Evaluation of the physical properties of cells for understanding the pathogenesis of inflammation

• Project/Area Number: 20K08794
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54020:Connective tissue disease and allergy-related
• Research Institution: Akita University
• Principal Investigator: Ueki Shigeharu 秋田大学, 医学系研究科, 教授 (60361234)
• Co-Investigator(Kenkyū-buntansha): 寺境 光俊 秋田大学, 理工学研究科, 教授 (70251618)
• Project Period (FY): 2020-04-01 – 2024-03-31
• Project Status: Completed (Fiscal Year 2023)
• Budget Amount: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000); Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2020: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: 好酸球 / 好中球 / 物性 / 粘液 / 鼻副鼻腔炎 / 粘弾性 / 疎水性 / 細胞外トラップ / レオロジー / 炎症 / 材料工学

Outline of Research at the Start

炎症組織を構成する顆粒球（崩壊した細胞や細胞外トラップ含む）そのものに注目し、細胞の固さ、弾力性、含水性といった材料工学的な性質を総体として評価し、全く新しい観点から炎症病態の理解を目指すものである。

Outline of Final Research Achievements

This study is the first to demonstrate that eosinophils and neutrophils, when activated in vitro and undergoing cell death (ETosis), exhibit properties similar to mucus (CT value, dry weight, hydrophobicity, and viscoelasticity). These properties are attributed to the distinct characteristics of extracellular traps formed by eosinophils and neutrophils, respectively. Furthermore, we found that eosinophil extracellular traps can be effectively degraded using heparin and DNase, and confirmed that this treatment has a similar effect on the mucus from actual eosinophilic sinusitis. These findings elucidate the mechanism of mucus retention mediated by granulocytes and suggest novel therapeutic strategies.

Academic Significance and Societal Importance of the Research Achievements

これまで好酸球性炎症疾患の粘液は粘性が高いことが知られていたが、この原因は主にムチンの分泌亢進や成分変化によるものと考えられてきた。本研究は、気道内腔に遊出する顆粒球に着目し、大量の顆粒球が細胞死を起こして集積すると、それのみで臨床的な粘液と同じような物理学的性状を示した。本研究は、新規バイオマーカーや、物性を改善させる新規治療法の可能性を示し、社会的にも重要であると考えられ、プレスリリースを行い、広く結果を公開している。

Research Products

• [Int'l Joint Research] Harvard Medical School(米国)
• [Int'l Joint Research] Federal University of Juiz de Fora(ブラジル)
• [Int'l Joint Research] Federal University of Juiz de Fora/University of Sao Paulo(ブラジル)
• [Int'l Joint Research] Harvard Medical School(米国)
• [Int'l Joint Research] Northwestern University/University of California/Harvard Medical School(米国)
• [Int'l Joint Research] Federal University of Juiz de Fora(ブラジル)
• [Int'l Joint Research] Harvard University(米国)
• [Int'l Joint Research] MacMaster University(カナダ)
• [Journal Article] Rapidly progressive mucus plugs in allergic bronchopulmonary mycosis (2024)
  • Author(s): Miyazaki, Osamu、Igarashi, Akira、Sato, Kento、Inoue, Sumito、Yokoyama, Ryuto、Nakane, Masaki、Kodama, Sahoko、Hasegawa, Ryo、Ueki, Shigeharu、Yaguchi, Takashi、Watanabe, Akira、Watanabe, Masafumi
  • Journal Title: Journal of Asthma Volume: in press Issue: 9 Pages: 1-6
  • DOI: 10.1080/02770903.2024.2312429
  • Peer Reviewed
• [Journal Article] Aggregated eosinophils and neutrophils characterize the properties of mucus in chronic rhinosinusitis (2024)
  • Author(s): Miyabe Yui、Fukuchi Mineyo、Tomizawa Hiroki、Nakamura Yuka、Jikei Mitsutoshi、Matsuwaki Yoshinori、Arima Misaki、Konno Yasunori .et al
