Analysis of molecular dynamics of epithelial-mesenchymal transition in sweat glands for elucidation of dyshidrosis

• Project/Area Number: 20K08654
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 53050:Dermatology-related
• Research Institution: Nagasaki University
• Principal Investigator: KOIKE Yuta 長崎大学, 病院(医学系), 講師 (10530412)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000); Fiscal Year 2021: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000); Fiscal Year 2020: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
• Keywords: 皮膚科学 / 難病 / 無汗症 / 発汗障害 / 上皮間葉移行 / エクリン汗腺 / 上皮間葉転換

Outline of Research at the Start

本研究は、エクリン汗腺における上皮間葉転換(EMT)に着目し、その分子動態を解析する。ヒトの皮膚に広範に分布するエクリン汗腺は発汗によって体温調整を担う。エクリン汗腺の機能異常は、近年社会問題となっている熱中症の一因となるため、生理・病態の理解が求められている。一方、EMTは上皮細胞が間葉系細胞の如く、細胞の性質と機能を変化させる現象である。本研究ではエクリン汗腺の機能変化をEMTの視点から詳細に解析し、発汗障害を伴う難治性皮膚疾患の、分子基盤構築を試みる。

Outline of Final Research Achievements

This study focuses on epithelial-mesenchymal transition (EMT) in cells of the eccrine sweat gland secretory zone and analyzes its molecular dynamics. Since functional abnormalities of the eccrine sweat gland contribute to heatstroke, which has become a social problem in recent years, understanding of the physiology and pathophysiology is required, especially in diseases involving sweating.
Transcriptome analysis of sweat gland sections cut from anhidrotic and normal skin samples of patients with acquired idiopathic generalized anhidrosis (AIGA) revealed changes in EMT-related molecules. In addition, specific EMT-related transcription factors were expressed in the skin of patients with systemic scleroderma. These results suggest that EMT-induced changes in cellular function are involved in pathological changes in the sweat glands.

Academic Significance and Societal Importance of the Research Achievements

本研究は、特発性後天性全身性無汗症や全身性強皮症といった無汗・低汗症を伴う疾患において、その病態がエクリン汗腺分泌部細胞の変化、特に上皮間葉移行（EMT）を伴う細胞形質変化を伴うところ検討した。これら難病の病態解析・症状発現調整の基盤となる可能性がある。

Research Products

• [Journal Article] The detailed obstetric course of the first Japanese patient with AEBP1-related Ehlers-Danlos syndrome (classical-like EDS, type 2) (2023)
  • Author(s): Sanai Hiromi、Nakamura Yasuhiko、Koike Yuta、Murota Hiroyuki、Kosho Tomoki、Sase Masakatsu
  • Journal Title: Journal of Obstetrics and Gynaecology Research Volume: 49 Issue: 3 Pages: 1043-1047
  • DOI: 10.1111/jog.15541
  • Peer Reviewed / Open Access
• [Journal Article] Clinical characteristics of patients with psoriasis with family history: A multicenter observational study (2023)
