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Expression and role of volume-activated anion channels in gastric cancer

Research Project

Project/Area Number 20K09084
Research Category

Grant-in-Aid for Scientific Research (C)

Allocation TypeMulti-year Fund
Section一般
Review Section Basic Section 55020:Digestive surgery-related
Research InstitutionKyoto Prefectural University of Medicine

Principal Investigator

Toma Atsushi  京都府立医科大学, 医学(系)研究科(研究院), 特任講師 (30516191)

Co-Investigator(Kenkyū-buntansha) 大辻 英吾  京都府立医科大学, 医学(系)研究科(研究院), 教授 (20244600)
塩崎 敦  京都府立医科大学, 医学(系)研究科(研究院), 講師 (40568086)
Project Period (FY) 2020-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2022: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Keywords胃癌 / 胃十二指腸外科学 / イオンチャネル / 低浸透圧
Outline of Research at the Start

本研究では、胃癌における容積活性化アニオンチャネル(VAAC)の構成蛋白であるLRRC8A、SLCO2A1の発現機能解析を行うとともに、"癌細胞のVAAC発現を制御すると調節性容積減少が抑制され、低浸透圧細胞破壊が促進される"という実験仮説の検証を行う。その結果から、VAACを分子標的とした低浸透細胞破壊療法という、術中遊離胃癌細胞・腹膜播種性転移に対する斬新な治療概念の構築を目指す。

Outline of Final Research Achievements

The depletion of LRRC8A using siRNA decreased cell proliferation and cellular movement, and promoted the induction of apoptosis in human gastric cancer (GC) cells. The microarray analysis showed the up- or down-regulated expression of genes related to the p53 signaling pathway (JNK, p53, p21, Bcl-2, and FAS) in LRRC8A-knockdown cells. An immunohistochemical analysis revealed a correlation between the expression of LRRC8A and the pT status, and multivariate analysis identifed the strong expression of LRRC8A as an independent prognostic factor for 5-year survival in GC patients. Further, the depletion of SLCO2A1 using siRNA decreased cell proliferation, and promoted the induction of apoptosis in human GC cells. The present results indicate that volume-activated anion channels functions as a mediator of and/or biomarker for GC.

Academic Significance and Societal Importance of the Research Achievements

LRRC8Aが胃癌組織において高発現し、そのRNA干渉が癌細胞に抑制効果を示すことを新たに見出した。LRRC8Aのp53 signaling pathwayを介する新たな腫瘍進展制御機構や、予後因子としての意義を明らかにし、バイオマーカーや治療標的としての可能性を示した。また、SLCO2A1のアポトーシス制御機構を解明し、容積活性化アニオンチャネルを標的とした新規治療への応用が期待される。

Report

(4 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Research-status Report
  • 2020 Research-status Report
  • Research Products

    (53 results)

All 2022 2021 2020

All Journal Article (17 results) (of which Peer Reviewed: 17 results,  Open Access: 7 results) Presentation (36 results) (of which Invited: 1 results)

  • [Journal Article] Functions and Clinical Significance of CACNA2D1 in Gastric Cancer2022

    • Author(s)
      Inoue Hiroyuki、Shiozaki Atsushi、Kosuga Toshiyuki、Shimizu Hiroki、Kudou Michihiro、Ohashi Takuma、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Otsuji Eigo
    • Journal Title

      Annals of Surgical Oncology

      Volume: - Issue: 7 Pages: 4522-4535

    • DOI

      10.1245/s10434-022-11752-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer2022

    • Author(s)
      Fukami Tomoyuki、Shiozaki Atsushi、Kosuga Toshiyuki、Kudou Michihiro、Shimizu Hiroki、Ohashi Takuma、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Morinaga Yukiko、Konishi Eiichi、Otsuji Eigo
    • Journal Title

      World Journal of Gastroenterology

      Volume: 28 Issue: 32 Pages: 4649-4667

    • DOI

      10.3748/wjg.v28.i32.4649

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Absolute lymphocyte count and Creactive proteinalbumin ratio can predict prognosis and adverse events in patients with recurrent esophageal cancer treated with nivolumab therapy2022

