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Regulation of glucose metabolism via microbial modification by dietary components

Research Project

Project/Area Number 20K08882
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 54040:Metabolism and endocrinology-related
Research InstitutionUniversity of Toyama

Principal Investigator

Fujisaka Shiho  富山大学, 学術研究部医学系, 准教授 (30512082)

Co-Investigator(Kenkyū-buntansha) 戸邉 一之 (戸辺 一之)  富山大学, 学術研究部医学系, 教授 (30251242)
薄井 勲  獨協医科大学, 医学部, 教授 (50377272)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2022: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2021: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2020: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Keywords腸内細菌 / インスリン抵抗性 / 糖代謝 / 肥満 / 糖代謝異常 / 腸内細菌叢
Outline of Research at the Start

ω6不飽和脂肪酸を主成分とする高脂肪食の摂取により形成される腸内細菌叢が、肥満、糖代謝異常を誘導するメカニズム、およびある発酵食品に含まれるポリフェノールX投与によって形成されたAkkermansia muchiniphila優位の腸内細菌叢が、肥満、インスリン抵抗性を改善するメカニズムを明らかにする。2019年に本学動物実験施設に飼育設備を立ち上げた無菌マウスに対する腸内細菌移植(ノトバイオート実験)を行い、レシピエントマウスの表現型を詳細に検討し、栄養素や食成分が腸内細菌叢の変化を通して代謝に与える影響とそのメカニズムを明らかにする。

Outline of Final Research Achievements

We administered diets of various nutritional compositions to mice and found that the microbiota established by the soybean-oil rich diet induced the most obesity and glucose intolerance. As a mechanism we found that the microbiota of soybean-oil rich diet had the greatest impact on the plasma lipid profile through plasma lipidomics analysis from germ-free and gnotobiotic mice model (iScience 2021). We also reported that the Japanese herb Bofu tsushosan improves glucose metabolism by increasing A. muciniphila (Sci. Rep. 2020). In addition, we found that X, a prenylated flavonoid, suppresses obesity and improves insulin resistance through promoting a bloom of A. miciniphila (paper in preparation).

Academic Significance and Societal Importance of the Research Achievements

近年腸内細菌叢の破綻が肥満や糖代謝異常の原因となることが明らかにとなり、腸内細菌叢の作用解明が注目されている。一方で特定の腸内細菌が宿主のエネルギー代謝や糖代謝にどのような影響を及ぼすのか明らかになっていない点が多かった。本研究で、私は無菌マウスと腸内細菌移植(ノトバイオート)実験の系を駆使して食餌の栄養組成、とくに高大豆油食や食品成分X、和漢薬、防風通聖散が腸内細菌叢をどのように変化させ、宿主の脂質代謝に作用して肥満やインスリン抵抗性を調節するのかの一端を明らかにすることができた。腸内細菌の作用を利用したメタボリック症候群の新たな治療戦略提案につながると期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (39 results)

All 2023 2022 2021 2020

All Journal Article (14 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 11 results,  Open Access: 14 results) Presentation (22 results) (of which Int'l Joint Research: 1 results,  Invited: 10 results) Book (3 results)

  • [Journal Article] Impact of Vancomycin Treatment and Gut Microbiota on Bile Acid Metabolism and the Development of Non-Alcoholic Steatohepatitis in Mice2023

    • Author(s)
      Kasai Kaichi、Igarashi Naoya、Tada Yuki、Kani Koudai、Takano Shun、Yanagibashi Tsutomu、Usui-Kawanishi Fumitake、Fujisaka Shiho、Watanabe Shiro、Ichimura-Shimizu Mayuko、Takatsu Kiyoshi、Tobe Kazuyuki、Tsuneyama Koichi、Furusawa Yukihiro、Nagai Yoshinori
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 24 Issue: 4 Pages: 4050-4050

    • DOI

      10.3390/ijms24044050

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD2023

    • Author(s)
      Park Se-Hyung、Helsley Robert N.、Fadhul Taghreed、Willoughby Jennifer L.S.、Noetzli Leila、Tu Ho-Chou、Solheim Marie H.、Fujisaka Shiho、Pan Hui、Dreyfuss Jonathan M.、Bons Joanna、Rose Jacob、King Christina D.、Kulkarni Rohit N.、Fitzgerald Kevin、Kern Philip A.、Divanovic Senad、Kahn C. Ronald、Softic Samir
    • Journal Title

      bioRxiv

      Volume: -

    • DOI

      10.1101/2023.01.27.525605

    • Related Report
      2022 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] The gut microbiome: a core regulator of metabolism2023