  • Author(s): Ohata C, Anezaki H, Kaneko S, Okazaki F, Ito K, Matsuzaka Y, Kikuchi S, Koike Y, Murota H, Miyagi T, Takahashi K, Sugita K, Hashimoto A, Nakahara T, Morizane S, Ohyama B, Saruwatari H, Yanase T, Yoshida Y, Yonekura K, Higashi Y, Hatano Y, Saito K, Katayama E, Yamane M, Yamazaki F, Tsuruta N, Imafuku S
  • Journal Title: The Journal of Dermatology Volume: - Issue: 6 Pages: 746-752
  • DOI: 10.1111/1346-8138.16733
  • Peer Reviewed / Open Access
• [Journal Article] Survival rates of systemic interventions for psoriasis in the Western Japan Psoriasis Registry: A multicenter retrospective study (2023)
  • Author(s): Yanase T, Murota H, Koike Y, Imafuku S, et al
  • Journal Title: The Journal of Dermatology Volume: - Issue: 6 Pages: 753-765
  • DOI: 10.1111/1346-8138.16737
  • Peer Reviewed / Open Access
• [Journal Article] Immune complexome analysis of a rich variety of serum immune complexes identifies disease-characteristic immune complex antigens in systemic sclerosis (2023)
  • Author(s): Kutsuna Yuki Jimbayashi、Iwamoto Naoki、Ichinose Kunihiro、Aibara Nozomi、Nakashima Katsumi、Nakamura Hideki、Koike Yuta、Murota Hiroyuki、Ueki Yukitaka、Miyamoto Hirotaka、Hashizume Junya、Kodama Yukinobu、Nakashima Mikiro、Kawakami Atsushi、Ohyama Kaname
  • Journal Title: Journal of Autoimmunity Volume: 134 Pages: 102954-102954
  • DOI: 10.1016/j.jaut.2022.102954
  • Peer Reviewed / Open Access
• [Journal Article] Skin microbiome analysis in a case of atopic dermatitis induced by an interleukin 17 inhibitor used to treat psoriasis (2023)
  • Author(s): Hattori Naoko、Koike Yuta、Murota Hiroyuki
  • Journal Title: The Journal of Dermatology Volume: 50 Issue: 1 Pages: 104-106
  • DOI: 10.1111/1346-8138.16586
  • Peer Reviewed
• [Journal Article] Evaluation of sweating responses in patients with systemic connective tissue disorders using the quantitative sudomotor axon reflex test (2022)
  • Author(s): Ashida Miwa、Morimoto Shimpei、Yozaki Mariko、Ehara Daisuke、Koike Yuta、Murota Hiroyuki
  • Journal Title: Journal of Cutaneous Immunology and Allergy Volume: 5 Issue: 6 Pages: 208-216
  • DOI: 10.1002/cia2.12269
  • Peer Reviewed / Open Access
• [Journal Article] Development of eosinophilic granulomatosis with polyangiitis during the clinical course of microscopic polyangiitis: A case report (2022)
  • Author(s): Ide Hiroyuki、Shimizu Toshimasa、Koike Yuta、Abe Kuniko、Shigematsu Kazuto、Nishihata Shinya、Kojima Kanako、Ichinose Kunihiro、Kawakami Atsushi
  • Journal Title: Medicine Volume: 101 Issue: 44 Pages: e31401-e31401
  • DOI: 10.1097/md.0000000000031401
  • Peer Reviewed / Open Access