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 4 Issue: 5 Pages: 1306-1318
  • DOI: 10.1016/j.jaci.2023.11.925
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Eosinophil extracellular trap formation in the giant papillae of atopic keratoconjunctivitis and vernal keratoconjunctivitis (2024)
  • Author(s): Onoue Miki、Saga Akiko、Adachi Keisuke、Asada Yosuke、Hirakata Toshiaki、Iwamoto Satoshi、Ueki Shigeharu、Ebihara Nobuyuki、Matsuda Akira
  • Journal Title: Allergology International Volume: 73 Issue: 1 Pages: 177-179
  • DOI: 10.1016/j.alit.2023.10.002
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Fungi and immune response: An update (2023)
  • Author(s): Ueki Shigeharu
  • Journal Title: Allergology International Volume: 72 Issue: 4 Pages: 491-492
  • DOI: 10.1016/j.alit.2023.09.004
  • ISSN: 1323-8930, 1440-1592
• [Journal Article] Eosinophil-derived galectin-10 upregulates matrix metalloproteinase expression in bullous pemphigoid blisters (2023)
  • Author(s): Sato Takahiko、Chiba Takahito、Nakahara Takeshi、Watanabe Ken、Sakai Sawako、Noguchi Natsuko、Noto Mai、Ueki Shigeharu、Kono Michihiro
  • Journal Title: Journal of Dermatological Science Volume: 112 Issue: 1 Pages: 6-14
  • DOI: 10.1016/j.jdermsci.2023.07.008
  • Peer Reviewed
• [Journal Article] Charcot‐Leyden crystals in tissues (2023)
  • Author(s): Sasaki Tomoko、Suzaki Isao、Ueki Shigeharu
  • Journal Title: Clinical and Translational Allergy Volume: 13 Issue: 7
  • DOI: 10.1002/clt2.12275
  • Peer Reviewed / Open Access
• [Journal Article] Allergic fungal rhinosinusitis: What we can learn from allergic bronchopulmonary mycosis (2023)
  • Author(s): Nakayama Tsuguhisa、Miyata Jun、Inoue Natsuki、Ueki Shigeharu
  • Journal Title: Allergology International Volume: 72 Issue: 4 Pages: 521-529
  • DOI: 10.1016/j.alit.2023.06.005
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Charcot-Leyden crystals in kidney (2023)
  • Author(s): Hayashi Saki、Sugiura Takeshi、Hakamata Suzu、Hattori Soken、Murakami Yoichi、Hasegawa Ryo、Matsushima Hideki、Ito Yukinobu、Ueki Shigeharu
  • Journal Title: Kidney International Volume: 104 Issue: 1 Pages: 206-206
  • DOI: 10.1016/j.kint.2023.02.007
  • Peer Reviewed
• [Journal Article] Presence of eosinophil extracellular trap cell death in the affected skin of eosinophilic granulomatosis with polyangiitis (2023)
  • Author(s): Kawakami Tamihiro、Yokoyama Kae、Ikeda Takaharu、Tomizawa Hiroki、Ueki Shigeharu
  • Journal Title: The Journal of Dermatology Volume: 50 Issue: 4 Pages: 551-555
  • DOI: 10.1111/1346-8138.16656
  • Peer Reviewed
• [Journal Article] Galectin-10 as a Potential Biomarker for Eosinophilic Diseases (2022)
  • Author(s): Tomizawa Hiroki、Yamada Yoshiyuki、Arima Misaki、Miyabe Yui、Fukuchi Mineyo、Hikichi Haruka、Melo Rossana C. N.、Yamada Takechiyo、Ueki Shigeharu
  • Journal Title: Biomolecules Volume: 12 Issue: 10 Pages: 1385-1385
  • DOI: 10.3390/biom12101385
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] In Vivo ETosis of Human Eosinophils: The Ultrastructural Signature Captured by TEM in Eosinophilic Diseases (2022)
  • Author(s): Neves Vitor H.、Palazzi Cinthia、Bonjour Kennedy、Ueki Shigeharu、Weller Peter F.、Melo Rossana C. N.
