Impact of gut mycobiome on acute graft-versus-host disease

• Project/Area Number: 20K08748
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54010:Hematology and medical oncology-related
• Research Institution: The University of Tokyo
• Principal Investigator: Konuma Takaaki 東京大学, 医科学研究所, 准教授 (00709553)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2020: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 造血細胞移植 / 移植片対宿主病 / 腸内真菌叢 / 腸内細菌叢 / 同酒造血細胞移植 / 常在真菌叢 / 急性移植片対宿主病 / 同種造血細胞移植 / 免疫再構築

Outline of Research at the Start

同種造血細胞移植症例の糞便サンプルの腸内真菌叢を経時的に評価して、急性GVHDや免疫再構築と腸内真菌叢の変容の関連を明らかにする。同時に、急性GVHD発症例で認められる腸内真菌優占種により活性化する免疫細胞を同定することができれば、腸内真菌叢の制御による急性GVHDに対する予防及び治療への応用の足がかりになることが期待できる。

Outline of Final Research Achievements

We have obtained fecal samples from 93 allogeneic hematopoietic cell transplantation patients at our institution. We are currently analyzing the relationship between the intestinal fungal flora and the intestinal microbiota, each leukocyte subset in the peripheral blood, the administration of antibacterial and antifungal agents, and the relationship between acute graft-versus-host disease (GVHD) and bacteremia or fungemia and intestinal fungal flora. We also plan to analyze the effects of intestinal fungal flora and intestinal microbiota on subsequent immune reconstitution. In the future, they plan to evaluate the effects of antifungal drug administration and intestinal fungal flora on immunocompetent cells in a mouse model of GVHD to determine the possibility of preventing or treating GVHD.

Academic Significance and Societal Importance of the Research Achievements

真菌感染症の予防または治療を行う上で、移植片対宿主病(GVHD)や免疫再構築に影響しうる腸内真菌叢の変容を抑制するための、適切な抗真菌剤の使用方法の確立に向けた非常に特色のある研究である。また、GVHD治療において有望とされている糞便微生物移植においても、適切な真菌叢を明らかにすることに繋がるものと期待される。本研究の成果は、ダイナミックな腸内真菌叢の変動と免疫細胞のクロストークを理解するうえで、ヒト免疫学の観点からも重要な知見を得られることが期待され、免疫異常に起因する多くの疾患に対し、腸内真菌叢の変容が与える影響の解明にも応用可能であり、その足がかりになることが期待できる。

Research Products

• [Journal Article] Effect of Graft-versus-Host Disease on Post-Transplantation Outcomes following Single Cord Blood Transplantation Compared with Haploidentical Transplantation with Post-Transplantation Cyclophosphamide for Adult Acute Myeloid Leukemia (2023)
  • Author(s): Konuma Takaaki、Matsuda Kensuke、Shimomura Yoshimitsu、et al.
  • Journal Title: Transplantation and Cellular Therapy Volume: Online ahead of print Issue: 6 Pages: 365.e1-365.e11
  • DOI: 10.1016/j.jtct.2023.03.001
  • Peer Reviewed
• [Journal Article] Progress in survival following three decades of allogeneic hematopoietic cell transplantation for myelodysplastic syndrome: A real‐world registry study in Japan (2023)
  • Author(s): Konuma Takaaki、Itonaga Hidehiro、Ishiyama Ken、Hamamura Atsushi、Uchida Naoyuki、Ozawa Yukiyasu、Katayama Yuta、Sakurai Masatoshi、Ueda Yasunori、Matsuoka Ken‐ichi、Kawakita Toshiro、Eto Tetsuya、Ara Takahide、Kanda Junya、Onizuka Makoto、Fukuda Takahiro、Atsuta Yoshiko
  • Journal Title: American Journal of Hematology Volume: 98 Issue: 4
  • DOI: 10.1002/ajh.26839
  • Peer Reviewed / Open Access
• [Journal Article] Comparison of transplant outcomes between haploidentical transplantation and single cord blood transplantation in non‐remission acute myeloid leukaemia: A nationwide retrospective study (2023)
  • Author(s): K Matsuda , T Konuma , K Fuse , M Masuko , K Kawamura , M Hirayama , N Uchida , K Ikegame , A Wake , T Eto , N Doki , S Miyakoshi , M Tanaka , S Takahashi , M Onizuka , K Kato , T Kimura , T Ichinohe , N Takayama , H Kobayashi , H Nakamae , Y Atsuta , J Kanda , M Yanada
  • Journal Title: British Journal of Haematology Volume: 201 Issue: 1 Pages: 106-113
  • DOI: 10.1111/bjh.18530
  • Peer Reviewed / Open Access
• [Journal Article] Thyrotoxicosis after unrelated cord blood transplantation for adults (2022)
  • Author(s): Konuma Takaaki、Tomonari Akira、Ooi Jun、Nagayama Hitomi、Kawakita Toshiro、Kato Seiko、Isobe Masamichi、Monna-Oiwa Maki、Tojo Arinobu、Nannya Yasuhito、Takahashi Satoshi
  • Journal Title: Annals of Hematology Volume: 102 Issue: 3 Pages: 673-676
  • DOI: 10.1007/s00277-022-05068-3
  • Peer Reviewed
• [Journal Article] Conditioning regimens for allogeneic hematopoietic cell transplantation in acute myeloid leukemia: Real-world data from the Japanese registry studies (2022)
  • Author(s): Yanada Masamitsu、Harada Kaito、Shimomura Yoshimitsu、Arai Yasuyuki、Konuma Takaaki
  • Journal Title: Frontiers in Oncology Volume: 12 Pages: 1050633-1050633
  • DOI: 10.3389/fonc.2022.1050633
  • Peer Reviewed / Open Access
• [Journal Article] Genetic deletion and pharmacologic inhibition of E3 ubiquitin ligase HOIP impairs the propagation of myeloid leukemia (2022)
  • Author(s): Jimbo Koji、Hattori Ayuna、Koide Shuhei、Ito Takahiro、Sasaki Katsuhiro、Iwai Kazuhiro、Nannya Yasuhito、Iwama Atsushi、Tojo Arinobu、Konuma Takaaki
  • Journal Title: Leukemia Volume: 37 Issue: 1 Pages: 122-133
  • DOI: 10.1038/s41375-022-01750-7
  • Peer Reviewed
• [Journal Article] Age and allogeneic hematopoietic cell transplantation outcomes in acute myeloid leukemia (2022)
  • Author(s): Yanada Masamitsu、Yamasaki Satoshi、Konuma Takaaki、Mizuno Shohei、Uchida Naoyuki、Onai Daishi、Fukuda Takahiro、Tanaka Masatsugu、Ozawa Yukiyasu、Eto Tetsuya、Ikegame Kazuhiro、Sawa Masashi、Katayama Yuta、Kawakita Toshiro、Onizuka Makoto、Kanda Yoshinobu、Ichinohe Tatsuo、Atsuta Yoshiko、Yano Shingo
  • Journal Title: International Journal of Hematology Volume: 117 Issue: 3 Pages: 398-408
  • DOI: 10.1007/s12185-022-03486-7
  • Peer Reviewed
• [Journal Article] Intensified conditioning regimens improved disease‐free survival and engraftment after unrelated single‐unit cord blood transplantation but not after matched sibling or matched unrelated donor allogeneic hematopoietic cell transplantation (2022)
  • Author(s): Konuma T, Kanda J, Uchida N, Nishijima A, Tanaka M, Ozawa Y, Sawa M, Onizuka M, Ota S, Maruyama Y, Kanda Y, Kawakita T, Ara T, Eto T, Nakamae H, Kimura T, Fukuda T, Atsuta Y; Donor/Source Working Group of theJapanese Society for Transplantation and Cellular Therapy.