• [Journal Article] Histopathological analysis of skin reactions after coronavirus disease 2019 vaccination: Increment in number of infiltrated plasmacytoid dendritic cell (2022)
  • Author(s): Watanabe Hanako、Ashida Miwa、Satomi Naoyoshi、Koike Yuta、Kuwatsuka Sayaka、Murota Hiroyuki
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 7 Pages: 732-735
  • DOI: 10.1111/1346-8138.16374
  • Peer Reviewed
• [Journal Article] Triple carcinomas detected in two patients with anti-transcription intermediary factor 1γ (TIF1γ) antibody-positive dermatomyositis (2022)
  • Author(s): Masahiro SHIMONO, Yuta KOIKE, Naoyoshi SATOMI, Hitomi MORISAKI, Miwa ASHIDA, Hiroyuki MUROTA
  • Journal Title: European Journal of Dermatology Volume: 32 Issue: 2 Pages: 285-287
  • DOI: 10.1684/ejd.2022.4232
  • Peer Reviewed / Open Access
• [Journal Article] Mutations in SAM syndrome and palmoplantar keratoderma patients suggest genotype/phenotype correlations in DSG1 mutations (2022)
  • Author(s): Takeuchi S, Takeichi T, Koike Y, Takama H, Tanahashi K, Okuno Y, Ishii N, Muro Y, Ogi T, Suga Y, Akiyama M
  • Journal Title: Journal of the European Academy of Dermatology and Venereology Volume: 36 Issue: 3
  • DOI: 10.1111/jdv.17752
  • Peer Reviewed / Open Access
• [Journal Article] Clinical practice guidelines for pseudoxanthoma elasticum (2017) (2022)
  • Author(s): Iwanaga Akira、Utani Atsushi、Koike Yuta、Okubo Yumi、Kuwatsuka Yutaka、Endo Yuichiro、Tanizaki Hideaki、Wataya‐Kaneda Mari、Hatamochi Atsushi、Minaga Kosuke、Ogi Tomoo、Yamamoto Yosuke、Ikeda Satoshi、Tsuiki Eiko、Tamura Hiroshi、Maemura Koji、Kitaoka Takashi、Murota Hiroyuki
  • Journal Title: The Journal of Dermatology Volume: 49 Issue: 3 Pages: 91-98
  • DOI: 10.1111/1346-8138.16301
  • Peer Reviewed / Open Access
• [Journal Article] Clinical Course of Atopic Dermatitis in an Adult with Amyotrophic Lateral Sclerosis: Aetiological Implications of Voluntary Movements and Dermatitis Severity (2022)
  • Author(s): Kiyohara Tatsushi、Fukudome Takayasu、Kamio Yoshiyuki、Koike Yuta、Murota Hiroyuki
  • Journal Title: Acta Dermato-Venereologica Volume: 102 Pages: adv00644-adv00644
  • DOI: 10.2340/actadv.v102.1121
  • Peer Reviewed / Open Access
• [Journal Article] Exacerbating factors and disease burden in patients with atopic dermatitis (2022)
  • Author(s): Murota Hiroyuki、Koike Yuta、Morisaki Hitomi、Matsumoto Mai、Takenaka Motoi
  • Journal Title: Allergology International Volume: 71 Issue: 1 Pages: 25-30
  • DOI: 10.1016/j.alit.2021.10.002
  • NAID: 130008145207
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed
