Changes in morphology and function of neonatally X-irradiated thyroid gland in rats

• Project/Area Number: 20K08886
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Review Section: Basic Section 54040:Metabolism and endocrinology-related
• Research Institution: Hiroshima University
• Principal Investigator: Fujimoto Nariaki 広島大学, 原爆放射線医科学研究所, 准教授 (40243612)
• Co-Investigator(Kenkyū-buntansha): 松山 睦美 (松鵜睦美) 長崎大学, 原爆後障害医療研究所, 助教 (00274639) ; 中島 正洋 長崎大学, 原爆後障害医療研究所, 教授 (50284683)
• Project Period (FY): 2020-04-01 – 2023-03-31
• Project Status: Completed (Fiscal Year 2022)
• Budget Amount: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000); Fiscal Year 2022: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000); Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2020: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
• Keywords: 小児期甲状腺被曝 / 小児期被曝 / 甲状腺がん / 甲状腺機能障害 / 放射線被曝甲状腺癌 / 小児甲状腺癌 / ラット甲状腺 / 頸部X線 / 甲状腺被曝 / 小児期被曝影響

Outline of Research at the Start

小児期の放射線被曝により甲状腺癌が誘発されることはよく知られる。一方、我々は、動物実験により、小児期甲状腺被曝が甲状腺機能へも影響を及ぼすことを明らかにした。甲状腺機能は個体発達に必須であり、障害されると成長遅延等の大きな健康リスクとなり得る。本研究では、小児期放射線被曝による甲状腺機能への影響についての詳細を明らかにし、その障害メカニズムを解明することを目的とする。被曝事故後のヒト影響評価、小児期被曝者への対応、および今後の放射線防護対策のために必須であり極めて重要な研究である。

Outline of Final Research Achievements

Exposure to ionizing radiation in childhood has been recognized as a risk factor for thyroid dysfunction/cancer. Wistar rats were subjected to cervical X-irradiation at different ages of 1-8 weeks old and at different doses of 1.5-12 Gy. For tumor promotion, neonatally X-irradiated rats were fed with an iodine-deficient diet (IDD). In cervically X-irradiated neonatal rats, the colloid size of thyroid follicles decreased, accompanied by an increase in the number of TUNEL-positive cells. Fas and Lgals3 mRNA levels increased, while Mct8 and Lat4 expressions decreased. The co-administration of IDD resulted in thyroid adenoma development. Our data showed that single neonatal X-irradiation induced continuous apoptotic activity in the thyroid with the long-term alternation in Fas, Mct8, Lat4, and Lgals3 mRNA expressions. Some of these changes were similar to those induced by IDD, suggesting that neonatal X-irradiation may partially act as a thyroid tumor promoter.

Academic Significance and Societal Importance of the Research Achievements

小児期放射線被曝が甲状腺発癌リスクであることは良く知られ、福島第一原発事故後にもその影響が憂慮された。しかし今日までそのメカニズムに関わる研究はほとんど行われておらず、科学的な知見が不足しておりリスクについての合理的な議論ができなかった。本研究は、小児期甲状腺が放射線高感受性であるメカニズムの一端を明らかにした重要な基礎科学的研究であり、その知見は放射線防護、放射線影響評価、リスクコミュニケーションに有用である。今後も起こりうる原発事故等において科学的根拠をもったリスク分析・判断を行うためには、さらなる発展研究が不可欠と考えるが、本研究の継続を求めた科研費申請は採択に至らなかった。

Research Products

• [Journal Article] Delayed Acute Perimyocarditis and Bilateral Facial Nerve Palsy in a Patient with COVID-19 (2022)
  • Author(s): Matsumura Kazuki、Kawano Hiroaki、Kurobe Masaya、Akashi Ryohei、Yoshimuta Tsuyoshi、Ikeda Satoshi、Ueki Nozomi、Nakashima Masahiro、Maemura Koji
  • Journal Title: Internal Medicine Volume: 61 Issue: 15 Pages: 2327-2332
  • DOI: 10.2169/internalmedicine.9752-22
  • ISSN: 0918-2918, 1349-7235
  • Year and Date: 2022-08-01
  • Peer Reviewed / Open Access
• [Journal Article] External dose estimates of laboratory rats and mice during exposure to dispersed neutron-activated 56Mn powder. (2022)
  • Author(s): Stepanenko V, Sato H, Fujimoto N, Shichijo K, Toyoda S, Kawano N, Endo S, Kaprin A, Ivanov S, Shegay P, Petukhov A
