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Understanding cancer stem cells and targeting colorectal cancer stem cells for therapy via isolation using cellular characteristics

Research Project

Project/Area Number 20K09056
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionOsaka University

Principal Investigator

Uemura Mamoru  大阪大学, 大学院医学系研究科, 講師 (10528483)

Co-Investigator(Kenkyū-buntansha) 高橋 秀和  大阪大学, 大学院医学系研究科, 特任講師(常勤) (10528508)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2021: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords大腸癌 / 癌幹細胞 / 低プロテアソーム活性 / 低酸素 / 低酸素誘導遺伝子 / 幹細胞 / 低プロテアソーム / 治療抵抗性
Outline of Research at the Start

大腸癌幹細胞研究では一般に、細胞表面に発現している蛋白である表面マーカーを利用し、造腫瘍性を根拠に研究が進められてきたが、分離された細胞集団は真の癌幹細胞とは隔たりがあり、癌幹細胞治療の実現にはつながっていない。
大腸癌根治のために、癌幹細胞の特性を解明し、癌幹細胞治療の実現を目指すことを本研究の目的としている。

Outline of Final Research Achievements

Our research targeted the low proteasome activity (LPA), a characteristic of colorectal cancer stem cells (CSCs). We isolated LPA-expressing cells using an imaging vector, confirming their tumorigenicity. We investigated the LPA-tumorigenicity link and changes in gene expression under LPA.
A gene in the Wnt pathway was suppressed in colorectal cancer. Its forced expression reduced cell proliferation, showing its tumor-suppressive role. The gene's knockout didn't lead to spontaneous carcinogenesis in mice. We're now working on a carcinogenesis model.
We focused on long-term hypoxia-induced genes, critical for malignancy and treatment resistance. Unlike short-term hypoxia-responsive genes, the long-term ones solidified changes in proliferation and CSC traits, irreversibly. We're studying if these changes are epigenetically regulated.

Academic Significance and Societal Importance of the Research Achievements

本研究では、大腸癌幹細胞(CSC)の低プロテアソーム活性(LPA)に注目し、新たながん治療戦略の可能性を探求しました。Wnt経路の上流遺伝子の発現抑制による癌細胞の増殖能低下は、新治療戦略への可能性を含むものと思います。また、長期低酸素環境下での遺伝子発現変化を分析し、悪性度や治療抵抗性に関与する遺伝子群を特定し、これらがエピジェネティックに制御される可能性は、新たな視点を提供するものと思われます。
これらの成果は、がん研究の新領域を開き、治療法開発への道筋を示し、学術的・社会的意義を有すると思われます。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (53 results)

All 2022 2021 2020

All Journal Article (25 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 25 results,  Open Access: 4 results) Presentation (28 results)

  • [Journal Article] Risk Factors for Predicting Lymph Node Metastasis in Submucosal Colorectal Cancer2022

    • Author(s)
      Tsuchihashi Kurumi、Miyoshi Norikatsu、Fujino Shiki、Kitakaze Masatoshi、Ohue Masayuki、Danno Katsuki、Nakamichi Itsuko、Ohshima Kenji、Morii Eiichi、Uemura Mamoru、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Journal of the Anus, Rectum and Colon

      Volume: 6 Issue: 3 Pages: 181-189

    • DOI

      10.23922/jarc.2022-002

    • ISSN
      2432-3853
    • Year and Date
      2022-07-28
    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Preoperative Chemoradiotherapy Plus Nivolumab Before Surgery in Microsatellite Stable and Microsatellite Instability-High Locally Advanced Rectal Cancer Patients2022

    • Author(s)
      Bando H, Tsukada Y, Inamori K, Togashi Y, Koyama S, Kotani D, Fukuoka S, Yuki S, Komatsu Y, Homma S, Taketomi A, Uemura M, Kato T, Fukui M, Wakabayashi M, Nakamura N, Kojima M, Kawachi H, Kirsch R, Yoshida T, Suzuki Y, Sato A, Nishikawa H, Ito M, Yoshino T
    • Journal Title