• [Journal Article] A case of bilateral plantar pseudo-Kaposi sarcoma successfully treated with propranolol (2021)
  • Author(s): Mine Takaaki、Koike Yuta、Ehara Daisuke、Murota Hiroyuki
  • Journal Title: JAAD Case Reports Volume: 18 Pages: 74-78
  • DOI: 10.1016/j.jdcr.2021.09.032
  • Peer Reviewed / Open Access
• [Journal Article] Establishment of the Western Japan Psoriasis Registry and first cross‐sectional analysis of registered patients (2021)
  • Author(s): Tsuruta Noriko、Imafuku Shinichi、Yamaguchi Kazuki、Katayama Eri、Nakama Takekuni、et all
  • Journal Title: The Journal of Dermatology Volume: 48 Issue: 11 Pages: 1709-1718
  • DOI: 10.1111/1346-8138.16092
  • Peer Reviewed / Open Access
• [Journal Article] Claudin-7 in keratinocytes is downregulated by the inhibition of HMG-CoA reductase and is highly expressed in the stratum granulosum of the psoriatic epidermis (2021)
  • Author(s): Kuwatsuka Sayaka、Koike Yuta、Kuwatsuka Yutaka、Yamaoka Toshifumi、Murota Hiroyuki
  • Journal Title: Journal of Dermatological Science Volume: 104 Issue: 2 Pages: 132-137
  • DOI: 10.1016/j.jdermsci.2021.10.002
  • Peer Reviewed
• [Journal Article] Evaluation of sweating responses in patients with collagen disease using the quantitative sudomotor axon reflex test (QSART): a study protocol for an investigator-initiated, prospective, observational clinical study (2021)
  • Author(s): Ashida Miwa、Koga Tomohiro、Morimoto Shimpei、Yozaki Mariko、Ehara Daisuke、Koike Yuta、Murota H
  • Journal Title: BMJ Open Volume: 11 Issue: 10 Pages: e050690-e050690
  • DOI: 10.1136/bmjopen-2021-050690
  • NAID: 120007186856
  • Peer Reviewed
• [Journal Article] 【古くて新しい自己炎症性角化症】(Part1.)症例からみる自己炎症性角化症(case1) 汎発性膿疱性乾癬(IL36RN変異による) (2021)
  • Author(s): 小池 雄太
  • Journal Title: Visual Dermatology Volume: 20 Pages: 676-679
• [Journal Article] A possible case of pseudoxanthoma elasticum (PXE) with histopathological features of PXE‐like papillary dermal elastolysis (2021)
  • Author(s): Yamazaki Yuki、Iwanaga Akira、Koike Yuta、Sato Tomohito、Murota Hiroyuki、Takeuchi Masaru、Satoh Takahiro
  • Journal Title: The Journal of Dermatology Volume: 48 Issue: 6 Pages: 265-266
  • DOI: 10.1111/1346-8138.15859
  • Peer Reviewed
• [Journal Article] 乾癬の生物学的製剤治療に対する結核対策実態の多施設共同調査 (2021)
  • Author(s): 金子 栄, 鶴田 紀子, 伊藤 宏太郎, 小池 雄太, 今福 信一ほか (西日本炎症性皮膚疾患研究会)
  • Journal Title: 日本皮膚科学会雑誌 Volume: 131 Pages: 1525-1532
  • NAID: 130008040654
  • Peer Reviewed
• [Journal Article] Erythema induratum of Bazin?A subcutaneous granulomatous vasculitis that caused difficulty in walking (2021)