  • Journal Title: Journal of Radiation Research Volume: 63(S1) Issue: Supplement_1 Pages: i16-i20
  • DOI: 10.1093/jrr/rrac032
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Microdistribution of internal radiation dose in biological tissues exposed to 56Mn dioxide microparticles. (2022)
  • Author(s): Stepanenko V, Kaprin A, Ivanov S, Shegay P, Viktoria B, Sato H, Shichijo K, Toyoda S, Kawano N, Ohtaki M, Fujimoto N, Endo S, Chaizhunusova N, Shabdarbaeva D, Zhumadilov K, Hoshi M
  • Journal Title: Journal of Radiation Research Volume: 63(S1) Issue: Supplement_1 Pages: i21-i25
  • DOI: 10.1093/jrr/rrac023
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effects of internal exposure to neutron-activated 56MnO2 powder on locomotor activity in rats (2022)
  • Author(s): Otani Keiko、Ohtaki Megu、Fujimoto Nariaki、Uzbekov Darkhan、Kairkhanova Ynkar、Saimova Aisulu、Chaizhunusova Nailya、Habdarbaeva Dariya、Azhimkhanov Almas、Zhumadilov Kassym、Stepanenko Valeriy、Hoshi Masaharu
  • Journal Title: Journal of Radiation Research Volume: 63 Issue: Supplement_1 Pages: i38-i44
  • DOI: 10.1093/jrr/rrac003
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Estimation of ‘dose-depth’ profile in the surface layers of a quartz-containing tile from the former Hiroshima University building indicates the possible presence of beta-irradiation from residual radioactivity after A-bombing (2022)
  • Author(s): Stepanenko Valeriy、Kaprin Andrey、Ivanov Sergey、Shegay Peter、Sato Hitoshi、Toyoda Shin、Kawano Noriyuki、Fujimoto Nariaki、Endo Satoru、Bogacheva Viktoria、Kolyzhenkov Timofey、Khailov Artem、Zhumadilov Kassym、Zhumalina Aidana、Yerimbetova Dana、Hoshi Masaharu
  • Journal Title: Journal of Radiation Research Volume: 63 Issue: Supplement_1 Pages: i54-i60
  • DOI: 10.1093/jrr/rrac029
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Molecular Pathological Characteristics of Thyroid Follicular-Patterned Tumors Showing Nodule-in-Nodule Appearance with Poorly Differentiated Component (2022)
  • Author(s): Ueda Mayu、Matsuda Katsuya、Kurohama Hirokazu、Mussazhanova Zhanna、Sailaubekova Yerkezhan、Kondo Hisayoshi、Shimizu Tomoki、Takada Nami、Matsuoka Yuki、Otsubo Chieko、Sato Shinya、Yamashita Hiroyuki、Kawakami Atsushi、Nakashima Masahiro
  • Journal Title: Cancers Volume: 14 Issue: 15 Pages: 3577-3577
  • DOI: 10.3390/cancers14153577
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Alvocidib inhibits IRF4 expression via super‐enhancer suppression and adult T‐cell leukemia/lymphoma cell growth (2022)
  • Author(s): Sakamoto Hikaru、Ando Koji、Imaizumi Yoshitaka、Mishima Hiroyuki、Kinoshita Akira、Kobayashi Yuji、Kitanosono Hideaki、Kato Takeharu、Sawayama Yasushi、Sato Shinya、Hata Tomoko、Nakashima Masahiro、Yoshiura Koh‐Ichiro、Miyazaki Yasushi
  • Journal Title: Cancer Science Volume: 113 Issue: 12 Pages: 4092-4103
  • DOI: 10.1111/cas.15550
  • Peer Reviewed / Open Access
• [Journal Article] Spinocerebellar ataxia type 17-digenic TBP/STUB1 disease: neuropathologic features of an autopsied patient (2022)
  • Author(s): Saito Rie、Tada Yui、Oikawa Daisuke、Sato Yusuke、Seto Makiko、Satoh Akira、Kume Kodai、Ueki Nozomi、Nakashima Masahiro、Hayashi Shintaro、Toyoshima Yasuko、Tokunaga Fuminori、Kawakami Hideshi、Kakita Akiyoshi