  • Journal Title: Hematological Oncology Volume: 41 Issue: 1 Pages: 147-158
  • DOI: 10.1002/hon.3094
  • Peer Reviewed
• [Journal Article] Salvage single-unit unrelated cord blood transplantation for graft failure following initial allogeneic transplantation in adult acute myeloid leukemia: trends in outcomes over the past 20 years (2022)
  • Author(s): Konuma T, Harada K, Kondo T, Masuko M, Uchida N, Yano S, Kawakita T, Onizuka M, Ota S, Sakaida E, Miyakoshi S, Ozawa Y, Imamura Y, Kimura T, Kanda Y, Fukuda T, Atsuta Y, Yanada M; Adult Acute Myeloid Leukemia Working Group of the Japanese Society for Transplantation and Cellular Therapy.
  • Journal Title: Bone Marrow Transplantation Volume: 57 Issue: 12 Pages: 1848-1850
  • DOI: 10.1038/s41409-022-01840-1
  • Peer Reviewed
• [Journal Article] Haploidentical transplantation with post‐transplant cyclophosphamide versus single cord blood transplantation for myelodysplastic syndrome: A retrospective study from the Adult Myelodysplastic Syndrome Working Group of the Japanese Society for Transplantation and Cellular Therapy (JSTCT) (2022)
  • Author(s): Konuma Takaaki、Shimomura Yoshimitsu、Ishiyama Ken、Ara Takahide、Nakamae Hirohisa、Hiramoto Nobuhiro、Eto Tetsuya、Maruyama Yumiko、Nagafuji Koji、Ishikawa Jun、Uchida Naoyuki、Tanaka Masatsugu、Onizuka Makoto、Ueda Yasunori、Anzai Naoyuki、Kimura Takafumi、Kanda Yoshinobu、Fukuda Takahiro、Atsuta Yoshiko
  • Journal Title: American Journal of Hematology Volume: 97 Issue: 12
  • DOI: 10.1002/ajh.26722
  • Peer Reviewed / Open Access
• [Journal Article] Higher Cryopreserved CD34+ Cell Dose Is Associated with Decreased Hepatic Veno-Occlusive Disease/Sinusoidal Obstruction Syndrome after Single-Unit Cord Blood Transplantation in Adults Given Prophylactic Ursodeoxycholic Acid and Intravenous Heparin (2022)
  • Author(s): Kato Seiko、Konuma Takaaki、Monna-Oiwa Maki、Isobe Masamichi、Takahashi Satoshi、Nannya Yasuhito
  • Journal Title: Transplantation and Cellular Therapy Volume: 28 Issue: 11 Pages: 779.e1-779.e9
  • DOI: 10.1016/j.jtct.2022.08.013
  • Peer Reviewed
• [Journal Article] Reducing Mortality of Single-Unit Unrelated Cord Blood Transplantation for Relapsed Acute Myeloid Leukemia after a Previous Allogeneic Transplantation: A Real-World Retrospective Study Over the Past 19 Years in Japan (2022)
  • Author(s): Konuma Takaaki、Mizuno Shohei、Harada Kaito、Uchida Naoyuki、Takahashi Satoshi、Eto Tetsuya、Ota Shuichi、Kobayashi Hikaru、Katayama Yuta、Mori Yasuo、Maruyama Yumiko、Onizuka Makoto、Yonezawa Akihito、Kawakita Toshiro、Kimura Takafumi、Kanda Yoshinobu、Fukuda Takahiro、Atsuta Yoshiko、Yanada Masamitsu
  • Journal Title: Transplantation and Cellular Therapy Volume: 28 Issue: 11 Pages: 777.e1-777.e11
  • DOI: 10.1016/j.jtct.2022.08.006
  • Peer Reviewed
• [Journal Article] Favorable Outcome with Conditioning Regimen of Flu/Bu4/Mel in Acute Myeloid Leukemia Patients in Remission Undergoing Cord Blood Transplantation. (2022)
  • Author(s): Mizuno S, Takami A, Kawamura K, Shimomura Y, Arai Y, Konuma T, Ozawa Y, Sawa M, Ota S, Takahashi S, Anzai N, Hiramoto N, Onizuka M, Nakamae H, Tanaka M, Murata M, Kimura T, Kanda J, Fukuda T, Atsuta Y, Yanada M.