  • Author(s): Irifune Satoshi、Yamamoto Kazuko、Ishijima Sosuke、Koike Yuta、Fukuoka Junya、Mukae Hiroshi
  • Journal Title: International Journal of Infectious Diseases Volume: 106 Pages: 183-184
  • DOI: 10.1016/j.ijid.2021.03.077
  • Peer Reviewed
• [Journal Article] Primary cutaneous post‐transplant lymphoproliferative disorder that rapidly improved upon reduction of immunosuppression and addition of everolimus (2020)
  • Author(s): Hattori Naoko、Koike Yuta、Hanatani Yumi、Ando Koji、Maruya Yasuhiro、Hidaka Masaaki、Eguchi Susumu、Taniguchi Kohei、Yoshino Tadashi、Murota Hiroyuki
  • Journal Title: The Journal of Dermatology Volume: 47 Issue: 11
  • DOI: 10.1111/1346-8138.15549
  • Peer Reviewed
• [Journal Article] Fibroblast growth factor 2 accelerates the epithelial-mesenchymal transition in keratinocytes during wound healing process (2020)
  • Author(s): Koike Yuta、Yozaki Mariko、Utani Atsushi、Murota Hiroyuki
  • Journal Title: Scientific Reports Volume: 10 Issue: 1 Pages: 18545-18545
  • DOI: 10.1038/s41598-020-75584-7
  • Peer Reviewed / Open Access
• [Journal Article] 血液透析患者に生じたMycobacterium chelonae皮膚感染症の 1 例. (2020)
  • Author(s): 森嵜仁美, 小池雄太, 江原大輔, 根井悠里江, 浅井幸, 岩永聰, 室田浩之
  • Journal Title: 西日本皮膚科 Volume: 82 Issue: 4 Pages: 294-298
  • DOI: 10.2336/nishinihonhifu.82.294
  • NAID: 130007905524
  • Peer Reviewed
• [Journal Article] Bright side of biologics uncovered the dark side of long‐term topical steroids: A psoriatic patient treated with biologics developed severe adrenal crisis (2020)
  • Author(s): Kuwatsuka Sayaka、Koike Yuta、Hanatani Yumi、Murayama Naoya、Iwanaga Akira、Murota Hiroyuki
  • Journal Title: The Journal of Dermatology Volume: 47 Issue: 8
  • DOI: 10.1111/1346-8138.15419
  • Peer Reviewed
• [Journal Article] Insight into innate immune response in “Yusho”: The impact of natural killer cell and regulatory T cell on inflammatory prone diathesis of Yusho patients (2020)
  • Author(s): Kamio Yoshiyuki、Gunge Yumi、Koike Yuta、Kuwatsuka Yutaka、Tsuruta Kazuto、Yanagihara Katsunori、Furue Masutaka、Murota Hiroyuki
  • Journal Title: Environmental Research Volume: 185 Pages: 109415-109415
  • DOI: 10.1016/j.envres.2020.109415
  • NAID: 120006988240
  • Peer Reviewed
• [Journal Article] Skin Mycobiome of Psoriasis Patients is Retained during Treatment with TNF and IL-17 Inhibitors (2020)
  • Author(s): Koike Yuta、Kuwatsuka Sayaka、Nishimoto Katsutaro、Motooka Daisuke、Murota Hiroyuki
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 11 Pages: 3892-3892
  • DOI: 10.3390/ijms21113892
  • NAID: 120006988163
  • Peer Reviewed / Open Access