  • Journal Title: Frontiers in Immunology Volume: 13 Pages: 938691-938691
  • DOI: 10.3389/fimmu.2022.938691
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantification of Aspergillus fumigatus antigen Asp f 1 in airway tissue and allergic inflammation (2022)
  • Author(s): Miyabe Yui、Tomizawa Hiroki、Saito Hidekazu、Yamada Toshiki、Shiina Kazuhiro、Koizumi Koh、Kawasaki Yohei、Suzuki Shinsuke、Fukuchi Mineyo、Ueki Shigeharu、Ebihara Takashi、Yamada Takechiyo
  • Journal Title: Allergy Volume: 77 Issue: 10 Pages: 3154-3156
  • DOI: 10.1111/all.15428
  • Peer Reviewed
• [Journal Article] Two cases of dupilumab-associated eosinophilic pneumonia in asthma with eosinophilic chronic rhinosinusitis: IL-5-driven pathology? (2022)
  • Author(s): Nishiyama Yuki、Koya Toshiyuki、Nagano Kei、Abe Seitaro、Kimura Yosuke、Shima Kenjiro、Toyama-Kosaka Mio、Hasegawa Takashi、Sasaki Takanobu、Shinbori Kaori、Ueki Shigeharu、Takamura Kaori、Kikuchi Toshiaki
  • Journal Title: Allergology International Volume: 71 Issue: 4 Pages: 548-551
  • DOI: 10.1016/j.alit.2022.03.005
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Increased Circulating Cell-Free DNA in Eosinophilic Granulomatosis With Polyangiitis: Implications for Eosinophil Extracellular Traps and Immunothrombosis (2022)
  • Author(s): Hashimoto Teppei、Ueki Shigeharu、Kamide Yosuke、Miyabe Yui、Fukuchi Mineyo、Yokoyama Yuichi、Furukawa Tetsuya、Azuma Naoto、Oka Nobuyuki、Takeuchi Hiroki、Kanno Kyoko、Ishida-Yamamoto Akemi、Taniguchi Masami、Hashiramoto Akira、Matsui Kiyoshi
  • Journal Title: Frontiers in Immunology Volume: 12 Pages: 801897-801897
  • DOI: 10.3389/fimmu.2021.801897
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Case Report: Eosinophilic Bronchiolitis With Eosinophil ETosis in Mucus Plugs Successfully Treated With Benralizumab (2022)
  • Author(s): Sasaki Hisashi、Miyata Jun、Irie Akiko、Kuwata Ayako、Kouzaki Yuji、Ueki Shigeharu、Kawana Akihiko
  • Journal Title: Frontiers in Pharmacology Volume: 12 Pages: 826790-826790
  • DOI: 10.3389/fphar.2021.826790
  • Peer Reviewed / Open Access
• [Journal Article] Elevated Serum Leptin Levels in Patients With Eosinophilic Chronic Rhinosinusitis (2022)
  • Author(s): Imoto Yoshimasa、Ueki Shigeharu、Kato Yukinori、Yoshida Kanako、Morikawa Taiyo、Kimura Yukihiro、Kidoguchi Masanori、Tsutsumiuchi Toshiki、Koyama Keisuke、Adachi Naoto、Ito Yumi、Ogi Kazuhiro、Sakashita Masafumi、Yamada Takechiyo、Schleimer Robert P.、Takabayashi Tetsuji、Fujieda Shigeharu
  • Journal Title: Frontiers in Pharmacology Volume: 12 Pages: 793607-793607
  • DOI: 10.3389/fphar.2021.793607
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] New clinical diagnostic criteria for allergic bronchopulmonary aspergillosis/mycosis and its validation (2021)
  • Author(s): Asano Koichiro、Hebisawa Akira、Ishiguro Takashi、Takayanagi Noboru、Nakamura Yasuhiko、Suzuki Junko、Okada Naoki、Tanaka Jun、Fukutomi Yuma、Ueki Shigeharu、Fukunaga Koichi、Konno Satoshi、Matsuse Hiroto、Kamei Katsuhiko、Taniguchi Masami、Shimoda Terufumi、Oguma Tsuyoshi
  • Journal Title: Journal of Allergy and Clinical Immunology Volume: 147 Issue: 4 Pages: 1261-1268
  • DOI: 10.1016/j.jaci.2020.08.029
  • Peer Reviewed / Open Access
• [Journal Article] Eosinophil ETosis‐mediated release of galectin‐10 in eosinophilic granulomatosis with polyangiitis (2021)
  • Author(s): Fukuchi Mineyo、Kamide Yosuke、Ueki Shigeharu、Miyabe Yui、Konno Yasunori、Oka Nobuyuki、Takeuchi Hiroki、Koyota Souichi、Hirokawa Makoto、Yamada Takechiyo、Melo Rossana C.N.、Weller Peter F.、Taniguchi Masami
  • Journal Title: Arthritis & Rheumatology Volume: 10 Issue: 9 Pages: 41727-41727
  • DOI: 10.1002/art.41727
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Charcot?Leyden Crystals in Rapidly Progressing Plastic Bronchitis (2021)
  • Author(s): Ikari Kota、Tezuka Junichiro、Matsumoto Tsubasa、Tsuji Moeri、Kawamura Masaru、Oda Takuya、Ueki Shigeharu
  • Journal Title: American Journal of Respiratory and Critical Care Medicine Volume: 204 Issue: 4 Pages: e54-e55
  • DOI: 10.1164/rccm.202012-4374im
  • Peer Reviewed
• [Journal Article] Eosinophil Extracellular Traps in the Casts of Plastic Bronchitis Associated With Influenza Virus Infection (2021)
  • Author(s): Yoshida Michiko、Miyahara Yoko、Orimo Keisuke、Kono Naoko、Narita Masami、Ohya Yukihiro、Matsumoto Kenji、Nakagawa Satoshi、Ueki Shigeharu、Morita Hideaki、Miyairi Isao
  • Journal Title: Chest Volume: 160 Issue: 3 Pages: 854-857
  • DOI: 10.1016/j.chest.2021.05.001
  • Peer Reviewed
• [Journal Article] Eosinophil extracellular traps in a patient with chronic eosinophilic pneumonia (2021)
  • Author(s): Takeda M, Sakamoto S, Ueki S, Miyabe Y, Fukuchi M, Okuda Y, Asano M, Sato K, Nakayama K.