  • Journal Title: Transplant Cell Ther Volume: 28 Issue: 11 Pages: 775.e1-775.e9
  • DOI: 10.1016/j.jtct.2022.07.026
  • Peer Reviewed
• [Journal Article] Prognostic impact of switching from cyclosporine to corticosteroids early after single cord blood transplantation (2022)
  • Author(s): Takano Kosuke、Konuma Takaaki、Monna-Oiwa Maki、Isobe Masamichi、Kato Seiko、Takahashi Satoshi、Nannya Yasuhito
  • Journal Title: Annals of Hematology Volume: 101 Issue: 10 Pages: 2377-2378
  • DOI: 10.1007/s00277-022-04916-6
  • Peer Reviewed
• [Journal Article] Improved trends in survival and engraftment after single cord blood transplantation for adult acute myeloid leukemia (2022)
  • Author(s): Konuma T, Mizuno S, Kondo T, Arai Y, Uchida N, Takahashi S, Tanaka M, Kuriyama T, Miyakoshi S, Onizuka M, Ota S, Sugio Y, Kouzai Y, Kawakita T, Kobayashi H, Ozawa Y, Kimura T, Ichinohe T, Atsuta Y, Yanada M; Adult Acute Myeloid Leukemia Working Group of the Japanese Society for Transplantation and Cellular Therapy.
  • Journal Title: Blood Cancer Journal Volume: 12 Issue: 5 Pages: 81-81
  • DOI: 10.1038/s41408-022-00678-6
  • Peer Reviewed / Open Access
• [Journal Article] Ideal Body Weight Is Useful For Predicting Neutrophil Engraftment and Platelet Recovery for Overweight and Obese Recipients in Single-Unit Cord Blood Transplantation (2022)
  • Author(s): Okada Yosuke、Nakasone Hideki、Konuma Takaaki、Uchida Naoyuki、Tanaka Masatsugu、Sugio Yasuhiro、Aotsuka Nobuyuki、Nishijima Akihiko、Katsuoka Yuna、Ara Takahide、Ota Shuichi、Onizuka Makoto、Sawa Masashi、Kimura Takafumi、Fukuda Takahiro、Atsuta Yoshiko、Kanda Junya、Kimura Fumihiko
  • Journal Title: Transplantation and Cellular Therapy Volume: 28 Issue: 8 Pages: 504.e1-504.e7
  • DOI: 10.1016/j.jtct.2022.05.006
  • Peer Reviewed
• [Journal Article] Early prediction of neutrophil engraftment using manual leukocyte differential count after cord blood transplantation (2022)
  • Author(s): Mizukami Motoko、Konuma Takaaki、Nagai Etsuko、Monna‐Oiwa Maki、Isobe Masamichi、Kato Seiko、Takahashi Satoshi、Tojo Arinobu、Nannya Yasuhito
  • Journal Title: International Journal of Laboratory Hematology Volume: 44 Issue: 4
  • DOI: 10.1111/ijlh.13803
  • Peer Reviewed
• [Journal Article] Immunoglobulin superfamily member 8 maintains myeloid leukemia stem cells through inhibition of β-catenin degradation (2022)
  • Author(s): Jimbo K, Nakajima-Takagi Y, Ito T, Koide S, Nannya Y, Iwama A, Tojo A, Konuma T
  • Journal Title: Leukemia Volume: In press Issue: 6 Pages: 1550-1562
  • DOI: 10.1038/s41375-022-01564-7
  • Peer Reviewed
• [Journal Article] Anti-spike protein antibody titer at the time of breakthrough infection of SARS-CoV-2 omicron (2022)
  • Author(s): Adachi E, Nagai E, Saito M, Isobe M, Konuma T, Koga M, Tsutsumi T, Nannya Y, Yotsuyanagi H
  • Journal Title: J Infect Chemother Volume: In press Issue: 7 Pages: 1015-1017
  • DOI: 10.1016/j.jiac.2022.03.021
  • Peer Reviewed / Open Access
• [Journal Article] Long-term incidence of varicella zoster virus disease in adults receiving single-unit cord blood transplantation (2022)
  • Author(s): Fukushi K, Konuma T, Monna-Oiwa M, Isobe M, Kato S, Kuroda S, Takahashi S, Nannya Y
  • Journal Title: Transplant Cell Ther Volume: In press Issue: 6 Pages: 339.e1-339.e7
  • DOI: 10.1016/j.jtct.2022.03.022
  • Peer Reviewed
• [Journal Article] HLA 1-3 antigen‐mismatched related peripheral blood stem cells transplantation using low‐dose antithymocyte globulin versus unrelated cord blood transplantation (2022)
  • Author(s): Wada F., Takahashi S., et al.
  • Journal Title: American Journal of Hematology Volume: 97 Issue: 3 Pages: 311-321
  • DOI: 10.1002/ajh.26446
  • Peer Reviewed
• [Journal Article] Respiratory syncytial virus pneumonia in an adult cord blood transplant recipient during the SARS-CoV-2 outbreak (2021)
  • Author(s): Konuma T, Isobe M, Kato S, Takahashi S, Nannya Y.
  • Journal Title: EJHaem Volume: 3 Issue: 1 Pages: 261-262
  • DOI: 10.1002/jha2.351
  • Peer Reviewed / Open Access
• [Journal Article] Total body irradiation-based versus busulfan-based myeloablative conditioning for single-unit cord blood transplantation in adults (2021)
  • Author(s): Konuma T, Ooi J, Monna-Oiwa M, Isobe M, Tomonari A, Kato S, Iseki T, Nannya Y, Tojo A, Takahashi S
  • Journal Title: Leuk Lymphoma Volume: In press Issue: 5 Pages: 1191-1201
  • DOI: 10.1080/10428194.2021.2018583
  • Peer Reviewed
• [Journal Article] Outcomes of third allogeneic hematopoietic stem cell transplantation in relapsed/refractory acute leukemia after a second transplantation (2021)
  • Author(s): Kobayashi S., Takahashi S., et al.