    • Author(s)
      Inoue Hiroyuki、Shiozaki Atsushi、Fujiwara Hitoshi、Konishi Hirotaka、Kiuchi Jun、Ohashi Takuma、Shimizu Hiroki、Arita Tomohiro、Yamamoto Yusuke、Morimura Ryo、Kuriu Yoshiaki、Ikoma Hisashi、Kubota Takeshi、Okamoto Kazuma、Otsuji Eigo
    • Journal Title

      Oncology Letters

      Volume: 24 Issue: 2 Pages: 257-257

    • DOI

      10.3892/ol.2022.13377

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NADPH Oxidase 2 Has a Crucial Role in Cell Cycle Progression of Esophageal Squamous Cell Carcinoma2022

    • Author(s)
      Shimizu Hiroki、Katsurahara Keita、Inoue Hiroyuki、Shiozaki Atsushi、Kosuga Toshiyuki、Kudou Michihiro、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Fujiwara Hitoshi、Morinaga Yukiko、Konishi Eiichi、Otsuji Eigo
    • Journal Title

      Annals of Surgical Oncology

      Volume: 29 Issue: 13 Pages: 8677-8687

    • DOI

      10.1245/s10434-022-12384-5

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Value of the Tumor Stroma Ratio and Structural Heterogeneity Measured by a Novel Semi-Automatic Image Analysis Technique for Predicting Survival in Patients with Colon Cancer2022

    • Author(s)
      Inoue Hiroyuki、Kudou Michihiro、Shiozaki Atsushi、Kosuga Toshiyuki、Shimizu Hiroki、Kiuchi Jun、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kuriu Yoshiaki、Morinaga Yukiko、Konishi Eiichi、Otsuji Eigo
    • Journal Title

      Diseases of the Colon & Rectum

      Volume: - Issue: 11 Pages: 1449-1461

    • DOI

      10.1097/dcr.0000000000002570

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TRPV2 Promotes Cell Migration and Invasion in Gastric Cancer via the Transforming Growth Factor-β Signaling Pathway2021

    • Author(s)
      Kato Shunji、Shiozaki Atsushi、Kudou Michihiro、Shimizu Hiroki、Kosuga Toshiyuki、Ohashi Takuma、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Otsuji Eigo
    • Journal Title

      Annals of Surgical Oncology

      Volume: 29 Issue: 5 Pages: 2944-2956

    • DOI

      10.1245/s10434-021-11132-5

    • Related Report
      2022 Annual Research Report 2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] LRRC8A influences the growth of gastric cancer cells via the p53 signaling pathway2021

    • Author(s)
      Kurashima Kento、Shiozaki Atsushi、Kudou Michihiro、Shimizu Hiroki、Arita Tomohiro、Kosuga Toshiyuki、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Otsuji Eigo
    • Journal Title

      Gastric Cancer

      Volume: - Issue: 5 Pages: 1063-1075

    • DOI

      10.1007/s10120-021-01187-4

    • NAID

      40022653221

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] The expression of the alpha1 subunit of Na+/K+-ATPase is related to tumor development and clinical outcomes in gastric cancer2021

    • Author(s)
      Nakamura Kei、Shiozaki Atsushi、Kosuga Toshiyuki、Shimizu Hiroki、Kudou Michihiro、Ohashi Takuma、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Otsuji Eigo
    • Journal Title

      Gastric Cancer

      Volume: 24 Issue: 6 Pages: 1278-1292

    • DOI

      10.1007/s10120-021-01212-6

    • NAID

      40022722074

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Roles of voltage-gated potassium channels in the maintenance of pancreatic cancer stem cells2021

    • Author(s)
      Shiozaki Atsushi、Konishi Tomoki、Kosuga Toshiyuki、Kudou Michihiro、Kurashima Kento、Inoue Hiroyuki、Shoda Katsutoshi、Arita Tomohiro、Konishi Hirotaka、Morimura Ryo、Komatsu Shuhei、Ikoma Hisashi、Toma Atsushi、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Otsuji Eigo
    • Journal Title

      International Journal of Oncology

      Volume: 59 Issue: 4

    • DOI

      10.3892/ijo.2021.5256

    • Related Report
      2021 Research-status Report
    • Peer Reviewed
  • [Journal Article] Expression and Role of CFTR in Human Esophageal Squamous Cell Carcinoma2021

    • Author(s)
      Matsumoto Yoshihisa、Shiozaki Atsushi、Kosuga Toshiyuki、Kudou Michihiro、Shimizu Hiroki、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Otsuji Eigo
    • Journal Title