  • Journal Title: Asia Pac Allergy Volume: 11 Issue: 3 Pages: e24-e24
  • DOI: 10.5415/apallergy.2021.11.e24
  • Peer Reviewed / Open Access
• [Journal Article] Eosinophilic annular erythema showing eosinophil cytolytic ETosis successfully treated with benralizumab (2021)
  • Author(s): Masaki Katsunori、Ueki Shigeharu、Tanese Keiji、Nagao Genta、Kanzaki Sho、Matsuki Eri、Irie Hidehiro、Kabata Hiroki、Miyata Jun、Kawada Ichiro、Fukunaga Koichi
  • Journal Title: Asia Pacific Allergy Volume: 11 Issue: 3 Pages: e28-e28
  • DOI: 10.5415/apallergy.2021.11.e28
  • Peer Reviewed / Open Access
• [Journal Article] Eosinophilic sialoadenitis in a patient with severe asthma: a case report (2021)
  • Author(s): Sano Tomoya、Miyata Jun、Sano Azusa、Ono Yosuke、Tanaka Yuji、Matsukuma Susumu、Ueki Shigeharu、Kawana Akihiko
  • Journal Title: Asia Pacific Allergy Volume: 11 Issue: 3 Pages: e29-e29
  • DOI: 10.5415/apallergy.2021.11.e29
  • Peer Reviewed / Open Access
• [Journal Article] Eosinophil-mediated inflammation in the absence of eosinophilia (2021)
  • Author(s): Miyabe Yui、Kobayashi Yoshiki、Fukuchi Mineyo、Saga Akiko、Moritoki Yuki、Saga Tomoo、Akuthota Praveen、Ueki Shigeharu
  • Journal Title: Asia Pacific Allergy Volume: 11 Issue: 3 Pages: e30-e30
  • DOI: 10.5415/apallergy.2021.11.e30
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Synthesis and Antiplatelet Adhesion Behavior of a Poly(L-lactide-<i>co</i>-glycolide)?Poly(1,5-dioxepan-2-one) Multiblock Copolymer (2021)
  • Author(s): Jikei Mitsutoshi、Takeda Mao、Kaneda Yoshiki、Kudo Kohei、Tanaka Nozomi、Matsumoto Kazuya、Hikida Masaki、Ueki Shigeharu
  • Journal Title: ACS Omega Volume: 6 Issue: 42 Pages: 27968-27975
  • DOI: 10.1021/acsomega.1c03846
  • Peer Reviewed / Open Access
• [Journal Article] シャルコー・ライデン結晶 (2021)
  • Author(s): 植木重治, 古谷千香子
  • Journal Title: アレルギー Volume: 70 Pages: 139-140
  • NAID: 130007996949
• [Journal Article] 好酸球の細胞死からみた好酸球性肺疾患 (2021)
  • Author(s): 有馬美咲，福地峰世，植木重治
  • Journal Title: 呼吸器内科 Volume: 40 Pages: 264-269
  • NAID: 40022709979
• [Journal Article] 生体内における好酸球の動体 (2021)
  • Author(s): 富澤宏基，植木重治
  • Journal Title: 臨床免疫・アレルギー科 Volume: 76 Pages: 386-391
• [Journal Article] Cadherin-related Family Member 3 Upregulates the Effector Functions of Eosinophils (2020)
  • Author(s): Nakagome K, Shimizu T, Bochkov YA, Noguchi T, Kobayashi T, Soma T, Ueki S, Gern JE, Nagata M.
  • Journal Title: Allergy Volume: － Issue: 7 Pages: 1805-1809
  • DOI: 10.1111/all.14229
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Galectin‐10, the protein that forms Charcot‐Leyden crystals, is not stored in granules but resides in the peripheral cytoplasm of human eosinophils (2020)
  • Author(s): Melo Rossana C. N.、Wang Haibin、Silva Thiago P.、Imoto Yoshimasa、Fujieda Shigeharu、Fukuchi Mineyo、Miyabe Yui、Hirokawa Makoto、Ueki Shigeharu、Weller Peter F.