  • Journal Title: Acta Neuropathologica Communications Volume: 10 Issue: 1 Pages: 177-177
  • DOI: 10.1186/s40478-022-01486-6
  • Peer Reviewed / Open Access
• [Journal Article] Pathological diagnosis of general rules for the description of thyroid cancer by Japanese Society of Thyroid Pathology and Japan Association of Endocrine Surgery (2022)
  • Author(s): Hiroshi Kamma, Kaori Kameyama, Tetsuo Kondo, Yoshiaki Imamura, Masahiro Nakashima, Tomohiro Chiba, Mitsuyoshi Hirokawa
  • Journal Title: Endocrine Journal Volume: 69 Issue: 2 Pages: 139-154
  • DOI: 10.1507/endocrj.EJ21-0388
  • NAID: 130008164726
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Single neonatal irradiation induces long-term gene expression changes in the thyroid gland, which may be involved in the tumorigenesis (2021)
  • Author(s): Fujimoto Nariaki、Matsuu-Matsuyama Mutsumi、Nakashima Masahiro
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 23620-23620
  • DOI: 10.1038/s41598-021-03012-5
  • Peer Reviewed / Open Access
• [Journal Article] Age-dependent effects on radiation-induced carcinogenesis in the rat thyroid (2021)
  • Author(s): Matsuyama M, Shichijo K, Matsuda K, Fujimoto N, Kondo H, Miura S, Kurashige T, Nagayama Y, Nakashima M.
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 19096-19096
  • DOI: 10.1038/s41598-021-98481-z
  • NAID: 120007175565
  • Peer Reviewed / Open Access
• [Journal Article] Biological impacts on the lungs in rats internally exposed to radioactive 56MnO2 particle (2021)
  • Author(s): Fujimoto Nariaki、Ruslanova Bakhyt、Abishev Zhaslan、Chaizhunussova Nailya、Shabdarbayeva Dariya、Amantayeva Gaukhar、Farida Rakhimzhanova、Sandybayev Marat、Nagano Kasuke、Zhumadilov Kassym、Kaprin Andrey、Ivanov Sergey、Stepanenko Valeriy、Hoshi Masaharu
  • Journal Title: Scientific Reports Volume: 11 Issue: 1 Pages: 11055-11055
  • DOI: 10.1038/s41598-021-90443-9
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Hepatic Gene Expression Changes in Rats Internally Exposed to Radioactive 56MnO2 Particles at Low Doses (2021)
  • Author(s): Ruslanova Bakhyt、Abishev Zhaslan、Chaizhunussova Nailya、Shabdarbayeva Dariya、Tokesheva Sholpan、Amantayeva Gaukhar、Kairkhanova Ynkar、Stepanenko Valeriy、Hoshi Masaharu、Fujimoto Nariaki
  • Journal Title: Current Issues in Molecular Biology Volume: 43 Issue: 2 Pages: 758-766
  • DOI: 10.3390/cimb43020055
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] 53BP1 expression as a biomarker to differentiate thyroid follicular tumors (2021)
  • Author(s): Sato Ayako、Matsuda Katsuya、Motoyama Takahiro、Mussazhanova Zhanna、Otsubo Ryota、Kondo Hisayoshi、Akazawa Yuko、Higuchi Miyoko、Suzuki Ayana、Hirokawa Mitsuyoshi、Miyauchi Akira、Nagayasu Takeshi、Nakashima Masahiro
  • Journal Title: Endocrine Connections Volume: 10 Issue: 3 Pages: 309-315
  • DOI: 10.1530/ec-20-0630
  • Peer Reviewed / Open Access
• [Journal Article] The Contribution of Genetic Variants to the Risk of Papillary Thyroid Carcinoma in the Kazakh Population: Study of Common Single Nucleotide Polymorphisms and Their Clinicopathological Correlations (2021)
  • Author(s): Mussazhanova Z, Rogounovitch TI, Saenko VA, Krykpayeva A, Espenbetova M, Azizov B, Kondo H, Matsuda K, Kalmatayeva Z, Issayeva R, Yeleubayeva Z, Madiyeva M, Mukanova A, Sandybayev M, Bolsynbekova S, Kozykenova Z, Yamashita S, Nakashima M.