    • Author(s)
      Fujisaka Shiho、Watanabe Yoshiyuki、Tobe Kazuyuki
    • Journal Title

      Journal of Endocrinology

      Volume: 256 Issue: 3

    • DOI

      10.1530/joe-22-0111

    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] Increased Number of Mucosal-Associated Invariant T Cells Is Associated with the Inhibition of Nonalcoholic Fatty Liver Disease in High Fat Diet-Fed Mice.2022

    • Author(s)
      Kishi H, Usui I, Jojima T, Fujisaka S, Wakamatsu S, Mizunuma-Inoue Y, Niitani T, Sakurai S, Iijima T, Tomaru T, Tobe K, Aso Y.
    • Journal Title

      Int J Mol Sci.

      Volume: 23 Issue: 23 Pages: 15309-15309

    • DOI

      10.3390/ijms232315309

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Depletion of CD206+ M2-like macrophages induces fibro-adipogenic progenitors activation and muscle regeneration2022

    • Author(s)
      Nawaz Allah et al.
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 7058-7058

    • DOI

      10.1038/s41467-022-34191-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A New Method for Albuminuria Measurement Using a Specific Reaction between Albumin and the Luciferin of the Firefly Squid Watasenia scintillans2022

    • Author(s)
      Ishimoto Tetsuya、Okada Takuya、Fujisaka Shiho、Yagi Kunimasa、Tobe Kazuyuki、Toyooka Naoki、Mori Hisashi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 15 Pages: 8342-8342

    • DOI

      10.3390/ijms23158342

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Perioperative C‐peptide index is associated with the status of diabetes management after pancreatectomy2022

    • Author(s)
      Shikata Masataka、Chujo Daisuke、Enkaku Asako、Takikawa‐Nishida Akiko、Honoki Hisae、Yamada‐Matsukoshi Shinnosuke、Nakagawa‐Yokoyama Maki、Kamigishi Miki、Inagawa Shinya、Fujisaka Shiho、Yagi Kunimasa、Shibuya Kazuto、Fujii Tsutomu、Tobe Kazuyuki
    • Journal Title

      Journal of Diabetes Investigation

      Volume: 13 Issue: 10 Pages: 1685-1694

    • DOI

      10.1111/jdi.13861

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Isoliquiritigenin Attenuates Adipose Tissue Inflammation and Metabolic Syndrome by Modifying Gut Bacteria Composition in Mice2022

    • Author(s)
      Ishibashi Riko、Furusawa Yukihiro、Honda Hiroe、Watanabe Yasuharu、Fujisaka Shiho、Nishikawa Miyu、Ikushiro Shinichi、Kurihara Shin、Tabuchi Yoshiaki、Tobe Kazuyuki、Takatsu Kiyoshi、Nagai Yoshinori
    • Journal Title

      Molecular Nutrition & Food Research

      Volume: - Issue: 10 Pages: 2101119-2101119

    • DOI

      10.1002/mnfr.202101119

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gut Microbiota Regulate Pancreatic Growth, Exocrine Function, and Gut Hormones2022

    • Author(s)
      Girdhar Khyati、Soto Marion、Huang Qian、Orliaguet Lucie、Cederquist Carly、Sundaresh Bharathi、Hu Jiang、Figura Maximilian、Raisingani Amol、Canfora Emanuel E.、Dirice Ercument、Fujisaka Shiho、Goossens Gijs H.、Blaak Ellen E.、Kulkarni Rohit N.、Kahn C. Ronald、Altindis Emrah
    • Journal Title

      Diabetes

      Volume: 71 Issue: 5 Pages: 945-960

    • DOI

      10.2337/db21-0382

    • Related Report
      2022 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Journal Article] Fragmented QRS on electrocardiography as a predictor for diastolic cardiac dysfunction in type?2 diabetes2022

    • Author(s)
      Yagi Kunimasa、Imamura Teruhiko、Tada Hayato、Liu Jianhui、Miyamoto Yukiko、Ohbatake Azusa、Ito Naoko、Shikata Masataka、Enkaku Asako、Takikawa Akiko、Honoki Hisae、Fujisaka Shiho、Chujo Daisuke、Origasa Hideki、Kinugawa Koichiro、Tobe Kazuyuki
    • Journal Title

      Journal of Diabetes Investigation

      Volume: - Issue: 6 Pages: 1052-1061

    • DOI

      10.1111/jdi.13759

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Astaxanthin, a Marine Carotenoid, Maintains the Tolerance and Integrity of Adipose Tissue and Contributes to Its Healthy Functions.2021