      Annals of Surgical Oncology

      Volume: - Issue: 11 Pages: 6424-6436

    • DOI

      10.1245/s10434-021-09752-y

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Amlodipine and Verapamil, Voltage-Gated Ca2+ Channel Inhibitors, Suppressed the Growth of Gastric Cancer Stem Cells2021

    • Author(s)
      Shiozaki Atsushi、Katsurahara Keita、Kudou Michihiro、Shimizu Hiroki、Kosuga Toshiyuki、Ito Hiroshi、Arita Tomohiro、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Otsuji Eigo
    • Journal Title

      Annals of Surgical Oncology

      Volume: - Issue: 9 Pages: 5400-5411

    • DOI

      10.1245/s10434-021-09645-0

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Functional Analysis and Clinical Significance of Chloride Channel 2 Expression in Esophageal Squamous Cell Carcinoma2021

    • Author(s)
      Mitsuda Masato、Shiozaki Atsushi、Kudou Michihiro、Shimizu Hiroki、Arita Tomohiro、Kosuga Toshiyuki、Konishi Hirotaka、Komatsu Shuhei、Kubota Takeshi、Fujiwara Hitoshi、Okamoto Kazuma、Kishimoto Mitsuo、Konishi Eiichi、Otsuji Eigo
    • Journal Title

      Annals of Surgical Oncology

      Volume: - Issue: 9 Pages: 5384-5397

    • DOI

      10.1245/s10434-021-09659-8

    • Related Report
      2021 Research-status Report 2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Roles of Ion and Water Channels in the Cell Death and Survival of Upper Gastrointestinal Tract Cancers2021

    • Author(s)
      Shiozaki Atsushi、Marunaka Yoshinori、Otsuji Eigo
    • Journal Title

      Frontiers in Cell and Developmental Biology

      Volume: 9 Pages: 616933-616933

    • DOI

      10.3389/fcell.2021.616933

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ANO9 regulates PD-L2 expression and binding ability to PD-1 in gastric cancer.2021

    • Author(s)
      Katsurahara K, Shiozaki A, Kosuga T, Shimizu H, Kudou M, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Otsuji E.
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 3 Pages: 1026-1037

    • DOI

      10.1111/cas.14796

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] Clinical safety and efficacy of neoadjuvant combination chemotherapy of tranilast in advanced esophageal squamous cell carcinoma: Phase I/II study (TNAC).2020

    • Author(s)
      Shiozaki A, Kudou M, Fujiwara H, Konishi H, Shimizu H, Arita T, Kosuga T, Yamamoto Y, Morimura R, Ikoma H, Kuriu Y, Kubota T, Okamoto K, Otsuji E.
    • Journal Title

      Medicine

      Volume: 99 Issue: 50 Pages: e23633-e23633

    • DOI

      10.1097/md.0000000000023633

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] ANO9 Regulated Cell Cycle in Human Esophageal Squamous Cell Carcinoma.2020

    • Author(s)
      Katsurahara K, Shiozaki A, Kosuga T, Kudou M, Shoda K, Arita T, Konishi H, Komatsu S, Kubota T, Fujiwara H, Okamoto K, Kishimoto M, Konishi E, Marunaka Y, Otsuji E.
    • Journal Title

      Ann Surg Oncol.

      Volume: ー Issue: 9 Pages: 3218-3230

    • DOI

      10.1245/s10434-020-08368-y

    • Related Report
      2020 Research-status Report
    • Peer Reviewed
  • [Journal Article] Clinical significance of the distance between the cricoid cartilage and upper edge of the tumor using PET?CT in cervical esophageal cancer2020

    • Author(s)
      Katsurahara Keita、Shiozaki Atsushi、Fujiwara Hitoshi、Konishi Hirotaka、Kudou Michihiro、Shoda Katsutoshi、Arita Tomohiro、Kosuga Toshiyuki、Morimura Ryo、Murayama Yasutoshi、Kuriu Yoshiaki、Ikoma Hisashi、Kubota Takeshi、Nakanishi Masayoshi、Okamoto Kazuma、Otsuji Eigo
    • Journal Title

      Oncology Letters

      Volume: -

    • DOI

      10.3892/ol.2020.11901

    • Related Report
      2020 Research-status Report
    • Peer Reviewed / Open Access
  • [Presentation] 胃癌におけるAnoctamin 5の機能解析と臨床的意義2022

