Analysis of molecular dynamics of epithelial-mesenchymal transition in sweat glands for elucidation of dyshidrosis
| Project/Area Number |
20K08654
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Multi-year Fund |
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| Section | 一般 |
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| Review Section |
Basic Section 53050:Dermatology-related
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| Research Institution | Nagasaki University |
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Principal Investigator |
KOIKE Yuta 長崎大学, 病院(医学系), 講師 (10530412)
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| Project Period (FY) |
2020-04-01 – 2023-03-31
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| Project Status |
Completed (Fiscal Year 2022)
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| Budget Amount *help |
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 皮膚科学 / 難病 / 無汗症 / 発汗障害 / 上皮間葉移行 / エクリン汗腺 / 上皮間葉転換 |
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| Outline of Research at the Start |
本研究は、エクリン汗腺における上皮間葉転換(EMT)に着目し、その分子動態を解析する。ヒトの皮膚に広範に分布するエクリン汗腺は発汗によって体温調整を担う。エクリン汗腺の機能異常は、近年社会問題となっている熱中症の一因となるため、生理・病態の理解が求められている。一方、EMTは上皮細胞が間葉系細胞の如く、細胞の性質と機能を変化させる現象である。本研究ではエクリン汗腺の機能変化をEMTの視点から詳細に解析し、発汗障害を伴う難治性皮膚疾患の、分子基盤構築を試みる。
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| Outline of Final Research Achievements |
This study focuses on epithelial-mesenchymal transition (EMT) in cells of the eccrine sweat gland secretory zone and analyzes its molecular dynamics. Since functional abnormalities of the eccrine sweat gland contribute to heatstroke, which has become a social problem in recent years, understanding of the physiology and pathophysiology is required, especially in diseases involving sweating.
Transcriptome analysis of sweat gland sections cut from anhidrotic and normal skin samples of patients with acquired idiopathic generalized anhidrosis (AIGA) revealed changes in EMT-related molecules. In addition, specific EMT-related transcription factors were expressed in the skin of patients with systemic scleroderma. These results suggest that EMT-induced changes in cellular function are involved in pathological changes in the sweat glands.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究は、特発性後天性全身性無汗症や全身性強皮症といった無汗・低汗症を伴う疾患において、その病態がエクリン汗腺分泌部細胞の変化、特に上皮間葉移行（EMT）を伴う細胞形質変化を伴うところ検討した。これら難病の病態解析・症状発現調整の基盤となる可能性がある。
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Report
(4 results)
Research Products
(58 results)
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[Journal Article] Clinical characteristics of patients with psoriasis with family history: A multicenter observational study2023
Author(s)
Ohata C, Anezaki H, Kaneko S, Okazaki F, Ito K, Matsuzaka Y, Kikuchi S, Koike Y, Murota H, Miyagi T, Takahashi K, Sugita K, Hashimoto A, Nakahara T, Morizane S, Ohyama B, Saruwatari H, Yanase T, Yoshida Y, Yonekura K, Higashi Y, Hatano Y, Saito K, Katayama E, Yamane M, Yamazaki F, Tsuruta N, Imafuku S
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Journal Title
The Journal of Dermatology
Volume: -
Issue: 6
Pages: 746-752
DOI
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Peer Reviewed
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[Journal Article] Mutations in SAM syndrome and palmoplantar keratoderma patients suggest genotype/phenotype correlations in DSG1 mutations2022
Author(s)
Takeuchi S, Takeichi T, Koike Y, Takama H, Tanahashi K, Okuno Y, Ishii N, Muro Y, Ogi T, Suga Y, Akiyama M
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Journal Title
Journal of the European Academy of Dermatology and Venereology
Volume: 36
Issue: 3
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Clinical practice guidelines for pseudoxanthoma elasticum (2017)2022
Author(s)
Iwanaga Akira、Utani Atsushi、Koike Yuta、Okubo Yumi、Kuwatsuka Yutaka、Endo Yuichiro、Tanizaki Hideaki、Wataya‐Kaneda Mari、Hatamochi Atsushi、Minaga Kosuke、Ogi Tomoo、Yamamoto Yosuke、Ikeda Satoshi、Tsuiki Eiko、Tamura Hiroshi、Maemura Koji、Kitaoka Takashi、Murota Hiroyuki
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Journal Title
The Journal of Dermatology
Volume: 49
Issue: 3
Pages: 91-98
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] 乾癬患者における HTLV-1 抗体陽性率と治療選択に与える影響を明らかにするための多施設共同観察研究2022
Author(s)
米倉健太郎, 鶴田紀子, 宮城拓也, 小池雄太, 東 裕子, 桑代麻希, 中原剛士, 大畑千佳, 金子 栄, 山口道也, 池田賢太, 原田佳代, 齊藤華奈実, 柳瀬哲至, 今福信一
Organizer
第74回日本皮膚科学会西部支部学術大会
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[Presentation] Mutations in SAM syndrome and palmoplantar keratoderma patients suggest genotype/phenotype correlations in DSG1 mutations2021
Author(s)
So Takeuchi, Takuya Takeichi, Yuta Koike, Hiroyuki Takama, Kana Tanahashi, Yusuke Okuno, Norito Ishii, Yoshinao Muro, Tomoo Ogi, Yasushi Suga, Masashi Akiyama
Organizer
The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
Related Report
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[Presentation] DSG1遺伝子変異による2つの皮膚疾患：その臨床像と形態学2021
Author(s)
竹内想, 武市拓也, 小池雄太, 高間寛之, 棚橋華奈, 奥野友介, 石井文人, 室慶直, 荻朋男, 須賀康, 秋山真志
Organizer
第47回皮膚かたち研究学会学術大会
Related Report
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[Presentation] 【教育講演 創傷・褥瘡・熱傷～専門医に欠かせないガイドライン(GL)の知識～】膠原病・血管炎に伴う皮膚潰瘍―ガイドラインから学ぶ治療方針の基本と最近10 年間の変遷―2021
Author(s)
石井貴之, 浅野善英, 浅井純, 岩田洋平, 内山明彦, 小川陽一, 岡村賢, 岸部麻里, 小池雄太, 寺雅, 本, 城拓, 部千, 口由, 吉崎歩
Organizer
第120回日本皮膚科学会総会
Related Report
Invited
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