• [Presentation] ケラチノサイトのクローディン7は、乾癬表皮の顆粒層に高発現し、HMG-CoA還元酵素阻害により発現が低下する (2022)
  • Author(s): 鍬塚さやか, 小池雄太, 鍬塚大, 山岡俊文, 室田浩之
  • Organizer: 第54回日本臨床分子形態学会総会・学術集会
• [Presentation] 乾癬患者における HTLV-1 抗体陽性率と治療選択に与える影響を明らかにするための多施設共同観察研究 (2022)
  • Author(s): 米倉健太郎, 鶴田紀子, 宮城拓也, 小池雄太, 東 裕子, 桑代麻希, 中原剛士, 大畑千佳, 金子 栄, 山口道也, 池田賢太, 原田佳代, 齊藤華奈実, 柳瀬哲至, 今福信一
  • Organizer: 第74回日本皮膚科学会西部支部学術大会
• [Presentation] 小児腹壁遠心性脂肪萎縮症の2例 (2022)
  • Author(s): 下農真弘、小池雄太、室田浩之
  • Organizer: 第74回日本皮膚科学会西部支部学術大会
• [Presentation] 結節性痒疹を伴う木村病にデュピルマブが著効した 1 例 (2022)
  • Author(s): 深水文惠、小池雄太、根井悠里江、室田浩之
  • Organizer: 第74回日本皮膚科学会西部支部学術大会
• [Presentation] IL-17阻害剤使用中にアトピー性皮膚炎を発症した乾癬患者における皮膚細菌叢変化 (2022)
  • Author(s): 小池雄太, 服部尚子, 元岡大祐, 室田浩之
  • Organizer: 第37回日本乾癬学会学術大会
• [Presentation] Severe dermatitis, multiple allergies, and metabolic wasting（SAM）syndromewith peeling skin and palmoplantar keratosis (2022)
  • Author(s): Yuta Koike、Takuya Takeichi、Norito Ishii、Tomoka Waseda、Naoya Murayama、Masashi Akiyama、Hiroyuki Murota
  • Organizer: 第86回日本皮膚科学会東部支部学術大会
• [Presentation] 全身性強皮症にリツキシマブを投与した１例 (2022)
  • Author(s): 中牟田瑠璃, 江原大輔, 下農真弘, 早稲田朋香, 森嵜仁美, 小池雄太, 室田浩之
  • Organizer: 日本皮膚科学会第348回長崎地方会
• [Presentation] ガイドラインに基づいた膠原病・血管炎に伴う皮膚潰瘍の治療 (2022)
  • Author(s): 宮部千恵，浅井純，石井貴之，岩田洋平，内山明彦，小川陽一，岡村賢，岸部麻里，小池雄太，小寺雅也、壽順久，藤本徳毅，宮城拓也，山口由衣，吉崎歩，大森礼子，浅野善英
  • Organizer: 第121回日本皮膚科学総会
  • Invited
• [Presentation] 乾癬と皮膚マイクロバイオーム (2022)
  • Author(s): 小池雄太
  • Organizer: 第121回日本皮膚科学総会
• [Presentation] ケラチノサイトのクローディン7は、乾癬表皮の顆粒層に高発現しており、HMG-CoA還元酵素阻害により発現が低下する (2022)
  • Author(s): 鍬塚さやか, 小池雄太, 鍬塚 大, 山岡俊文, 室田浩之
  • Organizer: 日本皮膚科学会第347回長崎地方会例会
• [Presentation] 乾癬に対するIL-17阻害剤投与中にアトピー性皮膚炎を発症した一例 (2022)
  • Author(s): 服部尚子, 小池雄太, 竹中 基, 室田浩之
  • Organizer: 日本皮膚科学会第347回長崎地方会例会
• [Presentation] 電子顕微鏡検査を施行しLangerhans細胞組織球症と診断した一例 (2021)
  • Author(s): 深水文惠, 村山直也, 渡辺華子, 小池雄太, 計盛幸子, 室田浩之
  • Organizer: 日本皮膚科学会第346回長崎地方会例会
• [Presentation] 痔疾患用外用剤による接触皮膚炎症候群の1例 (2021)
  • Author(s): 渡辺華子, 小池雄太, 森嵜仁美, 鍬塚さやか, 室田浩之, 小川文秀
  • Organizer: 日本皮膚科学会第346回長崎地方会例会
• [Presentation] Mutations in SAM syndrome and palmoplantar keratoderma patients suggest genotype/phenotype correlations in DSG1 mutations (2021)
  • Author(s): So Takeuchi, Takuya Takeichi, Yuta Koike, Hiroyuki Takama, Kana Tanahashi, Yusuke Okuno, Norito Ishii, Yoshinao Muro, Tomoo Ogi, Yasushi Suga, Masashi Akiyama
  • Organizer: The 46th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] 診断時精査で3 重複癌が判明した、抗TIF1 γ抗体陽性皮膚筋炎の2例 (2021)
  • Author(s): 下農 真弘, 小池 雄太, 里見 直義, 森嵜 仁美, 芦田 美輪, 室田 浩之
  • Organizer: 第73回日本皮膚科学会西部支部学術大会
• [Presentation] コロナワクチン接種後に生じた皮膚症状に対する病理組織学的検討 (2021)