    • Author(s)
      深見知之 、塩﨑敦 、木内純 、大橋拓馬 、清水浩紀 、有田智洋 、山本有祐 、小西博貴 、森村玲 、栗生宜明 、生駒久視 、窪田健 、藤原斉 、岡本 和真 、大辻英吾
    • Organizer
      第 122 回日本外科学会定期学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 大腸癌幹細胞の低浸透圧ショックへの抵抗性2022

    • Author(s)
      加藤俊治, 塩崎敦, 工藤道弘, 清水浩紀, 小菅敏幸, 木内純, 大橋拓馬, 有田智洋, 山本有祐, 小西博貴, 森村玲, 栗生宜明, 生駒久視, 窪田健, 藤原斉, 岡本和真, 大辻英吾
    • Organizer
      第 122 回日本外科学会定期学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 食道癌術後再発に対するニボルマブ療法の検討2022

    • Author(s)
      井上博之 塩﨑敦 藤原斉 小西博貴 木内純 大橋拓馬 清水浩紀 有田智洋 山本有祐 森村玲 栗生宜明 生駒久視 窪田健 岡本和真 大辻英吾
    • Organizer
      第 122 回日本外科学会定期学術集会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 胃癌におけるSLCO2A1の機能解析2022

    • Author(s)
      中村慶、塩﨑敦、小菅敏幸、清水浩紀、大橋拓馬、小西博貴、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第77回日本消化器外科学会総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Amlodipine, voltage-gated Ca2+ channel inhibitor, suppressed the growth of cancer stem cells in hepatocellular carcinoma2022

    • Author(s)
      Atsushi Shiozaki, Kento Kurashima, Michihiro Kudou, Hiroki Shimizu,Toshiyuki Kosuga, Takuma Ohashi, Tomohiro Arita, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Yoshiaki Kuriu, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Eigo Otsuji
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Tranilast and furosemide suppressed the growth of cancer stem cells in esophageal adenocarcinoma2022

    • Author(s)
      Hiroyuki Inoue, Atsushi Shiozaki, Toshiyuki Kosuga, Hiroki Shimizu, Michihiro Kudou, Takuma Ohashi, Tomohiro Arita, Hirotaka Konishi, Ryo Morimura, Takeshi Kubota, Hitoshi Fujiwara, Eigo Otsuji
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Correlation between TRPV2 and PD-L1 expression in advanced gastric cancer and its clinical significance2022

    • Author(s)
      Tomoyuki Fukami, Atsushi Shiozaki, Jun Kiuchi, Takuma Ohashi, Hiroki Shimizu, Tomohiro Arita, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Yoshiaki Kuriu, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Eigo Otsuji
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] The function analysis and clinical significance of CACNA2D1 in human gastric cancer2022

    • Author(s)
      Naosuke Nakamichi, Atsushi Shiozaki, Hiroyuki Inoue, Toshiyuki Kosuga, Hiroki Shimizu, Michihiro Kudou, Takuma Ohashi, Tomohiro Arita, Yusuke Yamamoto, Hirotaka Konishi, Yoshiaki Kuriu, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Eigo Otsuji
    • Organizer
      第81回日本癌学会学術総会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 食道腺癌幹細胞特異的に発現するイオン輸送体の同定と新規標的治療の開発2022

    • Author(s)
      塩崎敦 井上博之 清水浩紀 木内純 大橋拓馬 有田智洋 山本有祐 小西博貴 森村玲 栗生宜明 生駒久視 窪田健 藤原斉 大辻英吾
    • Organizer
      JDDW2022(第20回消化器外科学会大会)
    • Related Report
      2022 Annual Research Report
  • [Presentation] 消化器癌幹細胞に発現するイオン輸送体の同定と新規標的治療の開発2022

    • Author(s)
      塩崎敦 工藤道弘 清水浩紀 小菅敏幸 大橋拓馬 有田智洋 山本有祐 小西博貴 森村玲 小松周平 栗生宜明 生駒久視 窪田健 藤原斉 大辻英吾
    • Organizer
      第96回日本薬理学会年会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 胃癌におけるNa+/K+-ATPase発現の意義と機能解析について2021