  • Journal Title: Front Endocrinol (Lausanne) Volume: 11 Pages: 1-10
  • DOI: 10.3389/fendo.2020.543500
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Anticancer agent α-sulfoquinovosyl-acylpropanediol enhances the radiosensitivity of human malignant mesothelioma in nude mouse models (2021)
  • Author(s): Inamasu Eiko、Tsuchiya Tomoshi、Yamauchi Motohiro、Nishi Kodai、Matsuda Katsuya、Sugawara Fumio、Sakaguchi Kengo、Mori Ryoichi、Matsumoto Keitaro、Miyazaki Takuro、Hatachi Go、Doi Ryoichiro、Watanabe Hironosuke、Tomoshige Koichi、Matsuda Naoki、Higami Yoshikazu、Shimokawa Isao、Nakashima Masahiro、Nagayasu Takeshi
  • Journal Title: Journal of Radiation Research Volume: 63 Issue: 1 Pages: 19-29
  • DOI: 10.1093/jrr/rrab090
  • Peer Reviewed / Open Access
• [Journal Article] Detection of Endogenous DNA Double-strand Breaks in Oral Squamous Epithelial Lesions by P53-binding Protein 1 (2021)
  • Author(s): IMAIZUMI TOSHINOBU、MATSUDA KATSUYA、TANAKA KEI、KONDO HISAYOSHI、UEKI NOZOMI、KUROHAMA HIROKAZU、OTSUBO CHIEKO、MATSUOKA YUKI、AKAZAWA YUKO、MIURA SHIRO、NAKASHIMA MASAHIRO
  • Journal Title: Anticancer Research Volume: 41 Issue: 10 Pages: 4771-4779
  • DOI: 10.21873/anticanres.15292
  • Peer Reviewed / Open Access
• [Journal Article] <i>Itpr1</i> regulates the formation of anterior eye segment tissues derived from neural crest cells (2021)
  • Author(s): Kinoshita Akira、Ohyama Kaname、Tanimura Susumu、Matsuda Katsuya、Kishino Tatsuya、Negishi Yutaka、Asahina Naoko、Shiraishi Hideaki、Hosoki Kana、Tomiwa Kiyotaka、Ishihara Naoko、Mishima Hiroyuki、Mori Ryoichi、Nakashima Masahiro、Saitoh Shinji、Yoshiura Koh-ichiro
  • Journal Title: Development Volume: 148 Issue: 16 Pages: 188755-188755
  • DOI: 10.1242/dev.188755
  • Peer Reviewed / Open Access
• [Journal Article] Incidence Patterns of Sequential or Composite Lymphoma: A Population-Based Cancer Registry Study (2021)
  • Author(s): Niino Daisuke、My Hanh Luong Thi、Miura Shiro、Nakashima Masahiro、Iwanaga Masako
  • Journal Title: The Tohoku Journal of Experimental Medicine Volume: 254 Issue: 2 Pages: 123-127
  • DOI: 10.1620/tjem.254.123
  • NAID: 130008060014
  • ISSN: 0040-8727, 1349-3329
  • Peer Reviewed / Open Access
• [Journal Article] End of an Era of Sample Collection for the Nagasaki Atomic Bomb Survivor's Tumor Tissue Bank (2021)
  • Author(s): Akazawa Yuko、Araki Yuko、Miura Shiro、Kondo Hisayoshi、Hata Tomoko、Nakashima Masahiro
  • Journal Title: Radiation Research Volume: 196 Issue: 3 Pages: 323-325
  • DOI: 10.1667/rade-21-00058.1
  • Peer Reviewed / Open Access
• [Journal Article] How to identify indolent thyroid tumors unlikely to recur and cause cancer death immediately after surgery—Risk stratification of papillary thyroid carcinoma in young patients— (2021)
  • Author(s): Kakudo Kennichi、Liu Zhiyan、Bai Yanhua、Li Yaqiong、Kitayama Naomi、Satoh Shinya、Nakashima Masahiro、Jung Chan Kwon
  • Journal Title: Endocrine Journal Volume: 68 Issue: 8 Pages: 871-880
  • DOI: 10.1507/endocrj.EJ21-0018
  • NAID: 130008079309
  • ISSN: 0918-8959, 1348-4540
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comprehensive analysis for detecting radiation-specific molecules expressed during radiation-induced rat thyroid carcinogenesis. (2021)
  • Author(s): Kurohama H, Matsuda K, Kishino M, Yoshino M, Yamaguchi Y, Matsuu-Matsuyama M, Kondo H, Mitsutake N, Kinoshita A, Yoshiura KI, Nakashima M.