      Clinical Cancer Research

      Volume: 28 Issue: 6 Pages: 1136-1146

    • DOI

      10.1158/1078-0432.ccr-21-3213

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fibroblast Activation Protein and Tertiary Lymphoid Structure in Colorectal Cancer Recurrence2022

    • Author(s)
      HAYASE SHIMON、MIYOSHI NORIKATSU、FUJINO SHIKI、YASUI MASAYOSHI、OHUE MASAYUKI、MINAMI SOICHIRO、KATO SHINYA、NAGAE AYUMI、SEKIDO YUKI、HATA TSUYOSHI、HAMABE ATSUSHI、OGINO TAKAYUKI、TAKAHASHI HIDEKAZU、UEMURA MAMORU、YAMAMOTO HIROFUMI、DOKI YUICHIRO、EGUCHI HIDETOSHI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 12 Pages: 5897-5907

    • DOI

      10.21873/anticanres.16099

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Diagnosis of Depth of Submucosal Invasion in Colorectal Cancer with AI Using Deep Learning2022

    • Author(s)
      Minami Soichiro、Saso Kazuhiro、Miyoshi Norikatsu、Fujino Shiki、Kato Shinya、Sekido Yuki、Hata Tsuyoshi、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Yamamoto Hirofumi、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Cancers

      Volume: 14 Issue: 21 Pages: 5361-5361

    • DOI

      10.3390/cancers14215361

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Geriatric Nutritional Risk Index as a Prognosis Predictor in Patients With Rectal Cancer Receiving Neoadjuvant Chemotherapy2022

    • Author(s)
      MINAMI SOICHIRO、MIYOSHI NORIKATSU、FUJINO SHIKI、KATO SHINYA、SEKIDO YUKI、HATA TSUYOSHI、OGINO TAKAYUKI、TAKAHASHI HIDEKAZU、UEMURA MAMORU、YAMAMOTO HIROFUMI、DOKI YUICHIRO、EGUCHI HIDETOSHI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 7 Pages: 3759-3766

    • DOI

      10.21873/anticanres.15866

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PRKRIP1, A Splicing Complex Factor, Is a Marker of Poor Prognosis in Colorectal Cancer.2022

    • Author(s)
      Ozato Y, Masuda T, Kobayashi Y, Takao S, Hisamatu Y, Toshima T, Yonemura Y, Uemura M, Eguchi H, Doki Y, Mori M, Mimori K.
    • Journal Title

      Anticancer Res.

      Volume: 42(10) Issue: 10 Pages: 4701-4706

    • DOI

      10.21873/anticanres.15974

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Low G9a expression is a tumor progression factor of colorectal cancer via IL-8 promotion2022

    • Author(s)
      Ichikawa Yoshitoshi、Takahashi Hidekazu、Chinen Yoshinao、Arita Asami、Sekido Yuki、Hata Tsuyoshi、Ogino Takayuki、Miyoshi Norikatsu、Uemura Mamoru、Yamamoto Hirofumi、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Carcinogenesis

      Volume: 43 Issue: 8 Pages: 797-807

    • DOI

      10.1093/carcin/bgac050

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Combined Inflammation and Nutrition Factors Reinforce the Prognostic Prediction for Stage III Colorectal Cancer Patients2022

    • Author(s)
      KATO SHINYA、MIYOSHI NORIKATSU、FUJINO SHIKI、MINAMI SOICHIRO、MATSUDA CHU、YASUI MASAYOSHI、OHUE MASAYUKI、SEKIDO YUKI、HATA TSUYOSHI、OGINO TAKAYUKI、TAKAHASHI HIDEKAZU、UEMURA MAMORU、YAMAMOTO HIROFUMI、DOKI YUICHIRO、EGUCHI HIDETOSHI
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 10 Pages: 4989-4999

    • DOI

      10.21873/anticanres.16006

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PLXND1/SEMA3E Promotes Epithelia-Mesenchymal Transition Partly via the PI3K/AKT-Signaling Pathway and Induces Heterogenity in Colorectal Cancer2022