    • Author(s)
      中村慶、塩﨑敦、工藤道弘、清水浩紀、小菅敏幸、久保秀正、木内純、大橋拓馬、有田智洋、山本有祐、小西博貴、森村玲、栗生宜明、生駒久視、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第121回日本外科学会定期学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 胃癌におけるTRPV2の発現と役割2021

    • Author(s)
      加藤俊治、塩﨑敦、工藤道弘、清水浩紀、小菅敏幸、久保秀正、木内純、大橋拓馬、有田智洋、山本有祐、小西博貴、森村玲、栗生宜明、生駒久視、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第121回日本外科学会定期学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 胃癌におけるLeucine-Rich Repeat-Containing protein 8A(LRRC8A)の発現と機能解析2021

    • Author(s)
      倉島研人、塩﨑敦、小菅敏幸、清水浩紀、工藤道弘、久保秀正、木内純、大橋拓馬、有田智洋、山本有祐、小西博貴、森村玲、栗生宜明、生駒久視、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第121回日本外科学会定期学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 食道扁平上皮癌でのCFTR(cystic fibrosis transmembrane conductance regulator)の役割2021

    • Author(s)
      松本順久、塩﨑敦、工藤道弘、清水浩紀、小菅敏幸、久保秀正、木内純、大橋拓馬、有田智洋、山本有祐、小西博貴、森村玲、栗生宜明、生駒久視、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第121回日本外科学会定期学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] TNF-α刺激が食道癌幹細胞の癌幹細胞性と機能に与える影響2021

    • Author(s)
      満田雅人、小菅敏幸、塩﨑敦、清水浩紀、久保秀正、木内純、大橋拓馬、有田智洋、山本有祐、小西博貴、森村玲、栗生宜明、生駒久視、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第121回日本外科学会定期学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 食道癌幹細胞に高発現するイオン輸送体を標的とした新規治療法の開発2021

    • Author(s)
      深見知之、工藤道弘、松本順久、塩﨑敦、久保秀正、木内純、大橋拓馬、清水浩紀、有田智洋、山本有祐、小西博貴、森村玲、栗生宜明、生駒久視、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第121回日本外科学会定期学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] ALDH1A1陽性肝癌幹細胞に対するイオンチャネルブロッカーの治療薬としての可能性について2021

    • Author(s)
      倉島研人、塩﨑敦、清水浩紀、工藤道弘、小菅敏幸、生駒久視、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第76回日本消化器外科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 胃癌におけるTRPV2の役割:TGF-βシグナル経路を介した遊走能と浸潤能の促進2021

    • Author(s)
      加藤俊治、塩﨑敦、工藤道弘、清水浩紀、小菅敏幸、小西博貴、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第76回日本消化器外科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 食道扁平上皮癌とCFTR(cystic fibrosis transmembrane conductance regulator)の関係2021

    • Author(s)
      松本順久、塩﨑敦、清水浩紀、大橋拓馬、小西博貴、窪田健、藤原斉、岡本和真、岸本光夫、大辻英吾
    • Organizer
      第76回日本消化器外科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 食道扁平上皮癌におけるクロライドチャネル2発現の機能解析と臨床的意義2021

    • Author(s)
      満田雅人、塩﨑敦、清水浩紀、有田智洋、小西博貴、小松周平、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第76回日本消化器外科学会総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Gastric cancer stem cells are suppressed by voltage-gated Ca2+ channel inhibitors2021

    • Author(s)
      Atsushi Shiozaki, Keita Katsurahara, Toshiyuki Kosuga, Michihiro Kudou, Hiroki Shimizu, Takuma Ohashi, Tomohiro Arita, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Yoshiaki Kuriu, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] The expression and role of CACNA2D1 in human gastric cancer2021

    • Author(s)
      Hiroyuki Inoue, Atsushi Shiozaki, Toshiyuki Kosuga, Hiroki Shimizu, Michihiro Kudou, Tomohiro Arita, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Yoshiaki Kuriu, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] Colorectal cancer stem cells have resistance to hypotonic shock2021

    • Author(s)
      Shunji Kato, Atsushi Shiozaki, Hiroki Shimizu, Michihiro Kudou, Toshiyuki Kosuga, Tomohiro Arita, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Yoshiaki Kuriu, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Eigo Otsuji
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] ATP1A1 regulates tumor progression and affects postoperative prognosis in human gastric cancer2021