  • Journal Title: Journal of Leukocyte Biology Volume: - Issue: 1 Pages: 139-149
  • DOI: 10.1002/jlb.3ab0220-311r
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] The roles of IL-5 and anti-IL-5 treatment in eosinophilic diseases: Asthma, eosinophilic granulomatosis with polyangiitis, and eosinophilic chronic rhinosinusitis (2020)
  • Author(s): Nagase Hiroyuki、Ueki Shigeharu、Fujieda Shigeharu
  • Journal Title: Allergology International Volume: 69 Issue: 2 Pages: 178-186
  • DOI: 10.1016/j.alit.2020.02.002
  • NAID: 130007833071
  • ISSN: 1323-8930, 1440-1592
  • Peer Reviewed / Open Access
• [Journal Article] Focal eosinophilic myositis with Charcot-Leyden crystal formation (2020)
  • Author(s): Hamada Satoshi、Ueki Shigeharu、Miyabe Yui、Tsukino Mitsuhiro、Hirai Toyohiro
  • Journal Title: Allergology International Volume: - Issue: 4 Pages: 633-635
  • DOI: 10.1016/j.alit.2020.03.007
  • NAID: 130007926233
  • Peer Reviewed / Open Access
• [Journal Article] Sialodochitis fibrinosa: Salivary duct obstruction by eosinophil extracellular traps? (2020)
  • Author(s): Kawamura Yoshinobu、Ikeda Ryoukichi、Hori Toru、Sasaki Takatsuna、Miyabe Yui、Fukuchi Mineyo、Sakamoto Kazuhiro、Ohta Nobuo、Kawase Tetsuaki、Katori Yukio、Ueki Shigeharu
  • Journal Title: Oral Diseases Volume: 26 Issue: 7 Pages: 1459-1463
  • DOI: 10.1111/odi.13434
  • Peer Reviewed
• [Journal Article] Luminal Eosinophil Cell Death as a Biomarker for Loss of Asthma Control? (2020)
  • Author(s): Ueki Shigeharu、Mukherjee Manali、Nair Parameswaran
  • Journal Title: Chest Volume: 157 Issue: 6 Pages: 1680-1681
  • DOI: 10.1016/j.chest.2020.01.021
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hypereosinophilic syndrome with abundant Charcot-Leyden crystals in spleen and lymph nodes. (2020)
  • Author(s): Takeda M, Ueki S, Yamamoto Y, Nara M, Fukuchi M, Nakayama K, Omori Y, Takahashi N, Hirokawa M.
  • Journal Title: Asia Pac Allergy. Volume: 10(3) Issue: 3 Pages: e24-e24
  • DOI: 10.5415/apallergy.2020.10.e24
  • Peer Reviewed / Open Access
• [Journal Article] Adult‐onset eosinophilic airway diseases (2020)
  • Author(s): Asano Koichiro、Ueki Shigeharu、Tamari Mayumi、Imoto Yoshimasa、Fujieda Shigeharu、Taniguchi Masami
  • Journal Title: Allergy Volume: 75 Issue: 12 Pages: 3087-3099
  • DOI: 10.1111/all.14620
  • Peer Reviewed / Open Access
• [Presentation] Aggregated ETotic Eosinophils Characterize Airway Mucus Properties. (2023)
  • Author(s): Ueki, S., Miyabe, Y., Fukuchi, M., Tomizawa, H., Jikei, M., Matsuwaki, Y., Arima, M., Moritoki, Y., Takeda, M., Tanabe, N., Yamada, T., Asano, K., Melo, R.C.N. and Weller, P.F.
  • Organizer: 12th Biennial Symposium of the International Eosinophil Society, July, Hamilton, Canada.