  • Journal Title: Bone Marrow Transplantation Volume: 57 Issue: 1 Pages: 43-50
  • DOI: 10.1038/s41409-021-01485-6
  • Peer Reviewed / Open Access
• [Journal Article] Long-term outcomes following the addition of granulocyte colony-stimulating factor-combined high-dose cytarabine to total body irradiation and cyclophosphamide conditioning in single-unit cord blood transplantation for myeloid malignancies (2021)
  • Author(s): Konuma Takaaki、Ooi Jun、Nagayama Hitomi、Tomonari Akira、Tsukada Nobuhiro、Kato Seiko、Kawakita Toshiro、Isobe Masamichi、Monna-Oiwa Maki、Tojo Arinobu、Iseki Tohru、Takahashi Satoshi
  • Journal Title: Annals of Hematology Volume: 101 Issue: 1 Pages: 177-189
  • DOI: 10.1007/s00277-021-04676-9
  • Peer Reviewed
• [Journal Article] Molecular characterization of healthcare and community-associated methicillin-resistant Staphylococcus aureus using phage open-reading frame typing (2021)
  • Author(s): Konuma T, Takahashi S, Suzuki M, Tojo A
  • Journal Title: Iran J Microbiol Volume: 13 Pages: 560-564
  • DOI: 10.18502/ijm.v13i4.6985
  • Peer Reviewed / Open Access
• [Journal Article] Allogeneic Hematopoietic Cell Transplantation from Alternative Donors in Acute Myelogenous Leukemia: A Comparative Analysis (2021)
  • Author(s): Yanada M, Konuma T, Yamasaki S, Harada K, Iwasaki M, Kobayashi A, Nishijima A, Tanaka M, Uchida N, Nakamae H, Fukuda T, Onizuka M, Ozawa Y, Sawa M, Katayama Y, Yoshioka S, Kimura T, Ichinohe T, Atsuta Y, Kanda J, Yano S
  • Journal Title: Transplant Cell Ther Volume: 27 Issue: 12 Pages: 1005.e1-1005.e8
  • DOI: 10.1016/j.jtct.2021.08.027
  • Peer Reviewed
• [Journal Article] The differential effect of disease status at allogeneic hematopoietic cell transplantation on outcomes in acute myeloid and lymphoblastic leukemia (2021)
  • Author(s): Yanada M, Konuma T, Yamasaki S, Mizuno S, Hirabayashi S, Nishiwaki S, Uchida N, Doki N, Tanaka M, Ozawa Y, Sawa M, Eto T, Kawakita T, Ota S, Fukuda T, Onizuka M, Kimura T, Atsuta Y, Kako S, Yano S
  • Journal Title: Ann Hematol Volume: 100 Issue: 12 Pages: 3017-3027
  • DOI: 10.1007/s00277-021-04661-2
  • Peer Reviewed
• [Journal Article] Hematological effects on peri-transplant use of linezolid in adults undergoing single-unit cord blood transplantation (2021)
  • Author(s): Yasu T, Konuma T, Oiwa-Monna M, Takahashi S, Nannya Y, Tojo A
  • Journal Title: Ann Hematol Volume: 100 Issue: 11 Pages: 2867-2869
  • DOI: 10.1007/s00277-021-04597-7
  • Peer Reviewed
• [Journal Article] Prognostic value of measurable residual disease at allogeneic transplantation for adults with core binding factor acute myeloid leukemia in complete remission (2021)
  • Author(s): Konuma T, Kondo T, Masuko M, Shimizu H, Shiratori S, Fukuda T, Kato J, Sawa M, Ozawa Y, Ota S, Uchida N, Kanda Y, Kako S, Fujisawa S, Fukushima K, Ichinohe T, Atsuta Y, Yanada M
  • Journal Title: Bone Marrow Transplant Volume: 56 Issue: 11 Pages: 2779-2787
  • DOI: 10.1038/s41409-021-01409-4
  • Peer Reviewed
• [Journal Article] Cord blood index predicts engraftment and early non-relapse mortality in adult patients with single-unit cord blood transplantation (2021)
  • Author(s): Kondo G., Takahashi S., et al.
  • Journal Title: Bone Marrow Transplantation Volume: 56 Issue: 11 Pages: 2771-2778
  • DOI: 10.1038/s41409-021-01406-7
  • Peer Reviewed
• [Journal Article] Momentum of neutrophil recovery using an exponential growth model predicts the prognosis of single cord blood transplantation (2021)
  • Author(s): Isobe M, Konuma T, Monna-Oiwa M, Okabe M, Kato S, Takahashi S, Tojo A
  • Journal Title: Int J Lab Hematol Volume: 43 Issue: 6 Pages: 1465-1471
  • DOI: 10.1111/ijlh.13636
  • Peer Reviewed
• [Journal Article] Differential Effect of Graft-versus-Host Disease on Survival in Acute Leukemia according to Donor Type (2021)
  • Author(s): Konuma T, Kanda J, Kuwatsuka Y, Yanada M, Kondo T, Hirabayashi S, Kako S, Akahoshi Y, Uchida N, Doki N, Ozawa Y, Tanaka M, Eto T, Sawa M, Yoshioka S, Kimura T, Kanda Y, Fukuda T, Atsuta Y, Kimura F
  • Journal Title: Clin Cancer Res Volume: 27 Issue: 17 Pages: 4825-4835
  • DOI: 10.1158/1078-0432.ccr-20-4856
  • Peer Reviewed
• [Journal Article] Prognostic impacts of peripheral blood erythroblasts after single‐unit cord blood transplantation (2021)
  • Author(s): Kaito Yuta、Konuma Takaaki、Monna‐Oiwa Maki、Kato Seiko、Isobe Masamichi、Okabe Motohito、Imai Yoichi、Takahashi Satoshi、Tojo Arinobu
  • Journal Title: International Journal of Laboratory Hematology Volume: 43 Issue: 6 Pages: 1437-1442
  • DOI: 10.1111/ijlh.13622
  • Peer Reviewed
