドラインは何を目指すか 討論すべき問題点を整理する d.骨2022

    • Author(s)
      山本卓
    • Organizer
      第67回日本透析医学会学術集会・総会
    • Related Report
      2022 Research-status Report
    • Invited
  • [Presentation] β2-microglobulinアミロイドのプロテオミクスとヘキサデシル基固定セルロースビーズによる臨床的吸着効果2022

    • Author(s)
      山本卓, 山本恵子, 平尾嘉利, 河内美帆、今井直史, 後藤眞, 山本格, 下条文武, 成田一衛
    • Organizer
      第65回日本腎臓学会学術総会
    • Related Report
      2022 Research-status Report
  • [Presentation] ヘキサデシル基固定セルロースビーズに吸着する血漿タンパク質のプロテオミクス2022

    • Author(s)
      山本卓, 山本恵子, 平尾嘉利, 河内美帆、今井直史, 後藤眞, 山本格, 下条文武, 成田一衛山本卓, 山本恵子, 平尾嘉利, 河内美帆、今井直史, 後藤眞, 山本格, 下条文武, 成田一衛
    • Organizer
      第67回日本透析医学会学術集会・総会
    • Related Report
      2022 Research-status Report
  • [Presentation] Mass spectrometry-based proteomic analysis of adsorbed molecules in a hexadecyl-immobilized cellulose beads column for the treatment of dialysis-related amyloidosis.2021

    • Author(s)
      Suguru Yamamoto, Keiko Yamamoto, Yoshitoshi Hirao, Shin Goto, Tadashi Yamamoto, Fumitake Gejyo, Ichiei Narita
    • Organizer
      Kidney Week 2021
    • Related Report
      2021 Research-status Report
    • Int'l Joint Research
  • [Presentation] 運動機能面から2021

    • Author(s)
      山本卓, 白井信行, 北林紘, 成田一衛
    • Organizer
      第64回日本腎臓学会学術総会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 保存期においてPTH管理は必要か? Pro2021

    • Author(s)
      山本卓, 成田一衛
    • Organizer
      第64回日本腎臓学会学術総会.
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] pHによるウレミックトキシンの蛋白結合能の変化2021

    • Author(s)
      山本卓, 山口圭一, 土門美緒, 伊藤徹, 後藤眞, 後藤祐児, 成田一衛
    • Organizer
      第64回日本腎臓学会学術総会.
    • Related Report
      2021 Research-status Report
  • [Presentation] pH-Dependent Protein Binding Properties of Uremic Toxins In Vitro:2020

    • Author(s)
      Suguru Yamamoto, Kenichi Sasahara, Mio Domon, Keiichi Yamaguchi, Toru Ito, Shin Goto, Yuji Goto, and Ichiei Narita
    • Organizer
      Kidney Week 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prioritization by Medical Directors of Nutritional Protein versus Dietary Phosphorus Control in Hemodialysis Patients: Association with Mortality in the Dialysis Outcomes and Practice Patterns Study2020

    • Author(s)
      Suguru Yamamoto, Brian A. Bieber, Hirotaka Komaba, Hiroki Kitabayashi, Takanobu Nomura, Aleix Cases, Christian Combe, Ronald L. Pisoni, Bruce M. Robinson and Masafumi Fukagawa
    • Organizer
      Kidney Week 2020
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] 尿毒症毒素と骨代謝2020

    • Author(s)
      山本卓
    • Organizer
      第50回日本腎臓学会東部学術大会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 透析アミロイドーシス Up to date2020

    • Author(s)
      山本卓
    • Organizer
      第65回日本透析医学会学術集会総会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 5D-itch scaleとウレミックトキシン/透析モダリティ2020

    • Author(s)
      山本卓、田中崇裕、大森健太郎、惠以盛、北村信隆、成田一衛
    • Organizer
      第65回日本透析医学会学術集会総会
    • Related Report
      2020 Research-status Report
  • [Presentation] Severity of pruritis in hemodialysis patients: relationship to uremic toxins and dialysis modality2020

    • Author(s)
      Suguru Yamamoto, Takahiro Tanaka, Kentaro Omori, Isei In, Nobutaka Kitamura, Ichiei Narita
    • Organizer
      The 57th ERA-EDTA
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Presentation] Prioritization by medical directors of nutritional protein versus dietary phosphorus control in hemodialysis patients: Associations with mortality in the Dialysis Outcomes and Practice Patterns Study (DOPPS).2020

    • Author(s)
      Suguru Yamamoto, Brian A. Bieber, Hirotaka Komaba, Hiroki Kitabayashi, Takanobu Nomura, Aleix Cases, Christian Combe, Ronald L. Pisoni, Bruce M. Robinson and Masafumi Fukagawa
    • Organizer
      The 57th ERA-EDTA
    • Related Report
      2020 Research-status Report
    • Int'l Joint Research
  • [Book] 日本臨牀 血液症候群(第3版) III2024

    • Author(s)
      山本卓
    • Total Pages
      5
    • Publisher
      日本臨牀社
    • Related Report
      2023 Annual Research Report
  • [Book] 臨牀透析2024

    • Author(s)
      山本卓
    • Total Pages
      6
    • Publisher
      日本メディカルセンター
    • Related Report
      2023 Annual Research Report
  • [Book] 糖尿病性腎症(DKD)2023

    • Author(s)
      吉田栞、山本卓
    • Total Pages
      3
    • Publisher
      日本医事新報社
    • Related Report
      2023 Annual Research Report
  • [Book] 腎と透析2023

    • Author(s)
      山本卓
    • Total Pages
      6
    • Publisher
      東京医学社
    • Related Report
      2023 Annual Research Report
  • [Book] 透析フロンティア2023

    • Author(s)
      山本卓、青池郁夫
    • Total Pages
      3
    • Publisher
      メディカルレビュー
    • Related Report
      2023 Annual Research Report
  • [Book] 泌尿器外科2023

    • Author(s)
      山本卓
    • Total Pages
      5
    • Publisher
      医学図書出版
    • Related Report
      2023 Annual Research Report
  • [Book] 高齢腎不全患者のための保存的腎臓療法2022

    • Author(s)
      山本卓、成田一衛
    • Total Pages
      241
    • Publisher
      東京医学社
    • Related Report
      2022 Research-status Report
  • [Book] 今日の治療指針2022

    • Author(s)
      山本卓
    • Total Pages
      2151
    • Publisher
      医学書院
    • Related Report
      2022 Research-status Report
  • [Book] 内科2022

    • Author(s)
      山本卓
    • Total Pages
      157
    • Publisher
      南江堂
    • Related Report
      2022 Research-status Report
  • [Book] 腎臓内科2022

    • Author(s)
      山本卓、成田一衛
    • Total Pages
      125
    • Publisher
      科学評論社
    • Related Report
      2022 Research-status Report
  • [Book] 腎疾患・透析最新の治療2023-20252022

    • Author(s)
      山本卓、伊藤由美
    • Total Pages
      386
    • Publisher
      南江堂
    • Related Report
      2022 Research-status Report
  • [Book] 腎臓症候群IV2022

    • Author(s)
      山本卓
    • Total Pages
      408
    • Publisher
      日本臨牀社
    • Related Report
      2022 Research-status Report
  • [Book] Uremic Toxins and Organ Failure2020

    • Author(s)
      Suguru Yamamoto
    • Total Pages
      13
    • Publisher
      Springer
    • ISBN
      9789811577932
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2025-01-30  

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