  • Int'l Joint Research / Invited
• [Presentation] 細胞外トラップと肺・気道疾患 (2023)
  • Author(s): 植木重治
  • Organizer: 第63回日本呼吸器学会学術講演会
  • Invited
• [Presentation] 好酸球集団の物性を評価する (2023)
  • Author(s): 植木重治，宮部 結，松脇由典
  • Organizer: 第４回日本喘息学会総会学術大会
  • Invited
• [Presentation] 細胞の個と集団から見直す難治性中耳炎 (2023)
  • Author(s): 植木重治，富澤宏基，宮部 結，安部智恵，山田武千代
  • Organizer: 第33回日本耳科学会総会・学術集会
  • Invited
• [Presentation] 粘液栓形成と炎症細胞 (2023)
  • Author(s): 植木重治
  • Organizer: 第72回日本アレルギー学会学術集会
  • Invited
• [Presentation] Eosinophil ETosis, a cytolytic degranulation and diseases (2022)
  • Author(s): Ueki, S
  • Organizer: European Academy of Asthma and Clinical Immunology Hybrid Congress 2022
  • Int'l Joint Research / Invited
• [Presentation] Eosinophil cell death in allergic inflammation (2022)
  • Author(s): Ueki, S
  • Organizer: Chinese College of Allergy and Asthma annual meeting 2022
  • Int'l Joint Research / Invited
• [Presentation] Eosinophil cell death induces tissue damage in EGPA (2022)
  • Author(s): Ueki, S
  • Organizer: 第63回日本神経学会学術大会
  • Invited
• [Presentation] 好酸球ETosisを誘導する刺激の検討 (2022)
  • Author(s): 富澤宏基，有馬実咲，宮部 結，嵯峨亜希子，山田武千代，植木重治
  • Organizer: 第71回日本アレルギー学会学術大会
• [Presentation] 好酸球性多発血管炎性肉芽腫症患者の血清における好酸球細胞質蛋白galectin-10の測定 (2022)
  • Author(s): 有馬実咲，上出庸介，福地峰世，山本梨絵，高橋 縁，植木重治
  • Organizer: 第62回日本臨床化学会
• [Presentation] NON-type2に潜む好酸球性炎症 (2022)
  • Author(s): 植木重治
  • Organizer: 第71回日本アレルギー学会学術大会
  • Invited
• [Presentation] 好酸球の特性からみた病態の理解 (2022)
  • Author(s): 植木重治
  • Organizer: 第71回日本アレルギー学会学術大会
  • Invited
• [Presentation] Eosinophil ETosis, a cytolytic degranulation and disease (2021)
  • Author(s): Ueki S
  • Organizer: European Academy of Asthma and Clinical Immunology Hybrid Congress 2021
  • Int'l Joint Research / Invited
• [Presentation] 好酸球研究の温故知新 (2021)
  • Author(s): 植木重治
  • Organizer: 第61回日本呼吸器学会学術講演会
  • Invited
• [Presentation] ANCA関連血管炎におけるセルフリーDNAの測定 (2021)
  • Author(s): 上出庸介，橋本哲平，植木重治，谷口正実，松井 聖
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] EGPAの微小血栓におけるEETs/EETosisの証明 (2021)
  • Author(s): 竹田正秀，植木重治，橋本哲平，上出庸介，福地峰世，宮部 結，菅野恭子，竹内啓喜，岡 伸行，中村勝敏，谷口正実，松井 聖
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 好酸球性多発血管炎性肉芽腫症におけるgalectin-10産生と血清中IL-5濃度に関する検討 (2021)
  • Author(s): 藤田教寛，上出庸介，植木重治，福地峰世，宮部 結，岩田真樹，永山貴紗子，中村祐人，濱田祐斗，劉 楷，渡井健太郎，森 晶夫，谷口正実，福冨友馬，関谷潔史
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] 多発嚢胞形成をみとめた好酸球性肺疾患の１例 (2021)
  • Author(s): 野川ひとみ，鈴木博貴，河端美則，太田隆仁，結城嘉彦，片桐祐司，日野俊彦，植木重治
  • Organizer: 第61回日本呼吸器学会学術講演会
• [Presentation] EGPAにおける“好酸球性”炎症 (2021)
  • Author(s): 植木重治
  • Organizer: 第65回日本リウマチ学会総会・学術集会
  • Invited
• [Presentation] 線維素性唾液管炎の原因として好酸球細胞外トラップによる唾液管閉塞が示唆された一症例 (2021)
  • Author(s): 川村善宣，植木重治，池田怜吉，堀 亨，佐々木高綱，宮部 結，福地峰世，坂元和宏，太田伸男，川瀬哲明，香取幸夫
  • Organizer: 第122回日本耳鼻咽喉科学会総会・学術講演会
• [Presentation] インフルエンザ関連鋳型気管支炎における粘液栓の形成と好酸球活性化 (2021)
  • Author(s): 植木重治，有馬実咲，古谷千香子，山本梨絵，守時由起，富谷陽子，嵯峨知生
  • Organizer: 第68回日本臨床検査医学会学術集会