• [Journal Article] Radiation‐free myeloablative conditioning consisting of fludarabine added to full‐dose busulfan and cyclophosphamide in single‐unit cord blood transplantation for adults (2021)
  • Author(s): Konuma Takaaki、Monna‐Oiwa Maki、Isobe Masamichi、Okabe Motohito、Takahashi Satoshi、Tojo Arinobu
  • Journal Title: European Journal of Haematology Volume: 107 Issue: 3 Pages: 374-376
  • DOI: 10.1111/ejh.13669
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic stem cell transplantation for myelodysplastic syndrome in adolescent and young adult patients (2021)
  • Author(s): Shimomura Y, Hara M, Konuma T, Itonaga H, Doki N, Ozawa Y, Eto T, Uchida N, Aoki J, Kato J, Onishi Y, Takahashi S, Fukushima K, Nakamae H, Kawakita T, Tanaka J, Fukuda T, Atsuta Y, Ishikawa T, Ishiyama K
  • Journal Title: Bone Marrow Transplant Volume: 56 Issue: 10 Pages: 2510-2517
  • DOI: 10.1038/s41409-021-01324-8
  • Peer Reviewed
• [Journal Article] Pretransplantation Red Blood Cell and Platelet Transfusion Burden in De Novo Myelodysplastic Syndrome Undergoing Allogeneic Transplantation (2021)
  • Author(s): Konuma T, Aoki J, Ozawa Y, Uchida N, Kobayashi T, Onizuka M, Katayama Y, Ohta T, Nakano N, Ota S, Onishi Y, Kobayashi H, Fukuda T, Kanda Y, Atsuta Y
  • Journal Title: Transplant Cell Ther Volume: 27 Issue: 8 Pages: 671-678
  • DOI: 10.1016/j.jtct.2021.05.003
  • Peer Reviewed
• [Journal Article] Early-Phase Peripheral Blood Eosinophilia Predicts Lower Overall and Non-Relapse Mortality After Single-Unit Cord Blood Transplantation (2021)
  • Author(s): Konuma T, Monna-Oiwa M, Kaito Y, Isobe M, Okabe M, Kato S, Takahashi S, Tojo A.
  • Journal Title: Transplant Cell Ther. Volume: 27(4) Issue: 4 Pages: 336.e1-336.e9
  • DOI: 10.1016/j.jtct.2021.01.027
  • Peer Reviewed
• [Journal Article] Single cord blood transplantation for acute myeloid leukemia patients aged 60 years or older: a retrospective study in Japan (2021)
  • Author(s): Isobe Masamichi、Konuma Takaaki、Masuko Masayoshi、Uchida Naoyuki、Miyakoshi Shigesaburo、Sugio Yasuhiro、Yoshida Shuro、Tanaka Masatsugu、Matsuhashi Yoshiko、Hattori Norimichi、Onizuka Makoto、Aotsuka Nobuyuki、Kouzai Yasushi、Wake Atsushi、Kimura Takafumi、Ichinohe Tatsuo、Atsuta Yoshiko、Yanada Masamitsu
  • Journal Title: Annals of Hematology Volume: － Issue: 7 Pages: 1849-1861
  • DOI: 10.1007/s00277-021-04464-5
  • Peer Reviewed
• [Journal Article] Single Cord Blood Transplantation Versus Unmanipulated Haploidentical Transplantation for Adults with Acute Myeloid Leukemia in Complete Remission. (2021)
  • Author(s): Konuma T, Kanda J, Yamasaki S, Harada K, Shimomura Y, Terakura S, Mizuno S, Uchida N, Tanaka M, Doki N, Ozawa Y, Nakamae H, Sawa M, Matsuoka KI, Morishige S, Maruyama Y, Ikegame K, Kimura T, Kanda Y, Ichinohe T, Atsuta Y, Yanada M.
  • Journal Title: Transplant Cell Ther. Volume: 27(4) Issue: 4 Pages: 334.e1-334.e11
  • DOI: 10.1016/j.jtct.2021.01.023
  • Peer Reviewed
• [Journal Article] Prognostic Impact of the Fractionation of Total Body Irradiation for Patients with Acute Myeloid Leukemia Undergoing Myeloablative Allogeneic Hematopoietic Cell Transplantation. (2021)
  • Author(s): Ueda N, Konuma T, Aoki J, Takahashi S, Ozawa Y, Mori T, Ota S, Eto T, Takada S, Yoshioka S, Shiratori S, Kako S, Onizuka M, Fukuda T, Kanda Y, Atsuta Y, Yanada M.
  • Journal Title: Transplant Cell Ther. Volume: 27(2) Issue: 2 Pages: 185.e1-185.e6
  • DOI: 10.1016/j.jtct.2020.10.018
  • Peer Reviewed
• [Journal Article] Lower vancomycin trough levels in adults undergoing unrelated cord blood transplantation. (2021)
  • Author(s): Yasu T, Konuma T, Oiwa-Monna M, Kato S, Isobe M, Takahashi S, Tojo A.
  • Journal Title: Leuk Lymphoma. Volume: 62(2) Issue: 2 Pages: 348-357
  • DOI: 10.1080/10428194.2020.1834096
  • Peer Reviewed
• [Journal Article] Predicting non-relapse mortality following allogeneic hematopoietic cell transplantation during first remission of acute myeloid leukemia. (2021)
  • Author(s): Yanada M, Konuma T, Mizuno S, Saburi M, Shinohara A, Tanaka M, Marumo A, Sawa M, Uchida N, Ozawa Y, Onizuka M, Yoshioka S, Nakamae H, Kondo T, Kimura T, Kanda J, Fukuda T, Atsuta Y, Nakasone H, Yano S.
  • Journal Title: Bone Marrow Transplant. Volume: 56(2) Issue: 2 Pages: 387-394
  • DOI: 10.1038/s41409-020-01032-9
  • Peer Reviewed
• [Journal Article] Effect of polymorphism in base excision repair genes on outcomes in adults following myeloablative single-unit cord blood transplantation. (2021)
  • Author(s): Konuma T, Oiwa-Monna M, Isobe M, Kato S, Yokoyama K, Yusa N, Takahashi S, Tojo A.