    • Author(s)
      Hagihara Kiyotaka、Haraguchi Naotsugu、Nishimura Junichi、Yasueda Asuka、Fujino Shiki、Ogino Takayuki、Takahashi Hidekazu、Miyoshi Norikatsu、Uemura Mamoru、Matsuda Chu、Mizushima Tsunekazu、Yamamoto Hirofumi、Mori Masaki、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Annals of Surgical Oncology

      Volume: 29 Issue: 12 Pages: 7435-7445

    • DOI

      10.1245/s10434-022-11945-y

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The prediction of postoperative anorectal dysfunction after low anterior resection for lower rectal cancer by measuring the volume of defecation-related muscles2022

    • Author(s)
      Mori Ryota、Uemura Mamoru、Tsuboyama Takahiro、Fujino Shiki、Hata Tsuyoshi、Ogino Takayuki、Takahashi Hidekazu、Miyoshi Norikatsu、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Surgery Today

      Volume: 52 Issue: 5 Pages: 745-754

    • DOI

      10.1007/s00595-022-02478-8

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sarcopenia hinders the decline in disease activity after surgery for people with Crohn's disease: Preliminary results2022

    • Author(s)
      Yasueda Asuka、Sekido Yuki、Takeda Takashi、Ogino Takayuki、Miyoshi Norikatsu、Takahashi Hidekazu、Uemura Mamoru、Doki Yuichiro、Eguchi Hidetoshi、Mizushima Tsunekazu
    • Journal Title

      Nutrition

      Volume: 94 Pages: 111526-111526

    • DOI

      10.1016/j.nut.2021.111526

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Long noncoding RNA 01534 maintains cancer stemness by downregulating endoplasmic reticulum stress response in colorectal cancer2022

    • Author(s)
      Ichihara M, Takahashi H, Nishida N, Ivan C, Okuzaki D, Yokoyama Y, Ohtsuka M, Miyoshi N, Uemura M, Tanaka S, Calin G, Mori M, Doki Y, Eguchi, H, Yamamoto H
    • Journal Title

      Annals of Gastroenterological Surgery

      Volume: 7 Issue: 3 Pages: 458-470

    • DOI

      10.1002/ags3.12649

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High postoperative carcinoembryonic antigen as an indicator of high risk stageII colon cancer2022

    • Author(s)
      Morimoto Yoshihiro、Takahashi Hidekazu、Arita Asami、Itakura Hiroaki、Fujii Makoto、Sekido Yuki、Hata Tsuyoshi、Fujino Shiki、Ogino Takayuki、Miyoshi Norikatsu、Uemura Mamoru、Matsuda Chu、Yamamoto Hirofumi、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Oncology Letters

      Volume: 23 Issue: 5

    • DOI

      10.3892/ol.2022.13287

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A Phase II Study of Dose-reductive XELOX Plus Bevacizumab in Elderly or Vulnerable Patients With Metastatic Colorectal Cancer (MCSGO-1202)2022

    • Author(s)
      KATO AYA、MIYOSHI NORIKATSU、OHTSURU TORU、SAKAI DAISUKE、HASEGAWA JUNICHI、NAKATA KEN、IMASATO MITSUNOBU、KATO TAKESHI、IKENAGA MASAKAZU、KUDO TOSHIHIRO、TEI MITSUYOSHI、KAGAWA YOSHINORI、UEMURA MAMORU、et., al.
    • Journal Title

      Anticancer Research

      Volume: 42 Issue: 4 Pages: 1859-1865

    • DOI

      10.21873/anticanres.15662

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Functional assessment of miR-1291 in colon cancer cells2022

    • Author(s)
      Wang J, Hirose H, Yokoyama Y, Ikeshima R, Tsujimura N, Bonkobara S, Takeda K, Hata T, Inoue A, Hiraki M, Ohtsuka M, Nishida N, Takahashi H, Haraguchi N, Tanaka S, Wu X, Mori M, Yamamoto H.
    • Journal Title