• [Presentation] ETosis誘導刺激による末梢血白血球の反応の差異 (2021)
  • Author(s): 古谷千香子，有馬実咲，山本梨絵，守時由起，富谷陽子，嵯峨知生，涌井秀樹，植木重治
  • Organizer: 第68回日本臨床検査医学会学術集会
• [Presentation] 慢性肉芽腫症における好中球と好酸球のETosis (2021)
  • Author(s): 有馬実咲，古谷千香子，山本梨絵，守時由起，富谷陽子，嵯峨知生，植木重治
  • Organizer: 第68回日本臨床検査医学会学術集会
• [Presentation] クリスタロパチーとしてのシャルコー・ライデン結晶 (2021)
  • Author(s): 植木重治
  • Organizer: 第70回日本アレルギー学会学術大会
  • Invited
• [Presentation] NETs・EETs研究の潮流 (2021)
  • Author(s): 植木重治
  • Organizer: 第70回日本アレルギー学会学術大会
  • Invited
• [Presentation] 個と集団からみた好酸球のエフェクター機能 (2021)
  • Author(s): 植木重治
  • Organizer: 第70回日本アレルギー学会学術大会
  • Invited
• [Presentation] アレルギー炎症と組織中におけるアスペルギルス抗原Asp f 1同定の意義 (2021)
  • Author(s): 山田武千代，宮部 結，富澤宏基，齋藤秀和，福地峰世，植木重治
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] ETosis誘導刺激による白血球の反応の差異 (2021)
  • Author(s): 古谷千香子，福地峰世，宮部 結，有馬美咲，富澤宏基，嵯峨知生，涌井秀樹，植木重治
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 補体成分によるヒト好酸球のETosis誘導能 (2021)
  • Author(s): 有馬美咲，福地峰世，古谷千香子，富澤宏基，宮部 結，意元義政，藤枝重治，植木重治
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] ETs/ETosisの形態および安定性に関する検討 (2021)
  • Author(s): 富澤宏基，宮部 結，福地峰世，山田武千代，植木重治
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 好酸球性多発血管炎性肉芽腫症（EGPA）における血清中IL-5とgalectin-10に関する検討 (2021)
  • Author(s): 藤田教寛，上出庸介，植木重治，福地峰世，宮部 結，岩田真紀，永山貴紗子，中村祐人，濱田祐斗，劉 楷，渡井健太郎，森 晶夫，谷口正実，福冨友馬，関谷潔史
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 血清中galectin-10は活動性を有する好酸球性多発血管炎性肉芽腫症（EGPA）で高直を示す (2021)
  • Author(s): 上出庸介，福地峰世，河崎裕一郎，藤田教寛，岩本圭右，矢野光一，岩田真紀，永山貴紗子，中村祐人，濱田祐斗，劉 楷，渡井健太郎，林 浩昭，森 晶夫，谷口正実，福冨友馬，植木重治，関谷潔史
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 慢性副鼻腔炎/好酸球性副鼻腔炎の粘液CT値および物性に関する検討 (2021)
  • Author(s): 宮部 結，田辺直也，進藤 允，島 寛，谷村和哉，松脇由典，福地峰世，嵯峨知生，山田武千代，平井豊博，植木重治
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] EETs are structurally resistant to DNase and induce platelet adhesion (2021)
  • Author(s): Fukuchi, M., Miyabe, Y., Furutani, C., Tomisawa, H., Arima, M., Kamide, Y., Hashimoto, T., Matsui, K. and Ueki, S
  • Organizer: 第70回日本アレルギー学会学術大会
• [Presentation] 好酸球と喘息- Tissue is the issue? (2020)
  • Author(s): 植木重治
  • Organizer: 第60回 日本呼吸器学会学術講演会
  • Invited
• [Presentation] 好酸球性多発血管炎性肉芽腫症における好酸球の細胞死とヒストンのシトルリン化 (2020)
  • Author(s): 植木重治，福地峰世，上出庸介，宮部 結，竹田正秀，嵯峨知生，小代田宗一，守時由起，谷口正実，廣川 誠
  • Organizer: 第60回 日本呼吸器学会学術講演会
• [Presentation] 慢性好酸球性肺炎（CEP）患者のBALFに観察された好酸球ETosis (2020)
  • Author(s): 竹田正秀，坂本 祥，佐藤一洋，植木重治，宮部 結，佐野正明，奥田佑道，浅 真理子，長谷川幸保，熊谷奈保，廣川 誠，中山勝敏
  • Organizer: 第60回 日本呼吸器学会学術講演会
• [Presentation] 抗IL-5治療後に施行された副鼻腔炎手術検体組織の検討 (2020)
  • Author(s): 知花和行，内田信彦，中村祐介，正和明哲，塩原太一，池田直哉，堀金紀子，新井 良，武政聡浩，阿久津 誠，金谷洋明，春名眞一，植木重治，布村 聡，出原賢治，清水泰生
  • Organizer: 第60回 日本呼吸器学会学術講演会
• [Presentation] 血清中galectin-10は好酸球性多発血管炎性肉芽腫症（EGPA）で高値を示す (2020)
  • Author(s): 上出庸介，植木重治，藤田教寛，岩田真紀，永山貴紗子，中村祐人，渡井健太郎，濱田祐斗，劉 楷，林 浩昭，福冨友馬，関谷潔史，森 晶夫，福地峰世，谷口正実
  • Organizer: 第60回 日本呼吸器学会学術講演会
• [Presentation] Eosinophil ETosis-mediated extracellular traps and disease (2020)
  • Author(s): Ueki, S.