  • Journal Title: J Radiat Res. Volume: 62 Issue: Supplement_1 Pages: i78-i87
  • DOI: 10.1093/jrr/rraa139
  • Peer Reviewed / Open Access
• [Journal Article] Low-Dose Radiation Exposure with 56MnO2 Powder Changes Gene Expressions in the Testes and the Prostate in Rats (2020)
  • Author(s): Fujimoto Nariaki、Amantayeva Gaukhar、Chaizhunussova Nailya、Shabdarbayeva Dariya、Abishev Zhaslan、Ruslanova Bakhyt、Zhunussov Yersin、Azhimkhanov Almas、Zhumadilov Kassym、Petukhov Aleksey、Stepanenko Valeriy、Hoshi Masaharu
  • Journal Title: International Journal of Molecular Sciences Volume: 21 Issue: 14 Pages: 4989-4989
  • DOI: 10.3390/ijms21144989
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Internal doses in experimental mice and rats following various exposures to neutron-activated 56Mn02 powder: results of international multicenter study (2020)
  • Author(s): Stepanenko V, Zhumadilov K, Hoshi M, Zhunussov YT, Endo S, Ohtaki M, Otani M, Fujimoto N, Shichijo K, Kawano N, Sakaguchi A, Chaizhunusova N, Shabdarbaeva D, Gnyrya V, Аzimkhanov A, Kaprin A, Ivanov S, Yaskova E, Belukha I, Kolyzhenkov T, Petukhov A , Bogacheva V.
  • Journal Title: Radiation and Environmental Biophysics Volume: 59 Issue: 4 Pages: 683-692
  • DOI: 10.1007/s00411-020-00870-x
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Quantitative Analysis of Effects of a Single 60Co Gamma Ray Point Exposure on Time-Dependent Change in Locomotor Activity in Rats (2020)
  • Author(s): Otani Keiko、Ohtaki Megu、Fujimoto Nariaki、Saimova Aisulu、Chaizhunusova Nailya、Rakhypbekov Tolebay、Sato Hitoshi、Kawano Noriyuki、Hoshi Masaharu
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 17 Issue: 16 Pages: 5638-5638
  • DOI: 10.3390/ijerph17165638
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Causative role for defective expression of mitochondria-eating protein in accumulation of mitochondria in thyroid oncocytic cell tumors. (2020)
  • Author(s): Mussazhanova Z, Shimamura M, Kurashige T, Ito M, Nakashima M, Nagayama Y
  • Journal Title: Cancer Sci. Volume: 111 Issue: 8 Pages: 2814-2823
  • DOI: 10.1111/cas.14501
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Cervical Superficially Invasive Squamous Cell Carcinoma With Supraclavicular Lymph Node Metastasis: A Case Report (2020)
  • Author(s): Kawashita Sayaka、Matsuda Katsuya、Matsuwaki Takahiro、Kurohama Hirokazu、Ito Masahiro、Kishikawa Masao、Miura Kiyonori、Nakashima Masahiro
  • Journal Title: International Journal of Gynecological Pathology Volume: 40 Issue: 1 Pages: 78-83
  • DOI: 10.1097/pgp.0000000000000679
  • Peer Reviewed
• [Journal Article] Relationship between thyroid tumor radiosensitivity and nuclear localization of DNA-dependent protein kinase catalytic subunit (2020)
  • Author(s): Ihara M, Shichijo K, Ashizawa K, Matsuda K, Otsubo R, Horie I, Nakashima M, Kudo T
  • Journal Title: J Radiat Res Volume: 61 Issue: 4 Pages: 511-516
  • DOI: 10.1093/jrr/rraa032
  • NAID: 120006988124
  • Peer Reviewed / Open Access
• [Journal Article] Protective effects of a cystine and theanine mixture against acute radiation injury in rats (2020)
  • Author(s): Matsuu-Matsuyama Mutsumi、Shichijo Kazuko、Tsuchiya Takashi、Kondo Hisayoshi、Miura Shiro、Matsuda Katsuya、Sekine Ichiro、Nakashima Masahiro
  • Journal Title: Environmental Toxicology and Pharmacology Volume: 78 Pages: 103395-103395
  • DOI: 10.1016/j.etap.2020.103395
  • NAID: 120006988216
  • Peer Reviewed / Open Access
• [Journal Article] Acceleration of BRAFV600E-mediated thyroid carcinogenesis by TGFβ signal deficiency. (2020)
  • Author(s): Shimamura M, Kurashige T, Kuatov R, Nagayama Y.