  • Journal Title: Leuk Lymphoma. Volume: 62(4) Issue: 4 Pages: 1019-1021
  • DOI: 10.1080/10428194.2019.1683738
  • Peer Reviewed
• [Journal Article] Hematopoietic cell transplantation in adults with acute myeloid leukemia: A review of the results from various nationwide registry studies in Japan (2021)
  • Author(s): Yasuyuki Arai, Takaaki Konuma, Masamitsu Yanada
  • Journal Title: Blood Cell Therapy Volume: In press Issue: 2
  • DOI: 10.31547/bct-2020-023
  • Peer Reviewed
• [Journal Article] Disseminated Tuberculosis with Cholecystitis in a Patient after Cord Blood Transplantation (2020)
  • Author(s): Konuma T, Isobe M, Adachi E, Kato S, Takahashi S, Yotsuyanagi H, Tojo A.
  • Journal Title: Internal Medicine Volume: 59 Issue: 21 Pages: 2769-2771
  • DOI: 10.2169/internalmedicine.4923-20
  • NAID: 130007934211
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2020-11-01
  • Peer Reviewed
• [Journal Article] High Prevalence of Left Ventricular Non-Compaction and Its Effect on Chemotherapy-Related Cardiac Dysfunction in Patients With Hematological Diseases (2020)
  • Author(s): Hirano M, Kimura K, Ishigaki T, Nojima M, Daimon M, Morita H, Takenaka K, Xu B, Sawada N, Hirokawa M, Komuro I, Morisaki T, Yotsuyanagi H, Kawamata T, Yokoyama K, Konuma T, Kato S, Yasui H, Nagamura-Inoue T, Uchimaru K, Takahashi S, Imai Y, Tojo A.
  • Journal Title: Circulation Journal Volume: 84 Issue: 11 Pages: 1957-1964
  • DOI: 10.1253/circj.CJ-20-0344
  • NAID: 130007928999
  • ISSN: 1346-9843, 1347-4820
  • Year and Date: 2020-10-23
  • Peer Reviewed / Open Access
• [Journal Article] Impact of a prior history of cancer on prognosis after myeloablative single-unit cord blood transplantation (2020)
  • Author(s): Okabe Motohito、Konuma Takaaki、Oiwa-Monna Maki、Kato Seiko、Isobe Masamichi、Takahashi Satoshi、Tojo Arinobu
  • Journal Title: Japanese Journal of Clinical Oncology Volume: 51 Issue: 4 Pages: 657-660
  • DOI: 10.1093/jjco/hyaa250
  • Peer Reviewed
• [Journal Article] Relapse of acute myeloid leukemia after allogeneic hematopoietic cell transplantation: clinical features and outcomes. (2020)
  • Author(s): Yanada M, Konuma T, Yamasaki S, Kondo T, Fukuda T, Shingai N, Sawa M, Ozawa Y, Tanaka M, Uchida N, Nakamae H, Katayama Y, Matsuoka KI, Kimura T, Kanda Y, Ichinohe T, Atsuta Y, Yano S.
  • Journal Title: Bone Marrow Transplant. Volume: In press Issue: 5 Pages: 1126-1133
  • DOI: 10.1038/s41409-020-01163-z
  • Peer Reviewed
• [Journal Article] Randomised controlled trial of conditioning regimen for cord blood transplantation for adult myeloid malignancies comparing high-dose cytarabine/cyclophosphamide/total body irradiation with versus without G-CSF priming: G-CONCORD study protocol. (2020)
  • Author(s): Terakura S, Konuma T, Tanaka M, Ozawa Y, Onizuka M, Nanno S, Onishi Y, Aotsuka N, Kondo T, Kawakita T, Kato J, Kobayashi T, Nishida T, Yamaguchi T, Kuwatsuka Y, Takahashi S.
  • Journal Title: BMJ Open. Volume: 10(12) Issue: 12 Pages: e040467-e040467
  • DOI: 10.1136/bmjopen-2020-040467
  • Peer Reviewed / Open Access
• [Journal Article] Effects of Acute and Chronic Graft-versus-myelodysplastic Syndrome on Long-term Outcomes Following Allogeneic Hematopoietic Cell Transplantation. (2020)
  • Author(s): Konuma T, Ishiyama K, Igarashi A, Uchida N, Ozawa Y, Fukuda T, Ueda Y, Matsuoka KI, Mori T, Katayama Y, Onizuka M, Ichinohe T, Atsuta Y
  • Journal Title: Clin Cancer Res. Volume: 26(24) Issue: 24 Pages: 6483-6493
  • DOI: 10.1158/1078-0432.ccr-20-1104
  • Peer Reviewed
• [Journal Article] Impact of Intestinal Microbiota on Reconstitution of Circulating Monocyte, Dendritic Cell, and Natural Killer Cell Subsets in Adults Undergoing Single-Unit Cord Blood Transplantation. (2020)
  • Author(s): Konuma T, Kohara C, Watanabe E, Takahashi S, Ozawa G, Inomata K, Suzuki K, Mizukami M, Nagai E, Okabe M, Isobe M, Kato S, Oiwa-Monna M, Takahashi S, Tojo A.