  • Organizer: JSA/WAO ⅩⅩⅦ World Allergy Congress (WAC2020) conjoint with the APAPARI 2020 Congress
  • Int'l Joint Research / Invited
• [Presentation] Plasma galectin-10 levels and mucosal eosinophil infiltration in chronic rhinosinusitis (2020)
  • Author(s): Yamada, T., Miyabe, Y., Saito, H., Fujieda, S., Ueki, S.
  • Organizer: JSA/WAO ⅩⅩⅦ World Allergy Congress (WAC2020) conjoint with the APAPARI 2020 Congress
  • Int'l Joint Research
• [Presentation] Eosinophil extracellular trap formation in chronic granulomatous disease (2020)
  • Author(s): Miyabe, Y., Yano, M., Fukuchi, M., Furutani, C., Moritoki, Y., Saga, T., Takahashi, T., Ueki, S.
  • Organizer: JSA/WAO ⅩⅩⅦ World Allergy Congress (WAC2020) conjoint with the APAPARI 2020 Congress
  • Int'l Joint Research
• [Presentation] Detection of eosinophil ETosis in eosinophilic granulomatosis with polyangiitis (EGPA) by citrullinated histone H3 immunostaining (2020)
  • Author(s): Fukuchi, M., Kamide, Y., Ueki, S, Miyabe, Y., Furutani, C., Moritoki, Y., Saga, A., Saga, T., Taniguchi, M.
  • Organizer: JSA/WAO ⅩⅩⅦ World Allergy Congress (WAC2020) conjoint with the APAPARI 2020 Congress
  • Int'l Joint Research
• [Presentation] Circulating cell free DNA as a biomarker in Eosinophilic granulomatosis with polyangiitis (2020)
  • Author(s): Hashimoto, T., Ueki, S., Kamide, Y., Miyabe, Y., Yokoyama, Y., Furukawa, T., Azuma, N., Taniguch, M., Saga,T., Hashiramoto, A., Matsui, K
  • Organizer: JSA/WAO ⅩⅩⅦ World Allergy Congress (WAC2020) conjoint with the APAPARI 2020 Congress
  • Int'l Joint Research
• [Presentation] Loss of cytoplasmic galectin-10 in eosinophil ETosis-mediated cytolysis (2020)
  • Author(s): Fukuchi, M., Kamide, Y., Ueki, S., Miyabe, Y., Konno, Y., Oka, N., Takeuchi, H., Saga, T., Melo, R., Weller, P., Taniguchi, M.
  • Organizer: JSA/WAO ⅩⅩⅦ World Allergy Congress (WAC2020) conjoint with the APAPARI 2020 Congress
  • Int'l Joint Research
• [Presentation] Elevated serum levels of galectin-10 in active eosinophilic granulomatosis with polyangiitis (2020)
  • Author(s): Kamide, Y., Ueki, S., Fukuchi, M., Fujita, N., Iwata, M., Nagayama, K., Nakamura, Y., Yano, K., Watai, K., Hamada, Y., Ryu, K., Hayashi, H., Fukutomi, Y., Sekiya, K., Mori, A., Taniguchi, M.
  • Organizer: JSA/WAO ⅩⅩⅦ World Allergy Congress (WAC2020) conjoint with the APAPARI 2020 Congress
  • Int'l Joint Research
• [Presentation] シャルコー・ライデン結晶から広がる好酸球性炎症の理解 (2020)
  • Author(s): 植木重治
  • Organizer: 第29回国際喘息学会日本・北アジア部会
  • Invited
• [Presentation] 好酸球性多発血管炎性肉芽腫症における血清galectin-10の評価 (2020)
  • Author(s): 古谷千香子，福地峰世，小林則子，山本梨絵，植木重治，嵯峨知生
  • Organizer: 第67回日本臨床検査医学会学術集会
• [Presentation] 細胞外小胞（Extracellular microvesicles）によるアレルギー性炎症の病態解析とモニタリングへの応用 (2020)
  • Author(s): 植木重治，福地峰世，古谷千香子，嵯峨知生，小林則子，鎌田由美子，平澤裕之，山本梨絵，守時由起
  • Organizer: 第67回日本臨床検査医学会学術集会
• [Book] Allergic fungal diseases in the upper and lower airways (2022)
  • Author(s): Ueki, S., Fukutomi, Y., Miyabe, Y., Yamada, T., Oguma, T., and Asano, K
  • Total Pages: 11
  • Publisher: European Respiratory Society
• [Remarks] 難治性アレルギー疾患で「固い粘液」が作られる仕組みと新しい治療法の可能性を示す
  • URL: https://www.akita-u.ac.jp/honbu/event/item_mix_4078.html
• [Remarks] 秋田大学大学院総合診療・検査診断学講座
  • URL: http://www.med.akita-u.ac.jp/~gimclm/index.html