  • Journal Title: Endocrine Volume: in press Issue: 3 Pages: 571-577
  • DOI: 10.1007/s12020-020-02298-1
  • Peer Reviewed / Open Access
• [Journal Article] Significance of p53-Binding Protein 1 Nuclear Foci in Cervical Squamous Intraepithelial Lesions: Association With High-Risk Human Papillomavirus Infection and P16INK4a Expression (2020)
  • Author(s): Kawashita Sayaka、Matsuda Katsuya、Kondo Hisayoshi、Kitajima Yuriko、Hasegawa Yuri、Shimada Takako、Kitajima Michio、Miura Kiyonori、Nakashima Masahiro、Masuzaki Hideaki
  • Journal Title: Cancer Control Volume: 27 Issue: 1 Pages: 1-8
  • DOI: 10.1177/1073274819901170
  • NAID: 120006988289
  • Peer Reviewed
• [Presentation] ラット新生仔期被曝による甲状腺腫瘍化に関与する遺伝子発現変化II低ヨード腫瘍化モデルの解析 (2022)
  • Author(s): 藤本成明, 松山睦美, 中島正洋
  • Organizer: 第95回日本内分泌学会学術総会
• [Presentation] ラット新生仔期被曝による甲状腺の遺伝子発現変化と腫瘍化 (2022)
  • Author(s): 藤本成明, 松山睦美, 中島正洋
  • Organizer: 第6回放射線災害・医科学研究拠点カンファランス
• [Presentation] Single neonatal irradiation induces long-term morphological and gene expression changes in the thyroid of rats - a possible mechanism of thyroid carcinogenesis by childhood radiation (2022)
  • Author(s): Fujimoto N
  • Organizer: International Conference - Modern Perspectives for Biomedical Sciences
  • Int'l Joint Research / Invited
• [Presentation] 充実性成分を呈する結節内結節型甲状腺結節の分子病理学的特徴解析 (2022)
  • Author(s): 松田勝也, 上田真由, Mussazhanova Zhanna, Saiaubekova Yerkezhan, 黒濵大和, 松岡優毅,大坪智恵子, 佐藤伸也, 山下弘幸, 中島正洋
  • Organizer: 第111回日本病理学会総会
• [Presentation] 長崎被爆者組織バンク収集におけるコロナインパクト (2022)
  • Author(s): 赤澤祐子, 中島正洋, 三浦史郎
  • Organizer: 第111回日本病理学会総会
• [Presentation] p53-binding protein 1 免疫染色法による咽頭扁平上皮に多段階発がんにおける遺伝子損傷応答 (2022)
  • Author(s): 赤澤祐子, 川崎寛子, 田渕真惟子, 中尾一彦, 中島正洋
  • Organizer: 第111回日本病理学会総会
• [Presentation] 食道扁平上皮癌と53BP1核内フォーカス形成 (2022)
  • Author(s): 上木 望, 赤澤祐子, 三浦史郎, 松田勝也, 黒濵大和, 今泉利信, 近藤久義, 中島正洋
  • Organizer: 第111回日本病理学会総会
• [Presentation] 甲状腺濾胞性腫瘍のLBC検体を対象としたDNA損傷応答分子3BP1発現解析 (2022)
  • Author(s): 中島正洋, 松田勝也
  • Organizer: 第63回日本臨床細胞学会総会
• [Presentation] 低分化成分を有する非浸潤性甲状腺結節の分子病理学的特徴解析 (2022)
  • Author(s): 上田真由, 松田勝也, 黒濵大和, Mussazhanova Zhanna, Yerkezhan Sailaubekova, 近藤久義, 松岡優毅, 大坪智恵子, 佐藤信也, 山下弘幸, 川上 純, 中島正洋
  • Organizer: 第9回日本甲状腺病理学会学術集会
• [Presentation] 「子宮頸部細胞診AGCの診断と臨床」長崎県における子宮頸部細胞診AGC の現状と課題 (2022)
  • Author(s): 松田勝也, 中島正洋
  • Organizer: 第37回日本臨床細胞学会九州連合会学会
• [Presentation] Molecular Pathological Characteristics of Benign Thyroid Nodules with Poorly Differentiated Component (2022)
  • Author(s): Ueda M, Matsuda K, Kurohama H, Mussazhanova Z, Sailaubekova Y, Kondo H, Matsuoka Y, Otsubo C, Sato S, Yamashita H, Kawakami A, Nakashima
  • Organizer: 34th European Congress of Pathology