      International Journal of Oncology

      Volume: 60 Issue: 2 Pages: 13-13

    • DOI

      10.3892/ijo.2022.5303

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] A stem cell marker KLF5 regulates CCAT1 via three-dimensional genome structure in colorectal cancer cells2021

    • Author(s)
      Takeda Takashi、Yokoyama Yuhki、Takahashi Hidekazu、Okuzaki Daisuke、Asai Kaho、Itakura Hiroaki、Miyoshi Norikatsu、Kobayashi Shogo、Uemura Mamoru、Fujita Toshitsugu、Ueno Hiroo、Mori Masaki、Doki Yuichiro、Fujii Hodaka、Eguchi Hidetoshi、Yamamoto Hirofumi
    • Journal Title

      British Journal of Cancer

      Volume: 126 Issue: 1 Pages: 109-119

    • DOI

      10.1038/s41416-021-01579-4

    • Related Report
      2021 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] HNF1A regulates colorectal cancer progression and drug resistance as a downstream of POU5F12021

    • Author(s)
      Fujino Shiki、Miyoshi Norikatsu、Ito Aya、Yasui Masayoshi、Matsuda Chu、Ohue Masayuki、Uemura Mamoru、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 10363-10363

    • DOI

      10.1038/s41598-021-89126-2

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Specific activation of glycolytic enzyme enolase 2 in BRAF V600E‐mutated colorectal cancer2021

    • Author(s)
      Yukimoto Ryohei、Nishida Naohiro、Hata Tsuyoshi、Fujino Shiki、Ogino Takayuki、Miyoshi Norikatsu、Takahashi Hidekazu、Uemura Mamoru、Satoh Taroh、Yamamoto Hirofumi 、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 7 Pages: 2884-2894

    • DOI

      10.1111/cas.14929

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Crenolanib Regulates ERK and AKT/mTOR Signaling Pathways in RAS/BRAF-Mutated Colorectal Cancer Cells and Organoids2021

    • Author(s)
      Fujino Shiki、Miyoshi Norikatsu、Ito Aya、Yasui Masayoshi、Ohue Masayuki、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Matsuda Chu、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Molecular Cancer Research

      Volume: Feb12 Issue: 5 Pages: 812-822

    • DOI

      10.1158/1541-7786.mcr-20-0600

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] SIRT3-Mediated SOD2 and PGC-1α Contribute to Chemoresistance in Colorectal Cancer Cells2021

    • Author(s)
      Paku Masakatsu、Haraguchi Naotsugu、Takeda Mitsunobu、Fujino Shiki、Ogino Takayuki、Takahashi Hidekazu、Miyoshi Norikatsu、Uemura Mamoru、Mizushima Tunekazu、Yamamoto Hirofumi、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Annals of Surgical Oncology

      Volume: 28 Issue: 8 Pages: 4720-4732

    • DOI

      10.1245/s10434-020-09373-x

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The meiosis-specific cohesin component stromal antigen 3 promotes cell migration and chemotherapeutic resistance in colorectal cancer2021

    • Author(s)
      Sasaki Masaru、Miyoshi Norikatsu、Fujino Shiki、Saso Kazuhiro、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Yamamoto Hirofumi、Matsuda Chu、Yasui Masayoshi、Ohue Masayuki、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Cancer Letters

      Volume: 497 Pages: 112-122

    • DOI

      10.1016/j.canlet.2020.10.006

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Human NKp44+ ILC3 character associated with induction of tumor-associated tertiary lymphoid structures is altered in T3/T4 colorectal cancer.2020

    • Author(s)
      Ikeda A, Ogino T, Kayama H, Okuzaki D, Nishimura J, Fujino S, Miyoshi N, Takahashi H, Uemura M, Matsuda C, Yamamoto H, Takeda K, Mizushima T, Mori M, Doki Y
    • Journal Title

      Cancer Immunol. Res

      Volume: in press Issue: 6 Pages: 724-731

    • DOI

      10.1158/2326-6066.cir-19-0775

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Dipeptidyl Peptidase 9 Increases Chemoresistance and is an Indicator of Poor Prognosis in Colorectal Cancer2020