  • Author(s): 渡辺 華子, 里見 直義, 芦田 美輪, 鍬塚 さやか, 小池 雄太, 水田 玲美, 上木 望, 室田 浩之
  • Organizer: 第73回日本皮膚科学会西部支部学術大会
• [Presentation] 乾癬病態のバイプレイヤーズ (2021)
  • Author(s): 小池雄太
  • Organizer: 第73回日本皮膚科学会西部支部学術大会
  • Invited
• [Presentation] 乾癬と白斑が同一部位に共存する尋常性乾癬の1 例 (2021)
  • Author(s): 小池雄太, 鍬塚さやか, 室田浩之
  • Organizer: 第36回日本乾癬学会学術大
• [Presentation] DSG1遺伝子変異による2つの皮膚疾患：その臨床像と形態学 (2021)
  • Author(s): 竹内想, 武市拓也, 小池雄太, 高間寛之, 棚橋華奈, 奥野友介, 石井文人, 室慶直, 荻朋男, 須賀康, 秋山真志
  • Organizer: 第47回皮膚かたち研究学会学術大会
• [Presentation] 【教育講演 創傷・褥瘡・熱傷～専門医に欠かせないガイドライン(GL)の知識～】膠原病・血管炎に伴う皮膚潰瘍―ガイドラインから学ぶ治療方針の基本と最近10 年間の変遷― (2021)
  • Author(s): 石井貴之, 浅野善英, 浅井純, 岩田洋平, 内山明彦, 小川陽一, 岡村賢, 岸部麻里, 小池雄太, 寺雅, 本, 城拓, 部千, 口由, 吉崎歩
  • Organizer: 第120回日本皮膚科学会総会
  • Invited
• [Presentation] 多発皮膚腫瘤で発症し，ATLL との鑑別を要した原発性皮膚未分化大細胞リンパ腫の1 例 (2021)
  • Author(s): 渡辺華子, 小池雄太, 早稲田朋香, 福地麗雅, 岩永聰, 山田悠一, 安東恒史, 今泉芳孝, 室田浩之
  • Organizer: 第120回日本皮膚科学会総会
• [Presentation] 創傷治癒過程における表皮角化細胞の上皮間葉移行 (2021)
  • Author(s): 小池雄太
  • Organizer: 日本皮膚科学会第344回長崎地方会例会
  • Invited
• [Presentation] 【KSID-JSID-TSID Frontier Symposium】Epithelial-mesenchymal transition in keratinocytes during wound healing process (2021)
  • Author(s): Yuta Koike, Mariko Yozaki, Atsushi Utani & Hiroyuki Murota
  • Organizer: 2021 29th KSID annual meeting
  • Invited
• [Presentation] それぞれ原因の異なるHorlequin症候群の2例 (2020)
  • Author(s): 早稲田朋香、服部尚子、小池雄太、辻野彰、室田浩之
  • Organizer: 第119回日本皮膚科学会総会
• [Presentation] 乾癬患者におけるHTLV-1 抗体陽性率と治療選択に与える影響を明らかにするための多施設共同観察研究 (2020)
  • Author(s): 米倉健太郎、鶴田紀子、宮城拓也、小池雄太、東裕子、桑代麻希、中原剛士、大畑千佳、金子栄、山口道也、池田賢太、原田佳代、齋藤華奈実、柳瀬哲至、今福信一
  • Organizer: 第35回日本乾癬学会学術大会
• [Presentation] 関節拘縮を伴った丘疹性ムチン沈着症の一例 (2020)
  • Author(s): 早稲田朋香、小池雄太、室田浩之、鵜殿雅子
  • Organizer: 日本皮膚科学会長崎地方会第341回例会
• [Presentation] 膿瘍性穿掘性頭部毛包周囲炎に対してアダリムマブを投与した一例 (2020)
  • Author(s): 服部尚子、小池雄太、里見直義、森崎仁美、岩永聰、室田浩之
  • Organizer: 日本皮膚科学会第342回長崎地方会例会
• [Presentation] プロプラノロールで加療した両足底pseudo-Kaposi’s sarcoma の1 例 (2020)
  • Author(s): 峰隆明、小池雄太、江原大輔、室田浩之
  • Organizer: 第72回日本皮膚科学会西部支部学術大会
• [Presentation] 両下肢の紫斑を主訴とした顕微鏡的多発血管炎の1 例 (2020)
  • Author(s): 中村俊介、小池雄太、峰 隆明、室田浩之、友川拓也、森山咲子
  • Organizer: 日本皮膚科学会第343回長崎地方会例会
• [Presentation] Skin mycobiome in patients with psoriasis under treatment with biologic (2020)
  • Author(s): Yuta Koike, Sayaka Kuwatsuka, Katsutaro Nishimoto, Daisuke Motooka, Hiroyuki Murota
  • Organizer: The 45th Annual Meeting of the Japanese Society for Investigative Dermatology
• [Presentation] 膠原病患者における定量的軸索反射性発汗試験（QSART）を用いた発汗機能の検討 (2020)
  • Author(s): 芦田美輪、与崎マリ子、江原大輔、小池雄太、室田浩之、森本心平
  • Organizer: 第50回日本皮膚免疫アレルギー学会総会学術大会