• [Presentation] End of sample collection for the Nagasaki Atomic Bomb Survivor's Tissue Bank 長崎被爆者組織バンク収集におけるCovid-19 パンデミックのインパクト (2022)
  • Author(s): 赤澤祐子,中島正洋
  • Organizer: 日本放射線影響学会第65回大会
• [Presentation] 甲状腺腫瘍の 2022 年 WHO 病理分類の主な改訂ポイント (2022)
  • Author(s): 中島正洋
  • Organizer: 第26回日本臨床内分泌病理学会学術総会
• [Presentation] 甲状腺細胞診検体を用いた DNA 損傷応答分子 53BP1 発現型解析による濾胞性腫瘍診断の試み (2022)
  • Author(s): 松田勝也, 佐藤綾子, 樋口観世子, 鈴木彩菜, 廣川満良, 中島正洋
  • Organizer: 第26回日本臨床内分泌病理学会学術総会
• [Presentation] 低分化成分を有する結節内結節型甲状腺良性結節の分子病理学的特徴解析 (2022)
  • Author(s): 上田真由, 松田勝也, 黒濵大和, Mussazhanova Zhanna, Yerkezhan Sailaubekova, 近藤久義, 松岡優毅, 大坪智恵子, 佐藤信也, 山下弘幸, 川上 純, 中島正洋
  • Organizer: 第65回日本甲状腺学会学術集会
• [Presentation] Main revised points of the 2022 WHO classification of thyroid cancer (2022)
  • Author(s): Nakashima M
  • Organizer: Scientific and practical aspects of the treatment and diagnosis of oncological diseases
• [Presentation] A new indicator to differentiate thyroid follicular inclusions in the cervical lymph nodes from patients with thyroid cancer (2022)
  • Author(s): Mussazhanova Z, Otsubo C, Kurohama H, Shalgimbayeva G, Ueki N, Matsuoka Y, Madiyeva M, Sato S, Yamashita H, Nakashima M
  • Organizer: Scientific and practical aspects of the treatment and diagnosis of oncological diseases
• [Presentation] Animal studies of 56MnO2 exposure in 2018-19 (2022)
  • Author(s): Fujimoto N
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research / Invited
• [Presentation] Effects of internal exposure to neutron-activated 56MnO2 powder on locomotor activity in rats (2022)
  • Author(s): Keiko Otani, Megu Ohtaki, Nariaki Fujimoto, Darkhan Uzbekov, Ynkar Kairkhanova, Aisulu Saimova, Nailya Chaizhunussova, Dariya Habdarbaeva, Almas Azhimkhanov, Kassym Zhumadilov, Valeriy Stepanenko, Masaharu Hoshi
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research
• [Presentation] The effect of various doses of ionizing radiation on liver tissue in experiment (2022)
  • Author(s): Bakhyt Ruslanova, Nailya Chaizhunussova, Dariya Shabdarbayeva, Nariaki Fujimoto, Masaharu Hoshi
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research
• [Presentation] The effects of internal and external exposure on morphological indicators and gene expression in lungs in experiment (rats and mice) (2022)
  • Author(s): Zhaslan Abishev, Nailya Chaizhunussova, Dariya Shabdarbayeva, Nariaki Fujimoto, Masaharu Hoshi
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research
• [Presentation] Influence of internal and external ionizing radiation on gene expression of the reproductive system in male laboratory animals (2022)