    • Author(s)
      Saso Kazuhiro、Miyoshi Norikatsu、Fujino Shiki、Sasaki Masaru、Yasui Masayoshi、Ohue Masayuki、Ogino Takayuki、Takahashi Hidekazu、Uemura Mamoru、Matsuda Chu、Mizushima Tsunekazu、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      Annals of Surgical Oncology

      Volume: 27 Issue: 11 Pages: 4337-4347

    • DOI

      10.1245/s10434-020-08729-7

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Syntenin-1 promotes colorectal cancer stem cell expansion and chemoresistance by regulating prostaglandin E2 receptor2020

    • Author(s)
      Iwamoto Kazuya、Takahashi Hidekazu、Okuzaki Daisuke、Osawa Hideo、Ogino Takayuki、Miyoshi Norikatsu、Uemura Mamoru、Matsuda Chu、Yamamoto Hirofumi、Mizushima Tsunekazu、Mori Masaki、Doki Yuichiro、Eguchi Hidetoshi
    • Journal Title

      British Journal of Cancer

      Volume: 123 Issue: 6 Pages: 955-964

    • DOI

      10.1038/s41416-020-0965-9

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Some Gammaproteobacteria are enriched within CD14+ macrophages from intestinal lamina propria of Crohn’s disease patients versus mucus2020

    • Author(s)
      Sekido Yuki、Nishimura Junichi、Nakano Kazuhiro、Osu Takeaki、Chow Cheryl-Emiliane T.、Matsuno Hiroshi、Ogino Takayuki、Fujino Shiki、Miyoshi Norikatsu、Takahashi Hidekazu、Uemura Mamoru、Matsuda Chu、Kayama Hisako、Mori Masaki、Doki Yuichiro、Takeda Kiyoshi、Uchino Motoi、Ikeuchi Hiroki、Mizushima Tsunekazu
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 2988-2988

    • DOI

      10.1038/s41598-020-59937-w

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Presentation] 消化器外科分野におけるがん遺伝子パネル検査 および培養細胞解析の臨床応用を目指して2022

    • Author(s)
      三吉範克、藤野 志季、関戸 悠紀、波多 豪、 荻野 崇之、高橋 秀和、植村 守、佐藤 太郎、土岐 祐一郎、江口 英利
    • Organizer
      第77回日本消化器外科学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 炎症性腸疾患に対するオートファジー誘導効果の検討2022

    • Author(s)
      荻野崇之、関戸悠紀、多豪、三吉範克、高橋秀和、植村守、水島恒和、土岐祐一郎、江口英利
    • Organizer
      第108回日本消化器病学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 自然免疫細胞に着目した炎症性腸疾患の病態と治療戦略2022

    • Author(s)
      荻野崇之、関戸悠紀、多豪、三吉範克、高橋秀和、植村守、水島恒和、土岐祐一郎、江口英利
    • Organizer
      第30回日本消化器関連学会週間(JDDW)
    • Related Report
      2022 Annual Research Report
  • [Presentation] Development of a simple method for detecting circulating tumor cells (CTCs) in blood of colorectal cancer patients.2022

    • Author(s)
      吉村大士, 森本祥悠,野村勝俊,井上彬,関戸悠紀,波多豪,荻野崇之,高橋秀和,三吉範克,植村守,土岐裕一郎,江口英利,山本浩文
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 新鮮大腸癌サンプルを用いた大腸癌新規治療標的分子の探索と機能解析2022

    • Author(s)
      在田 麻美, 高橋 秀和, 関戸 悠紀, 波多 豪, 荻野 祟之, 三吉 範克, 植村 守, 土岐 祐一郎, 江口 英利
    • Organizer
      第122回日本外科学会定期学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大腸癌の発生・進展におけるMAF遺伝子の役割解明2022