  • Journal Title: Biol Blood Marrow Transplant. Volume: 26(11) Issue: 11 Pages: e292-e297
  • DOI: 10.1016/j.bbmt.2020.08.009
  • Peer Reviewed
• [Journal Article] Updated Comparison of 7/8 HLA Allele-Matched Unrelated Bone Marrow Transplantation and Single-Unit Umbilical Cord Blood Transplantation as Alternative Donors in Adults with Acute Leukemia. (2020)
  • Author(s): Miyao K, Terakura S, Kimura F, Konuma T, Miyamura K, Yanada M, Kako S, Morhishima S, Uchida N, Toya T, Ozawa Y, Fukuda T, Tanaka M, Sawa M, Takada S, Yoshida S, Kimura T, Ichinohe T, Atsuta Y, Kanda J
  • Journal Title: Biol Blood Marrow Transplant. Volume: 26(11) Issue: 11 Pages: 2105-2114
  • DOI: 10.1016/j.bbmt.2020.08.001
  • Peer Reviewed
• [Journal Article] Allogeneic hematopoietic cell transplantation for adults with acute myeloid leukemia conducted in Japan during the past quarter century (2020)
  • Author(s): Yanada Masamitsu、Takami Akiyoshi、Yamasaki Satoshi、Arai Yasuyuki、Konuma Takaaki、Uchida Naoyuki、Najima Yuho、Fukuda Takahiro、Tanaka Masatsugu、Ozawa Yukiyasu、Ikegame Kazuhiro、Takanashi Minoko、Ichinohe Tatsuo、Okamoto Shinichiro、Atsuta Yoshiko、Yano Shingo
  • Journal Title: Annals of Hematology Volume: 99 Issue: 6 Pages: 1351-1360
  • DOI: 10.1007/s00277-020-04051-0
  • Peer Reviewed
• [Journal Article] Clinical outcomes of persistent colonization with multidrug-resistant Gram-negative rods in adult patients undergoing single cord blood transplantation. (2020)
  • Author(s): Mizusawa M, Konuma T, Kato S, Isobe M, Shibata H, Suzuki M, Takahashi O, Oiwa-Monna M, Takahashi S, Tojo A.
  • Journal Title: Int J Hematol. Volume: 111(6) Issue: 6 Pages: 858-868
  • DOI: 10.1007/s12185-020-02854-5
  • Peer Reviewed
• [Journal Article] Telomere length in CD4+ and CD8+ T cells among long-term survivors of adults after single cord blood transplantation. (2020)
  • Author(s): Jimbo K, Konuma T, Mizukami M, Nagai E, Oiwa-Monna M, Isobe M, Kato S, Takahashi S, Tojo A.
  • Journal Title: Eur J Haematol. Volume: 104(5) Issue: 5 Pages: 509-511
  • DOI: 10.1111/ejh.13385
  • Peer Reviewed
• [Journal Article] Reconstitution of Circulating Mucosal-Associated Invariant T Cells after Allogeneic Hematopoietic Cell Transplantation: Its Association with the Riboflavin Synthetic Pathway of Gut Microbiota in Cord Blood Transplant Recipients (2020)
  • Author(s): Konuma Takaaki、Kohara Chisato、Watanabe Eri、Takahashi Shunsuke、Ozawa Genki、Suzuki Kei、Mizukami Motoko、Nagai Etsuko、Jimbo Koji、Kaito Yuta、Isobe Masamichi、Kato Seiko、Takahashi Satoshi、Chiba Asako、Miyake Sachiko、Tojo Arinobu
  • Journal Title: The Journal of Immunology Volume: 204 Issue: 6 Pages: 1462-1473
  • DOI: 10.4049/jimmunol.1900681
  • Peer Reviewed / Open Access
• [Journal Article] Improvement of early mortality in single-unit cord blood transplantation for Japanese adults from 1998 to 2017. (2020)
  • Author(s): Konuma T, Kanda J, Inamoto Y, Hayashi H, Kobayashi S, Uchida N, Sugio Y, Tanaka M, Kobayashi H, Kouzai Y, Takahashi S, Eto T, Mukae J, Matsuhashi Y, Fukuda T, Takanashi M, Kanda Y, Atsuta Y, Kimura F.
  • Journal Title: Am J Hematol. Volume: 95(4) Issue: 4 Pages: 343-353
  • DOI: 10.1002/ajh.25705
  • Peer Reviewed
• [Journal Article] Candida colonization is associated with severe acute GVHD in adult patients undergoing single-unit cord blood transplantation. (2020)
  • Author(s): Konuma T, Mizusawa M, Suzuki M, Kaito Y, Isobe M, Kato S, Shibata H, Takahashi O, Oiwa-Monna M, Takahashi S, Tojo A.
  • Journal Title: Eur J Haematol. Volume: 104(1) Issue: 1 Pages: 74-76
  • DOI: 10.1111/ejh.13341
  • Peer Reviewed
• [Presentation] 臍帯血移植の現状とユニット選択 (2023)
  • Author(s): 小沼貴晶
  • Organizer: 第45回 日本造血・免疫細胞療法学会総会
  • Invited
• [Presentation] 本邦における成人骨髄異形成症候群に対する同種造血細胞移植の年次推移 (2023)
  • Author(s): 小沼 貴晶、糸永 英弘、石山 謙、土岐 典子、内田 直之、小澤 幸泰、片山 雄太、片岡 圭亮、上田 恭典、 松岡 賢市、河北 敏郎、衛藤 徹也、荒 隆英、諫田 淳也、鬼塚 真仁、福田 隆浩、熱田 由子
  • Organizer: 第45回 日本造血・免疫細胞療法学会総会
• [Presentation] 臍帯血移植における強化前処置は無病生存率および生着率を改善する (2022)
  • Author(s): 小沼貴晶、諫田淳也、内田直之、西島曉彦、田中正嗣、小澤幸泰、澤正史、鬼塚真仁、太田秀一、 丸山ゆみ子、神田善伸、河北敏郎、荒隆英、衛藤徹也、中前博久、木村貴文、福田隆浩、熱田由子