  • Author(s): Nailya Chaizhunussova, Gauhar Amantayeva, Dariya Shabdarbayeva, Nariaki Fujimoto, Masaharu Hoshi
  • Organizer: The 24th Hiroshima International Symposium: Research on radiation and its effects in Kazakhstan and other countries
  • Int'l Joint Research
• [Presentation] ラット新生仔期被曝による甲状腺腫瘍化に関与する遺伝子発現変化(O2-7-1) (2021)
  • Author(s): 藤本成明, 松山睦美, 中島正洋
  • Organizer: 第94回日本内分泌学会学術総会
• [Presentation] 放射性56MnO2 微粒子曝露による低線量被曝でのラット雄性生殖線機能低下 (2021)
  • Author(s): 藤本成明, 星正治, Chaizhunussova N
  • Organizer: 第5回放射線災害 医科学研究拠点カンファランス
• [Presentation] Biological effects of radioactive particles produced by atomic bombing - animal studies (2021)
  • Author(s): Fujimoto, N
  • Organizer: 15th international scientific-practical conference <ecology. radiation. health>, Semey, Kazakhstan
  • Int'l Joint Research / Invited
• [Presentation] Biological effects of internal exposure to radioactive particles of 56MnO2 in rats (2021)
  • Author(s): Fujimoto N, Chaizhunussova N, Shabdarbayeva D, Gnyrya V, Azhimkhanov A, Kolbayenkov A, Zhumadilov K, Stepanenko V, Hoshi M
  • Organizer: 9th international conference semipalatinsk test site, Kurchatov, Kazakhstani
  • Int'l Joint Research
• [Presentation] Characterization of thyroid nodule with PTC-like nuclear features arising in Basedow's disease (2021)
  • Author(s): Kurohama H, Yamashita H, Nakashima M
  • Organizer: XXVII International Symposium of Morphological Sciences
  • Int'l Joint Research
• [Presentation] アミノ酸混合物シスチン・テアニンのラットにおける放射線防護効果 (2021)
  • Author(s): 松山睦美, 七條和子, 土屋 誉, 中島正洋
  • Organizer: 第5回放射線災害 医科学研究拠点カンファランス
• [Presentation] 腫瘍内不均一のみられる甲状腺Well-differentiated carcinoma (WDC), NOSの1例 (2021)
  • Author(s): 山下弘幸, 中島正洋
  • Organizer: 第110回日本病理学会総会
• [Presentation] Changes in morphology and gene expressions of neonatally X-irradiated thyroid gland in rats (2020)
  • Author(s): Fujimoto N, Matsuu-Matsuyama M, Nakashima M
  • Organizer: 22nd European Congress of Endocrinology
  • Int'l Joint Research
• [Presentation] 結節内結節を伴う甲状腺良性結節の53BP1による分子病理学的特徴解析 (2020)
  • Author(s): 清水智貴、松田勝也、高田奈美、黒濵大和、Mussazhanova Zhanna、Sailaubekova Yerkezhan、大坪智恵子、佐藤伸也、山下弘幸、中島正洋
  • Organizer: 第24回日本臨床内分泌病理学会
• [Presentation] 甲状腺乳頭癌の転移と異所性甲状腺組織の鑑別における53BP1の有用性 (2020)
  • Author(s): 大坪智恵子、中島正洋、ムサジャノワジャンナ、松田勝也、黒濵大和、ルオンチーマイハン
  • Organizer: 第109回日本病理学会総会
• [Presentation] ラット放射線誘発甲状腺癌モデルによる被曝特異的分子マーカーの網羅的探索 (2020)
  • Author(s): 黒濵大和、松田勝也、木住野美緒、松山睦美、赤澤祐子、木下 晃、吉浦孝一郎、中島正洋
  • Organizer: 第109回日本病理学会総会
• [Presentation] 口腔扁平上皮腫瘍でのDNA損傷応答分子53BP1発現：高異型度上皮内腫瘍での発現異常について (2020)
  • Author(s): 松田勝也、今泉利信、三浦史郎、近藤久義、中島正洋
  • Organizer: 第109回日本病理学会総会