    • Author(s)
      板倉弘明、波多豪、関戸悠紀、荻野崇之、高橋秀和、三吉範克、植村守、土岐祐一郎、江口英利、山本浩文
    • Organizer
      第122回日本外科学会定期学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大腸癌由来血液循環癌細胞を用いた治療応用を目指して2022

    • Author(s)
      板倉弘明、市原もも子、森本祥悠、野村雅俊、井上彬、関戸悠紀、波多豪、荻野崇之、高橋秀和、三吉範克、植村守、土岐祐一郎、江口英利、山本浩文
    • Organizer
      第20回日本消化器外科学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大腸癌肝転移におけるOct4の意義2022

    • Author(s)
      長江歩, 三吉 範克, 藤野 志季, 関戸 悠紀, 波多 豪, 荻野 崇之, 高橋 秀和, 植村 守, 土岐 祐一郎, 江口 英利
    • Organizer
      第122回日本外科学会定期学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Relationship between metastatic liver tumor and OCT4 in colorectal cancer2022

    • Author(s)
      長江歩, 三吉 範克, 藤野 志季, 関戸 悠紀, 波多 豪, 荻野 崇之, 高橋 秀和, 植村 守, 土岐 祐一郎, 江口 英利
    • Organizer
      第31回日本がん転移学会学術集会・総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高齢大腸癌患者における栄養・免疫因子と予後との関連2022

    • Author(s)
      長江歩, 三吉 範克, 藤野 志季, 関戸 悠紀, 波多 豪, 荻野 崇之, 高橋 秀和, 植村 守, 土岐 祐一郎, 江口 英利
    • Organizer
      第77回日本大腸肛門病学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] AIによる免疫組織化学染色を用いた腫瘍関連マクロファージと予後予測2022

    • Author(s)
      長江歩,三吉 範克, 藤野 志季, 関戸 悠紀, 波多 豪, 荻野 崇之, 高橋 秀和, 植村 守, 土岐 祐一郎, 江口 英利
    • Organizer
      第77回日本消化器外科学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 若年性大腸癌の臨床病理学的検討2022

    • Author(s)
      米田 直樹, 波多 豪, 山口 敏史, 関戸 悠紀, 荻野 崇之, 高橋 秀和, 三吉 範克, 植村 守, 佐藤 太郎, 山本 浩文, 土岐 祐一郎, 江口 英利 "
    • Organizer
      第122回日本外科学会定期学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Braf変異大腸癌における異常増殖シグナルに対する抑制機構消失のメカニズム2022

    • Author(s)
      植田隆太, 高橋秀和,関戸悠紀,波多豪,浜部敦史,荻野崇之,三吉範克,植村守,江口英利,土岐祐一郎
    • Organizer
      第60回日本癌治療学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大腸癌におけるCCSの発現意義とそのメカニズムの解明2022

    • Author(s)
      瀧口暢生、植村守、関戸悠紀、波多豪、荻野崇之、三吉範克、高橋秀和、山本浩文、土岐祐一郎、江口英利
    • Organizer
      第122回日本外科学会定期学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大腸癌におけるブロモドメイン含有蛋白質BRD9の発現意義の解明2022

    • Author(s)
      知念良直, 波多豪,関戸悠紀,荻野崇之,三吉範克,高橋秀和,植村守,山本浩文,江口英利,土岐祐一郎
    • Organizer
      第31回日本がん転移学会学術集会・総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大腸癌新規遺伝子候補SHANK Associated RH Domain Interactor(SHARPIN)の同定とその臨床的意義2022

    • Author(s)
      中野 祐輔, 橋本 雅弘, 大楽 勝司, 阿部 正, 斉藤 秀幸, 大里 祐樹, 安東 由貴, 中野 貴文, 高橋 純一, 久松 雄一, 戸島 剛男, 米村 祐輔, 植村 守, 江口 英利, 土岐 祐一郎, 三森 功士
    • Organizer
      第122回日本外科学会定期学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Identification of SHARPIN, a novel candidate driver gene of colorectal cancer, and its clinical significance2022