    • Author(s)
      Nawaz A, Nishida Y, Takikawa A, Fujisaka S, Kado T, Aminuddin A, Bilal M, Jeelani I, Rahil AM, Nishimura A, Kuwano T, Watanabe Y, Igarashi Y, Okabe K, Saeed A, Manzoor A, Usui I, Yagi K, Nakagawa T, Tobe K.
    • Journal Title

      Nutrients

      Volume: 13 Issue: 12 Pages: 4374-4374

    • DOI

      10.3390/nu13124374

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Gut microbiota, determined by dietary nutrients, drive modification of the plasma lipid profile and insulin resistance.2021

    • Author(s)
      Watanabe Y, Fujisaka S, Ikeda K, Ishikawa M, Yamada T, Nawaz A, Kado T, Kuwano T, Nishimura A, Bilal M, Liu J, Yagi K, Hase K, Tobe K.
    • Journal Title

      iScience

      Volume: 24 Issue: 5 Pages: 102445-102445

    • DOI

      10.1016/j.isci.2021.102445

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Gut microbiota, determined by dietary nutrients, drives modification of the plasma lipid profile and insulin resistance.2021

    • Author(s)
      Watanabe Y, Fujisaka S, Ikeda K, Ishikawa M, Yamada T, Nawaz A, Kado T, Kuwano T, Nishimura A, Bilal M, Liu J, Yagi K, Hase K, Tobe K
    • Journal Title

      iScience

      Volume: -

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The role of adipose tissue M1/M2 macrophages in type 2 diabetes mellitus.2020

    • Author(s)
      Fujisaka S
    • Journal Title

      Diabetol Int.

      Volume: 12 Issue: 1 Pages: 74-79

    • DOI

      10.1007/s13340-020-00482-2

    • NAID

      130007992488

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 肥満インスリン抵抗性における脂肪組織M1/M2マクロファージおよび腸内細菌叢の意義2023

    • Author(s)
      藤坂志帆
    • Organizer
      第36回日本糖尿病・肥満動物学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Isoxanthohumol improves obesity and insulin resistance through both pharmacological and gut microbial pathways.2022

    • Author(s)
      Watanabe Y, Fujisaka S, Watanabe S, Nawaz A, Kado T, Nishimura A, Bilal M, Rahil M, Morinaga Y, Tobe K
    • Organizer
      IHMC 9th congress
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脂肪組織M1/M2マクロファージと腸内細菌叢に着目した肥満によるインスリン抵抗性の機序の解明2022

    • Author(s)
      藤坂志帆
    • Organizer
      第42回日本肥満学会
    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Invited
  • [Presentation] 栄養素・薬剤によって構成される腸内細菌叢と宿主の代謝メカニズムに与える影響2022

    • Author(s)
      渡邊善之,藤坂志帆,桑野剛英,西村 歩,角 朝信,五十嵐喜子,Rahil Muhammad Aslam,Bilal Muhammad,Nawaz Allah,八木邦公,渡辺志朗,森永芳智,戸邉一之.
    • Organizer
      第65回日本糖尿病学会年次学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 糖尿病とは?100年後の糖尿病治療は?~未病の理解、そして個別化医療に向かって~.2022

    • Author(s)
      藤坂志帆
    • Organizer
      第65回日本糖尿病学会年次学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 糖尿病と腸内細菌.2022

    • Author(s)
      藤坂志帆
    • Organizer
      第65回日本糖尿病学会年次学術集会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 肥満における和漢薬や食品成分による腸内細菌叢を介したインスリン抵抗性改善作用2022

    • Author(s)
      藤坂志帆、戸邉一之.
    • Organizer
      第39回和漢医薬学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 腸内細菌を介した肥満症、インスリン抵抗性の新たな治療戦略.2022

    • Author(s)
      藤坂志帆,渡邊善之,戸邉一之
    • Organizer
      第43回日本肥満学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 腸内フローラと肥満症.2022

    • Author(s)
      藤坂志帆
    • Organizer
      第43回日本肥満学会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] イソキサントフモールは腸内細菌の変化を介して宿主の小腸栄養トランスポーターを制御し抗肥満作用を発揮する.2022

    • Author(s)
      渡邊善之,藤坂志帆 桑野剛英,西村歩,角朝信,五十嵐喜子,Muhammad Aslam Rahil,Muhammad Bilal,Allah Nawaz, 八木邦公,渡辺志朗,森永芳智,戸邉一之
    • Organizer
      第65回日本糖尿病学会年次学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 企業健診における生活習慣を含む食事記録の解析と健診データと腸内細菌叢の関係性について2022