    • Author(s)
      Kei Nakamura, Atsushi Shiozaki, Michihiro Kudou, Hiroki Shimizu, Toshiyuki Kosuga, Tomohiro Arita, Yusuke Yamamoto, Hirotaka Konishi, Ryo Morimura, Yoshiaki Kuriu, Hisashi Ikoma, Takeshi Kubota, Hitoshi Fujiwara, Kazuma Okamoto, Mitsuo Kishimoto, Eigo Otsuji
    • Organizer
      第80回日本癌学会学術総会
    • Related Report
      2021 Research-status Report
  • [Presentation] 膵癌幹細胞における電位依存性カリウムチャネルの発現機能解析2021

    • Author(s)
      塩崎敦 小西智規 小菅敏幸 工藤道弘 清水浩紀 有田智洋 山本有祐 小西博貴 森村玲 栗生宜明 生駒久視 窪田健 藤原斉 岡本和真 大辻英吾
    • Organizer
      第59回日本癌治療学会学術集会
    • Related Report
      2021 Research-status Report
  • [Presentation] 膵癌幹細胞特異的に発現するイオン輸送体の同定と新規標的治療の開発2021

    • Author(s)
      塩崎敦 小西智規 清水浩紀 久保秀正 木内純 大橋拓馬 有田智洋 山本有祐 小西博貴 森村玲 栗生宜明 生駒久視 窪田健 藤 原斉 岡本和真 大辻英吾
    • Organizer
      JDDW2021(第19回消化器外科学会大会)
    • Related Report
      2021 Research-status Report
  • [Presentation] 4-aminopyridineは膵癌幹細胞増殖抑制に関与する2020

    • Author(s)
      小西智規、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾.
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 食道扁平上皮癌におけるCFTR(cystic fibrosis transmembrane conductance regulator)の発現の意義2020

    • Author(s)
      松本順久、塩﨑敦、工藤道弘、小菅敏幸、庄田勝俊、有田智洋、小西智規、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾.
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 食道癌におけるTRPV2発現の意義2020

    • Author(s)
      加藤俊治、工藤道弘、塩﨑敦、小菅敏幸、山里有三、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾.
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 食道扁平上皮癌におけるTumor stroma ratioと,そのheterogeneityの臨床的意義2020

    • Author(s)
      倉島研人、工藤道弘、塩﨑敦、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 食道癌幹細胞におけるイオン輸送体の発現と意義2020

    • Author(s)
      深見知之、工藤道弘、松本順久、塩﨑敦、小菅敏幸、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、大辻英吾.
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 食道扁平上皮癌におけるCLCN2の発現と意義2020

    • Author(s)
      満田雅人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾.
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 食道癌におけるANO9の発現と機能解析2020

    • Author(s)
      井上博之、塩﨑敦、小菅敏幸、工藤道弘、葛原啓太、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 食道扁平上皮癌におけるNa+/K+-ATPase発現の意義と機能解析について2020

    • Author(s)
      中村慶、塩﨑敦、工藤道弘、小菅敏幸、小林利行、庄田勝俊、有田智洋、小西博貴、森村玲、村山康利、栗生宜明、生駒久視、窪田健、中西正芳、藤原斉、岡本和真、岸本光夫、大辻英吾
    • Organizer
      第120回日本外科学会定期学術集会
    • Related Report
      2020 Research-status Report
  • [Presentation] 胃癌におけるLeucine-Rich Repeat-Containing protein 8A (LRRC8A)の発現とその意義2020

    • Author(s)
      倉島研人、塩﨑敦、小菅敏幸、清水浩紀、工藤道弘、有田智洋、山本有祐、小西博貴、森村玲、栗生宜明、生駒久視、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第79回日本癌学会学術総会
    • Related Report
      2020 Research-status Report
  • [Presentation] 胃癌におけるLeucine-Rich Repeat-Containing protein 8A (LRRC8A)の機能と臨床的意義について2020

    • Author(s)
      倉島研人、塩﨑敦、小菅敏幸、工藤道弘、庄田勝俊、小西博貴、窪田健、藤原斉、岡本和真、大辻英吾
    • Organizer
      第75回日本消化器外科学会総会
    • Related Report
      2020 Research-status Report

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Published: 2020-04-28   Modified: 2024-01-30  

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