  • Organizer: 第84回日本血液学会学術集会
• [Presentation] Japanese experience of single-unit cord blood transplantation for adults (2022)
  • Author(s): Takaaki Konuma
  • Organizer: 44th JSTCT Annual Meeting
  • Invited
• [Presentation] Tips on how to success CBT (2022)
  • Author(s): 小沼貴晶、山本久史
  • Organizer: 第44回 日本造血・免疫細胞療法学会総会
  • Invited
• [Presentation] 臍帯血移植の適正な移植前処置 (2021)
  • Author(s): 小沼貴晶
  • Organizer: 第 43 回日本造血細胞移植学会総会
  • Invited
• [Presentation] Long-term outcomes of G-CSF-combined conditioning in single cord blood transplantation (2021)
  • Author(s): 小沼貴晶、大井淳,長山人三,塚田信弘,加藤せい子,河北敏郎,磯部優理,大岩真希,東條 有伸, 井関 徹, 高橋 聡
  • Organizer: 第 83 回日本血液学会学術集会
• [Presentation] 臍帯血移植の適正な移植前処置 (2021)
  • Author(s): 小沼 貴晶
  • Organizer: 第43回日本造血細胞移植学会総会
  • Invited
• [Presentation] 臍帯血移植後の末梢血赤芽球の出現は予後に影響を与えるか? (2021)
  • Author(s): 海渡 裕太、小沼 貴晶、加藤せい子、磯部 優理、岡部 基人、大岩 真希、今井 陽一、 高橋 聡、東條 有伸
  • Organizer: 第43回日本造血細胞移植学会総会
• [Presentation] AML 患者への骨髄破壊的同種造血幹細胞移植における TBI 分割回数の予後への影響 (2021)
  • Author(s): 上田 格弘、小沼 貴晶、青木 淳、高橋 聡、小澤 幸泰、森 毅彦、 太田 秀一、衛藤 徹也、高田 覚、吉岡 聡、白鳥 聡一、賀古 真一、 福田 隆浩、鬼塚 真仁、神田 善伸、熱田 由子、柳田 正光
  • Organizer: 第43回日本造血細胞移植学会総会
• [Presentation] AML 第 1 寛解期移植における非再発死亡予測モデルの構築 (2021)
  • Author(s): 柳田 正光、小沼 貴晶、水野 昌平、佐分利益穂、篠原 明仁、田中 正嗣、 丸毛 敦史、澤 正史、内田 直之、小澤 幸泰、鬼塚 真仁、吉岡 聡、 中前 博久、近藤 忠一、木村 貴文、諫田 淳也、福田 隆浩、熱田 由子、 仲宗根秀樹、矢野 真吾
  • Organizer: 第43回日本造血細胞移植学会総会
• [Presentation] 同種造血細胞移植サバイバーにおけるネット生存率と Conditional Survival:移植レジストリ解析 (2021)
  • Author(s): 鍬塚八千代、伊藤 秀美、田渕 健、小沼 貴晶、内田 直之、土岐 典子、 小澤 幸泰、池亀 和博、福田 隆浩、一戸 辰夫、木村 文彦、諫田 淳也、 熱田 由子、松尾恵太郎
  • Organizer: 第43回日本造血細胞移植学会総会
• [Presentation] 指数関数的増幅モデルを用いた好中球回復の勢いは臍帯血移植の予後を推定する (2021)
  • Author(s): 磯部 優理、小沼 貴晶、加藤せい子、岡部 基人、大岩 真希、高橋 聡、東條 有伸
  • Organizer: 第43回日本造血細胞移植学会総会
• [Presentation] 移植前の悪性腫瘍の既往歴は臍帯血移植後の予後に影響を与えるか？ (2021)
  • Author(s): 岡部 基人、小沼 貴晶、加藤せい子、磯部 優理、大岩 真希、高橋 聡、東條 有伸
  • Organizer: 第43回日本造血細胞移植学会総会
• [Presentation] Immunoglobulin superfamily member 8 is a critical regulator for myeloid leukemia (2020)
  • Author(s): Koji Jimbo，Takaaki Konuma，Takahiro Ito，Yaeko Nakajima， Atsushi Iwama，Arinobu Tojo
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] Updated comparison of outcomes of 7/8 allele matched UBMT and UCBT (2020)
  • Author(s): Kotaro Miyao，Seitaro Terakura，Fumihiko Kimura，Takaaki Konuma， Koichi Miyamura，Masamitsu Yanada，Shinichi Kako，Satoko Morishima， Naoyuki Uchida，Noriko Doki，Yukiyasu Ozawa，Takahiro Fukuda， Masatsugu Tanaka，Masashi Sawa，Satoru Takada，Tetsuya Eto， Takafumi Kimura，Tatsuo Ichinohe，Yoshiko Atsuta，Junya Kanda
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] Graft-versus-leukemia effects according to donor type (2020)
  • Author(s): Konuma T，Kanda J，Kuwatsuka Y，Yanada M， Kondo T，Hirabayashi S，Kako S，Akahoshi Y， Uchida N，Doki N，Ozawa Y，Tanaka M， Eto T，Sawa M，Yoshioka S，Kimura T， Kanda Y，Fukuda T，Atsuta Y，Kimura F
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] Cord blood transplantation for AML of the elderly: a retrospective study of adult AMLWG on JSHCT (2020)
  • Author(s): Isobe M, Konuma T, Masuko M, Uchida N, Miyakoshi S, Sugio Y, Yoshida S, Tanaka M, Matsuhashi Y, Hattori N, Onizuka M, Aotsuka N, Kouzai Y, Wake A, Kimura T, Ichinohe T, Atsuta Y, Yanada M
  • Organizer: 第82回日本血液学会学術集会
• [Presentation] Immunoglobulin Superfamily Member 8 Is Indispensable for Myeloid Leukemia Via Wnt/beta-Catenin Signaling Pathway (2020)
  • Author(s): Koji Jimbo, Takaaki Konuma, Takahiro Ito, Yaeko Nakajima-Takagi, Atsushi Iwama, Arinobu Tojo
  • Organizer: 62nd American Society of Hematology Annual Meeting
• [Presentation] SINGLE CORD BLOOD TRANSPLANTATION FOR ACUTE MYELOID LEUKEMIA PATIENTS AGED 60 YEARS OR OLDER: A RETROSPECTIVE STUDY OF THE JAPAN SOCIETY FOR HEMATOPOIETIC CELL TRANSPLANTATION (JSHCT) (2020)
  • Author(s): Isobe M, Konuma T, Masuko M, Uchida N, Miyakoshi S, Sugio Y, Yoshida S, Tanaka M, Matsuhashi Y, Hattori N, Onizuka M, Aotsuka N, Kouzai Y, Wake A, Kimura T, Ichinohe T, Atsuta Y, Yanada M
  • Organizer: 25th Congress of the European Hematology Association