    • Author(s)
      朴木久恵,藤坂志帆,圓角麻子,渡邊善之,瀧川章子,八木邦公,中條大輔,奥牧人,戸邉一之
    • Organizer
      第65回日本糖尿病学会年次学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] イソキサントフモールは腸内細菌叢を通じて脂質吸収を抑制し、抗肥満、耐糖能改善作用を示す2022

    • Author(s)
      渡邊 善之、藤坂 志帆 、渡辺 志朗 、桑野 剛英 、西村 歩 、角 朝信、Muhammad Rahil Aslam、 Muhammad Bilal 、Allah Nawaz、五十嵐 喜子、八木 邦公 、戸邉一之
    • Organizer
      第43回日本肥満学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] イソキサントフモールは腸内細菌の変化を介して宿主の小腸栄養トランスポーターを制御し抗肥満作用を発揮する2022

    • Author(s)
      渡邊 善之,藤坂 志帆,桑野 剛英 ,西村 歩, 角 朝信,五十嵐 喜子, Rahil Muhammad Aslam, Bilal Muhammad, Nawaz Allah,八木 邦公,渡辺 志朗, 森永 芳智,戸邉 一之
    • Organizer
      第95回日本内分泌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 腸内細菌叢が糖代謝に与えるインパクト2021

    • Author(s)
      藤坂志帆 戸邉一之
    • Organizer
      第41回日本肥満学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 防風通聖散投与中に腸内細菌Akkermansia muchiniphilaが増加した高度肥満症の一例2021

    • Author(s)
      藤坂志帆、朴木久恵、圓角麻子、山田眞之介、四方雅隆、瀧川章子、渡邊善之、角朝信、桑野剛英、西村歩、八木邦公、戸邉一之
    • Organizer
      第41回日本肥満学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 腸内細菌叢への介入が及ぼす糖・脂質代謝への影響2021

    • Author(s)
      藤坂志帆 戸邉一之
    • Organizer
      第64回日本糖尿病学会年次学術集会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 腸内細菌叢を介した脂質代謝が肥満、インスリン抵抗性に及ぼす影響2021

    • Author(s)
      藤坂志帆 戸邉一之
    • Organizer
      第94回日本生化学会
    • Related Report
      2021 Research-status Report
    • Invited
  • [Presentation] 栄養組成により確立した腸内細菌叢は、血中脂質プロファイルに大きな影響を与える2021

    • Author(s)
      渡邊善之 藤坂志帆 池田和貴 山田恭央 Allah Nawaz  角朝信 Muhammad Bilal 西村歩 桑野剛英 劉建輝 朴木久恵 八木邦公 長谷耕二 戸邉一之
    • Organizer
      第41回日本肥満学会
    • Related Report
      2021 Research-status Report
  • [Presentation] 腸内細菌叢が糖代謝に与えるインパクト2021

    • Author(s)
      藤坂 志帆, 戸邉 一之
    • Organizer
      第41回日本肥満学会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 栄養組成により確立した腸内細菌叢は、血中脂質プロファイルに大きな影響を与える2021

    • Author(s)
      渡邊 善之,藤坂 志帆,池田 和貴,山田 恭央,Allah Nawaz,角 朝信,Muhammad Bilal,西村 歩,桑野 剛英,劉 建輝,朴木 久恵,八木 邦公,長谷 耕二,戸邉 一之
    • Organizer
      第41回日本肥満学会
    • Related Report
      2020 Research-status Report
  • [Presentation] 肥満2型糖尿病における脂肪組織M1/M2マクロファージの役割2020

    • Author(s)
      藤坂 志帆
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Related Report
      2020 Research-status Report
    • Invited
  • [Presentation] 栄養組成による腸内細菌叢と糖代謝の相違2020

    • Author(s)
      藤坂 志帆,渡邊 善之,Allah Nawaz,角 朝信,Muhammad Bilal,西村 歩,桑野 剛英,劉 健輝,朴木 久恵,八木邦公,戸邉 一之
    • Organizer
      第63回日本糖尿病学会年次学術集会
    • Related Report
      2020 Research-status Report
  • [Book] Pharma Medica2020

    • Author(s)
      藤坂 志帆 戸邉 一之
    • Total Pages
      4
    • Publisher
      株式会社メディカルレビュー社
    • Related Report
      2020 Research-status Report
  • [Book] 医学のあゆみ2020

    • Author(s)
      藤坂志帆 渡邊善之 戸邉一之
    • Total Pages
      3
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2020 Research-status Report
  • [Book] 糖尿病2020

    • Author(s)
      藤坂志帆 戸邉一之
    • Total Pages
      4
    • Publisher
      (株) 杏林舎
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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