    • Author(s)
      中野 祐輔, 橋本 雅弘, 大楽 勝司, 阿部 正, 斉藤 秀幸, 大里 祐樹, 安東 由貴, 中野 貴文, 高橋 純一, 久松 雄一, 戸島 剛男, 米村 祐輔, 植村 守, 江口 英利, 土岐 祐一郎, 三森 功士
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大腸癌新規遺伝子候補RB Associated KRAB Zinc Finger(RBAK)の同定とその臨床的意義2022

    • Author(s)
      中野祐輔、増田隆明、久松雄一、戸島剛男、米村祐輔、植村守、江口英利、土岐祐一郎、三森功士
    • Organizer
      第31回日本がん転移学会学術集会・総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大腸癌新規ドライバー遺伝子候補BRD3の同定と臨床的意義2022

    • Author(s)
      橋本雅弘、増田隆明、久松雄一、戸島剛男、米村祐輔、植村守、江口英利、土岐祐一郎、森正樹、三森功士
    • Organizer
      第122回日本外科学会定期学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大腸癌における新規ドライバー遺伝子候補BRD3の臨床的意義について2022

    • Author(s)
      橋本雅弘、増田隆明、久松雄一、戸島剛男、米村祐輔、植村守、江口英利、土岐祐一郎、森正樹、三森功士
    • Organizer
      第77回日本消化器外科学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Clinical significance of CYHR1, a novel driver gene candidate for colorectal cancer2022

    • Author(s)
      橋本雅弘、増田隆明、渋田祥平、小野裕也、宮田裕輝、中野祐輔、平木嘉樹、大楽勝司、細田清孝、阿部正、安東由貴、本村有志、久松雄一、戸島剛男、米村祐輔、植村守、江口英利、土岐祐一郎、森正樹、三森功士
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Clinical significance of TNFRSF11A, decreased expression in colorectal cancer2022

    • Author(s)
      橋本雅弘増田隆明、中野祐輔、大楽勝司、阿部正、高橋純一、久松雄一、戸島剛男、米村祐輔、植村守、江口英利、土岐祐一郎、森正樹、三森功士
    • Organizer
      第60回日本癌治療学会学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大腸癌におけるSLC6A1遺伝子の生物学的意義2022

    • Author(s)
      中上勝一朗, 植村守, 関戸 悠紀, 波多 豪, 荻野 崇之, 三吉 範克, 高橋 秀和, 鄭 充善, 賀川 義規, 山本 浩文, 土岐 祐一郎, 江口 英利
    • Organizer
      第122回日本外科学会定期学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大腸がんにおけるTissue resident memory CD8+ T cells(Trm)が全生存期間、無再発生存期間を延長する2020

    • Author(s)
      北風雅敏、今野雅允、浅井歩、藤野志季、荻野崇之、高橋秀和、三吉範克、植村守、水島恒和、土岐祐一郎、江口英利、石井秀始
    • Organizer
      第29回日本がん転移学会学術集会・総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 大腸癌幹細胞関連長鎖非コードRNA LNC01534の機能的役割の解明2020

    • Author(s)
      大塚正久、市原もも子、廣瀬遥、高橋秀和、松田宙、赤松大樹、水島恒和、土岐祐一郎、山本浩文
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] MSS大腸癌や薬剤耐性大腸癌における新たな治療標的としてのHNF1Aの働きの解明2020

    • Author(s)
      藤野志季、三吉範吉、大植雅之、安井昌義、荻野 崇之、高橋秀和、植村 守、松田 宙、水島恒和、森 正樹、土岐祐一郎
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] PLXND1と上皮間葉移行の関わり2020

    • Author(s)
      萩原清貴、原口直紹、藤野志季、荻野崇之、高橋秀和、三吉範克、植村守、松田宙、水島恒和、山本浩文、森正樹、土岐祐一郎
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 大腸癌におけるDPP9遺伝子発現の意義と治療標的としての検討2020

    • Author(s)
      笹生和宏、三吉範克、藤野志季、荻野崇之、高橋秀和、植村守、松田宙、大植雅之、山本浩文、水島恒和、森正樹、土岐祐一郎
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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